Role and mechanism of action of leucine-rich repeat kinase 1 in bone

作     者：Weirong Xing Helen Goodluck Canjun Zeng Subburaman Mohan 

作者机构：Musculoskeletal Disease CenterJerry L.Pettis Memorial VA Medical CenterLoma LindaCAUSA Department of MedicineLoma Linda UniversityLoma LindaCAUSA Department of OrthopedicsThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2017年第5卷第1期

页      面：14-26页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by National Institutes of Health grant AR066831-01 ASBMR GAP grant to Weirong R Xing supported by a senior research career scientist award from the Department of Veteran’s Affairs 

主　　题：gene Role and mechanism of action of leucine-rich repeat kinase 1 in bone 

摘      要：Leucine-rich repeat kinase 1 （LRRK1） plays a critical role in regulating cytoskeletal organization, osteoclast activity, and bone resorption with little effect on bone formation parameters. Deficiency of Lrrkl in mice causes a severe osteopetrosis in the metaphysis of the long bones and vertebrae bones, which makes LRRK1 an attractive alternative drug target for the treatment of osteoporosis and other high-turnover bone diseases. This review recent advances on the functions of the Lrrkl-related family members, Lrrkl deficiency-induced skeletal phenotypes, LRRK1 structure-function, potential biological substrates and interacting proteins, and the mechanisms of LRRK1 action in osteoclasts.