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A preliminary report on adjuvant analgesic efficacy of HANS in opioid tolerant patients with cancer pain

Chinese Journal of Cancer Research 2014年第2期26卷 174-182页

作者： Xiaomei Li Jianhua Zhu Pingping Li Guangqing Zhu xiaoming wu Huoming Chen Huixia Zhao Wei Wang Ying Zhang Wenhua Xiao Duanqi Liu Department of Medical Oncology the First Affiliated Hospital of Chinese PLA General Hospital Department of No.3 Cadre Ward Expert Group Beijing Army General Hospital Key Laboratory of Carcinogenesis and Traditional Research (Ministry of Education) Department of Integrated Traditional Chinese and Western Medicine Peking University Cancer Hospital & Institute Department of Medical Oncology the General Hospital of the Air Force of the Chinese PLA Integrated Department Cancer Institute and Hospital Chinese Academy of Medical Sciences (CAMS) Department of Medical Oncology the Second Artillery General Hospital

Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS （2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks）. Cancer pain, quality of life （QOL）, anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale （SAS）/ self-rating depression scale （SDS）, respectively; the therapeutic frequency of breakthrough pain （BP） and daily opioid dose were also recorded. Results： Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient＇s ＂worst＂ and ＂least＂ pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions： To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients＇ QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.

关键词： Cancer pa!n opioid tolerance Han's Acupoint Nerve Stimulator (HANS)

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睡眠呼吸暂停综合征患者脑电的去趋势波动分析

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生物医学工程学杂志 2016年第5期33卷 842-846页

作者：周静吴效明华南理工大学材料科学与工程学院广州510640

睡眠呼吸暂停综合征(SAS)是一种发病率高且危害巨大的睡眠疾病,其病理机制复杂,诊治困难,从单一或少量生理信号中挖掘SAS的特征信息是近年来睡眠疾病研究的热点。本文基于脑电(EEG)的非平稳和非线性特性,采用去趋势波动分析(DFA)对SAS... 详细信息

睡眠呼吸暂停综合征(SAS)是一种发病率高且危害巨大的睡眠疾病,其病理机制复杂,诊治困难,从单一或少量生理信号中挖掘SAS的特征信息是近年来睡眠疾病研究的热点。本文基于脑电(EEG)的非平稳和非线性特性,采用去趋势波动分析(DFA)对SAS患者和健康人的睡眠脑电进行研究。研究发现,SAS患者和健康人睡眠脑电的标度指数α随着睡眠加深逐渐增大,而在快速眼动期(REM)则下降;与此同时,SAS组的标度指数在各个睡眠阶段均高于对照组,两组间存在明显差异(P<0.01);采用受试者工作特征(ROC)曲线对脑电标度指数区分SAS的性能进行评价,得到SAS组和对照组的睡眠脑电标度指数最佳临界值0.81,对应灵敏度为94.4%,特异度为99.2%,曲线下面积(AUC)为0.994。结果说明DFA标度指数用于SAS区分有很好的辨别能力和准确度,为SAS诊断提供了新的理论依据。

关键词：睡眠呼吸暂停综合征脑电去趋势波动分析标度指数

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Comparison between SSR and SNP systems of genetic diversity analysis in Brassica napus L.

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Oil Crop Science 2018年第2期3卷 86-91页

作者： Kun Xu Jinfeng wu Feng Li xiaoming wu Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of AgricultureOil Crops Research InstituteChinese Academy of Agricultural Sciences

Simple sequence repeat(SSR) capillary electrophoresis and single nucleotide polymorphism(SNP) array are widely used tools for investigating genetic diversity. However, efficiency between SSR and SNP on rapeseed genetic diversity has not been systematically assessed yet. In this study, both SSR and SNP were used on 446 worldwide B. napus germplasm lines. Data shows that 65 pairs of primers(70 SSRs) and 250 SNPs were necessary to identify the similar accessions. Furthermore, no significant differences were found between 2 systems on basic statistics, population structures, principal components and kinship parameters. In general, either SSR or SNP is efficient for genetic diversity estimation. However, our data revealed the fact that SNP array system shows slightly more accuracy than SSR system on ecotype groups division.

关键词： SSR capillary electrophoresis SNP array genetic diversity population structure,principal component

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Effect of Vegetation and Precipitation upon Runoff and Sediment Production on Slope Lands of the Loess Area in China

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Chinese Forestry Science and Technology 2006年第2期5卷 54-65页

作者： wu Sihong ZHANG xiaoming ZHU Qinke Key Laboratory of Soil and Water Conservation and Combating Desertification Ministry of Education College of Soil and Water Conservation Beijing Forestry University Beijing 100083 China

According to fixed-position data for 1992-2003 from 16 runoff plots of Caijiachuan watershed which lie in Jixian County, Shanxi Province, in the loess area, this paper studied the relationship between vegetation and runoff and sedimentproduction on slope lands. The results showed as follows: 1) Runoffand sediment production in Robinia pseudoacacia forestand Pinus tabulaeformis forest had a high correlation with precipitation amount and rainfall intensity, but the correlation decreased gradually with the increase of canopy density; 2) The secondary forest had better function of soil and water conservation than artificial R. pseudoacacia forest, and runoff and sedimentproduction in the former in an individual rain event was 65%-82% and 23%-92% lower than thosein the latter, respectively;3) The difference ofrunoff and sediment production in several land uses was very distinct. Runoff and sediment production in Ostryopsisdavidiana forest and the secondary forest were the least; runoff and sediment production in artificial R. pseudoacacia forest and P. tabulaeformis forest were 5-fold as much as those in O. davidiana forest. Besides, runoff and sediment production in mixed stand of apple trees and cropswere 16.14-fold and 2.96-fold higher than that in O. davidiana forest, respectively, but theamount decreased obviously after high-standard soil preparation for theformer;4) Based on gray correlation analysis of variousfactorsaffecting runoffand sedimentproduction on slope lands, it can be seen that stand canopy density and herb and litter biomass werethe most significant ones, whosegray correlation valuesall exceeded 0.6. Therefore, mixed forest with multi-layer stand structure and shrub forest should be developed in vegetation reconstruction of the loess area, which help to increase coverage and litter thicknessto cut down the runoffand sediment production dramatically on slope lands.

关键词： the loess area vegetation precipitation runoff production sediment production gray correlation analysis

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p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis

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Cancer Biology & Medicine 2019年第1期16卷 79-88页

作者： Haili Li Yongjin Zhang Juhua Dan Ruoyu Zhou Cui Li Rong Li xiaoming wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo Faculty of Environmental Science and Engineering Kunming University of Science and Technology Laboratory of Molecular Genetics of Aging &Tumor Kunming University of Science and Technology Division of Nephrology The First People's Hospital of Yunnan Province Department of Cancer Systems Imaging The University of Texas MD Anderson Cancer Center Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston Department of Pathology Kunming General Hospital

Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is ***: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological *** RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease ***: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc^(-/-)WRN^(-/-)p53^(S/S)(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and ***: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis.

关键词： p53 mutation telomere dysfunction polycystic kidney disease tumorigenesis

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基于ordered-EAMP模型的多材料传热结构拓扑优化

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航空动力学报 2021年第5期36卷 1007-1021页

作者：闫浩吴晓明厦门大学航天航空学院福建厦门361005

基于多材料变密度拓扑优化方法提出了一种密度指数函数插值的有序多材料性能近似(ordered exponential approximation of material properties, ordered-EAMP)模型,数学性质以及算例表明,与传统的SIMP/RAMP插值相比,该模型具有计算稳定... 详细信息

基于多材料变密度拓扑优化方法提出了一种密度指数函数插值的有序多材料性能近似(ordered exponential approximation of material properties, ordered-EAMP)模型,数学性质以及算例表明,与传统的SIMP/RAMP插值相比,该模型具有计算稳定,收敛速度快,优化结构灰度单元少的特点。在优化准则(OC)法求解变密度拓扑优化模型时,构造了一种适用于多材料的密度过滤格式,算例表明:可以有效减少灰度单元,且降低了优化的目标函数值。运用MATLAB-ANSYS联合优化,实现三类热边界条件下复杂热环境的多材料传热结构拓扑优化。相比于高热传导系数的单材料结构,多材料传热拓扑优化结构由于各种热传导系数材料的优化分布,结构的传热势容耗散更小,算例4中对比分析降低了20.3%,传热效率更高。

关键词：拓扑优化传热结构插值模型密度过滤联合拓扑优化

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地基Headwall高谱影像大气校正方法

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空间科学学报 2019年第4期39卷 537-543页

作者：吴晓明山东外贸职业学院基础教学部

遥感影像大气校正是定量遥感研究的前提与难点之一.大气校正有多种方法和模型.本文研究了目前常用的大气校正方法,包括FLAASH模型、6S模型、ELC方法和QUAC方法,并应用这几种方法对Headwall野外高光谱成像仪获取的高光谱影像进行大气校正... 详细信息

遥感影像大气校正是定量遥感研究的前提与难点之一.大气校正有多种方法和模型.本文研究了目前常用的大气校正方法,包括FLAASH模型、6S模型、ELC方法和QUAC方法,并应用这几种方法对Headwall野外高光谱成像仪获取的高光谱影像进行大气校正.通过对4种典型地物的表观反射率、校正后反射率以及实测反射率进行对比分析,发现4种模型均能有效去除大气的影响,能够较好地恢复地物光谱的典型特征.相对于其他3种大气校正方法,经验线性法对地基Headwall高光谱影像校正效果最好.

关键词：高光谱大气校正 FLAASH模型 6S模型经验线性法

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载荷敏度抑制下涡轮盘拓扑优化及结构演化

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航空学报 2022年第5期43卷 339-348页

作者：闫浩吴晓明厦门大学航空航天学院厦门361102

航空发动机涡轮盘工作时承受的离心载荷是一种典型设计相关载荷,这类问题的变密度结构拓扑优化需要解决低密度单元的材料附属效应和目标函数非单调等求解上的困难。基于变密度拓扑优化模型,运用指数型材料性能近似(EAMP)模型避免材料附... 详细信息

航空发动机涡轮盘工作时承受的离心载荷是一种典型设计相关载荷,这类问题的变密度结构拓扑优化需要解决低密度单元的材料附属效应和目标函数非单调等求解上的困难。基于变密度拓扑优化模型,运用指数型材料性能近似(EAMP)模型避免材料附属效应并提高收敛速度;构造了一种新的灰度抑制方法减小拓扑结构灰度;提出载荷敏度抑制算法求解设计相关载荷的拓扑优化问题。算例表明算法有效并且灰度单元少、收敛速度快。通过载荷敏度抑制系数讨论,从拓扑优化算法角度揭示了传统单辐板涡轮盘与近年广泛研究的双辐板涡轮盘结构之间的联系及演化规律。

关键词：设计相关载荷材料插值模型灰度抑制涡轮盘拓扑优化

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动脉中非线性血流的锥度效应

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华南理工大学学报（自然科学版） 1999年第4期27卷 69-74页

作者：吴效明岑人经华南理工大学生物力学研究所

研究了动脉中的锥度对非线性血流的影响，在假定锥度角很小的情况下，应用不可压缩粘性液体的动力学原理建立了一组描述非线性血流的偏微分方程导出了轴向和径向速度分布公式。了锥度角对流场的影响情况。

关键词：锥度效应非线性流动血液流动非定常流动动脉

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睡眠呼吸暂停综合征脑电关联维特性研究

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生物医学工程学杂志 2017年第2期34卷 168-172页

作者：周静吴效明华南理工大学材料科学与工程学院生物医学工程系广州510640

睡眠呼吸暂停综合征(SAS)是一种常见且危害巨大的全身性睡眠疾病。SAS患者存在明显的脑部结构和功能的影像学改变,而脑电图(EEG)能反映大脑组织的电活动及功能状态,是描述睡眠过程最直观的参数。基于EEG信号的非平稳和非线性特性,本文... 详细信息

睡眠呼吸暂停综合征(SAS)是一种常见且危害巨大的全身性睡眠疾病。SAS患者存在明显的脑部结构和功能的影像学改变,而脑电图(EEG)能反映大脑组织的电活动及功能状态,是描述睡眠过程最直观的参数。基于EEG信号的非平稳和非线性特性,本文采用非线性方法对SAS患者睡眠EEG信号的关联维特性进行分析。将6名SAS患者组成SAS组,6名健康人组成对照组。研究结果显示,SAS患者和健康人睡眠EEG信号的关联维变化规律一致,即随着睡眠加深,其关联维均逐渐减小,但到快速眼动期(REM)时,关联维又上升至觉醒和浅睡眠期的水平;与此同时,SAS组的关联维在各个睡眠阶段均低于对照组,两组间存在的差异具有统计学意义(P<0.01)。研究结果表明,SAS患者的EEG信号与健康人之间存在明显的非线性动力学差异,这为研究SAS的生理机制及实现SAS的自动检测提供了新的方向。

关键词：睡眠呼吸暂停综合征脑电图非线性关联维

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