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An excess of prostanoid EP3 receptors decreases hetero-oligomerization with thromboxane A2 receptors

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An excess of prostanoid EP3 receptors decreases hetero-oligo...

Velocity variation of internal shock waves in gamma ray bursts: Observational properties

第十五届国际药理学大会

作者： Chow Kevin Cheng Christopher wise helen Department of Pharmacology The Chinese University of Hong Kong. Department of Biochemistry The Chinese University of Hong Kong. Department of Pharmacology The Chinese University of Hong Kong.

＜正＞The prostaglandin E2receptor subtype EP3and thromboxane A2（TP）receptors mediate synergistic vasoconstrictor responses.N-terminally-tagged human TP（HA-hTPalpha）and human EP3（2myc-hEP3-I）receptors were prepared with Renilla lucifera se（Rluc）or Green Fluorescence Protein（GFP2）at the C-termini in order to assess oligomerization by the generation of a Bioluminescence Resonance Energy Transfer（BRET）*** values were0.37+/-0.06and0.16+/-0.00and BRET50values w ere1.54+/-0.61and0.9 +/-0.21in living HEK293cells transfected with hTP or hEP3receptors，reˉspectively（mean+/-SEM，n=3）.The hEP3-Rluc receptors were also able to oligomerize with hTP-GFP2receptors，producing BRETmax and BRET50values of0. 09+/-0.02and1.20+/-0.33，***ˉever，when the hEP3-GFP2cDNA was in excess of hTP-Rluc cDNA，Bret2signals *** conclusion，hTP and hEP3receptors constitutively form hoˉmooligomers，but the formation of hetero-oligomers b etween these prostanoid receptors is attenuated when hEP3receptors are in excess of hTP receptors.

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Science China(Physics,Mechanics & Astronomy) 2006年第4期49卷 505-512页

作者： Poon helen Astronomy Department Beijing Normal University

The work uses the data in the TTS mode of BATSE to analyze the time lags and pulse widths of GRB960113 and GRB960722 in high as well as low energy bands. The results show that their time lags increase monotonously. This phenomenon can reasonably be interpreted with the model of internal shock waves of γ-ray bursts (GRB). Perhaps we obtain the direct observational evidence for the fireball model of GRBs for the first time.

关键词： GRB, time lag, shock wave.

Creating the Conditions for Community Resilience: Aberdeen,Scotland——An Example of the Role of Community Planning Groups

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International Journal of Disaster Risk Science 2019年第2期10卷 244-260页

作者： helen Baxter National Centre for Resilience School of Interdisciplinary Studies The University of Glasgow Dumfries Campus

Governments are increasingly trying to ensure that communities are resilient to the effects of climate change and encourage community empowerment and autonomy. Local resilience planning groups(LRPGs),which include stakeholders with an interest in a local area,are emerging as one potential approach to building community resilience. A conceptual framework has been developed to identify the common requirements for community resilience, building upon existing work in the wider community resilience literature. Aberdeen Resilient,Included and Supported Group, Scotland, UK is an example of a LRPG. In this study the data collected during a workshop with the Aberdeen LRPG were used with the conceptual framework to identify some of the challenges faced when building community resilience. The study examined whether the Aberdeen LRPG illustrates the challenges and constraints faced by LRPGs more widely,and how the membership influences the potential to develop the attributes of community resilience outlined in the conceptual framework. The thematic analysis of the workshop revealed Aberdeen LRPG’s six dominant challenges: engaging with individuals, culture, attitudes,assumptions, terminology, and timescale. These challenges impede the group in utilizing the skills, knowledge, and resources that its members possess to build community resilience. While the Aberdeen LRPG cannot change all factors that affect community resilience, framing specific problems experienced by the group within a conceptual framework applicable to any community contributes to understanding the practical challenges to developing community resilience.

关键词： Community planning Community resilience Natural hazards Scotland

Performance and Enzyme Activity of Beet Armyworm Spodoptera exigua (Hübner) (Lepidoptera:Noctuidae) Under Various Nutritional Conditions

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Agricultural Sciences in China 2011年第5期10卷 737-746页

作者： helen Hull Sanders Chongqing Key Laboratory of Entomology and Pest Control Engineering Southwest University

We explored the influence of the artificial diets with different protein and glucose contents on larval development,fecundity and enzyme activities of the beet armyworm Spodoptera exigua （Hübner）.Our results suggested that development,fecundity and population growth index of beet armyworm increased with increased nutritional content in the artificial diets;however,when the yeast to cellulose content ratio reached 46.8：53.2,the fecundity and population growth had reached a maximum and additional protein did not yield additional ***,3rd instar beet armyworm larvae fed on different artificial diets had increased enzymatic activities of acetylcholinesterase （AChE） with the increased nutritional content,but carboxylesterase （CarE） activities did not significantly change under variation in the nutritional content.

关键词： beet armyworm nutritional variation acetylcholinesterase carboxylesterase protein carbohydrate enzymeactivity

Defining language impairments in a subgroup of children with autism spectrum disorder

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Science China(Life Sciences) 2015年第10期58卷 1044-1052页

作者： helen TAGER-FLUSBERG Department of Psychology Boston University

Autism spectrum disorder(ASD) is diagnosed on the basis of core impairments in pragmatic language skills, which are found across all ages and subtypes. In contrast, there is significant heterogeneity in language phenotypes, ranging from nonverbal to superior linguistic abilities, as defined on standardized tests of vocabulary and grammatical knowledge. The majority of children are verbal but impaired in language, relative to age-matched peers. One hypothesis is that this subgroup has ASD and co-morbid specific language impairment(SLI). An experiment was conducted comparing children with ASD to children with SLI and typically developing controls on aspects of language processing that have been shown to be impaired in children with SLI: repetition of nonsense words. Patterns of performance among the children with ASD and language impairment were similar to those with SLI, and contrasted with the children with ASD and no language impairment and typical controls, providing further evidence for the hypothesis that a subgroup of children with ASD has co-morbid SLI. The findings are discussed in the context of brain imaging studies that have explored the neural bases of language impairment in ASD and SLI, and overlap in the genes associated with elevated risk for these disorders.

关键词： ASD SLI language impairment comorbidity brain imaging

Editorial:Bilingual (multilingual) publications and duplicate publications: for or against?

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 687-690页

作者： Yue-hong (helen) ZHANG Journals of Zhejiang University-SCIENCE (A/B/C)

From the professional perspective of journal publishing, whether a bilingual (multilingual) publication is suspicious from an ethical point of view has been a topic of debate. Indeed this problem has

关键词：出版物多语言双语期刊编辑期刊出版作者出版业

Designing Visceral, Behavioural and Reflective Products

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1058-1068页

作者： Mersha Aftab helen Agustin Rusli Northumbria School of Design Northumbria University

Designers and manufacturers often see con- sumption as the primary objective of a product - with implications such as discarded products, obsolete wastes, and ecological degradation. The paper aims to find the answer to the question, how emotional design can adapt the discarded and undesirable products into something valu- able in a long term？ This paper presents a framework combining Chapman＇s theory and Norman＇s theory on three levels of emotional design to highlight what long lasting connection with products entails. A design approach is presented combing the Wabi Sabi philosophy that pro- motes the celebration of decay and damage. This is used as one of the design principles for the experiments conducted on discarded products. Through constant user interaction before, during and after the experiments the evaluation of design as an agent of transformation is done. The user conducted the evaluation based on the Kansei elements of looks, sound, smell, and feel of the product. The experi- ments confirmed that a long-term value is only achieved through redesigning and reconstructing the perception of people towards products on a reflective level, rather than the visceral and behavioural elements of the product. The research found attachment to the visceral and behavioural elements of a product instead of an emotional one was causing users to discard products faster than required. The research indicated that many people, including designers and manufacturers, are unconsciously focusing on usability （behavioural level） and physical look （visceral level） of a product that are easily replaced, than on a meaningful way （reflective level） to create and maintain long-lasting emo- tions. The research concluded with a proposition towards digitization of products which could perhaps be an all round solution to make products more appropriate to human emotions. Digitization could give products the ability to capture, store and then communicate the stories, journey and memories b

关键词： Research through design. Emotional design -Kansei design ~ Recycling ~ Upcycling ~ Product design

Multimodality management of resectable gastric cancer: A review

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World Journal of Gastrointestinal Oncology 2014年第10期6卷 393-402页

作者： helen Shum Lakshmi Rajdev Department of Oncology Montefiore Medical Center Albert Einstein College of MedicineBronx NY 10461 United States

Adenocarcinoma of the stomach carries a poor prognosis and is the second most common cause of cancer death worldwide. It is recommended that surgical resection with a D1 or a modified D2 gastrectomy(with at least 15 lymph nodes removed for examination), be performed in the United States, though D2 lymphadenectomies should be performed at experienced centers. A D2 lymphadenectomy is the recommended procedure in Asia. Although surgical resection is considered the definitive treatment, rates of recurrences are high, necessitating the need for neoadjuvant or adjuvant therapy. This review article aims to outline and summarize some of the pivotal trials that have defined optimal treatment options for non-metastatic non-cardia gastric cancer. Some of the most notable trials include the INT-0116 trial, which established a benefit in concurrent chemoradiation and adjuvant chemotherapy. This was again confirmed in the ARTIST trial, especially in patients with nodal involvement. Later, the Medical Research Council Adjuvant Gastric Infusional Chemotherapy trial provided evidence for the use of perioperative chemotherapy. Targeted agents such as ramucirumab and trastuzumab are also being investigated for use in locally advanced gastric cancers after demonstrating a benefit in the metastatic setting. Given the poor response rate of this difficult disease to various treatment modalities, numerous studies are currently ongoing in an attempt to define a more effective therapy, some of which are briefly introduced in this review as well.

关键词： Neoadjuvant chemotherapy Adjuvant che-motherapy Adjuvant chemoradiation Gastric cancer Gastric adenocarcinoma

Thermoregulatory value of cracking-clay soil shelters for small vertebrates during extreme desert conditions

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Integrative Zoology 2017年第3期12卷 237-249页

作者： helen P.WAUDBY Sophie PETIT Sustainable Environments Research Group School of Natural and Built EnvironmentsUniversity of South AustraliaMawson LakesSouth AustraliaAustralia Institute for Land Water and SocietyCharles Sturt UniversityAlburyNew South WalesAustralia

Deserts exhibit extreme climatic *** desert-dwelling vertebrates have physiological and behavioral adaptations to cope with these conditions,including the ability to seek *** investigated the temperature(T)and relative humidity(RH)regulating properties of the soil cracks that characterize the extensive cracking-clay landscapes of arid Australia,and the extent of their use by 2 small marsupial species:fat-tailed and stripe-faced dunnarts(Sminthopsis crassicaudata and Sminthopsis macroura).We measured hourly(over 24-h periods)the T and RH of randomly-selected soil cracks compared to outside conditions,during 2 summers and 2 *** tracked 17 dunnarts(8 Sminthopsis crassicaudata and 9 Sminthopsis macroura)to quantify their use of *** consistently moderated microclimate,providing more stable conditions than available from non-crack points,which often displayed comparatively dramatic fluctuations in T and *** dunnart species used crack shelters *** constitute important shelter for small animals during extreme conditions by providing a stable microclimate,which is typically cooler than outside conditions in summer and warmer in *** likely play a fundamental sheltering role by sustaining the physiological needs of small mammal ***,cracking-clay areas are dominated by agricultural land uses,including livestock *** of these systems should focus not only on vegetation condition,but also on soil integrity,to maintain shelter resources for ground-dwelling fauna.

关键词： arid zones Dasyuridae livestock grazing refuges survival strategies