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采用对比基因杂交技术建立嗅神经母细胞瘤基因畸变模型

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中华肿瘤杂志 2005年第1期27卷 16-21页

作者：游学俊 Iver Petersen Hartmut Arps wolfgang draf Ulrike Bockmhl 华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科武汉430030 德国柏林洪堡大学附属夏瑞特医院病理研究所德国富尔达市Fulda医院病理研究所德国富尔达市Fulda医院耳鼻咽喉头颈及颌面整形外科

目的　建立嗅神经母细胞瘤 (ENB)的基因畸变模型并分析其特征。方法　采用对比基因杂交 (CGH)技术对 12例原发、3例复发、7例转移ENB标本进行基因检测 ,用特殊软件系统对所采集照片的荧光信号进行量化分析 ,确定肿瘤DNA与正常对照DNA之... 详细信息

目的　建立嗅神经母细胞瘤 (ENB)的基因畸变模型并分析其特征。方法　采用对比基因杂交 (CGH)技术对 12例原发、3例复发、7例转移ENB标本进行基因检测 ,用特殊软件系统对所采集照片的荧光信号进行量化分析 ,确定肿瘤DNA与正常对照DNA之间的基因差别。结果　ENB常见DNA丢失主要见于 1p、2q、3p/q、4p/q、5p/q、6q、8p/q、9p、10p/q、11p、12q、13q、18q和 2 1q ,DNA过度表达见于 1p、7q、9q、11q、14q、16p/q、17p/q、19p/q、2 0p/q和 2 2p/q。ENB的 1p2 1 p31DNA丢失与该类肿瘤患者预后差有明显相关性。死于ENB的患者均具有以下共性 :1p2 1 p31DNA丢失、临床分期为C或D期、分化程度低 (Ⅲ或Ⅳ级 )。对 4例发生转移、复发的患者 ,将检测结果与其原发病灶基因畸变情况进行对比分析表明 ,转移、复发病灶与其原发病灶间具有高度的克隆一致性。结论　采用CGH能建立ENB的典型基因畸变模型 ,该模型有助于解释此肿瘤的生物学特性并对其预后进行评估 ,并与神经母细胞瘤、小细胞肺癌以及头颈部鳞癌进行鉴别。

关键词：嗅神经母细胞瘤瘤基因复发 CGH 原发病灶患者转移结论对比共性

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鼻腔鼻窦嗅神经母细胞瘤的手术径路探讨

中华耳鼻咽喉科杂志 2003年第3期38卷 206-209页

作者：游学俊 wolfgang draf Ulrike Bockmühl 华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科武汉430030 Department of Otorhinolaryngology Head and Neck and Facial Plastic SurgeryKlini kum FuldaTeaching Hospital of the Philipps University Marburg

目的　总结鼻腔鼻窦嗅神经母细胞瘤 (esthesioneuroblastoma,ENB)的临床经验。方法　对Fulda医院耳鼻咽喉头颈及面部整形外科 1 988年 7月～ 2 0 0 1年 1 2月经治的 1 7例ENB的临床资料、手术治疗的径路、方法及预后进行回顾性分析。... 详细信息

目的　总结鼻腔鼻窦嗅神经母细胞瘤 (esthesioneuroblastoma,ENB)的临床经验。方法　对Fulda医院耳鼻咽喉头颈及面部整形外科 1 988年 7月～ 2 0 0 1年 1 2月经治的 1 7例ENB的临床资料、手术治疗的径路、方法及预后进行回顾性分析。结果　据Morita等的临床分期标准 ,1 7例中A期1例 ,B期 6例 ,C期 9例 ,D期 1例。术后 8～ 1 63个月 (平均 44个月 )的随访观察结果表明 :2年既无复发、亦无转移的总生存率 90 90 % (1 0 / 1 1 ) ,其中A期为 1 / 1、B期为 6/ 6、C期为 3/ 3、D期为 0 / 1。所有经鼻内径路手术的 6例患者至今均存活 ,临床和影像学检查都无复发和转移迹象 ,存活最长者已达1 30个月 ;2例经额下径路手术的C期患者在随访的 8、2 7个月内均未发现复发和转移 ;经面正中掀翻径路手术的B、C期患者各 1例已分别存活 1 63个月和 82个月 ,均无复发和转移。 6例在此观察期间死于ENB :其中C期 5例、D期 1例 ;Ⅱ级 1例、Ⅲ级 1例、Ⅳ级 3例 (另 1例未行分级诊断 )。 1例 (C期/Ⅱ级 )于ENB术后 7年死于星形细胞瘤 ,此间一直无ENB复发。结论　联合应用手术和放射治疗ENB的效果最佳。前颅底恶性肿瘤的手术治疗径路选择应按照以下原则 :若病变组织没有浸润至颅内或眶内 ,采用鼻内径路 ;

关键词：鼻腔肿瘤鼻窦肿瘤嗅神经母细胞瘤手术径路临床特征放射治疗

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功能性鼻重建手术

国外医学（耳鼻咽喉科学分册） 2004年第3期28卷 192-192页

作者： Egbert H.Huizing John A.M.de Groot wolfgang draf 翟立杰大连医科大学附属第一医院耳鼻咽喉科 116011

一位鼻科学专家和他长期合作的伙伴们提出出版一本综合性的鼻手术学课本，题目为《功能性鼻重建手术》。这是鼻科手术学的一部杰作，它阐述了最近35年来鼻外科手术的进展。本书以启发式的方式安排：从基础开始，如：解剖、组织学特征、... 详细信息

一位鼻科学专家和他长期合作的伙伴们提出出版一本综合性的鼻手术学课本，题目为《功能性鼻重建手术》。这是鼻科手术学的一部杰作，它阐述了最近35年来鼻外科手术的进展。本书以启发式的方式安排：从基础开始，如：解剖、组织学特征、鼻的胚胎发育和生理学对手术的重要性，如第三章所述。紧接着是病理和诊断，在此基础上建立一般的手术学概念。对于初学者和高年资的医生，切口和手术路径县最重要的。本书还对专来术语、名词作了介绍．术语在讨论中是很重要的。

关键词：功能性鼻重建手术解剖组织学特征胚胎发育

New insights into the properties of high-manganese steel

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 782-796页

作者： wolfgang Bleck Steel Institute RWTH Aachen UniversityGermany

In the Collaborative Research Centre 761’s“Steel ab initio-quantum mechanics guided design of new Fe based materials,”scientists and engineers from RWTH Aachen University and the Max Planck Institute for Iron Research conducted research on mechanism-controlled material development with a particular focus on high-manganese alloyed *** 2007 to 2019,a total of 55 partial projects and four transfer projects with industrial participation(some running until 2021)have studied material and process design as well as material *** basic idea of the Collaborative Research Centre was to develop a new methodological approach to the design of structural *** paper focuses on selected results with respect to the mechanical properties of high-manganese steels,their underlying physical phenomena,and the specific characterization and modeling tools used for this new class of *** steels have microstructures that require characterization by the use of modern methods at the *** the process routes,the generation of segregations must be taken into ***,the mechanical properties show a characteristic temperature dependence and peculiarities in their fracture *** mechanical properties and especially bake hardening are affected by short-range ordering *** strain hardening can be adjusted in a never-before-possible range,which makes these steels attractive for demanding sheet-steel applications.

关键词： high-manganese steels stacking fault energy twinning short-range ordering mechanical properties

Cartography and the others-aspects of a complicated relationship

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Geo-Spatial Information Science 2020年第1期23卷 52-60页

作者： wolfgang Kainz Department of Geography and Regional Research University of ViennaWienAustria Collaborative Innovation Center of Geospatial Technology Wuhan UniversityWuhanChina

Cartographic visualizations have been known for thousands of years and have brought forth a wealth of different map projections and cartographic ***,cartography as an independent science has been established only about 100 years ago and sometimes its position among the spatial disciplines is challenged by the scientific *** this respect it is a young science based on a very long tradition of map making,globe production,and the development of map *** and map related visualizations play an important and indispensable role in many other spatial disciplines such as geography and *** has many overlaps with these traditional disciplines as well as with the more recent ones of photogrammetry and remote *** paper reviews fundamental aspects of the conception of space and time throughout human history,the historic development of cartography from a technique of map making to a spatial science,highlighting major milestones in the history of the *** a young science and confronted with major technological developments in the late 20^(th)century cartography underwent several crises as to what exactly is cartography and how it relates to other spatial sciences,in particular to geographic information *** pitfalls and misconceptions are discussed and the three major scientific pillars of cartography are *** relationships of cartography with neighboring disciplines are discussed and the position of cartography vis a vis the others is ***,desirable future developments of scientific cartography are discussed.

关键词： Cartography GIS geodesy photogrammetry remote sensing

How can neuromorphic hardware attain brain-like functional capabilities?

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National Science Review 2024年第5期11卷 11-13页

作者： wolfgang Maass Computer Science and Biomedical Engineering Graz University of Technology

Research on neuromorphic computing is driven by the vision that we can emulate brain-like computing capability, learning capability, and energy-efficiency in novel hardware. Unfortunately, this vision has so far been pursued in a half-hearted manner. Most current neuromorphic hardware (NMHW) employs brain-like spiking neurons instead of standard artificial neurons.

关键词： capabilities attain brain-like functional hardware neuromorphic

Friedrich Ackermann’s scientific research program

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Geo-Spatial Information Science 2023年第2期26卷 141-150页

作者： wolfgang Förstner Department of Photogrammetry UniversityBonnGermany

We sketch Friedrich Ackermann’s research program following the concept of Imre Lakatos,with some historical key developments in the theory and application of aerotriangulation and image *** research program,with its core being statistical estimation theory,has decisively influenced photogrammetry since the 60s,is still fully alive,and a challenge for today’s methods of image *** describe(1)Lakatos’concept of a scientific research program,with its negative and positive heuristics and(2)Ackermann’s research program,clearly made explicit in his PhD,with its mathematical model,the ability to predict theoretical precision and reliability,the potential of analyzing rigorous and approximate method,and the role of *** development of aerotriangulation,later augmented by image matching techniques,is closely connected to Ackermann’s successful attempts to integrate basic research and practical applications.

关键词： Friedrich Ackermann scientific research program aerotriangulation image matching role of theory and application

PREDICTIVE MODELS AND GENERATIVE COMPLEXITY

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Journal of Systems Science & Complexity 2012年第1期25卷 30-45页

作者： wolfgang LHR Max Planck Institute for Mathematics in the Sciences Inselstraβe 22D-04103 LeipziqGermany

The causal states of computational mechanics define the minimal sufficient memory for a given discrete stationary stochastic process. Their entropy is an important complexity measure called statistical complexity （or true measure complexity）. They induce the s-machine, which is a hidden Markov model （HMM） generating the process. But it is not the minimal one, although generative HMMs also have a natural predictive interpretation. This paper gives a mathematical proof of the idea that the s-machine is the minimal HMM with an additional （partial） determinism condition. Minimal internal state entropy of a generative HMM is in analogy to statistical complexity called generative complexity. This paper also shows that generative complexity depends on the process in a nice way. It is, as a function of the process, lower semi-continuous （w.r.t. weak-, topology）, concave, and behaves nice under ergodic decomposition of the process.

关键词： Causal states complexity s-machine generative complexity HMM partially deterministicHMM predictive model statistical.

U-Pb zircon ages for the Luzhenguan Complex in northern part of the eastern Dabie orogen

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Science China Earth Sciences 2005年第9期48卷 1357-1367页

作者： wolfgang Siebe Institut für Geowissenschaften Universit?t Tübingen Tübingen 72074 Germany

The study presents U-Pb zircon ages for granitic gneiss and amphibolite from the Luzhenguan Complex (LZC) in northern part of the eastern Dabie Orogen and their geological significance. Two granitic gneisses and one amphibolite give protolith zircon U-Pb ages of 740 Ma and 725 Ma, respectively. The ages show that the LZC is composed mainly of Neoproterzoic acid and basic igneous rocks, suggesting that there is no Paleozoic active continental marginal rock association in the southern margin of the North China Block in northern part of the eastern Dabie Mountain. Based on the ages and combining the geological and geophysical analyses, the middle-low grade metamorphic rocks in the North Huiyang Belt (NHB) can be divided into three parts, which are the LZC composed mainly of the Neoproterzoic acid and basic igneous rocks, the Neoproterzoic Xianrechong Formation and Xiangyunzhai Formation and the Devonian Zhu- foan Formation and Pangjialing Formation of the Foziling Group, and the suture zone between the Yongtze Block and the North China Block is inferred to be thrust under the NHB.

关键词： Dabie orogen, Luzhenguan Complex, U-Pb zircon age, Neoproterzoic.