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Perspective on ultramicroporous carbon as sulphur host for Li-S batteries

Journal of Energy Chemistry 2021年第8期30卷 242-256,I0006页

作者： helen Maria Joseph Maximilian Fichtner Anji Reddy Munnangi ASTUTE 2020 College of EngineeringSwansea UniversityFabian WaySA18EN SwanseaUnited Kingdom Helmholtz Institute Ulm(HIU)Electrochemical Energy Storage Helmholtzstraße 1189081 UlmGermany Institute of Nanotechnology Karlsruhe Institute of TechnologyP.O.Box 3640D-76021 KarlsruheGermany College of Engineering Swansea UniversityFabian WaySA18EN SwanseaUnited Kingdom

Lithium-sulphur(Li-S)batteries are currently considered as next-generation battery *** is an attractive positive electrode for lithium metal batteries,mainly due to its high capacity(1675 m Ah g^(-1))and high specific energy(2600 Wh kg^(-1)).The electrochemical reaction of lithium with sulphur in non-aqueous electrolytes results in the formation of electrolyte soluble intermediate *** dissolved polysulphides shuttle to the anode and get reduced at the anode resulting in Li metal *** solubility of polysulphide gradually reduces the amount of sulphur in the cathode,thereby limiting the cycle life of Li-S *** strategies have been proposed to improve the cycling stability of Li-S batteries.A unique approach to eliminate the polysulphide shuttle is to use ultramicroporous carbon(UMC)as a host for *** pore size of UMC which is below 7A,is the bottleneck for carbonate solvents to access sulphur/polysulphides confined in the pores,thereby preventing the polysulphide *** perspective article will emphasise the role of UMC host in directing the lithiation mechanism of sulphur and in inhibiting polysulphide dissolution,including the resulting parasitic reaction on the lithium ***,the challenges that need to be addressed by UMC-S based Li-S batteries,and the strategies to realise high power density,high Coulombic efficiency,and resilient Li-S batteries will be discussed.

关键词： Lithium-sulphur batteries Ultramicroporous carbon Sulphur Cathode Composites

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Anti-plagiarism policy of JZUS-A/B & FITEE

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第6期16卷 507-512页

作者： Yue-hong(helen)ZHANG Han-feng LIN Qing YE Journals of Zhejiang University-SCIENCE A/B Frontiers of Information Technology & Electronic Engineering

As Morris et al. （2013） indicated ＇it is a very good idea to have a policy in place for dealing with these [ethical] issues＇, and based on the ethical code and flowcharts of the Committee on Publication Ethics （COPE）1 and our experience at Journals of Zhejiang University-SCIENCE A/B ＆ FITEE, we have posted the 2015 JZUS-policy online （http：//***/jzus/***）. It includes three sections： Forms of Plagiarism, Anti-Plagiarism Policy, and CrossCheck Workflow. The following is the full text of this policy.

关键词：剽窃伦理规范浙江大学 HTTP 莫里斯流程图委员会 PHP

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Reversal of Tetracycline Resistance by Cepharanthine,Cinchonidine,Ellagic Acid and Propyl Gallate in a Multi-drug Resistant Escherichia coli

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Natural Products and Bioprospecting 2021年第3期11卷 345-355页

作者： Darko Jenic helen Waller helen Collins Clett Erridge School of Life Sciences Anglia Ruskin UniversityEast RoadCambridge CB11PTUK Diabetes Research Centre University of LeicesterLeicester General HospitalGwendolen RoadLeicester LE54PWUK Department of Health Sciences University of LeicesterUniversity RdLeicester LE17RHUK

Bacterial resistance to antibiotics is an increasing threat to global healthcare *** therefore sought compounds with potential to reverse antibiotic resistance in a clinically relevant multi-drug resistant isolate of Escherichia coli(NCTC 13400).200 natural compounds with a history of either safe oral use in man,or as a component of a traditional herb or medicine,were *** compounds;ellagic acid,propyl gallate,cinchonidine and cepharanthine,lowered the minimum inhibi-tory concentrations(MICs)of tetracycline,chloramphenicol and tobramycin by up to fourfold,and when combined up to *** compounds had no impact on the MICs of ampicillin,erythromycin or *** studies revealed that while cepharanthine potently suppressed efflux of the marker Nile red from bacterial cells,the other hit com-pounds slowed cellular accumulation of this marker,and/or slowed bacterial growth in the absence of *** cepharanthine showed some toxicity in a cultured HEK-293 mammalian cell-line model,the other hit compounds exhibited no toxicity at concentrations where they are active against *** NCTC *** results suggest that phytochemicals with capacity to reverse antibiotic resistance may be more common in traditional medicines than previously appreciated,and may offer useful scaffolds for the development of antibiotic-sensitising drugs.

关键词： Antibiotic resistance Natural products Phytochemical Screening Efflux pump inhibitor

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Anti-angiogenic agents in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2015年第7期7卷 71-86页

作者： Bhavana Konda helen Shum Lakshmi Rajdev Department of Medical Oncology Albert Einstein College of Medicine/Montefiore Medical Center

Colorectal cancer(CRC) is a major public health concern being the third leading cause of cancer mortality in the United States. The availability of better therapeutic options has led to a decline in cancer mortality in these patients. Surgical resection should be considered in all stages of the disease. The use of conversion therapy has made surgery a potentially curative option even in patients with initially unresectable metastatic disease. In this review we discuss the role of various antiangiogenic agents in patients with metastatic CRC(m CRC). We describe the mechanism of action of these agents, and the rationale for their use in combination with chemotherapy. We also review important clinical studies that have evaluated the safety and efficacy of these agents in m CRC patients. Despite the discovery of several promising anti-angiogenic agents, m CRC remains an incurable disease with a median overall survival of just over 2 years in patients exposed to all available treatment regimens. Further insights into tumor biology and tumor microenvironment may help improve outcomes in these patients.

关键词： Anti-angiogenic agents Metastatic colorectalcancer Targeted agents Conversion therapy Colorectalmetastasectomy

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Nutritional, health benefits and toxicity of underutilized garden cress seeds and its functional food products: a review

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Food Production, Processing and Nutrition 2022年第1期4卷 420-432页

作者： Meseret Azene Kifle Habte helen Tkuwab Center for Food Science and Nutrition Addis Ababa UniversityP.O.Box:1176Addis AbabaEthiopia Ethiopian Public Health Institute Food Science and Nutrition Research DirectorateP.O.Box:1242Addis AbabaEthiopia Mekelle University MekelleEthiopia

Garden cress seed is a potential source of macro and micronutrients including essential fatty acids and amino acids as well as minerals such as iron, potassium, calcium and phosphorus. The seed also provides appreciable amount of health-protective bioactive compounds used to treat diabetes, hypercholesterolemia, bone fracture, asthma, constipation and some forms of cancer. Besides,, it is used to develop functional foods of therapeutic value in food manufacturing industries and traditional food preparations. Even though, it is known for its superior health benefits, provision of essential nutrients, and wider application in functional food development it is among the most underutilized crop in the world. Additionally, majority of studies conducted on garden cress seeds are mainly animal trials and hence needs to conduct studies on human. Therefore, the aim of this review paper is to provide up to date research evidence on the nutrient composition and therapeutic use of underutilized garden cress seeds and its functional food products, promising for the prevention of non-communicable and communicable diseases.

关键词： Garden cress seeds Lepidium sativum L. Underutilized Phytochemicals Therapeutic value Chronic and infectious disease Functional foods

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Environmental Issues and Management for Hydropower Peaking Operations

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Small Hydro Power News 2005年第81期22卷 15-19页

作者： helen Locher Hydro Tasmania 4 Elizabeth St Hobart Tasmania Australia

Many hydropower plants are operated as peak generators or frequency controllers, because they can change their output quickly to follow the fluctuating power demand. When meeting peak load requirements, a power station is turned on at a particular time during the day, generates power at a constant load for a certain number of hours, and is then turned off or set to a different load for another time period, resulting in a high variability inflow discharges. Where reservoir hydro schemes are operated primarily to provide peak load services, there are particular environmental risks that should be considered in any environmental impact assessment. At a minimum these should focus on water quality, fluvial geomorphology, riparian vegetation, macro-invertebrate and fish communities underpinned by a sound hydrological analysis. Frequent temperature changes may occur downstream of a peaking power station; increased seepage-induced erosion of riverbanks due to frequent water level drawdowns; and impacts to macro-invertebrate and fish communities due to rapid and frequent in channel habitat conditions. With a sound understanding of the potential environmental issues, there are strategies that can be employed at the siting and design stage to minimize or mitigate these risks, including but not limited to minimum environmental flows, ramping rules, utilization of a re-regulation storage and localized treatment works.

关键词： hydropower environmental peaking hydropeaking mitigation

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Role and mechanism of action of leucine-rich repeat kinase 1 in bone

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Bone Research 2017年第1期5卷 14-26页

作者： Weirong Xing helen Goodluck Canjun Zeng Subburaman Mohan Musculoskeletal Disease Center Jerry L.Pettis Memorial VA Medical CenterLoma LindaCAUSA Department of Medicine Loma Linda UniversityLoma LindaCAUSA Department of Orthopedics The Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina

Leucine-rich repeat kinase 1 （LRRK1） plays a critical role in regulating cytoskeletal organization, osteoclast activity, and bone resorption with little effect on bone formation parameters. Deficiency of Lrrkl in mice causes a severe osteopetrosis in the metaphysis of the long bones and vertebrae bones, which makes LRRK1 an attractive alternative drug target for the treatment of osteoporosis and other high-turnover bone diseases. This review recent advances on the functions of the Lrrkl-related family members, Lrrkl deficiency-induced skeletal phenotypes, LRRK1 structure-function, potential biological substrates and interacting proteins, and the mechanisms of LRRK1 action in osteoclasts.

关键词： gene Role and mechanism of action of leucine-rich repeat kinase 1 in bone

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Delineation of a novel dendritic-like subset in human spleen

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Cellular & Molecular Immunology 2016年第4期13卷 443-450页

作者： Sawang Petvises Dipti Talaulikar helen C O'Neill Research School of Biology The Australian National University Canberra Australia John Curtin School of Medical Research The Australian National University Canberra Australia ANU Medical School College of Medicine Biology and Environment The Australian National University Canberra Australia Department of Haematology Canberra Hospital Canberra Australia

Dendritic cells （DCs） and monocyte subpopulations present in the human spleen were analyzed by flow cytometry in an attempt to identify the presence of a novel dendritic-like cell subset described previously in mice and named L-DCs. In this study, an equivalent of this novel murine subset was characterized in the human spleen, thus increasing our knowledge of the antigen-presenting cell types present in the human spleen. Human L-DCs were identified as a hCD11c^hCD11b＋HLA-DR-hCD86＋ subset in the spleen, along with the previously described subsets of hCDlc＋ DCs, hCD123＋ plasmacytoid DCs （pDCs）, hCD16＋ DCs and hCD141＋ DCs. Three subsets of monocytes were also characterized. DC and monocyte subsets in human spleen had phenotypes similar to those of subsets in human blood. In line with murine studies, the presence of L-DC progenitors within the spleen was also investigated. When human splenocytes depleted of T and B cells were cocultured with the murine stromal line 5G3, hematopoiesis ensued and hCD11c＋HLA-DR＋ and hCD11c＋HLA-DR- cells were produced. The latter resemble L-DCs, which are also produced in murine spleen cocultures. Both subsets expressed hCDSO and hCD86, which identifies them as antigen-presenting cells, particularly DCs, and were highly endocytic. It is noteworthy that murine splenic stroma can serve as a support matrix for human hematopoiesis and DC production. These results support the hypothesis that 5G3 must express both cell-associated and soluble factors that can signal hematopoiesis in human and murine progenitors.

关键词： dendritic cells myelopoiesis spleen stroma

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Combination therapy for male erectile dysfunction and urinary incontinence

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Asian Journal of Andrology 2008年第1期10卷 149-154页

作者： helen Zafirakis Run Wang O. Lenaine Westney Division of Urology University of Texas Health Science Center at Houston Houston TX 77030 USA Department of Urology MD Anderson Cancer Center Houston TX 77030 USA

Urinary incontinence （UI） and erectile dysfunction （ED） are both very prevalent conditions. Insertion of an artificial urinary sphincter （AUS） and penile prosthesis （PP） is an effective and proven method of treatment for both conditions. With advancing age, as well as with increasing populations of patients radically treated for prostate cancer, the occurrence of both conditions found in the same patient is increasing. The purpose of this article was to analyze the available evidence for simultaneous surgical management of male ED and UI using prosthetic devices. The existing literature pertaining to dual implantation of AUS and PP was reviewed. The concomitant insertion of the PP with the male perineal sling was also considered. Concurrent ED and UI are increasingly seen in the post radical prostatectomy population, who are often younger and less willing to suffer with these conditions. Insertion of an AUS and PP, either simultaneously or as a two-stage procedure, appears to be a safe, efficacious and long-lasting method of treatment. The improvements in design of both the AUS and PP as well as the development of the single transverse scrotal incision have made simultaneous insertion of these prostheses possible. Dual implantation of the PP and male sling looks promising in a selected population. In conclusion, the insertion of the AUS and PP for the treatment of concurrent UI and ED is safe and effective. Simultaneous insertion of these prostheses in the same patient offers potential advantages in operative and recovery time and is associated with high patient satisfaction. Combination therapy should therefore be included in the arsenal of treatment of these conditions.

关键词： urinary incontinence erectile dysfunction impotence penile prosthesis artificial urinary sphincter male sling

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Orthokeratology for myopia control: an optometrist’s view

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Annals of Eye Science 2018年第1期3卷 110-118页

作者： helen A.Swarbrick School of Optometry and Vision Science University of New South WalesSydneyAustralia

Orthokeratology(OK)is a clinical technique that uses reverse geometry design rigid contact lenses to reshape the corneal profile and modify its refractive power during overnight lens wear in order to correct refractive error *** achieves its reshaping effect through thinning of the central corneal *** raises concerns about the safety of this modality particularly in terms of microbial keratitis(MK).Since the mid 2000’s,with our increasing understanding of modifiable risk factors for MK in OK the prevalence of MK appears to have reduced *** is now clear that the relative risk of MK in overnight OK is equivalent to other modalities of contact lens wear,provided that safe practice is followed in terms of lens fitting,wear and *** OK was originally used predominantly for correction of low to moderate myopic refractive error,its use for myopia control have become more common in recent *** follows on from published clinical trials demonstrating an average of approximately 45%reduction in axial eye elongation when overnight OK is used in progressive myopic *** there is significant individual variability in efficacy,and one of the current challenges for OK in myopia control is to identify those children who will benefit most from this particular *** OK lens parameters to customise corneal reshaping for enhanced myopia control efficacy also remains a significant challenge for the future of this modality.

关键词： Orthokeratology myopia control myopia correction reverse geometry lenses microbial keratitis axial eye growth individual variability

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