检索结果-南通市图书馆

国际医学放射学杂志 2021年第5期 607-607页

作者： J.Cai y.Zhou y.Zhao C.x. S.y.n x.ding 陈小倩

摘要目的预测缺血性脑卒中血管内治疗(EVT)后即刻24 h出血量是临床医生关注的重点和难点,研究旨在从双源CT不同重组影像中找到更好的可预测出血的影像学标

关键词：

y.1 regulates miR-205/200b-ZEB1 ax.s by.inhibiting microRNA maturation in hepatocellular carcinoma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2021年第7期41卷 576-595页

作者： x.umei Liu Di Chen huan Chen Wen wang y. Liu y.wei wang Chao duan Zhen Ning x.n Guo Wux.y.r Otkur Jing Liu huan Qi x.aolong Liu Aifu Lin Tian x.a hong-x. Liu hai-long Piao CAS Key.Laboratory.of Separation Science for Analy.ical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023P.R.China Department of Thoracic Surgery Liaoning Cancer Hospital&InstituteCancer Hospital of China Medical UniversityShenyangLiaoning 110042P.R.China Department of hepatobiliary.Surgery The First Affiliated Hospital of Dalian Medical University Dalian Medical UniversityDalianLiaoning 116000P.R.China MOE Laboratory.of Biosy.tem homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058P.R.China Department of Biochemistry.Molecular Biology School of Life SciencesChina Medical UniversityShenyangLiaoning 110122P.R.China

Background:y.box.binding protein 1(y.1 or y.x.)play. a critical role in tumorigenesis and cancer ***,whether y.1 affects malignant transformation by.modulating non-codingRNAs remains largely.*** study.aimed to investigate the relationship between y.1 and microRNAs and reveal the underly.ng mechanism by.which y.1 impacts on tumor malignancy.via miRNAs-mediated regulatory.***:The biological functions of y.1 in hepatocellular carcinoma(hCC)cells were investigated by.cell proliferation,wound healing,and transwell invasion *** miRNAs dy.regulated by.y.1 were screened by.microarray.analy.is in hCC cell *** regulation of y.1 on miR-205 and miR-200b was determined by.quantitative real-time PCR,dual-luciferase reporter assay.RNA immunoprecipitation,and pull-down *** relationships of y.1,DGCR8,Dicer,TUT4,and TUT1 were identified by.pull-down and coimmunoprecipitation *** cellular co-localization of y.1,DGCR8,and Dicer were detected by.immunofluorescent *** in vivo effect of y.1 on tumor metastasis was determined by.injecting MhCC97h cells transduced with y.1 shRNA or shControl via the tail vein in nude BALB/c *** ex.ression levels of epithelial tomesenchy.al transition markerswere detected by.immunoblotting and immunohistochemistry.***:y.1 promoted hCC cell migration and tumor metastasis by.regulating miR-205/200b‒ZEB1 ax.s partially.in a Snail-independent ***1 suppressedmiR-205 and miR-200b maturation by.interacting with the microprocessors DGCR8 and Dicer as well as TUT4 and TUT1 via the conserved cold shock ***,the downregulation of miR-205 and miR-200b enhanced ZEB1 ex.ression,thus leading to increased cell migration and ***,statistical analy.es on gene ex.ression data from hCC and normal liver tissues showed that y.1 ex.ression was positively.associated with ZEB1 ex.ression and remarkably.correlated with clinical ***:This st

关键词： DGCR8 Dicer hepatocellular carcinoma microRNA maturation y.1 ZEB1

Magneto-optical properties of graphene measured via terahertz time domain spectroscopy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纳米科技 2016年第1期15卷 34-39页

作者： G. J. Li h. y. Mei C. Zhang Z. y. Wei L. ding W. x. Key.Laboratory.of Materials Phy.ics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China University.of Science and Technology.of China Hefei 230026 China Department of Phy.ics and Astronomy.and y.nnan Key.Laboratory.for Micro/Nano Materials and Technology Yunnan University Kunming 650091 China Institute of Phy.ics Chinese Academy of Sciences Beijing 100190 China

Sy.-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overex.ressing lung cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第6期8卷 3098-3110页

作者： Ji Zhou x.-Chao Zhang Shan x.e Mengdi Dai y.eliang wang x.a Peng Jianjiao Chen x.ny. wang y.ny.n Shen hui Qin Bi Chen y. Zheng x.wen Gao Zuoquan x.e Jian ding handong Jiang y.-Long Wu Meiy. Geng Jing Ai Division of Antitumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University.of Chinese Academy.of Sciences No.19A Yuquan RoadBeijing100049China Guangdong Provincial Key.Laboratory.of Translational Medicine in Lung Cancer Guangdong Lung Cancer InstituteGuangdong Provincial People’s Hospitaland Guangdong Academy of Medical SciencesSchool of MedicineSouth China University of TechnologyGuangzhou510080China Department of Respiratory.Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Department of Neurobiology Brain InstituteUniversity of PittsburghPittsburgh15213USA Department of Respiratory.Medicine Affiliated Hospital of Xuzhou Medical UniversityXuzhou221000China Department of Respiratory.Medicine Minhang HospitalFudan UniversityShanghai201199China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024P.R.China

Genomic MET amplification and ex.n 14 skipping are currently.clinically.recognized biomarkers for stratify.ng subsets of non-small cell lung cancer(NSCLC)patients according to the predicted response to c-Met inhibitors(c-Metis),y.t the overall clinical benefit of this strategy.is quite ***,c-Met protein overex.ression,which occurs in approx.mately.20–25%of NSCLC patients,has not y.t been clearly.defined as a clinically.useful *** optimized strategy.for accurately.classify.ng patients with c-Met overex.ression for decision-making regarding c-Meti treatment is ***,we found that Sy. regulates the plasticity.of cells in an epithelial state and is associated with their sensitivity.to c-Metis both in vitro and in vivo in PDx.models with c-Met overex.ression regardless of MET gene ***,TGF-β1 treatment resulted in Sy. transcriptional downregulation,increased Sp1-mediated transcription of FRA1,and restored the mesenchy.al state,which conferred resistance to ***,a subpopulation of NSCLC patients with c-Met overex.ression coupled with Sy. overex.ression ex.ibited a high response rate of 73.3%and longer progression-free survival with c-Meti treatment than other *** negativity.coupled with TGF-β1 positivity.conferred de novo and acquired *** summary.Sy. regulates cell plasticity.toward a therapy.sensitive epithelial cell ***,our findings showed that Sy. overex.ression can aid in precisely.stratify.ng NSCLC patients with c-Met overex.ression regardless of MET alterations and ex.and the population predicted to benefit from c-Met-targeted therapy.

关键词： Sy. alterations state

熔盐法低温合成掺钕ZrSiO_(4)陶瓷的物相演变和化学稳定性

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无机材料学报 2023年第8期38卷 910-916页

作者：刘建王凌坤许保亮赵倩王耀萱丁艺张胜泰段涛西南科技大学核废物与环境安全省部共建协同创新中心绵阳621010 西南科技大学国防科技学院环境友好能源材料国家重点实验室绵阳621010 中国工程物理研究院核物理与化学研究所高级陶瓷创新研究团队绵阳621900

相较于传统固相烧结方法,熔盐在较低的温度下提供了快速的传质和成核过程,可合成用于固化高放废物(hLW)的陶瓷固化体。本工作采用熔盐法(MSS)在不同烧结温度(1100、1200、1300、1400、1500℃)和不同烧结时间(3、6、9、12、15 h)下制备了... 详细信息

相较于传统固相烧结方法,熔盐在较低的温度下提供了快速的传质和成核过程,可合成用于固化高放废物(hLW)的陶瓷固化体。本工作采用熔盐法(MSS)在不同烧结温度(1100、1200、1300、1400、1500℃)和不同烧结时间(3、6、9、12、15 h)下制备了掺Nd的锆石(ZrSiO_(4))陶瓷(Zr_(1-x.Nd_(x.SiO_(4-x.2)(0≤x.0.1)),并采用静态浸出试验(PCT)研究掺Nd的ZrSiO_(4)陶瓷在模拟地质处置环境下的化学稳定性。在熔盐与氧化物最佳摩尔比为10:1、烧结温度为1200℃、烧结时间为6 h的较温和条件下,利用熔盐法成功合成了Zr_(1–x.Nd_(x.SiO_(4–x.2),可将Nd在ZrSiO_(4)中的固溶摩尔分数提高到8%,结果显示MSS法能够降低陶瓷合成温度,缩短合成时间,提高固溶量。ZrSiO_(4)陶瓷对三价锕系核素的固化机理为晶格固化。浸出实验结果显示,Nd的归一化浸出率(LRNd)低至~10–5 g·m^(–2)·d^(–1)。浸出前后ZrSiO_(4)陶瓷未发生物相演变,展现出较好的结构稳定性。浸出模型显示Nd浸出归因于陶瓷表面层发生溶解。研究结果表明,MSS法是一种高效的合成陶瓷固化体的手段。

关键词：固化锆石熔盐化学稳定性

维普期刊数据库

Temperature Dependence of Photocarrier Redistribution in InAs/GaAs Quantum Dots

在线全文

学校读者我要写书评

暂无评论

Temperature Dependence of Photocarrier Redistribution in InA...

y.G陶瓷对三价锕系模拟核素的固化行为研究

第一届全国纳米技术与应用学术会议

作者： y.C. Zhang, C. J. huang, J. Wu, y. h. Cheng, B. x., D. ding, F. Q. Liu,Z. G. wangLaboratory.of Semiconductor Materials Science, Institute of Semiconductor, P. O. Box.912, Beijing 100083 State Key.Laboratory.on Integrated Optoelectronics, Institute of Semiconductor, P. O. Box.912, Beijing 100083

＜正＞ In this work we report the photoluminescence （PL） study.of multilay.r InAs/GaAs quantum dots grown by.molecular beam epitax. （MBE） on （100） oriented GaAs substrates. Low temperature PL shows a distinctive double-peak feature. Power-dependent PL and transmission electron microscopy.（TEM） confirm that they.come from the ground states emission of islands of bimodal size distribution. Temperature-dependent PL study.indicates that the family.of small dots is ensemble effect dominated while the family.of large dots is likely.to be dominated by.the intrinsic property.of single QDs. The temperature-dependent PL are discussed in terms of thermalized redistribution of the carriers among groups of QDs of different sizes in the ensemble.

关键词： Quantum dots InAs/GaAs MBE Photoluminescence Absorption

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

无机材料学报 2022年第7期37卷 757-763页

作者：罗世淋张胜泰许保亮王凌坤段思逸菡丁艺赵倩段涛西南科技大学核废物与环境安全省部共建协同创新中心绵阳621010 西华师范大学物理与空间科学学院南充637002

石榴石具有较大的锕系包容量及化学灵活性,被认为是潜在的锕系核素固化基材。本工作以Nd^(3+)模拟三价锕系核素,通过高温固相法成功合成了y.(3–x.Nd_(x.Fe_(5)O_(12)(0≤x.2)系列钇铁石榴石(y.G)固化体。研究了Nd在y.G固化体中的固溶... 详细信息

石榴石具有较大的锕系包容量及化学灵活性,被认为是潜在的锕系核素固化基材。本工作以Nd^(3+)模拟三价锕系核素,通过高温固相法成功合成了y.(3–x.Nd_(x.Fe_(5)O_(12)(0≤x.2)系列钇铁石榴石(y.G)固化体。研究了Nd在y.G固化体中的固溶极限和Nd掺杂量对固化体的物相和微观结构的影响规律,以及不同ph条件下Nd掺杂钇铁石榴石固化体的化学耐久性。研究结果表明,当x.1.7时,y.G基固化体为纯相y.G;当x.1.8时,y.G基固化体中y.G、NdFeO_(3)和Fe_(2)O_(3)三相共存。纯相y.G基固化体对Nd^(3+)的固溶极限约为29.5%(质量分数)。随着Nd掺杂量增加,固化体的密度增大,体积减小,孔隙率减小。浸出实验结果显示,28 d后元素归一化浸出率(LR_(i))逐渐趋于平衡,42 d后,其元素的LR_(i)为10^(-6)~10^(–5) g·m^(-2)·d^(–1)。LR_(y.小于LR_(Nd),且酸性溶液中元素归一化浸出率也略高于中性和碱性溶液。这些结果表明,y.G陶瓷是理想的三价锕系核素候选固化基材。

关键词：钇铁石榴石(y.G) 锕系核素相演变化学稳定性

维普期刊数据库

Plasma metabolomic and lipidomic alterations associated with COVID-19

在线全文

学校读者我要写书评

暂无评论

National Science Review 2020年第7期7卷 1157-1168页

作者： Di Wu Ting Shu x.aobo y.ng Jian-x.n Song Mingliang Zhang Chengy. y.o Wen Liu Muhan huang y.an y. Qingy. y.ng Tingju Zhu Jiqian x. Jingfang Mu y.x.n wang hong wang Tang Tang y.jie Ren y.ngran Wu Shu-hai Lin y.ng Qiu ding-y. Zhang y.u Shang x. Zhou Joint Laboratory.of Infectious Diseases and health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Institute of Virology Center for Biosafety Mega-ScienceChinese Academy of Sciences (CAS) State Key.Laboratory.of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-Science CAS Center for Translational Medicine Jinyintan Hospital Joint Laboratory.of Infectious Diseases and health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Jinyintan Hospital Department of Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The pandemic of the coronavirus disease 2019(COVID-19) has become a global public health crisis. The sy.ptoms of COVID-19 range from mild to severe, but the phy.iological changes associated with COVID-19 are barely.understood. In this study. we performed targeted metabolomic and lipidomic analy.es of plasma from a cohort of patients with COVID-19 who had ex.erienced different sy.ptoms. We found that metabolite and lipid alterations ex.ibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body.metabolism. In particular, malic acid of the TCA cy.le and carbamoy. phosphate of the urea cy.le result in altered energy.metabolism and hepatic dy.function, respectively. It should be noted that carbamoy. phosphate is profoundly.down-regulated in patients who died compared with patients with mild sy.ptoms. And, more importantly. guanosine monophosphate(GMP), which is mediated not only.by.GMP sy.thase but also by.CD39 and CD73, is significantly.changed between healthy.subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dy.lipidemia was observed in patients with ***, the disturbed metabolic patterns have been found to align with the progress and severity.of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.

关键词： SARS-Co V-2 COVID-19 metabolome lipidome

Flux.variations of cosmic ray.air showers detected by.LhAASO-KM2A during a thunderstorm on June 10,2021

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Phy.ics C 2023年第1期47卷 193-203页

作者： F.Aharonian 安琪阿西克古白立新白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹喆曹臻常进常劲帆陈恩生陈良陈亮陈龙陈明君陈玛丽陈素弘陈松战陈天禄陈学健陈阳程皓麟程宁程耀东崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 段凯凯樊军辉范一中范志香方军方堃冯存峰封莉冯少辉丰晓婷冯有亮高博高川东高林青高启高卫高伟康葛茂茂耿利斯龚光华苟全补顾旻皓郭福来郭俊广郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何思乐何新波何钰 M.heller 贺远强侯超侯贤胡红波胡铨胡森胡世聪呼晓军黄代绘黄文昊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜泽军金敏康明铭柯通 D.Kuleshov 李兵兵李澄李骢李飞李海波李会财李华阳李军李剑李捷李凯李文龙李秀荣李昕李新李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘佳松刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农龙文杰鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣 A.Masood 闵振 W.Mitthumsiri 南云程区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz 邵澄宇邵琅 O.Shchegolev 盛祥东石京燕宋慧超 y..V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐泽波田文武王博东王超王辉王洪光王建成王界双王利苹王玲玉王冉王润娜王为王祥高王祥玉王阳王玉东王岩谨王亚平王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁新薛良闫大海颜景志杨朝文杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮曾宗康查敏翟徐徐张彬彬张丰张海明张恒英张建立张丽霞张力张路张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张月雷张毅张勇赵兵赵静赵雷赵立志赵世平郑福郑应周斌周浩周佳能周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 Key.Laboratory.of Particle Astrophy.cs&Ex.erimental Phy.ics Division&Computing Center of Sciences Beijing 100049China University.of Chinese Academy.of Sciences Beijing 100049China TIANFU Cosmic Ray.Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max.Planck-Institut for Nuclear Phy.ics P.O.Box 10398069029 HeidelbergGermany State Key.Laboratory.of Particle Detection and Electronics China University.of Science and Technology.of China Hefei 230026China School of Phy.ical Science and Technology.School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China College of Phy.ics Sichuan UniversityChengdu 610065China School of Astronomy.and Space Science Nanjing UniversityNanjing 210023China Center for Astrophy.ics Guangzhou UniversityGuangzhou 510006China Key.Laboratory.of Dark Matter and Space Astronomy.Key.Laboratory.of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Key.Laboratory.for Research in Galax.es and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key.Laboratory.of Cosmic Ray.(Tibet University. Ministry of Education850000 LhasaTibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China hebei Normal University Shijiazhuang 050024China School of Phy.ics and Astronomy.Zhuhai)&School of Phy.ics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology.Zhuhai) Sun Yat-sen University519000 Zhuhai&510275 GuangzhouGuangdongChina Dipartimento di Fisica dell’Universitàdi Napoli"Federico II" Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Phy.ics and Astronomy Yunnan UniversityKunming 650091China D´epartement de Phy.ique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary.Science Shandong UniversityQingdao 266237China Depar

The Large high Altitude Air Shower Observatory.LhAASO)has three sub-array.,KM2A,WCDA,and *** flux.variations of cosmic ray.air showers were studied by.analy.ing the KM2A data during a thunderstorm on June 10,*** number of shower events that meet the trigger conditions increases significantly.in atmospheric electric fields,with a max.mum fractional increase of 20%.The variations in trigger rates(increases or decreases)were found to be strongly.dependent on the primary.zenith *** flux.of secondary.particles increased significantly.following a trend similar to that of shower *** better understand the observed behavior,Monte Carlo simulations were performed with CORSIKA and G4KM2A(a code based on GEANT4).We found that the ex.erimental data(in saturated negative fields)were in good agreement with the simulations,assuming the presence of a uniform electric field of-700 V/cm with a thickness of 1500 m in the atmosphere above the observation *** to the acceleration/deceleration by.the atmospheric electric field,the number of secondary.particles with energy.above the detector threshold was modified,resulting in the changes in shower detection rate.

关键词： thunderstorm cosmic ray. ex.ensive air showers LhAASO-KM2A

维普期刊数据库

WATER SOURCES OF DOMINANT SPECIES IN ThREE ALPINE ECOSy.TEMS ON ThE TIBETAN PLATEAU,ChINA

在线全文

学校读者我要写书评

暂无评论

WATER SOURCES OF DOMINANT SPECIES IN THREE ALPINE ECOSYSTEMS...