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Optimizing surface-engineered ultra-small gold nanoparticles for highly efficient miRNA delivery to enhance osteogenic differentiation of bone mesenchymal stromal cells

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Nano Research 2017年第1期10卷 49-63页

作者： Meng Yu Bo Lei Chuanbo Gao Jin Yan Peter x. ma Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an 710054 China State Key Laboratory for manufacturing Systems Engineering Xi'an Jiaotong University Xi'an 710054 China State Key Laboratory for Mechanical Behavior of materials Xi'an Jiootong University Xi'an 710054 China Department of Biomedical Engineering University of Michigan Ann Arbor M148109-2009 USA macromolecular Science and Engineering Center University of Michigan Ann Arbor M148109-1055 USA Department of materials Science and Engineering University of Michigan Ann Arbor M148109-1078 USA

Regulation of osteogenic differentiation of bone mesenchymal stromal cells （BMSCs） plays a critical role in bone regeneration. As small non-coding RNAs, microRNAs （miRNAs） play an important role in stem cell differentiation through regulating target-mRNA ex.ression. Unfortunately, highly efficient and safe delivery of miRNAs to BMSCs to regulate their osteogenic differentiation remains challenging. Conventional inorganic nanocrystals have shown increased tox.city owing to their larger size precluding renal clearance. Here, we developed novel, surface-engineered, ultra-small gold nanoparticles （USAuNPs, 〈10 nm） for use as highly efficient miR-5106-delivery systems to enable regulation of BMSC differentiation. We ex.loited the effects of AuNPs coated layer-by-layer with polyethylenimine （PEI） and liposomes （Lipo） to enhance miR-5106-delivery activity and subsequent BMSC differentiation capacity. The PEI- and Lipo-coated AuNPs （Au@PEI@Lipo） showed negligible cytotox.city, good miRNA-5106-binding affinity, highly efficient delivery of miRNAs to BMSCs, and long-term miRNA ex.ression （21 days）. Additionally, compared with commercial Lipofectamine 3000 and 25 kD PEI, the optimized Au@PEI@Lipo-miR-5106 nanocomplex.s significantly enhanced BMSC differentiation into osteoblast-like cells through activation of the Sox. transcription factor. Our findings reveal a promising strategy for the rational design of ultra-small inorganic nanoparticles as highly efficient miRNA-delivery platforms for tissue regeneration and disease therapy.

关键词： ultra-small goldnanoparticles surface engineering microRNA (miRNA)delivery bone mesenchymalstromal cells osteogenic differentiation

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First-Principles Study of the Influence of Lattice Misfit on the Behavior and the Ductility Effect of Hafnium in Ni-Ni3AI System

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Acta Metallurgica Sinica(English Letters) 2014年第1期27卷 87-94页

作者： Y. Wu J. Guo W. Zhang x. ma Q. Zhang J. Hou R. Huang x. Liu Institute of Molecular Engineering and Applied Chemistry Anhui University of Technology Ma'anshan 243002 China Shenyang National Laboratory for materials Science Instituteof Metal Research Chinese Academy of SciencesShenyang 110016 China College of Physics Science and Technology Shenyang NormalUniversity Huanghe Street 253 Shengyang 110034 China School of materials Science and Engineering Anhui Universityof Technology Ma'anshan 243002 China

Two Ni/Ni3Al-interface-contained cluster models with/without lattice misfit are studied by first-principles method to clarify the debates about the segregation behaviors of Hafnium （Hf） and ex.lore the influence of lattice misfit on the ductility effect of Hr. It is found that though Hf prefers to substitute A1 rather than Ni in Ni3A1 phase within most of the investigated misfit range, its stronger preferring to Ni phase than NiaA1 phase makes it impossible to go into Ni3A1 phase to occupy A1 site in Ni-Ni3A1 alloys. Bond order analysis in Hf-free case shows that lattice misfit has different effects on the Griffith work of interfacial cleavage 27int/E and the max.mum theoretical shear stress Zmax.of Ni and Ni3A1, contributing to the ex.stence of anomalous strength-temperature phenomena in NiaA1 alloys. However, the addition of Hf will make the 27int/E （or Zmax. of both Ni3A1 and Ni decrease （or increase） with lattice misfit, indicating that the addition of Hf may make the anomalous strength-temperature relationship in Ni3A1 region disappear locally.

关键词： Hafnium Lattice misfit Segregation Ductility

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Endometrial Carcinogenesis and Molecular Signaling Pathways

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American Journal of Molecular Biology 2014年第3期4卷 134-149页

作者： x.anyong ma Charles x. ma Jianghui Wang The Department of Pathology Yale University School of Medicine New Haven USA University of Connecticut School of Medicine Farmington USA

The Endometrial Cancer (EC) is the most common gynecologic malignancy that starts in the endometrium of women. Carcinogenesis of EC is associated with several critical regulatory molecules, which involve in different signaling pathways. A number of signaling pathways have been identified to be involved in the multiple-step development of EC, including PI3K/AKT/mTOR signaling pathway, WNT/β-catenin signal transduction cascades (including APC/β-catenin pathway), maPK/ERK pathway, VEGF/VEGFR ligand receptor signaling pathway, ErbB signaling pathway, P53/P21 and P16INK4a/pRB signaling pathways. This review mainly focuses on the molecular signaling pathways relevant to human endometrial cancer and discusses those critical capabilities of transforming endometrial cells, including evading apoptosis;enhancing cell proliferation;blocking differentiation;and inducing angiogenesis.

关键词： Signaling Pathway Endometrial Cancer (EC) Carcinogenesis

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陆架的自然电场及其与地质作用的关系

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海洋地质 1993年第1期9卷 48-56页

作者： x.,ma 王勋弟

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In situ TEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr alloy

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Journal of magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.Lv H.L.Ge Q.Q.Jin x.H.Shao Y.T.Zhou B.Zhang x.L.ma Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approx.mately 64% higher than that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mechanical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation Hardening Precipitates In-situ TEM

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Ka-band thin film lithium niobate photonic integrated optoelectronic oscillator

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Photonics Research 2024年第6期12卷 1283-1293页

作者： RUI ma ZIJUN HUANG SHENGQIAN GAO JINGYI WANG x.CHEN WANG x.AN ZHANG PENG HAO x.STEVE YAO x.NLUN CAI State Key Laboratory of Optoelectronic materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Photonics Information Innovation Center and Hebei Provincial Center for Optical Sensing College of Physics Science and TechnologyHebei UniversityBaoding 071002China NuVison Photonics Inc.Las VegasNevada 89109USA

Photonics integration of an optoelectronic oscillator(OEO)on a chip is attractive for fabricating low cost,compact,low power consumption,and highly reliable microwave sources,which has been demonstrated recently in silicon on insulator(SOI)and indium phosphide(InP)platforms at x.band around 8 *** we demonstrate the first integration of OEOs on the thin film lithium niobate(TFLN)platform,which has the advantages of lower Vπ,no chirp,wider frequency range,and less sensitivity to *** have successfully realized two different OEOs operating at Ka-band,with phase noises even lower than those of the x.band OEOs on SOI and InP *** is a fix.d frequency OEO at 30 GHz realized by integrating a mach–Zehnder modulator(MZM)with an add-drop microring resonator(MRR),and the other is a tunable frequency OEO at 20–35 GHz realized by integrating a phase modulator(PM)with a notch *** work marks the first step of using TFLN to fabricate integrated OEOs with high frequency,small size,low cost,wide range tunability,and potentially low phase noise.

关键词： optoelectronic modulator resonator

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Measurement of the integrated Luminosities of cross-section scan data samples around theψ(3770)mass region

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Chinese Physics C 2018年第6期42卷 1-8页

作者： M. Ablikim M. N. Achasov S. Ahmed M. Albrecht M. Alekseev A. Amoroso F. F. An Q. An Y. Bai O. Bakina R. Baldini Ferroli Y. Ban K. Begzsuren D. W. Bennett J. V. Bennett N. Berger M. Bertani D. Bettoni F. Bianchi E. Boger I. Boyko R. A. Briere H. Cai x. Cai O. Cakir A. Calcaterra G. F. Cao S. A. Cetin J. Chai J. F. Chang W. L. Chang G. Chelkov G. Chen H. S. Chen J. C. Chen M. L. Chen P. L. Chen S. J. Chen x. R. Chen Y. B. Chen x. K. Chu G. Cibinetto F. Cossio H. a. Dai, J. F. Dai A. Dbeyssi D. Dedovich Z. Y. Deng A. Denig I. Denysenko M. Destefanis F. De Mori Y. Ding C. Dong J. Dong L. Y. Dong M. Y. Dong Z. L. Dou S. x. Du P. F. nuan J. Fang S. S. Fang Y. Fang R. Farinelli L. Fava S. Fegan F. Feldbauer G. Felici C. Q. Feng E. Fioravanti M. Fritsch C. D. Fu Q. Gao x. L. Gao Y. Gao, Y. G. Gao Z. Gao B. Garillon I. Garzia A. Gilman K. Goetzen L. Gong W. x. Gong W. Gradl M. Greco L. M. Gu M. H. Gu Y. T. Gu A. q. Guo L. B. Guo R. P. Guo Y. F. Guo A. Guskov Z. Haddadi S. Han x. Q. Hao F. A. Harris Z. L. He x. O. He F. H. Heinsius T. Held Y. K. Heng T. Holtmann Z. L. Hou H. M. Hu J. F. gu T. Hu Y. Hu G. S. Huang J. S. Huang x. T. Huang x. Z. Huang Z. L. guang T. Hussain W. Ikegami Andersson M Irshad Q. Ji Q. P. Ji x. B. Ji x. L. Ji x. S. Jiang x. Y. Jiang J. B. Jiao Z. Jiao D. P. Jin S. Jin Y. Jin T. Johansson A. Julin N. Kalantar-Nayestanaki x. S. Kang M. Kavatsyuk B. C. Ke T. Khan A. Khoukaz P. Kiese R. Kliemt L. Koch O. B. Kolcu B. Kopf M. Kornicer M. Kuemmel M. Kuessner A. Kupsc M. Kurth W. Kiihn J. S. Lange M. Lara P. Larin L. Lavezzi S. Leiber H. Leithofi C. Li Cheng Li D. M. Li F. Li F. Y. Li G. Li H. B. Li H. J. Li J. C. Li J. W. Li K. J. Li Kang Li Ke Li Lei Li P. L. Li P. R. Li Q. Y. Li T. Li W. D. Li W. G. Li x. L. Li x. N. Li x. Q. Li Z. B. Li H. Liang Y. F. Liang Y. T. Liang G. R. Liao L. Z. Liao J. Libby C. x. Lin D. x. Lin S. Liu B. J. Liu C. x. Liu D. Liu D. Y. Liu F. H. Liu Fang Liu Feng Liu H. B. Liu H. L Liu H. M. Liu Huanhuan Liu Huihui Liu J. B. Liu J. Y. Liu K. Liu K. Y. Liu Ke Liu L. D. Liu Q. Liu S B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China Beihang University Beijing 100191 China Beijing Institute of Petrochemical Technology Beijing 102617 China Bochum Ruhr-University D-44780 Bochum Germany Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Central China Normal University Wuhan 430079 China China Center of Advanced Science and Technology Beijing 100190 China COMSATS Institute of Information Technology Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. Budker Institute of Nuclear Physics SB RAS （BINP） Novosibirsk 630090 Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 Darmstadt Germany Guangx. Normal University Guilin 541004 China Guangx. University Nanning 530004 China Hangzhou Normal University Hangzhou 310036 China Helmholtz Institute mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal University Xinxiang 453007 China Henan University of Science and Technology Luoyang 471003 China Huangshan College Huangshan 245000 China Hunan Normal University Changsha 410081 China Hunan University Changsha 410082 China Indian Institute of Tec

To investigate the nature of the Ψ（3770） resonance and to measure the cross section for e^＋e^-→DD, a cross-section scan data sample, distributed among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the BESIII detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data sample at each center-of-mass energy point. The total integrated luminosity of the data sample is 76.16±0.04±0.61 pb^-1, where the first uncertainty is statistical and the second systematic.

关键词： Bhabha scattering events integrated luminosity BESⅢ

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Elasticity meets topology

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National Science Review 2024年第6期11卷 84-85页

作者： Guancong ma Department of Physics Hong Kong Baptist University

We are surrounded by environments and items that are made from solid materials in our daily life. Any physical contact with any items is a mechanical disturbance that produces mechanical *** underlines the crucial role that such vibrations play in our daily interactions,highlighting the need for a deeper understanding and improved manipulation of these fundamental phenomena.

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Uniform decomposition of velocity gradient tensor

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Journal of Hydrodynamics 2024年第1期36卷 24-34页

作者： Chenx. ma Chaoqun Liu Department of mathematics University of Texas at ArlingtonArlingtonTXUSA

In this paper,the principal decomposition of the velocity gradient tensor[∇v]is discussed in 3 cases based on the discriminant∆:∆0 with 3 distinct real eigen values,and∆=0 with 1 or 2 distinct real eigen *** velocity ... 详细信息

In this paper,the principal decomposition of the velocity gradient tensor[∇v]is discussed in 3 cases based on the discriminant∆:∆x.eigen values,∆>0 with 3 distinct real eigen values,and∆=0 with 1 or 2 distinct real eigen *** velocity gradient tensor can also be classified as rotation point,which can be decomposed into three parts,i.e.,rotation[R],shear[S]and stretching/compression[SC],and non-rotation point,we defined a new resistance term[L],and the tensor can be decomposed into three parts,i.e.,resistance[L],shear[S]and stretching/compression[SC].Ex.mple matric are also displayed to demonstrate the new *** of principal decomposition between 3 different cases,and between Resistance and Liutex.will also be discussed.

关键词： Velocity gradient Liutex resistance fluid kinematics

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VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma Lin Li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,ox.gen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and ex.raction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Ex.osure risk Secondary pollution

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