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Changes on optical coherence tomography angiography and fluorescein angiography in eyes with neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1837-1844页

作者： So Min Ahn Mihyun choi Cheolmin Yun Seong-woo Kim Jaeryung Oh Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea

AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or *** combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions *** capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly ***:Leakage on FA is associated with CNV morphology in OCTA and remained so after ***,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.

关键词： choroidal neovascularization fluorescein angiography leakage neovascular age-related macular degeneration optical coherence tomography angiography

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Changes in the distribution of South Korean forest vegetation simulated using thermal gradient indices

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Science China(Life Sciences) 2010年第7期53卷 784-797页

作者： choi Sungho LEE woo-Kyun SON Yowhan YOO Seongjin LIM Jong-Hwan Department of Environmental Science and Ecological Engineering Korea University Korea Forest Research Institute

To predict changes in South Korean vegetation distribution,the Warmth Index(WI) and the Minimum Temperature of the Coldest Month Index(MTCI) were *** climate data of the past 30 years,from 1971 to 2000,was obtained from the Korea Meteorological *** Fifth-Generation National Center for Atmospheric Research(NCAR) /Penn State Mesoscale Model(MM5) was used as a source for future climatic data under the A1B scenario from the Special Report on Emission Scenario(SRES) of the Intergovernmental Panel on Climate Change(IPCC).To simulate future vegetation distribution due to climate change,the optimal habitat ranges of Korean tree species were delimited by the thermal gradient indices,such as WI and *** categorize the Thermal Analogy Groups(TAGs) for the tree species,the WI and MTCI were orthogonally plotted on a two-dimensional grid *** TAGs were then designated by the analogue composition of tree species belonging to the optimal WI and MTCI *** a result of the clustering process,22 TAGs were generated to explain the forest vegetation distribution in *** primary change in distribution for these TAGs will likely be in the shrinkage of areas for the TAGs related to Pinus densiflora and ***,and in the expansion of the other TAG areas,mainly occupied by evergreen broad-leaved trees,such as Camellia japonica,Cyclobalanopsis glauca,and Schima *** the TAGs to explain the effects of climate change on vegetation distribution on a more regional scale resulted in greater detail than previously used global or continental scale vegetation models.

关键词： climate change forest distribution warmth index minimum temperature thermal analogy group

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Corporate pledgeable asset ownership and stock price crash risk

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Financial Innovation 2022年第1期8卷 855-882页

作者： Hail Jung Sanghak choi Junyoup Lee Sanggeum woo School of Management Engineering Ulsan National Institute of Science and TechnologyUNIST-Gil 50Ulsan 44919Republic of Korea School of Business Administration Ulsan National Institute of Science and TechnologyUNIST-Gil 50Ulsan 44919Republic of Korea

We investigate how a firm’s corporate pledgeable asset ownership(CPAO)affects the risk of future stock price *** pledgeable asset ownership and crash risk data for a large sample of ***,we provide novel empirical evidence that a firm’s risk of a future stock price crash decreases with an increase in its pledgeable *** main findings are valid after conducting various robustness *** channel tests reveal that firms with pledgeable assets increase their collateral value,thereby enhancing corporate transparency and limiting bad news hoarding,resulting in lower stock price crash ***,the results show that having more pledgeable assets enables easier access to external financing,making it less likely that managers will hoard bad news.

关键词： Asset pledgeability Stock price crash risk Endogeneity tests Information opacity

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3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung Yong Wonbin Park Yoo-mi choi In-Ho Jeon Homan Kang Jinah Jang Hak Soo choi Dong-woo Cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

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Text-mining analysis using national R&D project data of South Korea to investigate innovation in graphene environment technology

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International Journal of Innovation Studies 2023年第1期7卷 87-99页

作者： Ji Yeon Lee Jung woo choi Jae-Hak choi Byeong-Hee Lee NTIS Center Korea Institute of Science and Technology InformationDaejeon34141South Korea Department of Science and Technology Management Policy University of Science and TechnologyDaejeon34113South Korea Department of Polymer Science and Engineering Chungnam National UniversityDaejeon34134South Korea

This study investigates the possibilities offered by the development of graphene environment technology that can contribute to new and effective approaches for the transition to an ecologically benign *** analyze the research and development progress in graphene environment technology,graphene environment technology research trends of South Korea for the years 2009e2020 are investigated by acquiring information pertaining to national research and development projects related to graphene environment technology from the National Science and Technology Information *** structured and unstructured data are analyzed using diverse text-mining methods,such as keyword frequency analysis,association rule mining,and topic *** results indicate that graphene research in South Korea is focused primarily on graphene use in batteries and energy-storage devices,such as solar cells,fuel cells,and secondary *** study can help understand the manner by which the South Korean government has been investing in the research and development of graphene environment technology;additionally,it discusses the future applications and prospects of graphene for the next decade.

关键词： Graphene technology Environmental transition National R&D project information Text mining Trend analysis

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The Phytophthora nucleolar effector Pi23226 targets host ribosome biogenesis to induce necrotrophic cell death

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Plant Communications 2023年第5期4卷 263-276页

作者： Soeui Lee Jaehwan Kim Myung-Shin Kim Cheol woo Min Sun Tae Kim Sang-Bong choi Joo Hyun Lee Doil choi Plant Immunity Research Center Seoul National UniversitySeoul 08826Republic of Korea Plant Genomics and Breeding Institute Department of AgricultureForestry and BioresourcesCollege of Agriculture and Life ScienceSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Programs in Agricultural Genomics College of Agriculture and Life ScienceSeoul National UniversitySeoul 08826Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Division of Bioscience and Bioinformatics Myongji UniversityYongin 449-728Republic of Korea

Pathogen effectors target diverse subcellular organelles to manipulate the plant immune *** the nucleolus has emerged as a stress marker and several effectors are localized in the nucleolus,the roles of nucleolar-targeted effectors remain *** this study,we showed that Phytophthora infestans infection of Nicotiana benthamiana results in nucleolar inflation during the transition from the biotrophic to the necrotrophic *** *** effectors were localized in the nucleolus:Pi23226 induced cell death in *** and nucleolar inflation similar to that observed in the necrotrophic stage of infection,whereas its homolog Pi23015 and a deletion mutant(Pi23226DC)did not induce cell death or affect nucleolar *** immunoprecipitation and individual-nucleotide-resolution UV crosslinking and immunoprecipitation sequencing analysis indicated that Pi23226 bound to the 30 end of 25S rRNA precursors,resulting in accumulation of unprocessed 27S *** nucleolar stress marker NAC082 was strongly upregulated under Pi23226-expressing ***23226 subsequently inhibited global protein translation in host cells by interacting with ***23226 enhanced *** pathogenicity,indicating that Pi23226-induced ribosome malfunction and cell death were beneficial for pathogenesis in the *** results provide evidence for the molecular mechanism underlying RNA-binding effector activity in host ribosome biogenesis and lead to new insights into the nucleolar action of effectors in pathogenesis.

关键词： Phytophthora infestans hemibiotroph nucleolar effector cell death ribosome biogenesis translation inhibition

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Gain enhancement of perovskite nanosheets by a patterned waveguide:excitation and temperature dependence of gain saturation

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Light(Science & Applications) 2023年第12期12卷 2688-2699页

作者： Inhong Kim Ga Eul choi Ming Mei Min woo Kim Minju Kim Young woo Kwon Tae-In Jeong Seungchul Kim Suck Won Hong Kwangseuk Kyhm Robert A.Taylor Department of Opto&Cogno Mechatronics Engineering RCDAMPPusan National UniversityBusan 46241Republic of Korea Department of Nano-Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Clarendon Laboratory Department of PhysicsUniversity of OxfordOxford OX13PUUK

Optical gain enhancement of two-dimensional CsPbBr3 nanosheets was studied when the amplified spontaneous emission is guided by a patterned structure of *** the uncertainties and pitfalls in retrieving a gain coefficient from the variable stripe length method,a gain contour g((h))ω.x)was obtained in the plane of spectrum energy(hω)and stripe length(x),whereby an average gain was obtained,and gain saturation was *** and temperature dependence of the gain contour show that the waveguide enhances both gain and thermal stability due to the increased optical confinement and heat dissipation,and the gain origins were attributed to the two-dimensional excitons and the localized states.

关键词： waveguide saturation contour

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The Study on Effect of Exhaust Performance According to Active Muffler Valve Spring as Followed Spring Constant

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Journal of Thermal Science 2002年第4期11卷 372-377页

作者： Seuk Cheun choi Tae woo Kong Han Shik Chung Hyo Min Jeong Young Heung Chun Graduate School of Mechanical and Precision Engineering Gyeongsang National UniversityInpyeongdong 445 Tongyong Kyongnam 650-160Korea School of Transport Vehicle Engineering Gyeongsang National UniversityThe Institute of Marine IndustryInpyeongdong 445 Tongyong Kyongnam 650-160Korea

This study represents the influence on exhaust performance by active muffler valve *** main experimental parameters were engine speeds and torsion coil spring constants in the active *** the muffler valve spring has a low spring constant of k=0.75,the sound pressure level was low at the region of engine speed 2000 to 2500 r/min,and the velocity of exhaust gas was high at spring constant k=*** the engine speed was under 1500 r/min,the mean concentration of CO was high in case without muffler *** the engine speed in the range of 1600 to 2600 r/min with spring constant k=0.75,the mean HC concentration showed the lowest *** muffler valve,the temperature in the muffler was higher than the case with muffler *** research represented that the performance of the active muffler valve spring constant k=0.75 was higher than that without muffler valve and valve spring constant k=*** the three cases of experimental condition,with a spring constant k=0.75,0.70 and without muffler valve,the exhaust performance was high in case active muffler valve spring constant k=0.70.

关键词： active muffler torsion coil spring spring constant sound pressure level

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Outcome after gastrectomy in gastric cancer patients with type 2 diabetes

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World Journal of Gastroenterology 2012年第1期18卷 49-54页

作者： Jong Won Kim Jae-Ho Cheong woo Jin Hyung Seung-Ho choi Sung Hoon Noh Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Surgery Severance Hospital Yonsei University College of Medicine

AIM: To evaluate the prognosis of type Ⅱ diabetes mellitus (T2DM) after gastrectomy and related factors in gastric cancer patients. METHODS: 403 gastric cancer patients with T2DM were studied, who underwent gastrectomy between May 2003 and September 2009. A review of medica records and telephone interviews was performed in this cross-sectional study. The factors included in the statistical analysis were as follows: gender, age, type of surgery, preoperative body mass index (BMI), current BMI, BMI reduction ratio, preoperative insulin or oral diabetic medicine requirement, follow-up duration, and current state of diabetes. Assessment of diabetes status after surgery was classified into four categories according to the change in hypoglycemic agents after surgery and present status of T2DM: resolution, improvement, same, and worse.(± 20.6 mo), preoperative BMI was 24.7 kg/m2 (± 3.0 kg/m2), and BMI reduction ratio was 9.8% (± 8.6%). After surgery, T2DM was cured in 58 patients (15.1%) and was improved in 117 patients (30.4%). According to the type of surgery, the BMI reduction ratio was signif icantly higher in the total gastrectomy and Roux-en-Y reconstruction group [14.2% ± 9.2% vs 9.2% ± 7.7% (Billroth Ⅱ group), P < 0.001] and signif icantly lower in the subtotal gastrectomy and Billroth Ⅰ reconstruction group [7.6% ± 8.0%, 9.2% ± 7.7% (Billroth Ⅱ group), P < 0.001]. The BMI reduction ratio, follow-up duration after surgery, type of surgery, extent of gastrectomy, and performance of duodenal bypass were signif icantly correlated to the course of T2DM (P < 0.05). The BMI reduction ratio was the most influential factor on T2DM status. In a subgroup analysis of patients with a BMI reduction ratio of 10% or less (n = 206), T2DM was cured in 15 (7.6%) patients and was improved in 57 (28.8%) patients after surgery, and only the duration of surgery was signif icantly correlated to T2DM status (P = 0.022).

关键词： Gastric cancer Diabetes mellitus Metabolic surgery Bariatric surgery

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Effect of expanding nanocellulose sponge on nasal mucosal defects in an animal model

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Regenerative Biomaterials 2020年第1期7卷 47-52页

作者： JiWon Kim Kyungbae woo Jeong Mi Kim Mi Eun choi Young-Mo Kim Su-Geun Yang Bong Sup Shim Jeong-Seok choi Department of Otorhinolaryngology Inha UniversityCollege of Medicine27 Inhang-roJung-guIncheon 22332Republic of Korea Department of Chemical Engineering Inha University100 InharoMichuholguIncheon 22212Republic of Korea Department of New Drug Development Inha UniversityCollege of MedicineB-308Chungsuk Bldg.366Seohae-DaeroJung-GuIncheon 22332Republic of Korea

Nanocellulose has emerged for a wide range of applications in biomedical engineering because of its water absorption capacity,appropriate *** investigated the hemostatic and regenerative abilities of an expanding polyvinyl alcohol(PVA)-nanocellulose sponge on nasal mucosal defects.A 3 mm-diameter nasal defect was made in experimental *** were divided into four groups with control,vaseline,PVA and PVA-nanocellulose packing *** the defect was created,bleeding times and amounts were *** materials were removed on experimental day(ED)*** ED 3,7 and 14,histological analysis and immunohistochemical study for neutrophils were *** cells were counted and epithelial thicknesses were *** amounts and times in the vaseline packing group were smaller than in the PVA ***-nanocellulose group showed less neutrophils than in the other groups on ED *** epithelium thickness in the PVA-nanocellulose group was significantly smaller than in the control group at ED 7,but at ED 14,there was no significant intergroup *** group had a significant lower inflammatory cell count than the control group on ED ***-nanocellulose sponge applied to nasal mucosal defects can significantly enhance mucosal regeneration during early wound healing.

关键词： polyvinyl alcohol nasal mucosa nanocellulose

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