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Elaboration and validation of Crohn's disease anoperineal lesions consensual definitions

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World Journal of Gastroenterology 2017年第29期23卷 5371-5378页

作者： Clémence horaist Vincent de Parades Laurent Abramowitz Paul Benfredj Guillaume Bonnaud Dominique Bouchard Nadia Fathallah Agnès sénéjoux Laurent siproudhis Ghislain staumont manuelle Viguier Philippe marteau Department of Digestive Disease Centre Hospitalier Intercommunal Le Raincy-Montfermeil Department of Proctology Hopital Saint-Joseph Institut Léopold Bellan Department of Proctology and Digestive Diseases University Hospital Bichat Department of Digestive Diseases Clinique des Cèdres Department of Proctology Hopital Bagatelle Department of Proctology Centre Hospitalier Privé Rennes de Saint-Grégoire Department of Digestive Diseases Pontchaillou University Hospital Department of Proctology Clinique St Jean Languedoc AP-hP H0pital Saint Louis Dermatology and Denis Diderot-Paris 7 University sorbonne Universités UPMC Univ Paris 06 75005 Paris France iNsERm-ERL 1157 CHU Saint-Antoine 27 75012 Paris France CNRs UMR7203 75012 Paris France APhP Hépatologie et Gastroentérologie Hopital Saint Antoine

To establish consensual definitions of anoperineal lesions of Crohn’s (APLOC) disease and assess interobserver agreement on their diagnosis between experts. mEThODsA database of digitally recorded pictures of APLOC was examined by a coordinating group who selected two series of 20 pictures illustrating the various aspects of APLOC. A reading group comprised: eight experts from the société Nationale Française de Colo Proctologie group of study and research in proctology and one academic dermatologist. All members of the coordinating and reading groups participated in dedicated meetings. The coordinating group initially conducted a literature review to analyse verbatim descriptions used to evaluate APLOC. The study included two phases: establishment of consensual definitions using a formal consensus method and later assessment of interobserver agreement on the diagnosis of APLOC using photos of APLOC, a standardised questionnaire and Fleiss’s kappa test or descriptive statistics. REsULTsTerms used in literature to evaluate visible APLOC did not include precise definitions or reference to definitions. most of the expert reports on the first set of photos agreed with the main diagnosis but their verbatim reporting contained substantial variation. The definitions of ulceration (entity, depth, extension), anal skin tags (entity, inflammatory activity, ulcerated aspect), fistula (complexity, quality of drainage, inflammatory activity of external openings), perianal skin lesions (abscess, papules, edema, erythema) and anoperineal scars were validated. For fistulae, they decided to follow the American Gastroenterology Association’s guidelines definitions. The diagnosis of ulceration (κ = 0.70), fistulae (κ = 0.75), inflammatory activity of external fistula openings (86.6% agreement), abscesses (84.6% agreement) and erythema (100% agreement) achieved a substantial degree of interobserver reproducibility. CONCLUsiONThis study constructed consensual definitions of APLOC and the

关键词： Crohn’s disease Anoperineal lesions Fistula interobserver agreement

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组织因子在肺癌中的表达

中华结核和呼吸杂志 1997年第Z1期20卷 37-37页

作者： sawada m miyake s Ohdama s Watanabe A hosoda h matsubara O masuda s Yakumaru K Yoshizawa Y 刘兴荣(译) FirstDepartmentofinternalmedicine TokyoMedicaandDentalUniversity TokyoTeishinhospital TokyoJapan NationalDefencemedicalCollege

Tangential and Vertical Compact Torus injection Experiments on the sTOR-m Tokamak

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Plasma science and Technology 2005年第2期7卷 2701-2704页

作者：肖持进 s.Livingstone A.K.singh E.Zhang A.hirose Plasma Physics Laboratory Department of Physics & Engineering Physics University of SaskatchewanSaskatoonSaskatchewan S7N 5E2Canada

This paper describes the setup and results of compact torus (CT) injection experiments on the sTOR-m tokamak. Tangential CT injection into sTOR-m induced h-mode-like phenomena including doubling the electron density, reduction in the ha radiation level, suppression of the floating potential fluctuations, suppression of the m = 2 mirnov oscillations, and increase in the global energy confinement time. Experimental setup, bench-test results, and some preliminary injection data for vertical CT injection experiments on sTOR-m will be shown. in addition, numerical simulations of the CT trajectories in tokamak discharges for both tangential and vertical injection geometries will be discussed.

关键词： compact torus tokamak h-mode

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卒中介入治疗培训指南：国际多学会共识文件

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine sD Cockroft K hoh B Bambakidis N Khalessi AA Woo h Riina h siddiqui A hirsch JA Chong W Rice h Wenderoth J mitchell P Coulthard A signh TJ Phatorous C Khangure m Klurfan P ter Brugge K iancu D Gunnarsson T Pongpech s Rodesch G soderman m Taylor A Krings T Orbach D Picard L suh DC Zheng hQ Jansen O muto m szikora i Pierot L Brouwer P Gralla J Renowden s Andersson T Fiehler J Turjman F White P Januel AC spelle L Kulcsar Z Chapot R Biondi A Dima s Taschner C szajner m Krajina A sakai N matsumaru Y Yoshknura s Ezura m Fujinaka T iihara K ishii A higashi T hirohata m hyodo A ito Y Kawanishi m Kiyosue h Kobayashi E Kobayashi s Kuwayama N matsumoto Y miyachi s murayama Y Nagata i Nakahara i Nemoto s Niimi Y Oishi h satomi J satow T sugiu K Tanaka m Terada T Yamagami h Diaz O Lylyk P Jayaraman mV Patsalides A Gandhi CD Lee sK Abruzzo T Albani B Ansari sA Arthur As Baxter BW Bulsara KR Chen m Almandoz JE Fraser JF heck DV hetts sW hussain ms Klucznik RP Leslie-mawzi Tm mack WJ mcTaggart RA meyers Pm mocco J Prestigiacomo CA Pride GL Rasmussen PA starke Rm sunenshine PJ Tarr RW Frei DF Pabo m Nogueira RG Zaidat OO Jovin T Linfante i Yavagal D Liebeskind D Novakovic R Pongpech s 许岩孙瑞郭芮兵 From the American Association of Neurological surgeons/Congress of Neurological surgeons (AANs/CNs) Rolling Meadows IL USA American society of Neuroradiology (AsNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFiTN) Bali Indonesia Australian and New Zealand society of Neuroradiobgy-Conjomt Committee for Recognition of Training in interventional Neuroradiology (CCiNR) representing the RANZCR (ANZsNR) ANZAN and NSA Sydney Australia Canadian interventional Neuro Group (CiNG) Edmonton AB Canada World Federation of interventional and Therapeutic Neuroradiology (WFiTN) Gold Coast Australia European society of Neuroradiology (EsNR) Milan Italy European society of minimally invasive Neurologic Therapy (EsmiNT) Nice France Japanese society for Neuroendovascular therapy (JsNET) Okayama Japan sociedad ibero Latino Americana de Neuroradiologica (siLAN) Cartagena Colombia society of Neurolnterventional surgery (sNis) Washington DC USA society of Vascular and interventional Neurology (sViN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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使用斯塔克调制的光声探测

应用激光 1980年第3期 48-53页

作者： m.J.Kavaya J.s.margolis m.s.shumate 宋佩英美国加利福尼亚州技术研究所喷气式发动机实验室美国加利福尼亚州技术研究所喷气式发动机实验室美国加利福尼亚州技术研究所喷气式发动机实验室

本文报导的是在光声探测中（或声学光谱）吸收激光辐射的斯塔克调制。在总压力50托～760托的范围内作了测量,由于斯塔克位移吸收的调谐能力,认为可以大大地提高分子的辨别力。用这种方法工作得到的背景信号比用相同的光声探测器在常规... 详细信息

本文报导的是在光声探测中（或声学光谱）吸收激光辐射的斯塔克调制。在总压力50托～760托的范围内作了测量,由于斯塔克位移吸收的调谐能力,认为可以大大地提高分子的辨别力。用这种方法工作得到的背景信号比用相同的光声探测器在常规的斩波辐射方法中得到的背景信号小500多倍。光声探测器的响应率和 C2h4的吸收系数是总压力的函数。

关键词：声探测器响应率背景信号斩波光声探测斯塔克效应电光效应

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急性病毒性肝炎的诊疗

胃肠病学和肝病学杂志 2004年第2期13卷 116-123页

作者：王豪 J.heathcote A.Elewaut s.Fedail A.Gangl s.hamid m.shah D.Lavanchy h.Liu J.Krabshuis 北京大学人民医院肝病研究所

一、定义急性病毒性肝炎(AVh)是一种全身感染但主要侵犯肝脏的疾病.AVh主要由嗜肝病毒引起(甲、乙、丙、丁、戊型肝炎).其他病毒感染偶然情况下可累及肝脏(巨细胞病毒CmV,疱疹病毒,柯萨奇病毒,腺病毒).甲型肝炎和戊型肝炎是自限性疾病... 详细信息

一、定义急性病毒性肝炎(AVh)是一种全身感染但主要侵犯肝脏的疾病.AVh主要由嗜肝病毒引起(甲、乙、丙、丁、戊型肝炎).其他病毒感染偶然情况下可累及肝脏(巨细胞病毒CmV,疱疹病毒,柯萨奇病毒,腺病毒).甲型肝炎和戊型肝炎是自限性疾病,但丙型肝炎及次之的乙型肝炎则主要转变成慢性感染.

关键词：急性病毒性肝炎诊断治疗自限性疾病

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最佳粮库地址的选择

数学的实践与认识 2000年第3期30卷 267-274页

作者：林苗华杨奕群黄铭生中山大学电子信息工程系广州市510275 中山大学化学与化学工程学院

管理部门通常要选择适当的地方建造粮库 ,所需服务范围已知 ,各部门运输量给定 .需为他们选择合适的地方 ,使总运费最少 .某乡的九个村 (A,B,C,… ,h,i)如图 1 ,各村距离给出 ,并标明它们各自上缴公粮数 .管理部门希望在村内或道路上建... 详细信息

管理部门通常要选择适当的地方建造粮库 ,所需服务范围已知 ,各部门运输量给定 .需为他们选择合适的地方 ,使总运费最少 .某乡的九个村 (A,B,C,… ,h,i)如图 1 ,各村距离给出 ,并标明它们各自上缴公粮数 .管理部门希望在村内或道路上建立一个粮库 ,最大限度地减少运输费用 .问题的解法有几种方案 ,对于本题来说 ,穷举搜索法是可行的 .另外 ,我们提出一种分析求解法 ,可找到优化解 .它利用图论的基础知识先求出图 1的各顶点间的最小路径 ,再进一步求出图的绝对中心 (即粮库的地址 ) ,其中的有关计算利用了 C++语言程序 .在此基础上 ,还可对问题的参数作更精细的分析 .概括地说 ,穷举搜索法对于简单的区域是行之有效的 .但对于更加一般化的问题 ,利用计算机可快捷准确地得到答案 .通过建立模型 ,我们得到下面两个结论 :(1 )我们找到最优解是 E点 ,其总运费为 1 2 775元 .(2 )模型具有广泛性 ,对于更一般的区域 ,可利用计算机总可以求出最优解 .

关键词：数学建模最短路径选择粮库最佳地址

meningitis Outbreak Caused by Neisseria meningitidis serogroup C sT 10217 in 2019 in Diapaga, Burkina Faso

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Advances in infectious Diseases 2023年第1期13卷 66-76页

作者： Kambiré Dinanibè Tondé issa Ouédraogo W. h. Gautier sanou mahamoudou Ouédraogo L. s. L. Wilfrid savadogo mahamoudou Tamboura mamadou Zongo moumouni Ouédraogo Oumarou Zouré Abdou Azaque Compaoré Rebeca sagna Tani Zida sylvie soubeiga R. s. Théophile Aké Flavien sangaré Lassana méda isaïe Kouanda séni Ouédraogo-Traoré Rasmata Centre hospitalier Pédiatrique Universitaire Charles De Gaulle Ouagadougou Burkina Faso institut de Recherche en sciences de la santé Ouagadougou Burkina Faso Direction de la protection de la santé de la Population Ouagadougou Burkina Faso Centre hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Davycas international Ouagadougou Burkina Faso Direction Générale de la santé Publique Ouagadougou Burkina Faso

introduction: meningitis caused by Neisseria meningitidis constitutes a burden for the countries in the meningitis belt of sub-saharan in general and particularly for Burkina Faso. in 2019 the Diapaga health district experienced a meningitis epidemic due to N. meningitidis serogroup C. methods: This is a cross-sectional study with a descriptive aim in the health district of Diapaga where all cases of meningitis were included in this work. Rapid diagnostic tests (RDTs), culture as well as real-time PCR were used for the biological analysis of cerebral spinal fluid (CsF) samples. Results: Of 155 CsF samples analysed, 42% (65/155) were tested positve. Of them, N. meningitidis C accounted for 83% of all positive cases. Likewise, all thirteen (13) NmC strains were susceptible to oxacillin, ceftriaxone, penicillin and chloramphenicol. All strains of NmC belonged to the sequence type (sT) 10 217 and to the clonal complex (CC) 10 217. These CCs belonged to the same variant PorA type: P1.21-15.16;FetA type: F1-7;PorB type: 3-463. Conclusion: Burkina Faso had known an epidemic of meningitis caused by NmC in 2019 in the health district of Diapaga. This outbreak was contained in time due to the performance of the epidemiological surveillance system which made it possible to investigate on time and introduce the vaccine against the pathogen NmC.

关键词： meningitis Neisseria meningitidis Vs Diapaga Burkina Faso

Usefulness of hexamethylenetetramine as an Adjuvant to Radiotherapy and Cisplatin Treatment for solid Tumors:its independency of p53 status

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Usefulness of Hexamethylenetetramine as an Adjuvant to Radio...