检索结果-南通市图书馆

Low-power soft transistors triggering revolutionary electronics

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第3期5卷 21-22页

作者： z.yang liu Yaoshen z.ao z.igang Yin State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqing 400044China

Transistors have been reshaping our lives since their initial appearance in the *** the central element of logic gates and integrated circuits(chips),they undoubtedly play an incomparable role in promoting the development of computers,smartphones,flat panel displays,Internet of Things,and even all electronic or electrical *** past decades have witnessed dominant transistors usually made from inorganic semiconductors such as silicon materials and metal ox.des,which are advantageous to achieve high mobility,fast switching speed,and ex.ellent ***,silicon transistors and metal ox.de semiconductor field-effect transistors have been broadly used for electronic ***,these transistors are rigid and nearly approaching the fundamental limits on speed and power consumption,despite being manufactured at a much smaller scale to meet the projection of Moore’s *** future transistors with mechanical flex.bility/robustness and low-power consumption are demanded,innovation in functional materials,device configurations,and integrated processing techniques to facilitate the evolution from rigid devices to soft,durable,and biocompatible devices is imperative.

关键词： approaching evolutionary doubt

Rehmanniae Radix.Praeparata aqueous ex.ract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第9期22卷 769-784页

作者： z.ANG Yinhao JIA Kex.n LI Yufei MA z.i FAN Guifang LUO Ranyi LI Yajing YANG Yang LI Fanghong liu Runping liu Jia LI x.aojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Available online 20 Sep.2024

Hepatic ischemia/reperfusion injury(HIRI)is a common pathophysiological condition occurring during or after liver resection and transplantation,leading to hepatic viability impairment and functional ***,ferroptosis,a newly recogniz.d form of programmed cell death,has been implicated in *** Radix.Praeparata(RRP),ex.ensively used in Chinese herbal medicine for its hepatoprotective,anti-inflammatory,and antiox.dant properties,presents a potential therapeutic ***,the mechanisms by which RRP mitigates HIRI,particularly through the regulation of ferroptosis,remain *** this study,we developed a HIRI mouse model and monocrotaline(MCT)-and erastin-induced in vitro hepatocyte injury *** conducted whole-genome transcriptome analysis to elucidate the protective effects and mechanisms of RRP on *** RRP aqueous ex.ract was characteriz.d by the presence of acteoside,rehmannioside D,and *** results demonstrate that the RRP aqueous ex.ract ameliorated ox.dative stress,reduced intracellular iron accumulation,and attenuated HIRI-induced liver ***,RRP significantly inhibited hepatocyte death by restoring intracellular iron homeostasis both in vivo and in ***,the RRP aqueous ex.ract reduced intrahepatocellular iron accumulation by inhibiting z.P14-mediated iron uptake,promoting hepcidin-and ferroportin-mediated iron efflux.and ameliorating mitochondrial iron aggregation through upregulation of Cisd1 ***,siRNA-mediated inhibition of hamp synergistically enhanced the RRP aqueous ex.ract's inhibitory effect on *** conclusion,our study elucidates the mechanisms by which RRP aqueous ex.racts alleviate HIRI,highlighting the restoration of iron metabolic *** findings position RRP as a promising candidate for clinical intervention in HIRI treatment.

关键词： Hepatic ischemia/reperfusion injury Rehmanniae Radix.Praeparata Ferroptosis Intracellular iron homeostasis

Suppressing Fx. promotes antiviral effects of bile acids via enhancing the interferon transcription

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3513-3527页

作者： x.e Liang Kunpeng liu x.n Jia Cuiqin Cheng Meiqi z.ang Lingdong Kong Qiqi Li z.e liu Min Li Junliang Li Yao Wang Anlong x. School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Guangx. Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanning 530004China Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Bile acids(BAs)are natural metabolites in mammals and have the potential to function as drugs against viral ***,the limited understanding of chenodeox.cholic acid(CDCA)receptors and downstream signaling,along with its lower suppression efficiency in inhibiting virus infection limits its clinical *** this study,we demonstrate that farnesoid x.receptor(Fx.),the receptor of CDCA,negatively regulates interferon signaling,thereby contributing to the reduced effectiveness of CDCA against virus *** deficiency or pharmacological inhibition enhances interferon signaling activation to suppress virus ***,Fx. impairs the DNA binding and transcriptional abilities of activated interferon regulatory factor 3(IRF3)through *** IRF3 transcriptional activity by Fx.eIRF3 interaction significantly undermines the ex.ression of Interferon Beta 1(IFNB1)and the antiviral response of cells,especially upon the CDCA *** Fx.-deficient cells,or when combined with z.guggulsterone(GUGG)treatment,CDCA ex.ibits a more potent ability to restrict virus ***,these findings suggest that Fx. serves as a limiting factor for CDCA in inhibiting virus replication,which can be attributed to the“signaling-brake”roles of Fx. in interferon *** Fx. inhibition represents a promising pharmaceutical strategy for the clinical application of BAs metabolites as antiviral drugs.

关键词： Bile acids Fx. IRF3 Interferon transcription RNA virus z.guggulsterone Broad-spectrum antiviral activity Synergistic inhibitory effect

Diagnosing the Dynamic and Thermodynamic Effects for the Ex.eptional 2020 Summer Rainy Season in the Yangtz. River Valley

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2022年第1期36卷 26-36页

作者： Na WEN Shujie liu Laurent z.x.LI College of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science&TechnologyNanjing 210044China Qingdao Engineering Technology Research Center for Meteorological Disaster Prevention Qingdao Meteorological BureauQingdao 266003China Laboratoire de Météorologie Dynamique Centre National de la Recherche ScientifiqueSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75252France

An ex.eptional rainy season occurred in the Yangtz. River valley of eastern China in June-July *** relative importance of the dynamic and thermodynamic effects on this unusual event is evaluated through the budget equations of moisture and moist static energy(MSE).The moisture budget analysis suggests that the thermodynamic effect contributes to the precipitation anomaly by 8.5%through the advection of abnormal water vapor by mean vertical motion,while the dynamic effect,related to water vapor advection by anomalous vertical motion,has the dominant *** MSE budget analysis further reveals that the anomalous vertical motion is both constrained by the dynamic effect related to changes in atmospheric circulation and the thermodynamic effect related to changes of the atmospheric thermal state,with a ratio of thermodynamic versus total effects estimated at 45.3%.The dynamic effect is linked to the advection of warm and humid air by the abnormal southwesterly wind,which is related with an anomalous anticyclone over the Philippine *** thermodynamic effect is partly induced by the positive advection of anomalous MSE(mainly latent energy)by the mean vertical *** analysis of the dynamic and thermodynamic effects is useful to understand the underlying physical mechanisms leading to the unusual rainy season in the Yangtz. River valley in summer *** is also helpful to put forward a few speculations on the potential role of global warming whose primary effect is,after all,to change the thermal state of the atmosphere.

关键词： ex.eptional rainfall Yangtz. River valley global warming dynamic and thermodynamic effects

Distributed Secondary Control Based on Dynamic Diffusion Algorithm for Current Sharing and Average Voltage Regulation in DC Microgrids

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 597-607页

作者： Dawei Liao Fei Gao Daniel J.Rogers Wentao Huang Dong liu Houjun Tang Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Engineering Science University of OxfordOxford OX12JDU.K. IEEE

This paper introduces a distributed secondary control scheme for achieving current sharing and average voltage regulation objectives in a DC *** proposed scheme employs a dynamic diffusion algorithm(DDA)instead of the consensus algorithm to enable distributed communication among *** help understand DDA,the relation of DDA and other diffusion algorithms is discussed in detail and its superiority is shown by comparison with diffusion and consensus ***,considering the discrete nature and different sampling time of the digital controller and communication network,a z.domain model of the entire DC microgrid is *** influence of communication and secondary control parameters on the system stability is *** on the established model,the tolerable communication rates are ***-time simulations conducted on the OPAL-RT platform validate the effectiveness of the proposed scheme,showcasing its advantages in terms of convergence speed and stability.

关键词： Cooperative control DC microgrid diffusion algorithm discrete-time modeling distributed secondary control

Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 411-425页

作者： Mengmeng Guo Pan Hu Jiayi x.e Kefu Tang Shix.u Hu Jialiang Sun Yundong He Jing Li Weiqiang Lu Huirong liu Mingyao liu z.engfang Yi Shihong Peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengx.an Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characteriz.d by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 ex.ibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

Recent advances and perspectives in Mx.ne-based cathodes for aqueous z.nc-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1752-1765页

作者： Aiduo Wu Tianhao Wang Long z.ang Chen Chen Qiaomin Li x.anhui Qu Yongchang liu Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Economics and Management University of Science and Technology BeijingBeijing 100083China

Aqueous z.nc-ion batteries(Az.Bs)show great potential for applications in grid-scale energy storage,given their intrinsic safety,cost effectiveness,environmental friendliness,and impressive electrochemical ***,strong electrostatic interactions ex.st between z.nc ions and host materials,and they hinder the development of advanced cathode materials for efficient,rapid,and stable z.-ion *** and their derivatives possess a large interlayer spacing,ex.ellent hydrophilicity,outstanding electronic conductivity,and high redox.*** materials are considered“rising star”cathode candidates for *** comprehensive review discusses recent advances in Mx.nes as Az.B cathodes from the perspectives of crystal structure,z.-storage mechanism,surface modification,interlayer engineering,and conductive network design to elucidate the correlations among their composition,structure,and electrochemical *** work also outlines the remaining challenges faced by Mx.nes for aqueous z.-ion storage,such as the urgent need for improved tox.c preparation methods,ex.loration of potential novel Mx.ne cathodes,and suppression of layered Mx.ne restacking upon cycling,and introduces the prospects of Mx.ne-based cathode materials for high-performance Az.Bs.

关键词： aqueous z.nc-ion batteries Mx.nes terminal groups interlayer engineering conductive network design

Real-time identification of multiple nanoclusters with a protein nanopore in single-cluster level

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第1期17卷 262-269页

作者： Ling z.ang Peilei He Huang Chen Qingda liu Libo Li x.n Wang Jinghong Li Department of Chemistry Center for BioAnalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China School of Chemistry and Chemical Engineering Guangdong Prov Key Lab Green Chem Prod TechnolSouth China University of TechnologyGuangzhou 510640China New Cornerstone Science Laboratory Shenzhen 518054China Beijing Institute of Life Science and Technology Beijing 102206China Center for BioAnalytical Chemistry Hefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

It is important and challenging to analyz. nanocluster structure with atomic ***,α-hemolysin nanopore was used to identify nanoclusters at the single molecule level by providing two-dimensional(2D)dwell time–current blockage spectra and translocation event frequency which sensitively depended on their *** such as Anderson,Keggin,Dawson,and a few lacunary Dawson polyox.metalates with very similar structures,even with only a two-atom difference,could be *** nanopore device could simultaneously measure multiple nanoclusters in a mix.ure qualitatively and ***,molecular dynamics(MD)simulations provided microscopic understandings of the nanocluster translocation dynamics and yielded 2D dwell time–current blockage spectra in close agreement with *** nanopore platform provides a novel powerful tool for nanocluster characteriz.tion.

关键词： nanopore single-molecule nanocluster polyox.metalates real-time detection

A computational model to identify fertility-related proteins using sequence information

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第1期18卷 229-237页

作者： Yan LIN Jiashu WANG x.aowei liu x.eqin x.E De WU Junjie z.ANG Hui DING Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China School of Life Science and Technology and Center for Informational Biology University of Electronic Science and Technology of ChinaChengdu 610054China

Fertility is the most crucial step in the development process,which is controlled by many fertility-related proteins,including spermatogenesis-,oogenesis-and embryogenesis-related *** identification of fertility-related proteins can provide important clues for studying the role of these proteins in ***,in this study,we constructed a two-layer classifier to identify fertility-related *** this classifier,we first used the composition of amino acids(AA)and their physical and chemical properties to code these three fertility-related ***,the feature set is optimiz.d by analysis of variance(ANOVA)and incremental feature selection(IFS)to obtain the optimal feature *** five-fold cross-validation(CV)and independent data tests,the performance of models constructed by different machine learning(ML)methods is evaluated and ***,based on support vector machine(SVM),we obtained a two-layer model to classify three fertility-related *** the independent test data set,the accuracy(ACC)and the area under the receiver operating characteristic curve(AUC)of the first layer classifier are 81.95%and 0.89,respectively,and them of the second layer classifier are 84.74%and 0.90,*** results show that the proposed model has stable performance and satisfactory prediction accuracy,and can become a powerful model to identify more fertility related proteins.

关键词： sfertility-related proteins machine1 learning sequence information feature selection