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Proteomic identification of cryostress in epididymal spermatozoa

Journal of Animal Science and Biotechnology 2017年第2期8卷 478-489页

作者： sung Jae Yoon Md Saidur Rahman woo sung kwon Do Yeal Ryu Yoo Jin Park Myung Geol Pang Department of Animal Science&Technology Chung-Ang UniversityAnseongGyeonggi-Do 456-756Republic of Korea

Background： Cryopreservation of epididymal spermatozoa is important in cases in which it is not possible to collect semen using normal methods, as the sudden death of an animal or a catastrophic injury. However, the freezing and thawing processes cause stress to spermatozoa, including cold shock, osmotic damage, and ice crystal formation,thereby reducing sperm quality. We assessed the motility（%）, motion kinematics, capacitation status, and viability of spermatozoa using computer-assisted sperm analysis and Hoechst 33258/chlortetracycline fluorescence ***, we identified proteins associated with cryostress using a proteomic approach and performed western blotting to validate two-dimensional electrophoresis（2-DE） results using two commercial ***： Cryopreservation reduced viability（%）, motility（%）, straight-line velocity（VSL）, average path velocity（VAP）, amplitude of lateral head displacement（ALH）, and capacitated spermatozoa, whereas straightness（STR）and the acrosome reaction increased after cryopreservation（P 3 fold, P ＆lt; 0.05） before and after cryopreservation. The proteins differentially expressed following cryopreservation are putatively related to several signaling pathways, including the ephrinR-actin pathway, the ROS metabolism pathway, actin cytoskeleton assembly, actin cytoskeleton regulation,and the guanylate cyclase ***： The results of the current study provide information on epididymal sperm proteome dynamics and possible protein markers of cryo-stress during cryopreservation. This information will further the basic understanding of cryopreservation and aid future studies aiming to identify the mechanism of cryostress responses.

关键词： Cryopreservation Cryostress Protein Spermatozoa

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Effect of atractylenolide Ⅲ on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2081-2092页

作者： Na Yeon Kim Myoung Ok Kim Sangsu Shin woo‑sung kwon Bomi Kim Joon Yeop Lee Sang In Lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑sangbuk‑do37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National UniversitySangjuGyeongsangbuk‑do 37224Republic of Korea National Institute for Korean Medicine Development Gyeongsan 38540Republic of Korea

Background The intestinal epithelium performs essential physiological functions,such as nutrient absorption,and acts as a barrier to prevent the entry of harmful *** are prevalent contaminants found in ani-mal feed that exert harmful effects on the health of ***(ZEA)is produced by the Fusarium genus and induces gastrointestinal dysfunction and disrupts the health and immune system of ***,we evaluated the molecular mechanisms that regulate the effects of ZEA on the porcine intestinal *** Treatment of IPEC-J2 cells with ZEA decreased the expression of E-cadherin and increased the expression of Snai1 and Vimentin,which induced Snail1-mediated epithelial-to-mesenchymal transition(EMT).In addition,ZEA induces Snail-mediated EMT through the activation of TGF-β*** treatment of IPEC-J2 cells with atractyle-nolideⅢ,which were exposed to ZEA,alleviated *** Our findings provide insights into the molecular mechanisms of ZEA toxicity in porcine intestinal epi-thelial cells and ways to mitigate it.

关键词： Atractylenolide III Epithelial–mesenchymal transition IPEC-J2 cells Snail TGF-beta signaling Zearalenone

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QKD system with fast active optical path length compensation

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 1-7页

作者： Byung kwon Park Min Soo Lee Min Ki woo Yong-Su Kim Sang-wook Han sung Moon Center for Quantum Information Korea Institute of Science and Technology Department of Nano-materials Science and Engineering Korea University of Science and Technology

We develop a quantum key distribution (QKD) system with fast active optical path length compensation. A rapid and reliable active optical path length compensation scheme is proposed and applied to a plug-and-play QKD system. The system monitors changes in key rates and controls it is own operation automatically. The system achieves its optimal performance within three seconds of operation, which includes a sifted key rate of 5.5 kbps and a quantum bit error rate of less than 2% after an abrupt temperature variation along the 25 km quantum channel. The system also operates well over a 24 h period while completing more than 60 active optical path length compensations.

关键词： quantum key distribution optical path length compensation plug and play field programmable gate array

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Decomposing Composite Changes for Code Review and Regression Test Selection in Evolving Software

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Journal of Computer Science & Technology 2019年第2期34卷 416-436页

作者： Bo Guo Young-woo kwon Myoungkyu Song Department of Global Operations PayPal Omaha Nebraska 68128 U.S.A. School of Computer Science and Engineering Kyungpook National University Daegu 702-701 South Korea Department of Computer Science University of Nebraska at Omaha Omaha 68128 U.S.A.

Inspecting and testing code changes typically require a significant amount of developer *** a system evolves,developers often create composite changes by mixing multiple development issues,as opposed to addressing one independent issue—an atomic *** composite changes often becomes time-consuming and *** test unrelated edits on composite changes,rerunning all regression tests may require excessive *** address the problem,we present an interactive technique for change decomposition to support code reviews and regression test selection,called *** a developer specifies code change within a diff patch,ChgCutter partitions composite changes into a set of related atomic changes,which is more cohesive and self-contained regarding the issue being *** composite change inspection,it generates an intermediate program version that only includes a related change subset using program dependence *** cost reduction during regression testing,it safely selects only affected tests responsible for changes to an intermediate *** the evaluation,we apply ChgCutter to 28 composite changes in four open source *** partitions these changes with 95.7% accuracy,while selecting affected tests with 89.0% *** conduct a user study with professional software engineers at PayPal and find that ChgCutter is helpful in understanding and validating composite changes,scaling to industry projects.

关键词： software maintenance and evolution code review test selection program slicing

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Bright and stable near-infrared perovskite light emitters supported by multifunctional molecule design strategy

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Light(Science & Applications) 2023年第10期12卷 1995-1997页

作者： Joo sung Kim Tae-woo Lee SN Display Co.Ltd. SeoulRepublic of Korea Soft Foundry Seoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSchool of Chemical and Biological EngineeringInstitute of Engineering ResearchSeoul National UniversitySeoulRepublic of Korea

Perovskite light emitters can realize bright,stable and efficient light-emitting diodes through a molecular design strategy that enables strong endurance on high-current operation.

关键词： emitter light diodes

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Early rehabilitation programs after laparoscopic colorectal surgery:Evidence and criticism

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World Journal of Gastroenterology 2013年第46期19卷 8543-8551页

作者： Duck-woo Kim sung-Bum Kang Soo-Young Lee Heung-kwon Oh Myung-Hoon In Department of Surgery Seoul National University Bundang Hospital

During the past several decades,early rehabilitation programs for the care of patients with colorectal surgery have gained *** randomized controlled trials and meta-analyses have confirmed that the implementation of these evidence-based detailed perioperative care protocols is useful for early recovery of patients after colorectal *** cared for based on these protocols had a rapid recovery of bowel movement,shortened length of hospital stay,and fewer complications compared with traditional care ***,most of the previous evidence was obtained from studies of early rehabilitation programs adapted to open colonic ***,limited evidence exists on the effects of early rehabilitation after laparoscopic rectal resection,although this procedure seems to be associated with a higher morbidity than that reported with traditional *** this article,we review previous studies and guidelines on early rehabilitation programs in patients undergoing rectal *** investigated the status of early rehabilitation programs in rectal surgery and analyzed the limitations of these *** also summarized indications and detailed protocol components of current early rehabilitation programs after rectal surgery,focusing on laparoscopic resection.

关键词： Colorectal cancer Enhanced recovery after surgery Early rehabilitation Fast-track Laparoscopy Rectal

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Free ubiquitin: a novel therapeutic target for neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1781-1782页

作者： Chul-woo Park kwon-Yul Ryu Department of Life Science University of SeoulSeoulRepublic of Korea

Neurodegenerative diseases are widespread and the increasing number of patients with these diseases can no longer be ignored. Dementia is a symptom of many neurodegenerative diseases, and Alzheimer's disease(AD), which is associated with memory and learning disabilities, accounts for approximately 60 to 80% of all dementia cases(Wyss-Coray, 2016).

关键词： diseases degenerative Alzheimer

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Recommendation application for video head impulse test based on fuzzy logic control

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Journal of Central South University 2016年第5期23卷 1208-1214页

作者： NGUYEN Thi Anh Dao KIM Dae Young LEE Sang Min KIM Kyu sung Seong Ro Lee kwon Jang woo Department of Computer and Information Engineering Inha University Department of Otorhinolaryngology Inha University Hospital Department of Electronic Engineering Inha University Department of Information and Electronics Engineering Mokpo National University

Vestibulo-ocular reflex(VOR) is an important biological reflex that controls eye movement to ensure clear vision while the head is in ***,VOR measurement is commonly done with a video head impulse test based on a velocity gain algorithm or a position gain algorithm,in which velocity gain is a VOR calculation on head and eye velocity,whereas position gain is calculated from head and eye *** aim of this work is first to compare the two algorithms' performance and to detect covert catch-up saccade,then to propose a stand-alone recommendation application for the patient's *** the first experiment,for ipsilesional and contralesional sides,the calculated position gain(0.94±0.17) is higher than velocity gain(0.84±0.19).Moreover,gain asymmetry of both lesion and intact sides using velocity gain is mostly higher than that from using position gain(four out of five subjects).Consequently,for subjects who have unilateral vestibular neuritis diagnosed from clinical symptoms and a vestibular function test,vestibular weakness is depicted by velocity gain much better than by position *** catch-up saccade and position gain then are used as inputs for recommendation applications.

关键词： vestibulo-ocular response video head impulse velocity gain position gain desaccade

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Small-scale multi-axial hybrid simulation of a shear-critical reinforced concrete frame

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Earthquake Engineering and Engineering Vibration 2017年第4期16卷 727-743页

作者： Vahid Sadeghian Oh-sung kwon Frank Vecchio Department of Civil Engineering University of Toronto35 St.George St.TorontoONCanada

This study presents a numerical multi-scale simulation framework which is extended to accommodate hybrid simulation （numerical-experimental integration）. The framework is enhanced with a standardized data exchange format and connected to a generalized controller interface program which facilitates communication with various types of laboratory equipment and testing configurations. A small-scale experimental program was conducted using a six degree-of-freedom hydraulic testing equipment to verify the proposed framework and provide additional data for small-scale testing of shear- critical reinforced concrete structures. The specimens were tested in a multi-axial hybrid simulation manner under a reversed cyclic loading condition simulating earthquake forces. The physical models were 1/3.23-scale representations of a beam and two columns. A mixed-type modelling technique was employed to analyze the remainder of the structures. The hybrid simulation results were compared against those obtained from a large-scale test and finite element analyses. The study found that if precautions are taken in preparing model materials and if the shear-related mechanisms are accurately considered in the numerical model, small-scale hybrid simulations can adequately simulate the behaviour of shear-critical structures. Although the findings of the study are promising, to draw general conclusions additional test data are required.

关键词： hybrid simulation small-scale testing reinforced concrete structures, shear behaviour multi-scale modelling

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Intestinal microbiota and its interaction to intestinal health in nursery pigs

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Animal Nutrition 2022年第1期8卷 169-184页

作者： Marcos Elias Duarte sung woo Kim Department of Animal Science North Carolina State UniversityRaleighNC27695United States

The intestinal microbiota has gained increased attention from researchers within the swine industry due to its role in promoting intestinal maturation,immune system modulation,and consequently the enhancement of the health and growth performance of the *** review aimed to provide updated scientific information on the interaction among intestinal microbiota,dietary components,and intestinal health of *** small intestine is a key site to evaluate the interaction of the microbiota,diet,and host because it is the main site for digestion and absorption of nutrients and plays an important role within the immune *** diet and its associated components such as feed additives are the main factors affecting the microbial composition and is central in stimulating a beneficial population of *** microbiotaehost interaction modulates the immune system,and,concurrently,the immune system helps to modulate the microbiota *** direct interaction between the microbiota and the host is an indication that the mucosa-associated microbiota can be more effective in evaluating its effect on health *** was demonstrated that the mucosa-associated microbiota should be evaluated when analyzing the interaction among diets,microbiota,and *** addition,supplementation of feed additives aimed to promote the intestinal health of pigs should consider their roles in the modulation of mucosa-associated microbiota as biomarkers to predict the response of growth performance to dietary interventions.

关键词： Intestinal health Mucosa-associated microbiota Nursery pig

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