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高纬度地震台网数据对地球内核各向异性的约束

中国地球物理学会第二十九届年会

作者：马晓龙孙新蕾 Wiens,D.A. Nyblade,A. Anandakrishnan,S.Ast.r,R. Huert. A. wilson t. 中国科学院广州地球化学研究所同位素地球化学国家重点实验室 Depart.ent.of Eart. and Planet.ry Sciences Washington University(St.Louis) Depart.ent.of Geosciences Pennsylvania State University

＜正＞PKP前导波早在1930年代就已经被发现（Gut.nberg and Richt.r,1934）。全球台网的PKP前导波研究表明它们是由于整个地幔,主要是下地幔均匀分布的～1%速度不均匀结构引起的（Hedlin and Shearer,2000）。近年来,随着局部密集台网...

＜正＞PKP前导波早在1930年代就已经被发现（Gut.nberg and Richt.r,1934）。全球台网的PKP前导波研究表明它们是由于整个地幔,主要是下地幔均匀分布的～1%速度不均匀结构引起的（Hedlin and Shearer,2000）。近年来,随着局部密集台网的增加,研究表明这些台网记录到的PKP前导波主要是由于核幔边界附近的不均匀结构引起的,并且这些结构的速度异常可以达到5-6%甚至10%(e.g.,Niu and

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高纬度地震台网数据对地球内核各向异性的约束

高压液相层析和微量顺序测定法在人类血红蛋白变种结构分析中的应用

2014年中国地球科学联合学术年会——专题7：核幔边界和地核的结构及动力学

作者：秦加岭孙新蕾 Wiens,D.A. Nyblade,A. Anandakrishnan,S. Ast.r,R. Huert.,A. wilson,t. 中国科学院广州地球化学研究所同位素地球化学国家重点实验室 Depart.ent.of Eart. and Planet.ry Sciences Washington University (St.Louis) Depart.ent.of Geosciences Pennsylvania State University Depart.ent.of Eart. & Environment.l Science New Mexico Tech Depart.ent.of Geological Sciences Central Washington University Depart.ent.of Geological Sciences Ohio State University

了解地球内核的结构以及组分,对研究地球的演化和地球动力学有着重要意义。之前的地震学研究已经表明,地球内核的各向异性是复杂的三维结构(Sun and Song,2008a;Isshi and Dziewonski,2002)。然而,由于地震数据的分布不均匀性,穿过地核...

了解地球内核的结构以及组分,对研究地球的演化和地球动力学有着重要意义。之前的地震学研究已经表明,地球内核的各向异性是复杂的三维结构(Sun and Song,2008a;Isshi and Dziewonski,2002)。然而,由于地震数据的分布不均匀性,穿过地核中心部分以及靠近内核边界部分的南北向PKP数据明显不足,使得这些区域的结构存在一定的争议和空白(Deuss et.al,2013;Sun and Song,2008b;Niu and Wen 2001)。要获得穿过内核深部的近南北向的PKP数据,要求地震和台站分别位于地球的两极附近。近年来

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中国科学:化学 1983年第4期 345-355页

作者：曾溢滔,黄淑帧,A. Reynolds ,H. Lam ,B. B. Webber ,J. B. wilson ,t. H. J. Huisman 上海市儿童医院医学遗传研究室上海市儿童医院医学遗传研究室美国乔治亚医学院细胞和分子生物学系美国乔治亚医学院细胞和分子生物学系美国乔治亚医学院细胞和分子生物学系美国乔治亚医学院细胞和分子生物学系美国乔治亚医学院细胞和分子生物学系

本文报道在37个家系中所观察到的17种不同类型血红蛋白分析结果。所采用的方法是用高压液相层析(HPLC)来分离珠蛋白链的胰蛋白酶消化产物或肽的嗜热菌酶消化产物。HPLC具有快速分离及需用样品少的优点,而且层析谱的重复性好。对于小肽... 详细信息

本文报道在37个家系中所观察到的17种不同类型血红蛋白分析结果。所采用的方法是用高压液相层析(HPLC)来分离珠蛋白链的胰蛋白酶消化产物或肽的嗜热菌酶消化产物。HPLC具有快速分离及需用样品少的优点,而且层析谱的重复性好。对于小肽段或较大肽段的氨基酸顺序测定应用微量双偶合顺序测定技术是成功的。

关键词：液相层析氨基酸氨基羧酸血红蛋白胰蛋白酶家系家族亲缘关系嗜热菌变种结构分析分析(力学) 顺序分析人类测定法

LXI inst.ument.development.plat.orm based on an open embedded operat.ng syst.m

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仪器仪表学报 2007年第5期28卷 788-791页

作者： Yu wilson Deovo t.chnologics Inc. 45 Bristol Rd.E Suite 21Mississauga ONCCanada L4Z 3P5

t.is paper int.oduces t.e archit.ct.re and component. of LXI inst.ument.development.plat.orm based on an open embedded operat.ng syst.m,which is a modular and configurable *** plat.orm is a t.t.l solut.on t. develop LXI inst.ument.modules and *** t.e ot.er hand,it.also support. ot.er t.pes of inst.ument.*** is a generic and efficient.*** t.e end,t.is paper addresses t.e t.chnical t.nds, challenges,and recormnends solut.ons.

关键词：开放式嵌入操作系统仪器扩展 LXI 技术对策 LAN接口

Funct.onal-t.ait.ecology of t.e plat.au pika Ochot.na curzoniae in t.e Qinghai-t.bet.n Plat.au ecosyst.m

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Int.grat.ve Zoology 2019年第1期14卷 87-103页

作者： Andrew t.SMIt. BADINGQIUYING Maxwell C.wilson Brigit.e W.HOGAN School of Life Sciences Arizona State UniversityTempeArizonaUSA School of Geographical Sciences Qinghai Normal UniversityXiningChina

Underst.nding a species’funct.onal t.ait. allows for a direct.d and product.ve perspect.ve on t.e role a species plays in nat.re,and t.us it. relat.ve import.nce t. conservat.on *** funct.onalt.ait.ecology of t.e plat.au pika Ochot.na curzoniae is examined t. bet.er underst.nd t.e resilience and sust.inabilit. of t.e high alpine grasslands of t.e Qinghai-t.bet.n Plat.au(Qt.).t.e key funct.onal t.ait. of plat.au pikas are t.eir abundance and behavior of digging ext.nsive burrow *** pikas have been poisoned over a significant.part.of t.eir original geographic dist.ibut.on across t.e Qt.,allowing comparison of ecological communit.es wit. and wit.out.*** all mammalian and avian carnivores,most.of which are obligat. predat.rs on pikas,have been lost.in regions where pikas have been *** endemic birds on t.e Qt. nest.in pika burrows;when pikas are poisoned,burrows collapse,and t.ese birds are great.y reduced in *** t. t.e biopedt.rbat.on result.ng from t.eir burrows,regional plant.species richness is higher in areas wit. pikas t.an *** presence of pika burrows allows higher rat.s of infilt.at.on during heavy monsoon rains compared t. poisoned areas,possibly mit.gat.ng runoff and t.e pot.nt.al for serious downslope erosion and ***,t.e funct.onal t.ait. of plat.au pikas enhance nat.ve biodiversit. and ot.er import.nt.ecosyst.m funct.ons;t.ese t.ait. are *** plat.au pikas are not.nat.ral colonizers,act.ve reint.oduct.on programs are needed t. rest.re pikas t. areas from which t.ey have been poisoned t. rest.re t.e import.nt.funct.onal ecological t.ait. of pikas.

关键词： ecosyst.m engineer funct.onal-t.ait.ecology keyst.ne species Ochot.na curzoniae re-int.oduct.on

Correlat.on of in vivo t.mor response and singlet.oxygen luminescence det.ct.on in mt.PC-mediat.d phot.dynamic t.erapy

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Journal of Innovat.ve Opt.cal Healt. Sciences 2015年第1期8卷 106-112页

作者： Brian C.wilson Michael S.Pat.erson Buhong Li Mark t.Jarvi Depart.ent.of Medical Biophysics Universit. of t.ront./Universit. Healt. Net.ork t.ront. Ontario M5G 1L7Canada Juravinski Cancer Cent.e and McMast.r Universit. Hamilt.n Ontario L8V 5C2Canada MOE Key Laborat.ry of Opt.Elect.onic Science and t.chnology for Medicine Fujian Provincial Key Laborat.ry for Phot.nics t.chnology Fujian Normal Universit. FuzhouFujian 350007P.R.China

Excit.d-st.t. singlet.axygen(^(1)O_(2)),generat.d during phot.dynamic t.erapy(PDt.,is believed t. be t.e primary cyt.t.xic agent.wit. a number of clinically approved *** relat.ve concent.at.on in cells or t.ssues can be measured direct.y t.rough it. near-infrared(NIR)luminescence emission,which has correlat.d well wit. in vit.o cell and in t.iro normal skin t.eat.ent.***,it. correlat.on wit. t.e response of t.mor t.ss1e in vit. is examined,using t.e phot.sensit.zer meso-t.t.alydroxyphenylchlorin(mt.PC)in an animal model comprising luciferase-and green fluorescent.prot.in(GFP)-t.ansduced gliosarcoma grown in a dorsal window *** change in t.e bioluminescence signal,imaged pre-t.eat.ent.and at.2,5 and 9 d post.t.eat.ent.was used as a quant.t.t.ve measure of t.e t.mor response,which was classified in individual t.mors as"non","moderat."and"st.ong"in order t. reduce t.e variance in t.e *** t.e bioluminescence-based response vs t.e^(1)O_(2)count. demonst.at.d clear correlat.on,indicat.ng t.a^(1)O_(2)luminescence provides a valid do-simet.ic t.chnique for PDt.in t.mor t.ssue.

关键词： Phot.dynamice t.erapy singlet.axygen lumninescence dosinet.y bioluminescence

Low yield of rout.ne duodenal biopsies for evaluat.on of abdominal pain

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World Journal of Gast.oent.rology 2015年第24期21卷 7495-7499页

作者： St.rling M Dubin wilson t.Kwong Denise Kalmaz t.omas J Savides Depart.ent.of Medicine Division of Gastroenterology University of California San Diego La Jolla

AIM: t. det.rmine t.e yield of biopsying normal duodenal mucosa for invest.gat.on of abdominal ***: t.is is a ret.ospect.ve chart.review of consecut.ve pat.ent. who underwent.esophagogast.oduodenoscopy(EGD) wit. duodenal biopsies of normal appearing duodenal mucosa for an indicat.on t.at.included abdominal pain. All t.e pat.ent. in t.is st.dy were ident.fied from an elect.onic endoscopy dat.base at.a single academic medical cent.r and had an EGD wit. duodenal biopsies performed over a 4-year period. New diagnoses t.at.were made as a direct.result.of duodenal biopsies were ident.fied. All duodenal pat.ology report. and endoscopy records were reviewed for indicat.ons t. perform t.e examinat.on as well as t.e findings; all t.e medical records were reviewed. Exclusion crit.ria included age less t.an 18 years, duodenal mass, nodule, or polyp, endoscopic duodenit.s, duodenal scalloping, known celiac disease, posit.ve celiac serology, Crohns disease, or hist.ry of bone marrow t.ansplant. Informat.on was collect.d in a de-ident.fied dat.base wit. pert.nent.demographic informat.on including human immunodeficiency virus(HIV) st.t.s, and descript.ve st.t.st.cs were ***: About.300 pat.ent. underwent.EGD wit. biopsies of benign appearing or normal appearing duodenal mucosa. t.e mean age of pat.ent. was 44.1 ± 16.8 years; 189 of 300(63%) were female. A mean of 4.3 duodenal biopsies were performed in eachpat.ent. In t.e subgroup of pat.ent. wit. abdominal pain wit.out.anemia, diarrhea, or weight.loss t.e mean age was 43.4 ± 16.3 years. Duodenal biopsies performed for an indicat.on t.at.included abdominal pain result.ng in 4 new diagnoses(3 celiac disease and 1 giardiasis) for an overall yield of 1.3%. 183 pat.ent. wit. abdominal pain wit.out.anemia, diarrhea, or weight.loss(out.of t.e t.t.l 300 pat.ent.) underwent.duodenal biopsy of duodenal mucosa result.ng in t.ree new diagnoses(t.o cases of celiac disease and one giardiasis) for a yield of 1.6%. Duodenal

关键词： Duodenum Celiac disease Esophagogast.oduodenoscopy Abdominal pain Anemia Iron deficiencyanemia Diarrhea

Evaluat.on of safet. profile of black shilajit.aft.r 91 days repeat.d administ.at.on in rat.

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Asian Pacific Journal of t.opical Biomedicine 2012年第3期2卷 210-214页

作者： Velmurugan C Vivek B wilson E Bharat.i t.Sundaram t Depart.ent.of Pharmacology Sri Krishna Chaithanya College of Pharmacy Depart.ent.of Pharmacology Sri K.V College of PharmacyM.G RoadChickballapurKarnataka SRF National Institute of Indian Medical HeritageHyderabad Depart.ent.of Pharmaceut.cal Biot.chnology Sri Krishna Chaithanya College of Pharmacy Depart.ent.of Pharmaceut.cs Sri Krishna Chaithanya College of pharmacy

Object.ve:t. evaluat. t.e safet. of shilajit.by 91 days repeat.d administ.at.on in different.dose levels in ***:In t.is st.dy t.e albino rat. were divided int. four groups. Group Ⅰ received vehicle and group Ⅱ,Ⅲ and Ⅳ received 500,2500 and 5000 mg/kg of shilajit. *** animals were sacrificed and subject.d t. hist.pat.ology and iron was est.mat.d by flame at.mic absorpt.on spect.oscopy and graphit. ***:t.e result.showed t.at.t.ere were no significant.changes in iron level of t.eat.d groups when compared wit. cont.ol except.liver(5000 mg/kg) and hist.logical slides of all organs revealed normal except.negligible changes in liver and int.st.ne wit. t.e highest.dose of *** weight.of all organs was normal when compared wit. ***:t.e result.suggest. t.at.black shilajit.an Ayurvedic formulat.on,is safe for long t.rm use as a diet.ry supplement.for a number of disoniers like iron deficiency anaemia.

关键词： Shilajit Graphit. furnace Hist.pat.ology Flame at.mic absorpt.on spect.oscopy

Current.st.t.s and fut.re direct.ons of high-t.roughput.ADME screening in drug discovery

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Journal of Pharmaceut.cal Analysis 2020年第3期10卷 201-208页

作者： wilson Z.Shou Brist.l-Myers Squibb PO Box 4000PrincetonNJ08540USA

During t.e last.decade high-t.roughput.in vit.o absorpt.on,dist.ibut.on,met.bolism and excret.on(Ht.DME)screening has become an essent.al part.of any drug discovery effort.of synt.et.c *** conduct.of Ht.ADME screening has been"indust.ialized"due t. t.e ext.nsive development.of soft.are and aut.mat.on t.ols in cell cult.re,assay incubat.on,sample analysis and dat. *** Ht.ADME assay port.olio cont.nues t. expand in emerging areas such as drug-t.ansport.r int.ract.ons,early soft.spot.ident.ficat.on,and ADME screening of pept.de drug ***,t.anks t. t.e very large and high-qualit. Ht.ADME dat. set. available in many biopharma companies,in silico predict.on of ADME propert.es using machine learning has also gained much moment.m in recent.*** t.is review,we discuss t.e current.st.t.-of-t.e-art.pract.ces in Ht.ADME screening including assay port.olio,assay aut.mat.on,sample analysis,dat. processing,and predict.on model *** addit.on,we also offer perspect.ves in fut.re development.of t.is excit.ng field.

关键词： In vit.o Ht.ADME Aut.mat.on Bioanalysis Mass spect.omet.y Acoust.c eject.on mass spect.omet.y