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Microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with different prestrain levels

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Journal of Materials Science & Technology 2024年第4期171卷 80-93页

作者： Y.H.zhang H.Li Z.W.Yang x.Liu Q.f.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of High-Performance Precision forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory alloy(SMA)is a promising material in the aerospace field due to its wide transformation *** application of shape memory effect depends on multistep thermomechan-ical loading,viz.,low-temperature deformation and subsequent heating to ***-temperature deformation prestrain plays a pivotal role in shape memory properties tailoring of SMA ***,microstructure evolution and deformation mechanisms of Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate that the stress-strain curve of the specimen exhibits four distinct stages at a maximal prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced martensitic transformation is accompanied by the dislocation slip of the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density of dislocations and further growth of stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of the(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and heating,a higher density of{114}austenite twins form in the specimen with a larger prestrain of 16%.With increasing prestrain from 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and then ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the formation of new SIMVs,the further growth of existing SIMVs,and the recoverable(001)compound *** the decrease ofε_(re)^(T)is mainly associated with the irrecoverable strain by{20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory alloy Wide transformation hysteresis Thermomechanical loading Microstructure evolution Shape memory behaviors Stress-induced martensitic transformation Deformation twinning

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Precipitation of multi-type nano-quasicrystals in a Mg-Zn-Y alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 997-1008页

作者： W.Z.Wang x.Z.Zhou L.f.zhang H.Q.Ye Z.Q.Yang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji Hua Laboratory Foshan 528251China foshan University Foshan 528231China

Mg-6Zn-1Y(at.%)ribbons with strengthening precipitates of multi-type nanoquasicrystals were prepared by melt-spinning followed by aging *** evolution of the rapidly solidified ribbons during isothermal aging was comprehensively studied using various electron microscopy *** new kinds of decagonal quasicrystals were formed in aged ribbons,in addition to precipitation of nanometer icosahedral ***-resolution observations reveal that both decagonal quasicrystals can be modeled by quasiperiodic tiling with decagonal clusters of 2.5 nm in diameter,but overlap of neighboring clusters in both decagonal quasicrystals is different from the Gummelt model observed in other quasicrystals.A shell composed of complex Laves Mg-Zn domains was formed surrounding each decagonal quasicrystal precipitate upon prolonged *** addition,all kinds of nanoprecipitates exhibit excellent structure and size stability at 573 *** findings may have implications for not only fundamental studies about quasicrystals,but also microstructural manipulation of high-performance Mg alloys.

关键词： Quasicrystal Mg alloys Rapid solidification Scanning-transmission electron microscopy.

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In situ digital testing method for quality assessment of soft soil improvement with polyurethane

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1732-1748页

作者： x.f.Wang C.J.Wang W.V.Yue Z.J.zhang Z.Q.Yue Department of Civil Engineering China University of Geosciences (Beijing)BeijingChina Department of Water Science and Engineering Zhengzhou UniversityZhengzhouChina Department of Geotechnical Engineering Tongji UniversityShanghaiChina Department of Civil Engineering The University of Hong KongChina

This study purposes an in situ testing method on quality assessment of soil *** drilling data includes the spatial distribution and in situ strength of untreated and treated soil along three different drillholes measured by on-site drilling monitoring *** factual drilling data can characterize the degree of soil improvement by penetration injection with permeable *** from on-site drilling monitoring shows that the linear zones represent constant drilling speeds shown in the plot of drill bit advancement *** drilling time,which indicates the spatial distributions of soil *** soil profile at the study site is composed of four layers,which includes fill,untreated silty clay,treated silty clay,and mucky *** results of soil profile are verified by the parallel site *** constant drilling speeds profile the coring-resistant strength of drilled *** comparing with the untreated silty clay,the constant drilling speeds of the treated silty clay have been decreased by 13.0-62.8%.Two drilling-speed-based indices of 61.2%and 65.6%are proposed to assess the decreased average drilling speed and the increased in situ strength of treated silty *** tests,*** compressive strength(UCS)test,have been performed with core sample to investigate and characterize in situ strength by comparing that with drilling *** show that the average predicted strengths of treated silty clay are 2.4-6.9 times higher than the average measured strength of untreated silty *** UCS-based indices of 374.5%and 344.2%verified the quality assessment(QA)results by this new in situ *** method provides a cost-effective tool for quality assessment of soil improvement by utilizing the digital drilling data.

关键词： Drilling process monitoring system Hydraulic rotary drilling process Constant drilling speed Soil improvement Quality assessment

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Electron kinetic effects in back-stimulated Raman scattering bursts driven by broadband laser pulses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.Liu L.Deng Q.Wang x.zhang f.Q.Meng Y.P.Wang Y.Q.Gao H.B.Cai S.P.Zhu Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Shanghai Institute of Laser Plasma Shanghai 201800China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China School of Physics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BSRS)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity *** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the spectrum is *** asymmetry is amplified and transferred to electron phase space by high-intensity broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly influence the BSRS evolution driven by broadband lasers.

关键词： scattering kinetic simplified

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Thermo-kinetic characteristics on stabilizing hetero-phase interface of metal matrix composites by crystal plasticity finite element method

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Journal of Materials Science & Technology 2024年第2期169卷 53-67页

作者： Y.B.zhang S.J.Song f.Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China

Using dislocation-based constitutive modeling in three-dimension crystal plasticity finite element(3D CPfE)simulations,co-deformation and instability of hetero-phase interface in different material systems were herein studied for polycrystalline metal matrix composites(MMCs).Local stress and strain fields in two types of 3layer MMCs such as fcc/fcc Cu-Ag and fcc/bcc Cu-Nb have been predicted under simple compressive ***,more severe strain-induced interface instability can be observed in the fcc/bcc systems than in the fcc/fcc systems upon refining to metallic nanolayered composites(MNCs).By detailed analysis of stress and strain localization,it has been demonstrated that the interface instability is always accompanied by high-stress concentration,i.e.,thermodynamic characteristics,or high strain prevention i.e.,kinetic characteristics,at the hetero-phase *** then follows that the thermodynamic driving forceG and the kinetic energy barrier Q during dislocation and shear banding can be adopted to classify the deformation modes,following the so-called thermo-kinetic *** by inserting a high density of high-energy interfaces into the Cu-Nb composites,such thermo-kinetic integration at the hetero-phase interface allows a successful establishment of MMCs with the high△G-high Q deformation mode,which ensures high hardening and uniform strain distri-bution,thus efficiently suppressing the shear band,stabilizing the hetero-phase interface,and obtaining an exceptional combination in strength and *** hetero-phase interface chosen by a couple of thermodynamics and kinetics can be defined as breaking the thermo-kinetic correlation and has been proposed for artificially designing MNCs.

关键词： Thermodynamics and kinetics Physics-based constitutive modeling Hetero-phase interface Crystal plasticity finite element

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Ka-band thin film lithium niobate photonic integrated optoelectronic oscillator

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Photonics Research 2024年第6期12卷 1283-1293页

作者： RUI MA ZIJUN HUANG SHENGQIAN GAO JINGYI WANG xICHEN WANG xIAN zhang PENG HAO x.STEVE YAO xINLUN CAI State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Photonics Information Innovation Center and Hebei Provincial Center for Optical Sensing College of Physics Science and TechnologyHebei UniversityBaoding 071002China NuVison Photonics Inc.Las VegasNevada 89109USA

Photonics integration of an optoelectronic oscillator(OEO)on a chip is attractive for fabricating low cost,compact,low power consumption,and highly reliable microwave sources,which has been demonstrated recently in silicon on insulator(SOI)and indium phosphide(InP)platforms at x-band around 8 *** we demonstrate the first integration of OEOs on the thin film lithium niobate(TfLN)platform,which has the advantages of lower Vπ,no chirp,wider frequency range,and less sensitivity to *** have successfully realized two different OEOs operating at Ka-band,with phase noises even lower than those of the x-band OEOs on SOI and InP *** is a fixed frequency OEO at 30 GHz realized by integrating a Mach–Zehnder modulator(MZM)with an add-drop microring resonator(MRR),and the other is a tunable frequency OEO at 20–35 GHz realized by integrating a phase modulator(PM)with a notch *** work marks the first step of using TfLN to fabricate integrated OEOs with high frequency,small size,low cost,wide range tunability,and potentially low phase noise.

关键词： optoelectronic modulator resonator

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The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite

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天文和天体物理学研究:英文版 2023年第9期23卷 66-78页

作者： Z.x.Ling x.J.Sun C.zhang S.L.Sun G.Jin S.N.zhang x.f.zhang J.B.Chang f.S.Chen Y.f.Chen Z.W.Cheng W.fu Y.x.Han H.Li J.f.Li Y.Li Z.D.Li P.R.Liu Y.H.Lv x.H.Ma Y.J.Tang C.B.Wang R.J.xie Y.L.xue A.L.Yan Q.zhang C.Y.Bao H.B.Cai H.Q.Cheng C.Z.Cui Y.f.Dai D.W.fan H.B.Hu J.W.Hu M.H.Huang Z.Q.Jia C.C.Jin D.Y.Li J.Q.Li H.Y.Liu M.J.Liu Y.Liu H.W.Pan Y.L.Qiu M.Sugizaki H.Sun W.x.Wang Y.L.Wang Q.Y.Wu x.P.xu Y.f.xu H.N.Yang x.Yang B.zhang M.zhang W.D.zhang Z.zhang D.H.Zhao x.Q.Cong B.W.Jiang L.H.Li x.B.Qiu J.N.Sun D.T.Su J.Wang C.Wu Z.xu x.M.Yang S.K.zhang Z.zhang N.zhang Y.f.Zhu H.Y.Ban x.Z.Bi Z.M.Cai W.Chen x.Chen Y.H.Chen Y.Cui x.L.Duan Z.G feng Y.Gao J.W.He T.He J.J.Huang f.Li J.S.Li T.J.Li T.T.Li H.Q.Liu L.Liu R.Liu S.Liu N.Meng Q.Shi A.T.Sun Y.M.Wang Y.B.Wang H.C.Wu D.x xu Y.Q Yang Y.Yang x.S.Yu K.x.zhang Y.L.zhang Y.H.zhang Y.T.zhang H.Zhou x.C.Zhu J.S.Cheng L.Qin L.Wang Q.L.Wang M.Bai R.L.Gao Z.Ji Y.R.Liu f.L.Ma Y.J.Shi J.Su Y.Y.Tan J.Z.Tong H.T.xu C.B.xue G.f.xue W.Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China North Night Vision Technology Co. LTDNanjing 211106China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Science and Technology on Low-Light-Level Night Vision Laboratory Xi'an 710065China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201204China Institute of Electrical Engineering Chinese Academy of ScienceBeijing 100190China National Space Science Center Chinese Academy of ScienceBeijing 100190China

The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field x-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July *** this paper,we introduce the design and on-ground test results of the LEIA *** stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the x-ray imager is *** optical assembly composed of 36 MPO chips is used to focus incident x-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane *** instrument has an angular resolution of 4’-8’(in terms of fWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of *** detection passband is 0.5-4 keV in soft x-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s *** total weight of LEIA is 56 kg and the power is 85 *** satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 *** is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for x-ray observation,and by optimizing the working setups of the instrumental *** addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft x-ray band,albeit with limited useful observing time available.

关键词： instrumentation detectors-space vehicles instruments-telescopes-x-rays genera

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Asymmetric reversible structural switching of a diene coordination polymer promoted by UV-visible light

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Science China Chemistry 2024年第2期67卷 536-541页

作者： Yong Wang Qiaoqiao zhang Yong-Yong Cao Qi Liu Brendan f.Abrahams Jian-Ping Lang College of Chemistry Chemical Engineering and MaterialsSoochow UniversitySuzhou215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing314001China School of Chemistry University of MelbourneVictoria3010Australia

In natural and artificial systems,reversible reactions are commonly asymmetric with respect to the time scale and nature of the stimuli which drive the forward and backward *** applications for which switching behavior is required,it is desirable that the reversible reaction goes as close to symmetric as possible;however,such systems are ***,we report an example of ultraviolet(UV)-visible light-regulated asymmetric reversible structural switching involving a diene-based coordination polymer,CP1 and its monocyclobutane product,*** is possible to cycle at least ten times through a forward [2+2] photocycloaddition reaction and the reverse,photocleavage reaction.A single cycle can be completed within a few *** transformation is accompanied by fast and distinct fluorescence changes,arising from optimisation of the reaction *** functional theory calculations allow rationalisation of the asymmetric reversible transformation between CP1 and CP1a rather than between CP1 and its dicyclobutane product *** work provides a clear illustration of reversible structural switching which approaches symmetric behaviour with respect to reaction rate and *** insights gained from this work also assist in the design of fast,reversible switching materials.

关键词： asymmetrical reversible structural switching coordination polymer photocycloaddition UV-visible light-controlled fluorescence switching

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STCf conceptual design report (Volume 1): Physics & detector

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frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov x.C.Ai L.P.An R.Aliberti Q.An x.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu f.M.Cai H.Cai J.J.Cao Q.H.Cao x.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.x.Chen J.f.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen x.Chen x.f.Chen x.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai x.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.fan S.S.fang Z.J.fang G.fedotovich C.Q.feng x.feng Y.T.feng J.L.fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo f.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han x.Q.Hao J.B.He S.Q.He x.G.He Y.L.He Z.B.He Z.x.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu x.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang x.T.Huang x.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing x.L.Kang x.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li f.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li x.Li x.H.Li x.Q.Li x.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.x.Lin D.x.Lin x.S.Lin B.J.Liu C.W.Liu D.Liu f.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu x.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.x.Lu N.Lu Q.f.Lü Y.Lu Y.Lu Z.Lu P.Lukin f.J.Luo T.Luo x.f.Luo Y.H.Luo H.J.Lyu x.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma f.Maas S.Malde D.Matvienko Z.x.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova x.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng x.Y.Peng x.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.f.Qiao J.J.Qin J.J.Qin L.Q.Qin x.S.Qin T.L.Qiu J.Rademacker C.f.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique fédérale de Lausanne(EPfL) LausanneSwitzerland fudan University Shanghai 200433China Goethe University frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCf)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCf will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCf project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCf,describes conceptual designs of the STCf detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCf detector conceptual design

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fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement:insights into COvID-19 pathogenesis

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Journal of Genetics and Genomics 2024年第6期51卷 608-616页

作者： Han Du Zhongtao Du Liang Wang Hong Wang Mingjun Jia Chunge zhang Yun Liu Cheng zhang Ya zhang Ruifeng zhang Shuang zhang Ning zhang Zhenghai Ma Chen Chen Wenjun Liu Hui Zeng George f.Gao xiaotong Hou Yuhai Bi College of Life Science and Technology Xinjiang UniversityUrumchiXinjiang 830046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China College of Veterinary Medicine Shanxi Agricultural UniversityTaiyuanShanxi 030031China University of Chinese Academy of Sciences Beijing 100049China Beijing Shijitan Hospital Capital Medical UniversityBeijing 100038China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection often leads to pulmonary *** sequelae,including myocarditis and heart failure,have also been ***,the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarkable elevation of cardiac biomarkers without significant pulmonary injury,as determined by imaging *** staining reveals the viral antigen within cardiomyocytes,indicating that SARSCoV-2 could directly infect the *** full viral genomes from respiratory,anal,and myocardial specimens are obtained via next-generation *** analyses of the whole genome and spike gene indicate that viruses in the myocardium/pericardial effusion and anal swabs are closely related and cluster together yet diverge from those in the respiratory *** addition,unique mutations are found in the anal/myocardial strains compared to the respiratory strains,suggesting tissue-specific virus mutation and *** findings indicate genetically distinct SARS-CoV-2 variants have infiltrated and disseminated within myocardial tissues,independent of pulmonary injury,and point to different infection routes between the myocardium and respiratory tract,with myocardial infections potentially arising from intestinal *** findings highlight the potential for systemic SARS-CoV-2 infection and the importance of a thorough multi-organ assessment in patients for a comprehensive understanding of thepathogenesisof COVID-19.

关键词： COVID-19 SARS-CoV-2 fulminant myocarditis Myocardium Infection

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