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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities

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中国神经肿瘤杂志 2008年第2期6卷 131-131页

作者： Ng SS Yew DT wong bc Kung HF Department of Chemistry Open laboratory of Chemical BiologyUniversity of Hong Kong

Glia. 2008 Jul ***-and-a-half-LIM protein 2 (FHL2) is a member of FHL protein family, which plays a crucial role in regulating geneexpression, cell survival, and *** its function in oncogenesis appears to be tumor typ... 详细信息

关键词：蛋白质神经胶质瘤临床分析诊断方法病因分析

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中华流行病学杂志 2006年第6期27卷 508-512页

作者：张茂俊何利华王振宇周增芬张建中中国疾病预防控制中心传染病预防控制所诊断室北京102206 香港大学皇家玛丽医院内科昆明医学院第一附属医院消化科

目的分析中国不同人群及不同胃部疾病病例来源的幽门螺杆菌致病相关基因cagA、iceA、vacA及HP0519的分布。方法采用特异引物聚合酶链式反应(PCR)方法分析150株幽门螺杆菌上述基因的多态性分布特点,并对其分布作初步统计分析。结果93％(... 详细信息

目的分析中国不同人群及不同胃部疾病病例来源的幽门螺杆菌致病相关基因cagA、iceA、vacA及HP0519的分布。方法采用特异引物聚合酶链式反应(PCR)方法分析150株幽门螺杆菌上述基因的多态性分布特点,并对其分布作初步统计分析。结果93％(139／150)中国菌株cagA基因3′端重复序列的PCR产物具有东方菌株特征。75％(113／150)菌株iceA基因为iceA1, 19％(29／150)为iceA2,不同地区间iceA基因的分布差异无统计学意义。云南菌株iceA1、iceA2的分布与菌株分离个体的种族特点及临床疾病类型无显著关系。96％中国菌株(144／150)vacA基因s区的等位基因为s1;m区等位基因m2、m1b和m1b-m2的比例分别为57％(85／150)、27％(41／150)和11％(16／150),仅2株福建菌株为m1a。不同地区间vacA s1、m2、m1b分布的差异无统计学意义。云南菌株m1b-m2的分布高于福建和北京菌株。云南菌株vacA s区等位基因的多样性与分离个体的种族及临床疾病类型无显著关系。vacA m区等位基因的多样性与分离个体的临床疾病类型无显著关系,但不同民族间m2的分布有显著差异,白族人群m2的分布显著少于汉族和纳西族。93％(140／150)的中国菌株HP0519基因具有24 bp和15 bpDNA插入和缺失的多态性特点。不同地区间HP0519基因的多态性无显著不同。云南菌株HP0519的多态性与菌株分离个体的临床疾病类型无显著关系,但来源不同民族菌株的HP0519基因存在差异。结论幽门螺杆菌中国菌株cagA 3′端JF/TR特异引物的扩增结果具有东亚菌株特点。中国菌株vacA基因多为s1,其分布与菌株分离个体的临床疾病类型无关。中国菌株mcA基因m区的分布具有多样性。中国菌株HP0519基因具有24 bp和15 bp插入和缺失的多态性特点。

关键词：幽门螺杆菌致病相关基因

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science China Chemistry 2025年

作者： Jie Zhang Yi Chen Guijun Li Zelin Sun Zhengong Meng Wai-Yeung wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染

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胃肠病学 2007年第1期12卷 40-52页

作者： Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL wong bc Krabshuis JH 杜颖丛衍群戴宁

我非常高兴向大家推荐这份发展中国家幽门螺杆菌（***）临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。

关键词：幽门螺杆菌感染发展中国家临床指南胃肠病学世界组织临床经验

Deep residual learning for denoising Monte Carlo renderings

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Computational Visual Media 2019年第3期5卷 239-255页

作者： Kin-Ming wong Tien-Tsin wong Artixels Hong Kong S.A.R.China Department of Computer Science and Engineering the Chinese University of Hong KongHong Kong S.A.R.China

Learning-based techniques have recently been shown to be effective for denoising Monte Carlo rendering methods. However, there remains a quality gap to state-of-the-art handcrafted denoisers. In this paper, we propose a deep residual learning based method that outperforms both state-of-the-art handcrafted denoisers and learning-based *** the indirect nature of existing learning-based methods(which e.g., estimate the parameters and kernel weights of an explicit feature based filter), we directly map the noisy input pixels to the smoothed output. Using this direct mapping formulation, we demonstrate that even a simple-and-standard ResNet and three common auxiliary features(depth, normal,and albedo) are sufficient to achieve high-quality denoising. This minimal requirement on auxiliary data simplifies both training and integration of our method into most production rendering pipelines. We have evaluated our method on unseen images created by a different renderer. Consistently superior quality denoising is obtained in all cases.

关键词： Monte Carlo rendering denoising deep learning deep residual learning filter-free denoising

Answering Reachability Queries on Incrementally Updated Graphs by Hierarchical Labeling Schema

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Journal of Computer Science & Technology 2016年第2期31卷 381-399页

作者： Tak-Lam wong Department of Mathematics and Information Technology The Hong Kong Institute of Education Hong Kong China

We proposed a novel solution schema called the Hierarchical Labeling Schema （HLS） to answer reachability queries in directed graphs. Different from many existing approaches that focus on static directed acyclic graphs （DAGs）, our schema focuses on directed cyclic graphs （DCGs） where vertices or arcs could be added to a graph incrementally. Unlike many of the traditional approaches, HLS does not require the graph to be acyclic in constructing its index. Therefore, it could, in fact, be applied to both DAGs and DCGs. When vertices or arcs are added to a graph, the HLS is capable of updating the index incrementally instead of re-computing the index from the scratch each time, making it more efficient than many other approaches in the practice. The basic idea of HLS is to create a tree for each vertex in a graph and link the trees together so that whenever two vertices are given, we can immediately know whether there is a path between them by referring to the appropriate trees. We conducted extensive experiments on both real-world datasets and synthesized datasets. We compared the performance of HLS, in terms of index construction time, query processing time and space consumption, with two state-of-the-art methodologies, the path-tree method and the 3-hop method. We also conducted simulations to model the situation when a graph is updated incrementally. The performance comparison of different algorithms against HLS on static graphs has also been studied. Our results show that HLS is highly competitive in the practice and is particularly useful in the cases where the graphs are updated frequently.

关键词： graph indexing reachability query Hierarchical Labeling Schema (HLS) incremental update directed cyclic graph

Effects of green roof damping and configuration on structural seismic response

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Frontiers of Structural and Civil Engineering 2023年第8期17卷 1133-1144页

作者： Jenika McCLAY Jenna wong School of Engineering San Francisco State UniversitySan FranciscoCA 94132USA

Sustainable structures are critical for addressing global climate ***,their structural resilience or ability to recover from natural events must be considered *** roofs are a widely used sustainable feature that improve the environment while providing excellent occupant *** expand their usage,their inherent damping and layout sensitivity to seismic performance are investigated in this *** soil of a green roof can serve as a damper to dissipate the energy generated by earthquakes or other dynamic *** of preliminary analysis show that a green roof soil can increase localized damping by 2.5%under both dry and saturated *** on these findings,nonlinear time-history analyses are conducted on a three-story building in SAP2000 to monitor the structural behavior with and without a green *** increased damping in the green roof soil is beneficial to the structural performance,i.e.,it reduces the building displacement and acceleration by 10%and 12%,***,certain configurations are more effective and beneficial to the structural response than others,which suggests the possibility of design *** on the findings of this study,new methods of modeling and considering green roofs in structural design are established.

关键词： green infrastructure green roof structural resilience seismic design

Global Asymptotics of Krawtchouk Polynomials——a Riemann-Hilbert Approach

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Chinese Annals of Mathematics,Series B 2007年第1期28卷 1-34页

作者： Roderick wong Department of Mathematics City University of Hong Kong Tat Chee AvenueKowloonHong KongChina

In this paper, we study the asymptotics of the Krawtchouk polynomials Kn^N（z;p,q） as the degree n becomes large. Asymptotic expansions are obtained when the ratio of the parameters n/N tends to a limit c E （0, 1） as n →∞. The results are globally valid in one or two regions in the complex z-plane depending on the values of c and p; in particular, they are valid in regions containing the interval on which these polynomials are orthogonal, Our method is based on the Riemann-Hilbert approach introduced by Delft and Zhou.

关键词： Global asymptotics Krawtchouk polynomials Parabolic cylinderfunctions Airy functions Riemann-Hilbert problems