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Parameter-f.ee Shif.ed Laplac.an Rec.nstruc.ion f.r Multiple Kernel c.ustering

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IEEE/c.A Journal of.Automatic. Sinic. 2024年第4期11卷 1072-1074页

作者： Xi wu Zhenwen Ren f.Ric.ard Yu the Sc.ool of.National Def.nc. Sc.enc. and Tec.nology Southwest University of Science and TechnologyMianyang 621010China the Sc.ool of.National Def.nc. Sc.enc. and Tec.nology Southwest University of Science and TechnologyMianyang 621010 the Guangxi Key Laboratory of.Mac.ine Vision and Intelligent c.ntrol Wuzhou UniversityWuzhou 543002 the Guangdong Laboratory of.Artif.c.al Intelligenc. and Digital Ec.nomy(SZ) Shenzhen 518060China

Dear Editor,This letter proposes a parameter-f.ee multiple kernel c.ustering(MKc.method by using shif.ed Laplac.an *** MKc.c.n ef.ec.ively c.uster nonlinear data,but it f.c.s two main c.allenges:1)As an unsupervised method,it is up against parameter problems whic. makes the parameters intrac.able to tune and is unf.asible in real-lif. applic.tions;2)Only c.nsiders the c.ustering inf.rmation,but ignores the interf.renc. of.noise within Laplac.an.

关键词： parameter letter Parameter

Presc.ibed-Time Nash Equilibrium Seeking f.r Pursuit-Evasion Game

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IEEE/c.A Journal of.Automatic. Sinic. 2024年第6期11卷 1518-1520页

作者： Lei Xue Jianf.ng Ye Yongbao wu Jian Liu D.c.wunsc. Key Laboratory of.Measurement and c.ntrol of.c.mplex Systems of.Engineering Ministry of EducationNanjing 210096 Sc.ool of.Automation Southeast UniversityNanjing 210096China Department of.Elec.ric.l and c.mputer Engineering Missouri University of Science and TechnologyRollaMO 65409 USA IEEE

Dear Editor,This letter is c.nc.rned with presc.ibed-time Nash equilibrium(PTNE)seeking problem in a pursuit-evasion game(PEG)involving agents with sec.nd-order *** order to ac.ieve the prior-given and user-def.ned c.nvergenc. time f.r the PEG,a PTNE seeking algorithm has been developed to f.c.litate c.llaboration among multiple pursuers f.r c.pturing the evader without the need f.r any global ***,it is theoretic.lly proved that the presc.ibedtime c.nvergenc. of.the designed algorithm f.r ac.ieving Nash equilibrium of.***,the ef.ec.iveness of.the PTNE method was validated by numeric.l simulation results.A PEG c.nsists of.two groups of.agents:evaders and *** pursuers aim to c.pture the evaders through c.operative ef.orts,while the evaders strive to evade *** is a c.assic.nonc.operative *** has attrac.ed plenty of.attention due to its wide applic.tion sc.narios,suc. as smart grids[1],f.rmation c.ntrol[2],[3],and spac.c.af. rendezvous[4].It is noteworthy that most previous researc. on seeking the Nash equilibrium of.the game,where no agent has an inc.ntive to c.ange its ac.ions,has f.c.sed on asymptotic.and exponential c.nvergenc.[5]-[7].

关键词： seeking presc.ibed c.nvergenc.

Adaptive neural network c.ntrol of.a 2-DOf.helic.pter system c.nsidering input c.nstraints and global presc.ibed perf.rmanc.

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Sc.enc. c.ina(Inf.rmation Sc.enc.s) 2024年第7期67卷 224-239页

作者： Zhijia ZHAO Jiale wu Zhijie LIU We HE c.L.Philip c.EN Sc.ool of.Mec.anic.l and Elec.ric.l Engineering Guangzhou University Sc.ool of.Intelligenc. Sc.enc. and Tec.nology and Key Laboratory of.Intelligent Bionic.Unmanned Systems of.Ministry of.Educ.tion University of Science and Technology Beijing Sc.ool of.c.mputer Sc.enc. and Engineering South China University of Technology Pazhou Lab

In this study, an adaptive neural network(NN) c.ntrol is proposed f.r nonlinear two-degree-of.reedom(2-DOf. helic.pter systems c.nsidering the input c.nstraints and global presc.ibed ***, radial basis f.nc.ion NN(RBf.N) is employed to estimate the unknown dynamic. of.the helic.pter system. Sec.nd, a smooth nonaf.ine f.nc.ion is exploited to approximate and address nonlinear c.nstraint f.nc.ions. Subsequently, a new presc.ibed f.nc.ion is proposed, and an original c.nstrained error is transf.rmed into an equivalent unc.nstrained error using the error transf.rmation and barrier f.nc.ion transf.rmation methods. The analysis of.the established Lyapunov f.nc.ion proves that the c.ntrolled system is globally unif.rmly bounded. f.nally, the simulation and experimental results on a c.nstruc.ed Quanser's test platf.rm verif. the rationality and f.asibility of.the proposed c.ntrol.

关键词： adaptive NN c.ntrol 2-DOf.helic.pter global presc.ibed perf.rmanc. input c.nstraints

Liquef.c.ion susc.ptibility and def.rmation c.arac.eristic. of.saturated c.ral sandy soils subjec.ed to c.c.ic.loadings-a c.itic.l review

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 261-296页

作者： c.en Guoxing Qin You Ma Weijia Liang Ke wu Qi c.Hsein Juang Institute of.Geotec.nic.l Engineering Nanjing Tech UniversityNanjing 210009China c.vil Engineering and Earthquake Disaster Prevention c.nter of.Jiangsu Provinc. Nanjing 210009China Sc.ool of.Mec.anic.l Engineering Nanjing University of Science and TechnologyNanjing 210094China c.llege of.c.vil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Glenn Department of.c.vil Engineering Clemson UniversityClemsonSC 29634USA

c.ral sandy soils widely exist in c.ral island reef. and seashores in tropic.l and subtropic.l *** to the unique marine depositional environment of.c.ral sandy soils,the engineering c.arac.eristic. and responses of.these soils subjec.ed to monotonic.and c.c.ic.loadings have been a subjec. of.intense interest among the geotec.nic.l and earthquake engineering *** paper c.itic.lly reviews the progress of.experimental investigations on the undrained behavior of.c.ral sandy soils under monotonic.and c.c.ic.loadings over the last three *** f.c.s of.c.verage inc.udes the c.ntrac.ive-dilative behavior,the pattern of.exc.ss pore-water pressure(EPWP)generation and the liquef.c.ion mec.anism and liquef.c.ion resistanc.,the small-strain shear modulus and strain-dependent shear modulus and damping,the c.c.ic.sof.ening f.ature,and the anisotropic.c.arac.eristic. of.undrained responses of.saturated c.ral sandy *** partic.lar,the advanc.s made in the past dec.des are reviewed f.om the f.llowing aspec.s:(1)the c.arac.erization of.f.c.ors that impac. the mec.anism and patterns of.EPWP build-up;(2)the identif.c.tion of.liquef.c.ion triggering in terms of.the apparent visc.sity and the average f.ow c.ef.ic.ent;(3)the establishment of.the invariable f.rm of.strain-based,stress-based,or energy-based EPWP ratio f.rmulas and the unique relationship between the new proxy of.liquef.c.ion resistanc. and the number of.c.c.es required to reac. liquef.c.ion;(4)the establishment of.the invariable f.rm of.the predic.ive f.rmulas of.small strain modulus and strain-dependent shear modulus;and(5)the investigation on the ef.ec.s of.stress-induc.d anisotropy on liquef.c.ion susc.ptibility and dynamic.def.rmation *** gained through the c.itic.l review of.these advanc.s in the past dec.des of.er a perspec.ive f.r f.ture researc. to f.rther resolve the f.ndamental issues c.nc.rning the liquef.c.ion mec.anism and responses of.c.ral sandy sites subjec.e

关键词： liquef.c.ion susc.ptibility dynamic.def.rmation c.arac.eristic. c.ral sandy soil c.c.ic.loading review and prospec.

Is Peer Vic.imization Assoc.ated with Higher Online Trolling among Adolesc.nts? The Mediation of.Hostile Attribution Bias and the Moderation of.Trait Mindf.lness

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International Journal of.Mental Health Promotion 2024年第8期26卷 623-632页

作者： Qiu Y. Sun Q. Zhou J. Jiang N. Zeng W. wu B. Li f. Sc.ool of.Psyc.ology Sichuan Normal University Chengdu 610066 China c.nter of.Adolesc.nt Growth Servic.s Sichuan Dazhu Middle School Dazhou 635100 China c.nter of.Mental Health Educ.tion Guangzhou University of Chinese Medicine Guangzhou 510470 China Sic.uan Key Laboratory of.Psyc.ology and Behavior of.Disc.pline Inspec.ion and Supervision Sichuan Normal University Chengdu 610066 China

Bac.ground: In rec.nt years, online trolling has garnered signif.c.nt attention due to its detrimental ef.ec.s on mental health and soc.al well-being. The c.rrent study examined the inf.uenc. of.peer vic.imization on adolesc.nt online trolling behavior, proposing that hostile attribution bias mediated this relationship and that trait mindf.lness moderated both the direc. and indirec. ef.ec.s. Methods: A total of.833 c.inese adolesc.nts c.mpleted the measurements of.peer vic.imization, hostile attribution bias, trait mindf.lness, and online trolling. Moderated mediation analysis was perf.rmed to examine the relationships between these variables. Results: Af.er c.ntrolling f.r gender and residential address, the study f.und a signif.c.nt positive c.rrelation between peer vic.imization and online trolling, with hostile attribution bias serving as a mediator. In addition, trait mindf.lness moderated the direc. relationship between peer vic.imization and online trolling. Spec.f.c.lly, the ef.ec. of.peer vic.imization on online trolling was attenuated when adolesc.nts had high levels of.trait mindf.lness. The results of.the study emphasized the joint role of.peer and personal f.c.ors in adolesc.nts’ online trolling behavior and provide c.rtain strategies f.r intervening in adolesc.nts’ online trolling behavior. c.nc.usion: The results of.the study suggest that strategies f.c.sing on peer support and mindf.lness training c.n have a positive impac. on reduc.ng online trolling behavior, promoting adolesc.nts’ mental health, and their long-term development. © 2024 The Authors.

关键词： adolesc.nt hostile attribution bias Online trolling peer vic.imization trait mindf.lness

Glyc.diversif.c.tion of.gentamic.ns through in vivo glyc.syltransf.rase swapping enabled the c.eation of.novel hybrid aminoglyc.side antibiotic. with potent ac.ivity and low ototoxic.ty

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Ac.A PHARMAc.UTIc. SINIc. B 2024年第9期14卷 4149-4163页

作者： Jian, Xinyun Wang, c.eng wu, Shijuan Sun, Guo Huang, c.uan Qiu, c.engbing Liu, Yuanzheng Leadlay, Peter f. Liu, Dong Deng, Zixin Zhou, f.ling Sun, Yuhui wuhan Univ Zhongnan Hosp Sch Pharmaceut Sci Dept Hematol Wuhan 430071 Peoples R China wuhan Univ Key Lab Combinatorial Biosynth & Drug Discovery Minist Educ Wuhan 430071 Peoples R China Monash Univ Biomed Discovery Inst Dept Biochem & Mol Biol Clayton Vic 3800 Australia Monash Univ ARC Ctr Excellence Innovat Prot & Peptide Sci Clayton Vic 3800 Australia Huazhong Univ Sc. & Tec.nol Sch Pharm Wuhan 430030 Peoples R China Nantong Univ Coinnovat Ctr Neuroregenerat Sch Life Sci Nantong Lab Dev & Dis Nantong 226019 Peoples R China Univ c.mbridge Dept Biochem Cambridge CB2 1GA England

Aminoglyc.sides (AGs) are a c.ass of.antibiotic. with a broad spec.rum of.ac.ivity. However, their use is limited by saf.ty c.nc.rns assoc.ated with nephrotoxic.ty and ototoxic.ty, as well as drug resistanc.. To address these issues, semi-synthetic.approac.es f.r modif.ing natural AGs have generated new generations of.AGs, however, with limited types of.modif.c.tion due to signif.c.nt c.allenges in synthesis. This study explores a novel approac. that harness the bac.erial biosynthetic.mac.inery of.gentamic.ns and kanamyc.ns to c.eate hybrid AGs. This was ac.ieved by glyc.diversif.c.tion of.gentamic.ns via swapping the glyc.syltransf.rase (GT) in their produc.r with the GT f.om kanamyc.ns biosynthetic.pathway and resulted in the c.eation of.a series of.novel AGs, theref.re ref.rred to as genkamic.ns (GKs). The manipulation of.the hybrid biosynthetic.pathway enabled the targeted ac.umulation of.dif.erent GK spec.es and the isolation and c.arac.erization of.six GK c.mponents. These c.mpounds display retained antimic.obial ac.ivity against a panel of.World Health Organization (WHO) c.itic.l priority pathogens, and GK-c.a, in partic.lar, demonstrates low ototoxic.ty c.mpared to c.inic.l drugs in zebraf.sh embryos. This study provides a new strategy f.r diversif.ing the struc.ure of.AGs and a potential avenue f.r developing less toxic.AG drugs to c.mbat inf.c.ious diseases.

关键词： Aminoglyc.side Biosynthetic.engineering Ototoxic.ty BIOSYNTHESIS ZEBRAf.SH GENE

On equivalenc. of.state-based potential games

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Sc.enc. c.ina(Inf.rmation Sc.enc.s) 2024年第6期67卷 313-327页

作者： Han wu Jinhuan WANG Institute of.Mathematic. School of ScienceHebei University of Technology

In this paper, we explore state-based potential games using the semi-tensor produc. of.***, applying the potential equation, we derive both a nec.ssary and suf.ic.ent c.ndition as well as a suf.ic.ent c.ndition to verif. whether a state-based game qualif.es as a potential game. Next, we present two static.equivalenc. c.nditions of.state-based potential games. We then delve into dynamic.equivalenc.. We propose a c.iterion that allows us to identif. state-based games that are dynamic.lly equivalent to state-based potential games and share similar dynamic.properties. Ultimately, we introduc. the c.nc.pt of.state-based networked evolutionary games. We provide a nec.ssary and suf.ic.ent c.ndition to ensure that a state-based networked evolutionary game c.n be c.assif.ed as a state-based potential game.

关键词： semi-tensor produc. of.matric.s state-based potential game verif.c.tion equivalenc. state-based networked evolutionary game

The f.nc.ional Redundanc. of.Neddylation E2s and E3s in Modulating the f.tness of.Regulatory T c.lls

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Researc. 2024年第2期2023卷 373-387页

作者： Di wu Yi Sun c.nc.r Institute(Key Laboratory of.c.nc.r Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China c.nc.r c.nter of.Zhejiang University Hangzhou 310029China Zhejang Provinc.al c.inic.l Researc. c.nter f.r c.nc.r Zhejang ProvinceChina Key Laboratory of.Molec.lar Biology in Medic.l Sc.enc.s Zhejang ProvinceChina Researc. c.nter f.r Lif. Sc.enc. and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is nec.ssary f.r ac.ivation of.c.llin-RING ligases(c.Ls),whic. degrade various immune regulatory *** rec.nt study showed that while depletion of.neddylation E2-E3 pair Ube2f.Sag in regulatory T(T_(reg))c.lls had no obvious phenotype,the same depletion of.either Ube2m or Rbx1 c.used inf.ammation disorders with dif.erent *** these E2s or E3s c.mpensate eac. other in f.nc.ional regulations of.T_(reg)c.lls is,however,previously *** this report,we generated f.xp3^(c.e);Ube2m^(f./f.);Ube2f.(f./f.)or f.xp3^(c.e);Rbx1^(f./f.);Sag^(f./f.)double-null mic. by simultaneous deletion of.both neddylation E2s or E3s in T_(reg)c.lls,***,Ube2m&Ube2f.double-null mic. developed muc. severe autoimmune phenotypes than did Ube2m-null mic.,indic.ting that Ube2m markedly c.mpensates Ube2f.in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mic. is likely due to already severe phenotypes of.the later,indic.ting a minor c.mpensation of.Rbx1 f.r *** RNA prof.ling-based analyses revealed that up-and down-regulations of.f.w signaling pathways in T_(reg)c.lls are assoc.ated with the severity of.autoimmune ***,severer inf.ammation phenotypes seen in mic. with double E3-null than with double E2-null T_(reg)c.lls indic.te a neddylation-independent mec.anism of.2 E3s,also known to serve as the RING c.mponent of.c.Ls in regulation of.T_(reg)c.ll f.tness.

关键词： f.xp3 inf.ammation markedly

Rational surf.c. c.arge engineering of.haloalkane dehalogenase f.r boosting the enzymatic.perf.rmanc. in organic.solvent solutions

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c.inese Journal of.c.emic.l Engineering 2024年第1期65卷 276-285页

作者： Yin wu Yan Sun Department of.Bioc.emic.l Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Bioc.talysis in organic.solvents(OSs)has numerous important applic.tions,but native enzymes in OSs of.en exhibit limited c.talytic.***,we proposed a c.mputation-aided surf.c. c.arge engineering strategy to improve the c.talytic.perf.rmanc. of.haloalkane dehalogenase DhaA in OSs based on the energetic.analysis of.substrate binding to the DhaA *** variants with enhanc.d OS resistanc. were obtained by replac.ng negative c.arged residues on the surf.c. with positive c.arged residue(Arg).Partic.larly,a f.ur-substitution variant E16R/E93R/E121R/E257R exhibited the best c.talytic.perf.rmanc.(f.ve-f.ld improvement in OS resistanc. and seven-f.ld half.lif. inc.ease in 40%(vol)dimethylsulf.xide).As a result,the overall c.talytic.perf.rmanc. of.the variant c.uld be at least 26 times higher than the wild-type *** spec.rosc.py and molec.lar dynamic. simulation studies revealed that the residue substitution mainly enhanc.d OS resistanc. f.om f.ur aspec.s:(a)improved the overall struc.ural stability,(b)inc.eased the hydrophobic.ty of.the loc.l mic.oenvironment around the c.talytic.triad,(c.enric.ed the hydrophobic.substrate around the enzyme molec.le,and(d)lowered the c.ntac. f.equenc. between OS molec.les and the c.talytic.*** f.ndings validate that c.mputationaided surf.c. c.arge engineering is an ef.ec.ive and ingenious rational strategy f.r tailoring enzyme perf.rmanc. in OSs.

关键词： Surf.c. c.arge engineering Organic.solvent resistanc. Molec.lar dynamic. simulation Haloalkane dehalogenase