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The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 71-76页

作者： Alessandro Fugazza Matteo Colombo Michel Kahaleh V.Raman Muthusamy Bick Benjamin wim laleman Carmelo Barbera Carlo Fabbri Jose Nieto Abed Al-Lehibi Mohan Ramchandani Amy Tyberg Haroon Shahid Avik Sarkar Dean Ehrlich Stuart Shermand Cecilia Binda Marco Spadaccini Andrea Iannone Kareem Khalaf Nageshwar Reddy Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSVia Manzoni 5620089RozzanoMilanoItaly Gastroenterology Rutgers Robert Wood JohnsonNew BrunswickNew JerseyUSA Vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos Angeles School of Medicine at UCLALos AngelesCaliforniaUSA Division of Digestive and Liver Disorders Indiana University School of MedicineIndianapolisINUSA Department of Gastroenterology and Hepatology University Hospitals LeuvenKU Leuven3000 LeuvenBelgium U.O.C.di Gastroenterologia ed Endoscopia Digestiva Ospedale Giuseppe MazziniASL TeramoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly Borland Groover Clinic JacksonvilleFloridaUSA Department of Gastroenterology and Hepatology King Fahad Medical CityRiyadhSaudi Arabia Asian Institute of Gastroenterology HyderabadIndia Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly

Background: Duodenoscope-related multidrug-resistant organism(MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERCP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy. Methods: This is a multicenter international, retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope. The primary outcome was technical success defined as ERCP completion for the intended clinical indication. Secondary outcomes were procedural duration, rate of cross-over to reusable duodenoscope, operator-reported satisfaction score(1 to 10) on performance rating of the single-use duodenoscope, and adverse event(AE) rate. Results: A total of 66 patients(26, 39.4% female) were included in the study. ERCP was categorized according to ASGE ERCP grading system as 47(71.2%) grade 3 and 19(28.8%) grade 4. The technical success rate was 98.5%(65/66). Procedural duration was 64(interquartile range 15-189) min, cross-over rate to reusable duodenoscope was 1/66(1.5%). The satisfaction score of the single-use duodenoscope classified by the operators was 8.6 ± 1.3 points. Four patients(6.1%) experienced AEs not directly related to the single-use duodenoscope, namely 2 post-ERCP pancreatitis(PEP), 1 cholangitis and 1 ***: Single-use duodenoscope is effective, reliable and safe even in technically challenging procedures with a non-inferiority to reusable duodenoscope, making these devices a viable alternative to standard reusable equipment.

关键词： Single-operator cholangioscopy Single-use duodenoscope Endoscopic retrograde cholangiopancreatography Indeterminate biliary stricture Difficult biliary stones

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Potential importance of early treatment of SARS-CoV-2 infection in intestinal transplant patient: A case report

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World Journal of Transplantation 2022年第4期12卷 72-78页

作者： Mathias Clarysse Laurens J Ceulemans Lucas Wauters Nicholas Gilbo Viktor Capiau Gert De Hertogh wim laleman Chris Verslype Diethard Monbaliu Jacques Pirenne Tim Vanuytsel Department of Abdominal Transplant Surgery&Transplant Coordination University Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Leuven Intestinal Failure and Transplantation Center(LIFT) University Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Abdominal Transplant Surgery Department of MicrobiologyImmunology and TransplantationKU LeuvenLeuven 3000Vlaams-BrabantBelgium Department of Thoracic Surgery University Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Respiratory Diseases and Thoracic Surgery(BREATHE) Department of Chronic Diseases and Metabolism(CHROMETA)KU LeuvenLeuven 3000Vlaams-BrabantBelgium Department of Gastroenterology and Hepatology University Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Translational Research Center for Gastrointestinal Disorders(TARGID) Department Chronic Diseases and Metabolism(CHROMETA)KU LeuvenLeuven 3000Vlaams-BrabantBelgium Department of Pathology University Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Translational Cell&Tissue Research KU LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Clinical Digestive Oncology Department of Digestive OncologyKU LeuvenLeuven 3000Vlaams-BrabantBelgium

BACKGROUND Predispositions for severe coronavirus disease 2019(COVID-19)are age,immunosuppression,and *** levels of maintenance immunosuppression render intestinal transplant(ITx)patients vulnerable for severe ***-19 also provokes several gastroenterological pathologies which have not been discussed in ITx,so *** SUMMARY During the second European COVID-19 wave in November 2020,an ITx recipient was admitted to the hospital because of electrolyte disturbances due to *** consisted of tacrolimus,azathioprine,and low-dose *** hospitalization,she tested positive on screening COVID-19 nasopharyngeal polymerase chain reaction swab,while her initial test was *** was initially asymptomatic and had normal inflammatory *** levels were slightly raised,as Azathioprine was temporarily *** to elevated Ddimers at that time,prophylactic low-molecular weight heparin was *** days after the positive test,dyspnea,anosmia,and C-reactive protein increase(25 mg/L)were *** was administered during 5 d in *** stomal output was noted in two consecutive days and several days *** exclude infection or rejection,an ileoscopy and biopsy were performed and excluded *** weeks later,she was discharged from the hospital and remains in good health since *** Early eradication of severe acute respiratory syndrome coronavirus 2 in ITx recipients may be warranted to prevent acute rejection provocation by it.

关键词： COVID-19 Intestinal transplantation Outcome SARS-CoV-2 Treatment Case report

栓塞术治疗对内科及内镜治疗无效的胆道括约肌切开术后出血:技术结果、临床疗效和预测因素

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国际医学放射学杂志 2015年第1期 85-86页

作者： G.Maleus J.Bielen A.Laenen S.Heye J.Vaninbroukx W.laleman Department of Radiology University Hospital Leuven

目的回顾性分析血管栓塞术治疗对内科及内镜治疗无效的胆道括约肌切开术后出血的技术要点及临床效果,并且分析30 d死亡率的潜在影响因素。方法从1998年

关键词：内镜治疗胆道括约肌括约肌切开术栓塞术内科术后出血

肝细胞癌化学栓塞术采用术后1个月的ADC值作为预测预后的独立因素

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国际医学放射学杂志 2014年第3期 273-274页

作者： V.Vandecaveye K.Michielsen F.D.Keyzer W.laleman M.Komuta K.Op de beeck 李晓琼 Department of Radiology and Medical Imaging Research Center.University Hospitals Leuven Herestraat 493000 LeuvenBelgium

摘要目的通过与实体肿瘤反应评估(RECIST)标准1.1、欧洲肝脏研究学会(EASL)标准以及RECIST修订版本(mRECIST)对照,评价肝细胞癌(HCC)经导管动脉化学栓塞

关键词：肝细胞癌 TACE 无进展生存个月 ADC

Journal of Hepatology|内镜肝脏病学的现状与未来

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临床肝胆病杂志 2024年第5期40卷 960-960页

作者：李扬杰范春蕾丁惠国首都医科大学附属北京佑安医院

胃肠内镜一直是消化系统疾病诊断与治疗的重要武器。内镜操作技术及相关辅助设备及材料的不断发展提高了胃肠内镜对胃肠道以外器官的适用性。临床实践中将高级内镜技术与肝脏疾病进行整合和应用,为各种肝脏疾病的诊疗与评估开辟了新途径... 详细信息

胃肠内镜一直是消化系统疾病诊断与治疗的重要武器。内镜操作技术及相关辅助设备及材料的不断发展提高了胃肠内镜对胃肠道以外器官的适用性。临床实践中将高级内镜技术与肝脏疾病进行整合和应用,为各种肝脏疾病的诊疗与评估开辟了新途径,也由此衍生出了一个迅速发展且受关注的新概念——内镜肝脏病学。近期,比利时加斯苏伊斯堡大学laleman W等学者就内镜肝脏病学的定义、分支及相关内镜技术的应用进行详细综述。

关键词：肝脏病学内镜技术消化系统疾病肝脏疾病内镜操作临床实践胃肠内镜胃肠道

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“瓷的旅程”双年展作品选辑

中国陶瓷工业 2024年第2期 137-148页

作者： MariaTen Kortenaar Lut laleman Ryan Matthew Mitchell Jason Walker 徐子文郭其林梁成镇 SilviaPiani 祁吉 Simcha Even-Chen Bruce Taylor Shamai Gibsh 白娟娟 Russell Orlando 张威李昭欣谭丹武 Dora Varkonyi FerdaTazeoglu Filiz 卢银丰 Matt Watterson 金盛华孙玥 Hanna Miadzvedzeva Hanna Marshava 钞子伟钞子艺郅敏刘丹华吴小艳余平张家祺赵淋李洲洲刘兵饶舜彭洪丽孟胡蝶 Rose Schreibe 孙奕周孟繁朴白月洪张良郑芳井野基美惠拾双双山田柏芝陈红欧阳宁远

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