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The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

Biosafety and Health 2024年第2期6卷 101-115页

作者： Yanan Wang Mengqi Qu Yuhai Bi william J.Liu Sufang Ma Bo Wan Yongfei Hu Baoli Zhu Gaiping Zhang George F.Gao International Joint Research Center of National Animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu Laboratory Zhengzhou 450046China University of Chinese Academy of Sciences Beijing 100049China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene

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Plant growth and metabolism of exotic and native Crotalaria species for mine land rehabilitation in the Amazon

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Journal of Forestry Research 2024年第1期35卷 143-154页

作者： Hemelyn Soares das Chagas Rafael Silva Guedes Markus Gastauer Paula Godinho Ribeiro Allan Klynger da Silva Lobato Cecílio Frois Caldeira Fabrício william deÁvila AndréRodrigues dos Reis Silvio Junio Ramos Instituto Tecnológico Vale Rua Boaventura da Silva955BelémPA 66055-090Brazil Universidade Federal do Sul e Sudeste do Pará XinguaraPABrazil Núcleo de Pesquisa Vegetal Básica e Aplicada Universidade Federal Rural da AmazôniaParagominasPABrazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste/UNICENTROIratiPRBrazil School of Sciences and Engineering São Paulo State University(UNESP)TupãSP.CEP 17602-496Brazil

Despite its enormous benefits,mining is respon-sible for intense changes to vegetation and soil ***,after extraction,it is necessary to rehabilitate the mined areas,creating better conditions for the establishment of plant species which is *** study evaluated mineral and organic fertilization on the growth,and carbon and nitrogen(N)metabolism of two Crotalaria species[Cro-talaria spectabilis(exotic species)and Crotalaria maypu-rensis(native species from Carajás Mineral Province(CMP)]established on a waste pile from an iron mine in CMP.A control(without fertilizer application)and six fertilization mixtures were tested(i=NPK;ii=NPK+micronutrients;iii=NPK+micronutrients+organic compost;iv=PK;v=PK+micronutrients;vi=PK+micronutrients+organic compost).Fertilization contributed to increased growth of both species,and treatments with NPK and micronutrients had the best results(up to 257%***),while organic fertilization did not show *** Crotalaria had a greater number of nodules,higher nodule dry mass,chlorophyll a and b contents and showed free ammonium as the predominant N form,reflecting greater increments in biomass compared to native *** having lower growth,the use of this native species in the rehabilitation of mining areas should be considered,mainly because it has good development and meets current government legislation as an opportunity to restore local biodiversity.

关键词： Biological nitrogen fixation Mining Nitrogen metabolism Plant nutrition

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Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

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Genes & Diseases 2024年第1期11卷 413-429页

作者： Dongsheng Zhang Wenjuan Tang Haitao Niu william Tse Hai-Bin Ruan Helmut Dolznig Thomas Knosel Friedrich Karl-Heinz Madeleine Themanns Jiang Wang Mingquan Song Lee Denson Lukas Kenner Richard Moriggl Yi Zheng Xiaonan Han Division of Hematology and Oncology Division of Cancer BiologyDepartment of MedicineMetroHealth Medical Center(MHMC)Case Western Reserve University(CWRU)School of MedicineClevelandOH 44109USA Cancer Genomics and Epigenomics Program Case Comprehensive Cancer CenterCase Western Reserve University(CWRU)ClevelandOH 44106USA Division of Gastroenterology Hepatology and NutritionCincinnati Children’s Hospital Medical Center(CCHMC)CincinnatiOH 45229USA Children’s Hospital of Fudan University Shanghai 201102China School of Medicine Jinan UniversityGuangzhouGuangdong 510632China Laboratory Animal Science(ILAS) Chinese Academy of Medical Science(CAMS)and Peking Union Medical College(PUMC)Beijing 100006China Department of Integrative Biology and Physiology University of Minnesota Medical SchoolMinneapolisMI 55455USA Institute of Medical Genetics Medical University of ViennaVienna 1040Austria Institute of Pathology Ludwig-Maximilians-University MunichMunich 80539Germany Institute of Biochemistry II University Hospital JenaJena 07743Germany Laboratory Animal Pathology University of Veterinary Medicine ViennaVienna 1210Austria Department of Pathology University of CincinnatiCincinnatiOH 45221USA Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266005China Department of Pathology Medical University of ViennaVienna 1040Austria Ludwig Boltzmann Institute for Cancer Research Vienna 1090Austria Medical University of Vienna Vienna 1040Austria Institute of Animal Breeding and Genetics University of Veterinary Medicine ViennaVienna 1210Austria Division of Experimental Hematology CCHMCCincinnatiOH 45229USA

CDC42 controls intestinal epithelial(IEC)stem cell(IESC)*** aberrant CDC42 initiates intestinal inflammation or neoplasia is *** utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and *** specimens were collected to determine the levels of CDC42 in IBD or colorectal ***42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient ***,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC *** studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD *** Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt *** Cdc42 depletion markedly enhanced irra-diation-or chemical-induced *** or inhibition of Cdc42 reduced colonic Lgr5+IESC *** conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal *** monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.

关键词： Cell divisioncycle 42(CDC42) Colitis Colorectal cancer(CRC) Inflammatory bowel diseases(IBD) Intestinal epithelial cell(IEC) Intestinal epithelial stem cell(IESC) Irradiation

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Vertical plane depth-resolved surface potential and carrier separation characteristics in flexible CZTSSe solar cells with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-Ho Son Ha Kyung Park Dae-Hwan Kim Jin-Kyu Kang Shi-Joon Sung Dae-Kue Hwang Jaebaek Lee Dong-Hwan Jeon Yunae Cho william Jo Taeseon Lee JunHo Kim Sang-Hoon Nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

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SiP的模块化发展趋势

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电子与封装 2024年第7期24卷 21-28页

作者： william Koh Pacrim Technology Inc. IrvineCA 92602

系统级封装(SiP)技术已广泛应用于移动设备、可穿戴设备、健康和医疗设备、人工智能(AI)、物联网(IoT)和汽车电子。SiP采用异构集成的方式,将各种芯片和元件集成到一个封装中,以实现特定功能,并具有节省电路板空间、简化布局设计和降低... 详细信息

系统级封装(SiP)技术已广泛应用于移动设备、可穿戴设备、健康和医疗设备、人工智能(AI)、物联网(IoT)和汽车电子。SiP采用异构集成的方式,将各种芯片和元件集成到一个封装中,以实现特定功能,并具有节省电路板空间、简化布局设计和降低制造成本等优势。随着电子组件的小型化发展方向不断持续,一些SiP已经发展成为模块或系统级模块(SiM),可以直接连接并安装到器件中。回顾了SiP从多芯片模块(MCM)、多芯片封装(MCP)到高级芯粒封装和共封装光学器件(CPO)的演变。未来几年,更多的SiP将变成SiM,直接连接器件或系统。

关键词：系统级封装系统级模块多芯片模块

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Periodic Addition of Glucose Suppressed Cyanobacterial Abundance in Additive Lake Water Samples during the Entire Bloom Season

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Journal of Water Resource and Protection 2024年第2期16卷 140-155页

作者： David Linz Ian Struewing Nathan Sienkiewicz Alan David Steinman Charlyn Gwen Partridge Kyle McIntosh Joel allen Jingrang Lu Stephen Vesper United States Environmental Protection Agency Cincinnati Ohio USA Annis Water Resources Institute Grand Valley State University Muskegon USA Oak Ridge Institute for Science and Education Oak Ridge Tennessee USA

Previously, we showed that prophylactic addition of glucose to Harsha Lake water samples could inhibit cyanobacteria growth, at least for a short period of time. The current study tested cyanobacterial control with glucose for the entire Harsha Lake bloom season. Water samples (1000 ml) were collected weekly from Harsha Lake during the algal-bloom season starting June 9 and lasting until August 24, 2022. To each of two 7-liter polypropylene containers, 500 ml of Harsha Lake water was added, and the containers were placed in a controlled environment chamber. To one container labeled “Treated,” 0.15 g of glucose was added, and nothing was added to the container labeled “Control.” After that, three 25 ml samples from each container were collected and used for 16S rRNA gene sequencing each week. Then 1000 ml of Harsha Lake water was newly collected each week, with 500 ml added to each container, along with the addition of 0.15 g glucose to the “Treated” container. Sequencing data were used to examine differences in the composition of bacterial communities between Treated and Control containers. Treatment with glucose altered the microbial communities by 1) reducing taxonomic diversity, 2) largely eliminating cyanobacterial taxa, and 3) increasing the relative abundance of subsets of non-cyanobacterial taxa (such as Proteobacteria and Actinobacteriota). These effects were observed across time despite weekly inputs derived directly from Lake water. The addition of glucose to a container receiving weekly additions of Lake water suppressed the cyanobacterial populations during the entire summer bloom season. The glucose appears to stimulate the diversity of certain bacterial taxa at the expense of the cyanobacteria.

关键词： Glucose Cyanobacteria 16S Amplicon Sequencing Microbial Community

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Enhancing the clinical relevance of haemorrhage prediction models in trauma

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Military Medical Research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared M.Wohlgemut Max E.R.Marsden Erhan Pisirir Evangelia Kyrimi Rebecca S.Stoner william Marsh Zane B.Perkins Nigel R.M.Tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal London Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of Military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

We read with interest the recent systematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive transfusion Prediction Artificial intelligence Machine learning

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Two-step exhumation of Caucasian intraplate rifts:A proxy of sequential plate-margin collisional orogenies

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Geoscience Frontiers 2024年第2期15卷 68-84页

作者： william Cavazza Thomas Gusmeo Massimiliano Zattin Victor Alania Onise Enukidze Sveva Corrado Andrea Schito Department of Biological Geologicaland Environmental SciencesUniv.of BolognaItaly Department of Geosciences Univ.of PaduaItaly Institute of Geophysics I.Javakhishvili State UniversityTbilisiGeorgia Department of Sciences Roma Tre UniversityRomeItaly Department of Geology and Geophysics Univ.of AberdeenUnited Kingdom

Intraplate structural deformation is diagnostic of tectonic stress regime changes linked to plate interactions and can result from superposed tectonic events whose single contributions are hardly *** this paper,we present a set of integrated thermochronologic inverse models along a 140 km-long transect across the central Greater Caucasus and the adjacent Adjara-Trialeti fold-and-thrust belt of Georgia,two intraplate orogens produced by structural inversion of parallel continental rift zones located on the Eurasian *** dataset allows to distinguish discrete and superposed deformation episodes and quantify their respective contributions to orogenic *** integration of(U-Th)/He analysis on apatite and zircon,fission-track analysis on apatite,and peak-temperature determinations(clay mineralogy,organic matter petrography,Raman spectroscopy)shows that structural inversion was punctuated by two incremental steps starting respectively in the latest Cretaceous and the *** Cretaceous partial inversion of the Greater Caucasus is documented here for the first time and placed in a geographically wider context of coeval *** two episodes of intraplate structural inversion,exhumation,and sediment generation are chronologically and physically correlated with docking of(i)the Anatolide-Tauride-Armenian terrane(Late Cretaceous-Paleocene)and(ii)Arabia(Miocene hard collision)against the southern Eurasian plate *** deformation in the Caucasian domain was triggered by far-field propagation of plate-margin collisional stress which focused preferentially along rheologically weak rift zones.

关键词： Intraplate deformation Far-field tectonics Greater Caucasus Structural reactivation Terrane accretion

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行星科学研究中热发射光谱的实验测量与定标方法

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空间科学学报 2024年第2期44卷 270-286页

作者：杨亚洲 MILLIKEN Ralph E BRAMBLE Michael S PATTERSON william R 邹永廖刘洋中国科学院国家空间科学中心空间天气学国家重点实验室北京100190 布朗大学地球环境与行星科学学院普罗维登斯02912

准确的物质组成信息是解译行星体形成与演化历史的关键,可见–近红外遥感光谱探测一直是获取行星表面成分的主要技术手段.在热红外谱段光谱特征更为丰富,因此随着探测技术的发展,其在行星探测中得到越来越多的应用.尤其是在目前已经实... 详细信息

准确的物质组成信息是解译行星体形成与演化历史的关键,可见–近红外遥感光谱探测一直是获取行星表面成分的主要技术手段.在热红外谱段光谱特征更为丰富,因此随着探测技术的发展,其在行星探测中得到越来越多的应用.尤其是在目前已经实施与立项的国内外小行星探测任务中,都将热发射光谱仪作为核心载荷之一.为了更好地对将来获取的热发射光谱数据进行解译,建立科学合理的数据处理与定标方案是必不可少的.本文对用于行星科学研究的热发射光谱测量装置的设计、测量及数据处理方法进行了系统分析.针对低温、真空条件下热发射测量过程中样品辐射信号与仪器辐射信号难以分离的问题,提出并论证了基于傅里叶变换红外光谱仪原始测量信号–干涉图的数据处理方法.该方法可以更为有效地分离出样品实际辐射信号,从而获得更为准确的发射率光谱数据.研究结果可为国内相关热发射测量装置的设计与搭建以及未来天问二号等探测数据的处理与科学解译提供参考.

关键词：行星探测热发射光谱实验室测量定标

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Targeting AMPKa1 Gene in PC3 Cells by Triphenylmethanol Derivatives

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Natural Science 2024年第7期16卷 111-120页

作者： william Yaw Boadi Jamari Jemison Kennedy Welbert Sanaa Dudley Tayalla Hizer Ryan Beni Departments of Chemistry and Biology Tennessee State University Nashville USA

Epidemiological studies indicate that treatment with metformin, an AMP-activated protein kinase (AMPK) activator, reduces the incidence of cancers. Activation of AMPK has also been reported to oppose tumor progression in diverse types of cancers and offers promising cancer therapy. Furthermore, AMPK is a primary regulator of energy metabolism and has also been implicated in cell cycle progression, angiogenesis, cell transformation, migration, and cancer. We have recently synthesized novel flavonoids, namely, triphenylmethanol derivatives (TPMs), but the effectiveness of the TPMs on the activity of AMPK remains unclear. We hypothesized that the novel TPMs would inhibit cancer cell proliferation through the activation of AMPK isoforms in cells. The effects of TPMs on prostate cells (PC-3) were investigated. Cells were exposed to TPMs for either 12 or 24 hr. at the respective doses of 0, 25, 50 100, and 200 µM based on the cell viability studies by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) (MTT) assay. The results indicate that cells exposed to the respective doses of TPMs increased both phospho- and total-AMPKα1 in a dose- and time-dependent manner. The effects of the increases for the phospho- and total-AMPKα in cells were greater for the 24-hr than the 12-hr. incubation. Further studies are currently going on to elucidate the specificities of the said insults in increasing the phospho- and total-AMPKα activities and for the other respective isoforms.

关键词： Prodrugs AMP-Activated Protein Kinase Polyphenols Prostate Cancer Triphenylmethanol

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