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Combined transplantation of GDAs^(BMP) and hr-decorin in spinal cord contusion repair

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Neural Regeneration Research 2013年第24期8卷 2236-2248页

作者： Liang Wu Jianjun Li Liang Chen Hong Zhang Li Yuan Stephen ja Davies School of Rehabilitation Medicine Capital Medical University Department of Neural Functional Reconstruction of Spine and Spinal Cord China Rehabilitation Research Center Rehabilitation Center Beijing Xiaotangshan Rehabilitation Hospital Department of Neurosurgery University of Colorado Denver

Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astro- cytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, dou- ble-immunofluorescent histochemistry revealed that combined transplantation inhibited the early in- flammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was se- creted by transplanted cells, protected injured axons. The combined transplantation promoted ax- onal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte prolif- eration and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.

关键词： neural regeneration spinal cord injury astrocytes glial scar neural stem cells combined trans-plantation glial progenitor cells glial cells human recombinant decorin brain-derived growth factor glial fibrillary acidic protein grants-supported paper neuroregeneration

Acute liver failure is frequent during heat stroke

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World Journal of Gastroenterology 2008年第1期14卷 158-159页

作者： JM Garcin ja Bronstein S Cremades P Courbin F Cointet Clinique médicale hpital d'instruction des armées Bégin F 94163 Saint Mandé France Service de pathologie digestive hpital d'instruction des armées Clermont Tonnerre F 29200 Brest France

Acute liver failure （ALF） is relatively frequent during heat stroke （HS）. This risk must be emphasized, because its inddence is higher than is usually thought. In a recent study by Weigand et al, two cases were reported in which liver failure was the leading symptom. We have confirmed their conclusion in a study of 25 cases of HS with ALF, compared with 25 other cases without ALE Moreover, we observed that hypophosphatemia on admission could predict occurrence of ALF during HS. As for clinical and other biological parameters, phosphatemia should be monitored for at least 3 d in all cases of HS, even when it is thought to be mild.

关键词： Heat stroke, Hypophosphatemia Liver failure

Combination of korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice

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Chinese Journal of Integrative Medicine 2020年第5期26卷 361-369页

作者： ja Yoon ku Min Jung Park Hyun Jun Park Nam Cheol Park Bo Sun Joo Department of Urology Pusan National University HospitalPusan National University School of MedicineBusan(49241)Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan(49241)Republic of Korea The korea Institute for Public Sperm Bank Busan(49241)Republic of Korea

Objective: To investigate the effect of hydrogen-rich korean Red Ginseng(kRG) water(HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young(3 month-old) and aged(12 month-old) male mice were randomly assigned to 4 groups(n=10 per group) including control group, hydrogen-rich water(HRW) group(10 m L/kg daily), kRG group(50 mg/kg daily) and HRGW group(10 m L/kg HRW and 50 mg/kg kRG daily) by an oral zoned needle for 4 weeks. Sperm count and motility were measured using sperm suspension released from cauda epididymis. Serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone, and reactive oxygen species(ROS) in serum have also been estimated. Tubular changes were examined through histological hematoxylin and eosin staining. Expression of antioxidation(PPx3, PPx4, GSTm5 and GPx4), spermatogenesis(inhibin-α, neptin-2 and CREM), antiaging(SIRT1 and SIRT2), and angiogenesis [visfatin and vascular endothelial growth factor(VEGF)] related genes were examined through realtime polymerase chain reaction. Results: HRW and kRG treatment stimulated spermatogenesis followed by increasing sperm production and sperm motility(P<0.05). These effects were strengthened synergistically by a HRGW mixture(P<0.05 or P<0.01). HRGW greatly increased the expressions of antioxidation, antiaging, spermatogenesis related genes and VEGF especially in aged mice(P<0.05). Serum testosterone and FSH levels also increased, while serum ROS level decreased(all P<0.05). Conclusion: HRGW increases sperm production and motility by enhancing antioxidation and stimulating spermatogenesis and sex hormone production, particularly in aged mice.

关键词： aging ginseng infertlit mineral waters sperm mtility

Comparison of carbon-stock changes, eddycovariance carbon fluxes and model estimates in coastal Douglas-fir stands in British Columbia

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Forest Ecosystems 2015年第2期2卷 104-122页

作者： Colin J Ferster ja (Tony) Trofymow Nicholas C Coops Baozhang Chen Thomas Andrew Black Department of Forest Resources Management University of British Columbia Canadian Forest Service (Pacific Forestry Centre) Natural Resources Canada Department of Biology University of Victoria Faculty of Land and Food Systems University of British Columbia

Background： The global network of eddy-covariance （EC） flux-towers has improved the understanding of the terrestrial carbon （C） cycle, however, the network has a relatively limited spatial extent compared to forest inventory data and plots. Developing methods to use inventory-based and EC flux measurements together with modeling approaches is necessary evaluate forest C dynamics across broad spatial extents. Methods： Changes in C stock change （AC） were computed based on repeated measurements of forest inventory plots and compared with separate measurements of cumulative net ecosystem productivity （~NEP） over four years （2003 - 2006） for Douglas-fir （Pseudotsuga menzies# var menziesil} dominated regeneration （HDF00）, juvenile （HDF88 and HDF90） and near-rotation （DF49） aged stands （6, 18, 20, 57 years old in 2006, respectively） in coastal British Columbia. AC was determined from forest inventory plot data alone, and in a hybrid approach using inventory data along with litter fall data and published decay equations to determine the change in detrital pools. These AC-based estimates were then compared with Y_NEP measured at an eddy-covariance flux-tower （EC-flux） and modelled by the Carbon Budget Model - Canadian Forest Sector （CBM-CFS3） using historic forest inventory and forest disturbance data. Footprint analysis was used with remote sensing, soils and topography data to evaluate how well the inventory plots represented the range of stand conditions within the area of the flux-tower footprint and to spatially scale the plot data to the area of the EC-flux and model based estimates, Results： The closest convergence among methods was for the juvenile stands while the largest divergences were for the regenerating clearcut, followed by the near-rotation stand. At the regenerating clearcut, footprint weighting of CBM-CFS3 TNEP increased convergence with EC flux Z_NEP, but not for AC. While spatial scaling and footprint weighting did not increase convergence for AC, they d

关键词： Forest carbon Micrometeorology Blometry Remote sensing Geographic information systems

Theoretical Simulation of Surface Evolution Using the Random Deposition and Surface Relaxation for Metal Oxide Film in Atomic Layer Deposition

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Journal of Materials Science & Technology 2010年第4期26卷 371-374页

作者： Ji-Hoon Ahn Se-Hun kwon Jin-Hyock kim ja-Yong kim Sang-Won kang Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology373-1Kusong-dongYusong-guTaejon 305-701Korea Hynix Semiconductor Incorporated San 136-1Ami-riBubal-eubIcheon-siKyongki-do467-701Korea

Atomic layer deposition （ALD） has become an essential deposition method for forming nanometer scale thin films in the microelectronics industry, and its applications have been extended to multi-component thin films, as well as to single metal oxide films. In order to investigate the development of the surface structure of ultra-thin film qualitatively as well as quantitatively, ALD processes are simulated with a molecular scale. For this simulation, the film materials are deposited on a imaginary substrate that consists of small lattice. The deposition behaviors are described by using random deposition （RD） model or random deposition with surface relaxation （RDSR） model as the ALD growth mode, and the proposed model was applied to the deposition of SrO-TiO2 thin films. Through this work, growth characteristics such as surface morphology, deposited film coverage can be predicted.

关键词： Atomic layer deposition Random deposition SrO-TiO2

Impact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells

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World Journal of Gastroenterology 2021年第29期27卷 4879-4889页

作者： Yeon Ji kim Bu kyung kim Seun ja Park.jae Hyun kim Institute of Gastroenterology Kosin University College of MedicineBusan 49267Spain Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

BACkGROUND Gut microbial dysbiosis contributes to the development and progression of colorectal cancer(CRC).Natural killer(Nk)cells are involved in early defense mechanisms to kill infective pathogens and tumor cells by releasing chemokines and *** better understand the relationship between the gut microbiome and CRC,it was hypothesized here that a high abundance of Fusobacterium nucleatum(***)in the gastrointestinal tract could cause reduced Nk cell *** To identify associations between gastrointestinal tract *** levels and Nk cell *** In vitro experiments were performed on Nk cells treated with ***,Peptostreptococcus anaerobius,and Parvimonas micra to identify the effects of gut microbiome species on Nk *** 24 and 48 h of treatment,Nk cell counts were *** parallel studies,C57BL/6 mice were given broadspectrum antibiotics in their drinking water to reduce resident gut *** 3 wk,the mice received the various bacterial species or phosphate-buffered saline(PBS)via oral gavage every 2 d for 6 *** the study end,blood samples were acquired to perform Nk cell activity assessment and cytokine *** tissues were collected and analyzed via immunohistochemistry(IHC).RESULTS The data show that after 3 wk of broad-spectrum antibiotic treatment,levels of total bacteria and *** were markedly decreased in *** of *** significantly decreased Nk cell activity relative to the activities of cells from mice treated with antibiotics only and *** administration of *** decreased the proportion of Nk46+cells based on IHC staining and increased the production of interleukin-1βand tumor necrosis factor-α.CONCLUSION High levels of *** in the gastrointestinal tract reduced Nk cell activity in mice,and the decrease in Nk cell activity might be affected by increased proinflammatory cytokines after *** treatment.

关键词： Fusobacterium nucleatum Natural killer cells Colorectal cancer

Tai Chi for Management of Type 2 Diabetes Mellitus:A Systematic Review

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Chinese Journal of Integrative Medicine 2011年第10期17卷 789-793页

作者： Myeong Soo Lee Tae-Young Choi Hyun-ja Lim Edzard Ernst Division of Standard Research Korea Institute of Oriental MedicineDaeieonSouth Korea Complementary Medicine Peninsula Medical SchoolUniversity of ExeterExeterUK Division of Standard Research Korea Institute of Oriental MedicineDaejeonSouth Korea Department of Nursing Chodang UniversityMuanSouth Korea

Objective： Tai chi has been recommended for treating type 2 diabetes mellitus. The purpose of this systematic review was to evaluate evidence from controlled clinical trials testing the effectiveness of tai chi in treating type 2 diabetes mellitus. Methods： Systematic searches were conducted on 14 electronic databases without restrictions on either population characteristics or language of publication. The outcome measures considered for inclusion were changes in fasting blood glucose （FBG）, glycosylated haemoglobin A1c （HbA1c） and quality of life （QOL）. Results： Eight randomised clinical trials （RCTs） and two controlled clinical trials （CCTs） met all inclusion criteria. Three RCTs from 1 trial compared the effects of tai chi with sham exercise and failed to show effectiveness of tai chi on FBG, HbA1c, or QOL. The other 3 RCTs tested the effects of tai chi compared with other types of exercise on FBG. The meta-analysis failed to show an FBG-lowering effect of tai chi [n=118, weighted mean difference （WMD）： -0.14 mmol/L, 95% CI：-0.86 to 0.58,P=0.70]. Four studies （2 RCTs and 2 CCT） compared tai chi with no treatment or self-management programme and failed to report significant differences between the experimental and control groups except for QOL from 1 RCT and 1 CCT. Conclusion： The existing evidence does not suggest that tai chi is an effective therapy for type 2 diabetes. Currently, there are few high-quality trials on which to make definitive judgements.

关键词： type 2 diabetes mellitus tai chi fast blood glucose complementary medicine

The soil fungi producing siderophores of ***,Tawang,La Trinidad,Benguet

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Studies in Fungi 2019年第1期4卷 1-13页

作者： Hipol RM Baldelomar ja Bolinget kC Solis AFF Department of Biology College of ScienceUniversity of the Philippines Baguio

Siderophores,being iron-chelators,have received much attention in environmental research,medicine,and biotechnology because of their high affinity and specificity to a wide range of *** study aimed to investigate siderophore production of culturable soil fungi from ***,Tawang,La Trinidad,Benguet and to determine their chemical *** production was detected and quantified using Chrome Azurol Sulphonate assay while the siderophore characterization was through FeCl_(3),Csáky’s and Arnow’s *** was found that 11 out of 20 pure cultures,which showed positive CAS assay results,produce *** primers were used in PCR amplification for the molecular identification of the top-four *** on BLASTn analyses of their sequences,the isolates were found to be most homologous to species of Talaromyces,Byssochlamys,Paecilomyces,and *** identified species were subjected to phylogenetic analysis using MEGA 7 to the show evolutionary history and relationship among the fungal species.

关键词： CAS assay hydroxamates iron chelators

Diagnosis,treatment and complications of radial head and neck fractures in the pediatric patient

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World Journal of Orthopedics 2022年第3期13卷 238-249页

作者： Arno A Macken Denise Eygendaal Christiaan ja van Bergen Department of Orthopedic Surgery Amphia HospitalBreda 4818 CKNoord-BrabantNetherlands Department of Orthopedic Surgery and Sports medicine Erasmus Medical CentreRotterdam 3015 GDSouth-HollandNetherlands

Radial head and neck fractures represent up to 14%of all pediatric elbow fractures and can be a difficult challenge in the pediatric *** up to 39%of proximal radius fractures,there is a concomitant fracture,which can easily be overlooked on the initial standard *** treatment options for proximal radius fractures in children range from non-surgical treatment,such as immobilization alone and closed reduction followed by immobilization,to more invasive options,including closed reduction with percutaneous pinning and open reduction with internal *** choice of treatment depends on the degree of angulation and displacement of the fracture and the age of the patient;an angulation of less than 30 degrees and translation of less than 50%is generally accepted,whereas a higher degree of displacement is considered an indication for surgical *** with limited displacement and non-surgical treatment generally result in superior outcomes in terms of patient-reported outcome measures,range of motion and complications compared to severely displaced fractures requiring surgical *** proper management,good to excellent results are achieved in most cases,and long-term sequelae are ***,severe complications do occur,including radio-ulnar synostosis,osteonecrosis,rotational impairment,and premature physeal closure with a malformation of the radial head as a result,especially after more invasive *** follow-up is therefore warranted.

关键词： Radial head Proximal radius Fracture Pediatrics Closed fracture reduction Open reduction fracture Fracture fixation Synostosis Osteonecrosis