Potential importance of early treatment of SARS-CoV-2 infection in intestinal transplant patient: A case report

作     者：Mathias Clarysse Laurens J Ceulemans Lucas Wauters Nicholas Gilbo Viktor Capiau Gert De Hertogh Wim Laleman Chris Verslype Diethard Monbaliu Jacques Pirenne Tim Vanuytsel 

作者机构：Department of Abdominal Transplant Surgery&Transplant CoordinationUniversity Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Leuven Intestinal Failure and Transplantation Center(LIFT)University Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Abdominal Transplant SurgeryDepartment of MicrobiologyImmunology and TransplantationKU LeuvenLeuven 3000Vlaams-BrabantBelgium Department of Thoracic SurgeryUniversity Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Respiratory Diseases and Thoracic Surgery(BREATHE)Department of Chronic Diseases and Metabolism(CHROMETA)KU LeuvenLeuven 3000Vlaams-BrabantBelgium Department of Gastroenterology and HepatologyUniversity Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Translational Research Center for Gastrointestinal Disorders(TARGID)Department Chronic Diseases and Metabolism(CHROMETA)KU LeuvenLeuven 3000Vlaams-BrabantBelgium Department of PathologyUniversity Hospitals LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Translational Cell&Tissue ResearchKU LeuvenLeuven 3000Vlaams-BrabantBelgium Laboratory of Clinical Digestive OncologyDepartment of Digestive OncologyKU LeuvenLeuven 3000Vlaams-BrabantBelgium 

出 版 物：《World Journal of Transplantation》 (世界移植杂志)

年 卷 期：2022年第12卷第4期

页      面：72-78页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：COVID-19 Intestinal transplantation Outcome SARS-CoV-2 Treatment Case report 

摘      要：BACKGROUND Predispositions for severe coronavirus disease 2019(COVID-19)are age,immunosuppression,and *** levels of maintenance immunosuppression render intestinal transplant(ITx)patients vulnerable for severe ***-19 also provokes several gastroenterological pathologies which have not been discussed in ITx,so *** SUMMARY During the second European COVID-19 wave in November 2020,an ITx recipient was admitted to the hospital because of electrolyte disturbances due to *** consisted of tacrolimus,azathioprine,and low-dose *** hospitalization,she tested positive on screening COVID-19 nasopharyngeal polymerase chain reaction swab,while her initial test was *** was initially asymptomatic and had normal inflammatory *** levels were slightly raised,as Azathioprine was temporarily *** to elevated Ddimers at that time,prophylactic low-molecular weight heparin was *** days after the positive test,dyspnea,anosmia,and C-reactive protein increase(25 mg/L)were *** was administered during 5 d in *** stomal output was noted in two consecutive days and several days *** exclude infection or rejection,an ileoscopy and biopsy were performed and excluded *** weeks later,she was discharged from the hospital and remains in good health since *** Early eradication of severe acute respiratory syndrome coronavirus 2 in ITx recipients may be warranted to prevent acute rejection provocation by it.