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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN KIM YUN SUN LEE SEUNG MYUNG DONG HYO JUNG KIM DA EUN LEE HYEON WOONG KANG MYEONG JIN KIM JOON SEONG park Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

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Recipient artery dissection during extracranial-intracranial bypass surgery:Two case reports

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World Journal of Clinical Cases 2024年第31期12卷 6479-6485页

作者： Yong-Jun Lee Wan park Sung-Pil Joo Department of Neurosurgery Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Neurosurgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Superficial temporal artery to middle cerebral artery(STA-MCA)bypass is a valuable treatment for preventing ischemia and hemorrhage in occlusive cerebrovascular *** site dissection is rarely reported among the various bypass-related *** SUMMARY In this case report,we describe two patients,who were 63-and 59-years-old with middle cerebral artery occlusion treated by STA-MCA *** bypass surgery,the recipient M4 artery intima was *** sacrificed the dissecting portion,and no complications occurred during the follow-up *** brain imaging revealed improved brain *** report rare cases of recipient artery dissection located in the extracranial to intracranial bypass site,and we suggest atherosclerotic changes in the recipient artery and insufficient puncture as the *** Appropriate recipient artery selection is critical,and if dissection occurs,it is essential to sacrifice the dissecting portion quickly.

关键词： Anastomosis site dissection Pseudoaneurysm Bypass Atherosclerosis Recipient artery Case report

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Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes

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Acta Pharmacologica Sinica 2005年第5期26卷 551-558页

作者： Cuk-seongKIM Sook-jinSON Hyo-shinKIM Yong-dukKIM kyu-seungLEE Byeong-hwaJEON Kwang-jinKIM Jin-kyu park Jin-bong park Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea Korea Ginseng and Tobacco Research Institute Daejeon 305-805 Korea Department of Physiology College of Medicine Chungnam National University Daejeon 301-131 Korea

Aim:To examine the effects of ginseng saponins on the heterologously expressedhuman ether-a-go-go related gene（HERG）that encodes the rapid component ofthe delayed rectifier K+***:A two-electrode voltage clamp tech-nique was *** currents were recorded in Xenopus oocytes injected withHERG ***:Crude saponins of Korean red ginseng（GS）induced aminimal increase of the maximal HERG conductance without changes in the volt-age-dependent HERG current activation and inactivation ***,however,decelerated HERG current deactivation in a concentration-dependent manner,which was more noticeable with panaxitriol（PT）than panaxidiol（PD）.Consistently,ginseng saponins increased the HERG deactivation time constants with the orderof potency of Rg1（a maj or component of PT）>Rf1>Rb1（a major component of PD）.Re had little effect on HERG *** a cardiac action potential,GSincreased the outward HERG ***:Ginseng saponins enhanceHERG currents,which could be in part a possible mechanism of the shorteningcardiac action potential of ginseng saponins.

关键词： Ginseng saponins Xenopus laevis potassium channels action potentials patch-clamp techniques

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Recent advances in electronic devices for monitoring and modulation of brain

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Nano Research 2021年第9期14卷 3070-3095页

作者： Yong won Kwon Yoon Sun Jun Young-Geun park Jiuk Jang Jang-Ung park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery

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Local Energy and Planned Ramping Product Joint Market Based on a Distributed Optimization Method

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1357-1368页

作者： Zhong Zhang Furong Li Sung-won park Sung-Yong Son Dalian University of Technology DalianChina Department of Electronic and Electrical Engineering University of BathBathU.K. the University of Bath BathU.K. the Department of Electrical and Electronic Engineering Youngsan UniversitySouth Korea Gachon University SeoulSouth Korea

High penetration of renewable energy generation(REG)in the distribution system increases both the power uncertainty at a given interval and the power variation between two *** markets addressing power uncertainty have been widely ***,there is a lack of market mechanisms regarding the power variation of the load and *** paper thus defines a planned ramping(PR)product to follow the net load variation and extends the local energy market to include the trading of PR *** are economically compensated for their PR *** models of dispatchable generators and flexible load aggregators in the joint market are *** solve the market problem in polynomial time,a distributed market clearing method is developed based on the ADMM *** joint market is tested on a modified IEEE 33-bus *** verifies that introducing the PR market can encourage flexible loads to provide more PR service to accommodate the net load *** such,the ramping cost of dispatchable generators is reduced by 29.09%in the test *** planned energy curtailment from REG is also *** computational efficiency of the proposed distributed clearing method is validated by comparing it with a centralized method.

关键词： Distributed market clearing flexible load aggregator local electricity market planned ramping product renewable energy generation

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Enriching Middle School Students’Learning Through Digital Storytelling:A Multimodal Analytical Framework

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ECNU Review of Education 2024年第2期7卷 357-383页

作者： Deoksoon Kim Ho-Ryong park Oksana Vorobel Boston College Lynch School of Education-Teaching Curriculumand SocietyI40 Commonwealth AvenueChestnut HillMassachusetts 02467-3800US Murray State University City University of New York

Purpose This study investigates middle school students’learning experiences through digital storytelling,applying a multimodal analytical framework to uncover patterns in digital *** study explores how participants engage in pedagogical activities,reflect on their learning experiences,and articulate their voices through digital ***/Approach/Methods Employing qualitative case study methods,we purposefully selected three 12-year-old female students at an urban school in the northern *** of digital stories and other data sources(interviews,classroom observations,and reflective journals)show that the students were engaged in both teaching and *** The findings describe(1)participants and their learning experiences,(2)students’representational and interpersonal constructs as used in their digital stories,and(3)their participation as teachers as well as ***/Value Our multimodal analytical framework illuminates how students express themselves through digital *** discussion focuses on students’learning,their identity development,the effectiveness of the analytical framework,and pedagogical implications.

关键词： Analytical framework digital stories identity middle school students multimodality

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Colonic J-pouch anal anastomosis after ultralow anterior resection with upper sphincter excision for low-lying rectal cancer

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World Journal of Gastroenterology 2005年第17期11卷 2570-2573页

作者： Jae-Gahb park Min Ro Lee Seok-Byung Lim Chang won Hong Sang Nam Yoon Sung-Bum Kang Seung Chul Heo Seung-Yong Jeong kyu Joo park Department of Surgery Seoul National University College of Medicine 28 Yongon-dongChongno-guSeoul 110-744Korea Cancer Research Institute and Cancer Research CenterSeoul National University28 Yongon-dongChongno-guSeoul 110-744Korea Research Institute and HospitalNational Cancer Center809 Madu-dongIlsan-guGoyangGyeonggi 411-764Korea Department of Surgery Seoul National University College of Medicine 28 Yongon-dongChongno-guSeoul 110-744Korea Research Institute and Hospital National Cancer Center 809 Madu-dongIlsan-guGoyangGyeonggi 411-764Korea

AIM:There is some evidence of functional superiority of colonic J-pouch over straight coloanal anastomosis (CM) in ultralow anterior resection (ULAR) or intersphincteric resection. On the assumption that colonic J-pouch anal anastomosis is superior to straight CM in ULAR with upper sphincter excision (USE: excision of the upper part of the internal sphincter) for low-lying rectal cancer, we compare functional outcome of colonic J-pouch vsthe straight CM. METHODS: Fifty patients of one hundred and thirty-three rectal cancer patients in whom lower margin of the tumors were located between 3 and 5 cm from the anal verge received ULAR including USE from September 1998 to January 2002. Patients were randomized for reconstruction using either a straight (n = 26) or a colonic J-pouch anastomosis (n = 24) with a temporary diverting-loop ileostomy. All patients were followed-up prospectively by a standardized questionnaire [Fecal Inco-ntinence Severity Index (FISI) scores and Fecal Incontinence Quality of Life (FIQL) scales]. RESULTS: We found that, compared to straight anastomosis patients, the frequency of defecation was significantly lower in J-pouch anastomosis patients for 10 mo after ileostomy takedown. The FISI scores and FIQL scales were significantly better in J-pouch patients than in straight patients at both 3 and 12 mo after ileostomy takedown. Furthermore, we found that FISI scores highly correlated with FIQL scales. CONCLUSION: This study indicates that colonic J-pouch anal anastomosis decreases the severity of fecal incontinence and improves the quality of life for 10 mo after ileostomy takedown in patients undergoing ULAR with USE for low-lying rectal cancer.

关键词： Upper sphincter excision Ultralow anterior resection Coloanal anastomosis Rectal cancer

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Effects of air movement in a hot air dryer on the drying characteristics of colored potato (Solanum tuberosum L.) using computational fluid dynamics

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 232-240页

作者： Hyeon Woo park won Byong Yoon Department of Food Science and Biotechnology College of Agriculture and Life ScienceKangwon National UniversityChuncheonGangwon 200-701S.Korea

The flow fields of hot air in the dryer for drying colored potatoes of which characteristics are highly sensitive to the temperature were simulated using computational fluid dynamics(CFD)*** local air velocity decreased as the distance from the flow inlet *** mass and heat transfer coefficients increased from 0.666×10^(-2) m/s to 1.711×10^(-2) m/s,and 6.555 W/(m^(2)·K)to 16.834 W/(m^(2)·K),respectively,as the air velocity increased from 0.207 m/s to 1.567 m/s at 60°*** drying simulation model using the heat and mass transfer model made accurate *** thermal properties of colored potato,such as the thermal conductivity and specific heat,decreased significantly from 0.440 W/(m·K)to 0.034 W/(m·K)and 3906.45 J/(kg·K)to 2198.52 J/(kg·K),respectively,as the moisture content decreased from 78% to 5%.With the variable thermal and physical properties,the heat transfer simulation model made accurate predictions of the hot-air drying characteristics for the colored potatoes,and the RMSE values for all cases were(1.85±0.27)℃.

关键词： colored potato hot air drying drying characteristics computational fluid dynamics thickness air velocity

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Overcoming the fundamental light-extraction efficiency limitations of deep ultraviolet light-emitting diodes by utilizing transverse-magnetic-dominant emission

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Light(Science & Applications) 2015年第1期4卷 422-429页

作者： Dong Yeong Kim Jun Hyuk park Jong won Lee Sunyong Hwang Seung Jae Oh Jungsub Kim Cheolsoo Sone EFred Schubert Jong kyu Kim Department of Materials Science and Engineering Pohang University of Science and TechnologyPohang 790-784Korea LED Business Samsung ElectronicsYongin 446-920Korea Future Chips Constellation Department of ElectricalComputerand Systems EngineeringRensselaer Polytechnic InstituteTroyNY 12180USA

While the demand for deep ultraviolet(DUV)light sources is rapidly growing,the efficiency of current AlGaN-based DUV light-emitting diodes(LEDs)remains very low due to their fundamentally limited light-extraction efficiency(LEE),calling for a novel LEE-enhancing approach to deliver a real ***,we propose sidewall emission-enhanced(SEE)DUV LEDs having multiple light-emitting mesa stripes to utilize inherently strong transverse-magnetic polarized light from the AlGaN active region and three-dimensional reflectors between the *** SEE DUV LEDs show much enhanced light output power with a strongly upward-directed emission due to the exposed sidewall of the active region and Al-coated selective-area-grown n-type GaN *** devices also show reduced operating voltage due to better n-type ohmic contact formed on the regrown n-GaN stripes when compared with conventional ***,the proposed approach simultaneously improves optical and electrical *** addition,strategies to further enhance the LEE up to the theoretical optimum value and control emission directionality are discussed.

关键词： deep ultraviolet light-emitting diodes light-extraction efficiency

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Fingerprint inspired advanced end-effector and its applications

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Friction 2022年第10期10卷 1739-1750页

作者： Sung Ho LEE Hyo Sung KIM Han Jun park Moon kyu KWAK Department of Electrical Engineering and Computer Science University of MichiganAnn Arbor 48109USA Department of Mechanical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

The human fingertip consists of a fingerprint with many micro-grating *** main roles of the fingerprint could be divided into two purposes,namely,the enhancement of the frictional force and the effective transmittance of the *** this study,we present the fingerprint-inspired end-effector that has not only admirable frictional force but also electric *** end-effector is composed of fluorocarbon rubber,one of the famous materials to achieve high frictional force and *** various experiments,the novel performance of micro structured fluorocarbon rubber end-effector(MSFE)is characterized by comparing with a macroscale patterned sample(MPS),which has been already used in real industrial *** results are analyzed ***,as feasible applications,we suggest two applications based on the role of the *** is the conductive astronaut glove with high frictional force,and the other one is a non-slip pad for the next-generation glass transfer *** these experiments,we successfully observe the enhanced system performance and confirm the possibility of using the MSFE as feasible *** believe that the MSFE could be a useful and powerful alternative as an end-effector,not only in the aerospace industry but also in display manufacturing processes.

关键词： fingerprint end-effector fluorocarbon rubber(FKM) glass transfer system spacesuit

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