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动脉粥样硬化多种族研究中代谢综合征和糖尿病作为主动脉瓣膜钙化预测因素的特点

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 41-42页

作者： Katz R. wong n.d. Kronmal R. K.d. O'Brien 刘少伟 division of Cardiology Box 354622 University of Washington 1959 NE Pacific St Seattle WA United States Dr.

Background -Calcific aortic valve disease is common in the elderly, is correlated with common cardiovascular risk factors, and is associated with increased cardiovascular event risk; however, whether metabolic syndrome is associated with an increased prevalence of aortic valve calcium(AVC) is not known. Methods and Results -The prevalence of AVC, as assessed by computed tomography, was compared in 6780 Multi-Ethnic Study of Atherosclerosis(MESA) participants with metabolic syndrome(n=1550; national Cholesterol Education Program’s Adult Treatment Panel III[ATP III] criteria), diabetes mellitus(n=1016), or neither condition(n=4024). The prevalence of AVC for those with neither condition, metabolic syndrome, or diabetes mellitus was, respectively, 8%, 12%, and 17%in women(Pnd 14%, 22%, and 24%in men(Pd with those with neither condition, the adjusted relative risks for the presence of AVC were 1.45(95%CI 1.11 to 1.90) for metabolic syndrome and 2.12(95%CI 1.54 to 2.92) for diabetes mellitus in women and 1.70(95%CI 1.32 to 2.19) for metabolic syndrome and 1.73(95%CI 1.33 to 2.25) for diabetes mellitus in men. There was a graded, linear relationship between AVC prevalence and the number of metabolic syndrome components in both women and men(both Pn.d.when the International diabetes Federation metabolic syndrome definition was used. Conclusions -In the MESA cohort, the metabolic syndrome and diabetes mellitus are associated with increased risk of AVC, and AVC prevalence is increased with increasing number of metabolic syndrome components.

关键词：代谢综合征瓣膜钙化钙化性疾病危险因素心血管事件相对风险教育计划组成因素线性相关关系

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血压分类、高血压亚型与代谢综合征

世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 53-54页

作者： Franklin S.S. Barboza M.G. Pio J.R. wong n.d. 何燕萍 Heart disease Prevention Program C240 Medical SciencesUniversity of California Irvine IrvineCA92697 United States.Dr.

背景:血压升高是代谢综合征(MetS)的表现之一,然而,各血压分类和高血压亚型与代谢综合征患病可能之间的关系尚未确定。方法:在1999—2002年国家健康和营养状况调查中选择了5968例年龄≥18岁、未经抗高血压治疗的受试者(加权为124700000... 详细信息

背景:血压升高是代谢综合征(MetS)的表现之一,然而,各血压分类和高血压亚型与代谢综合征患病可能之间的关系尚未确定。方法:在1999—2002年国家健康和营养状况调查中选择了5968例年龄≥18岁、未经抗高血压治疗的受试者(加权为124700000)进行横断面研究,确定不同血压分类组的MetS(依据nCEP标准)患病可能性。根据JnC-VI血压分类,非高血压情况被分为理想血压、正常血压和高正常血压。

关键词：代谢综合征抗高血压治疗横断面研究国家健康营养状况总胆固醇水平

Crosstalk between.d.gradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham naidu Bhupana Ching-On wong department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between.d.gradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between.d.gradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Role of salivary matrix metalloproteinase-8 （MMP-8） in chronic periodontitis diagnosis

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Frontiers of Medicine 2015年第1期9卷 72-76页

作者： namita Gupta n.d. Gupta Akash Gupta Saif Khan neha Bansa department of Periodontics and Community dentistry Dr. Z. A. Dental College Aligarh Muslim University Aligarh U.P. India department of Biochemistry Rama Medical College and Hospital Pilakhua Hapur. U.P. India

Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases （MMPs） secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPd of dr. Ziauddin Ahmad dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups： group I consisted of 20 periodontally healthy subjects （controls） while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth （PPd）, clinical attachment level （CAL）, gingival index （GI）, and plaque index （PI）. Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. data were analyzed using STATISTICA （Windows version 6） software. Salivary MMP-8 levels of groups I and II were 190.91 ± 143.89 ng/ml and 348.26± 202.1 ng/ml, respectively. The MMP-8 levels and periodontal status （PPd, CAL, GI, and PI） of groups I and II showed positive and significant correlations （for PPd, r = 0.63, P 〈 0.001; for CAL, r = 0.54, P 〈 0.001; for GI, r = 0.49, P 〈 0.001; and for PI, r = 0.63, P 〈 0.001）. The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index

The Internationalization of Traditional Chinese Medicine into the Western World

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Chinese Medicine and Culture 2018年第1期1卷 32-36页

作者： Isa-Allean Blacksher n.d. International College Shanghai University of TCMShanghaiChina

This paper introduces the internationalization of traditional Chinese medicine into the western *** of traditional Chinese medicine(TCM)into the Western world is not a simple or easy *** exposure and exportation into the rest of the world should be a task taken on with a special focus and determination on staying strong along the *** the truth,strength,and integrity in TCM medicine as it is exported is the highest priority and the best way to promote *** this will give it a solid foundation in its new land and for its new ***’s study and analyze what really is required to help TCM avoid all problems and hardships of this exportation process as TCM goes west.

关键词： Acupuncture and moxibustion alternative medicine cultural trade exploration of traditional Chinese medicine integrative medicine internationalization of traditional Chinese medicine traditional Chinese medicine traditional Chinese medicine tradition

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration.d.e to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic diseases(ACCdiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification.d.es not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal tran.d.ction Thy-1(Cd90)

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin.d.monstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(Ad),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain.d.sorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic