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Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management

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World Journal of Gastroenterology 2024年第13期30卷 1780-1790页

作者： Katsuhiro Kita allen Burdowski Department of Biology St.Francis CollegeBrooklynNY 11201United States

Colorectal cancer(CRC)has remained the second and the third leading cause of cancer-related death worldwide and in the United States,*** significant improvement in overall survival has been achieved,death in adult populations under the age of 55 appears to have increased in the past *** new classes of therapeutic strategies such as immunotherapy have emerged,their application is very limited in CRC so ***(MT)inhibitors such as taxanes,are not generally successful in *** may be some way to make MT inhibitors work effectively in *** potential advantage that we can take to treat CRC may be the combination of optical techniques coupled to an endoscope or other fiber optics-based devices.A combination of optical devices and photo-activatable drugs may allow us to locally target advanced CRC cells with highly potent MT-targeting *** this Editorial review,we would like to discuss the potential of optogenetic approaches in CRC management.

关键词： Colorectal cancer Chemotherapy Microtubule Combretastatin Photopharmacology

Physiology of medicinal and aromatic plants under drought stress

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The Crop Journal 2024年第2期12卷 330-339页

作者： Zohreh Emami Bistgani allen V.Barker Masoud Hashemi Isfahan Agricultural and Natural Resources Research and Education Center Agricultural Research Education and Extension Organization(AREEO)Isfahan 81748-35117Iran Stockbridge School of Agriculture University of MassachusettsAmherstMA 01002USA

Drought poses a significant challenge,restricting the productivity of medicinal and aromatic *** strain induced by drought can impede vital processes like respiration and photosynthesis,affecting various aspects of plants’growth and *** response to this adversity,medicinal plants employ mechanisms such as morphological and structural adjustments,modulation of drought-resistant genes,and augmented synthesis of secondary metabolites and osmotic regulatory substances to alleviate the *** water scarcity can lead to leaf wilting and may ultimately result in plant *** cultivation and management of medicinal plants under stress conditions often differ from those of other *** is because the main goal with medicinal plants is not only to increase the yield of the above-ground parts but also to enhance the production of active ingredients such as essential *** elucidate these mechanisms of drought resistance in medicinal and aromatic plants,the current review provides a summary of recent literature encompassing studies on the morphology,physiology,and biochemistry of medicinal and aromatic plants under drought conditions.

关键词： Drought stress Medicinal and aromatic plants Phytochemistry Physiology

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货币政策中的透明度及责任制

金融科学（中国金融学院学报） 1998年第3期 106-110页

作者： william A allen 于海中国光大银行总行

关于货币政策的基础结构问题,就是以什么样的程序制定货币政策,促使各个机构间责任的分配,以带来最佳的货币政策。人们曾大量讨论过这个问题,这个讨论尚未结束。七十年代的通货膨胀及其负面影响引起了这些讨论。人们希望能建立一种制... 详细信息

关于货币政策的基础结构问题,就是以什么样的程序制定货币政策,促使各个机构间责任的分配,以带来最佳的货币政策。人们曾大量讨论过这个问题,这个讨论尚未结束。七十年代的通货膨胀及其负面影响引起了这些讨论。人们希望能建立一种制度结构从而尽量减少通货膨胀复发而造成的风险。下面以英国为例阐明问题。通过1945年以来的通货膨胀率(以零售衡量)和长期英国政府债券收益,我们可以看到60年代中期以前英国没有明显的通货膨胀上升趋势,60年代后期到70年代前期通货膨胀不断加剧,并在1975年达到顶值25％。至此以后通货膨胀一直处在下降趋势,尽管有时中断。

关键词：货币政策透明度责任制中央银行货币信用

Developing a new agenda for increased food and climate security

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 35-54页

作者： william J.DAVIES Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUK

In many countries, political and environmental pressures are currently combining to generate a perfect storm of circumstances that is reducing food availability, increasing food costs and thereby reducing the availability of food to many. The UK is currently considering new national food and land management policies, and attention is also being given to legislation to address diet-related health issues. Many now argue for a revolution in UK farming practices to reduce their impact on the natural environment. The UK is not alone in facing these and other challenges. Both the contribution of agriculture to greenhouse gas(GHG) emissions and the effects of climate change on food production are issues receiving worldwide *** agricultural practices can result in greater C capture, reduced GHG emissions, enhanced soil quality and enhanced biodiversity. However, it is questioned if such farming systems will be productive enough to feed a growing population with the food required for social and health benefits. To fully exploit the impact of new plant science in farmer fields, it is imperative to effectively link science to farming practices and conduct a broader conversation around the food revolution with social scientists and with the general public.

关键词： Climate resilience food security human health planetary health regenerative agriculture

Detection of onset of agglomeration in a bubbling fluidized bed biomass combustor using reactive Eulerian computational fluid dynamics

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Particuology 2024年第7期90卷 504-515页

作者： Abdullah Tasleem Atta Ullah Fei Li Qun Yi william Nimmo Syed Sheraz Daood Department of Chemical Engineering Pakistan Institute of Engineering and Applied Sciences(PIEAS)Lehtrar RoadP.O.Nilore45650IslamabadPakistan Institute of Process Engineering Chinese Academy of SciencesBeijing100190China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan430205China Energy Engineering Group Energy 2050Department of Mechanical EngineeringUniversity of SheffieldSheffieldS37RDUnited Kingdom Institute of Energy and Environmental Engineering Faculty of ElectricalEnergy&Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahorePakistan Energy Engineering Research and Development Centre Faculty of ElectricalEnergy&Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahorePakistan

The choice of a type of combustion technology to be used for heat or power generation depends on economic,technical,operational and fuel availability *** benefits associated with the evolving market driven by the fluidised bed combustion(FBC)technology cannot be overlooked especially when gauged at 65 GWth of worldwide installed capacity alongside added benefits of handling fuel variation,low pollutant emissions and high combustion *** or biomass waste will continue to have a vital role to play in the future FBC technology-based power *** often contains high levels of inorganic species that can form sticky agglomerates posing a significant risk to boiler operation resulting in unscheduled *** added complexity of the behaviour of the fuel and bed material mix highlights the requirement for simulation models to identify agglomeration to help improve the overall performance and reliability of FBC *** resolve this problem,this research devised a simulation strategy for the detection of agglomeration using the Eulerian–Eulerian *** developed modelling strategy is validated with the experimental data available in literature for two-dimensional simplified geometry of a pilot-scale fluidised bed *** model results were found promising and robust to predict bed defluidisation times and other parameters consistent with the experimental data.

关键词： Fluidized bed combustion Eulerian Models Biomass Agglomeration Defluidisation

william Morris,Establishing the Foundation for the Advancement of TCM in the US

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Chinese Medicine and Culture 2024年第1期7卷 29-40页

作者： Ioannis Solos Charles Buck william Morris Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom AOMA Graduate School of Integrative Medicine Austin 78745the United States of America

The interview was conducted on March 2nd, 2023 by Ioannis Solos and Charles Buck. william Morris has sustained practice since 1980. He has served on the California, Texas and Massachusetts Professional Associations, as well as the National Association. He has tendered 20 years of service to the field through academic medicine, earning a master’s degree in medical education to assist in developing Chinese medical doctoral programs and institutional review boards. He earned an OM.D. in 1988, a DAOM in 2002, and a Ph.D. focused on pulse diagnosis as clinical epistemology in 2009. He has published five books, including TCM Case Studies Dermatology, Li Shi-zhen Pulse Studies: An Illustrated Guide, Neoclassical Pulse Diagnosis, Cycles in Medical Astrology, and Transformation: Treating Trauma with Acupuncture and Herbs.

关键词： Acupuncture sustained diagnosis

Flame Structure of Methane and Kerosene Combustion with a Compact Concave Flame-Holder using the LES-pdf Method

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Journal of Thermal Science 2024年第1期33卷 222-234页

作者： WANG Fang WANG Yunfan WEI Guanyi LIU Denghuan JIN Jie JONES P.william School of Energy and Power Engineering Beihang UniversityBeijingBeijing 100191China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Compact flame-holders for afterburners are an increasing requirement for modern aero ***,flame-holder design is non-trivial since high inlet temperatures,velocities,and elaborate structures induce complex turbulence,combustion,and spray coupling in modern *** this work,the LES-pdf and stochastic fields-Lagrangian particle spray methods are used to investigate methane and aviation kerosene combustion structures formed by new-type concave *** flow pattern,combustion mode,and flame structure of gaseous and liquid fuel around a concave flame-holder are analyzed,discussed,and compared with experimental *** reveal that the flame stability of a concave flame-holder is better than that of the non-concave ***,when using liquid fuel,the concave flame-holder forms a stable and compact *** results suggest concave flame-holders are a promising design for compact afterburners.

关键词： concave structure flame-holder LES-pdf spray combustion flame structure AECSC

Unicompartmental knee arthroplasty vs high tibial osteotomy for knee osteoarthritis:A comparison of clinical and radiological outcomes

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World Journal of Orthopedics 2024年第5期15卷 444-456页

作者： Frederick william Wyatt Oday Al-Dadah Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE24HHUnited Kingdom Department of Trauma and Orthopaedic Surgery South Tyneside District HospitalSouth Shields NE340PLUnited Kingdom

BACKGROUND Unicompartmental knee arthroplasty(UKA)and high tibial osteotomy(HTO)are well-established operative interventions in the treatment of knee ***,which intervention is more beneficial to patients with knee osteoarthritis remains unknown and a topic of much ***,there is a paucity of research assessing the relationship between radiographic parameters of knee joint alignment and patient-reported clinical outcomes,preoperatively and following HTO or *** To compare UKAs and HTOs as interventions for medial-compartment knee osteoarthritis:Examining differences in clinical outcome and investigating the relationship of joint alignment with respect to *** This longitudinal observational study assessed a total of 42 patients that had undergone UKA(n=23)and HTO(n=19)to treat medial compartment knee ***-reported outcome measures(PROMs)were collected to evaluate clinical *** included two disease-specific(Knee Injury and Osteoarthritis Outcome Score,Oxford Knee Score)and two generic(EQ-5D-5L,Short Form-12)*** radiographic parameters of knee alignment assessed were the:Hip-knee-ankle angle,mechanical axis deviation and angle of Mikulicz *** Statistical analyses demonstrated significant(P<0.001),preoperative to postoperative,improvements in the PROM scores of both *** were,however,no significant inter-group differences in the postoperative PROM scores of the UKA and HTO *** significant correlations associated a more distolaterally angled Mikulicz line with worse knee function and overall health preoperatively(P<0.05).Postoperatively,two clusters of significant correlations were observed between the disease-specific PROM scores and knee joint alignment parameters(hip-knee-ankle angle,mechanical axis deviation)within the HTO group;yet no such associations were observed within the UKA *** UKAs and HTOs are both efficacious operations that provide a comp

关键词： Arthroplasty Osteotomy Medial compartment Osteoarthritis Knee alignment Patient reported outcome measures

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微塑料和纳米塑料威胁青藏高原环境

Science Bulletin 2024年第5期69卷 589-592页

作者：张玉兰康世昌罗犀 Tanuj Shukla 高坛光 Deonie allen Steve allen Melanie Bergmann State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham 200003UK Ocean Frontiers Institute Dalhousie UniversityHalifax B3H 4R2Canada Alfred-Wegener-Institut Helmholtz-Zentrum für Polar-und Meeresforschung Bremerhaven D-27515Germany University of Chinese Academy of Sciences Beijing 100049China

Plastic pollution is a planetary level threat which affects Earth’s environment and *** the poles to deep ocean basins,the growth of plastic waste has already exceeded its *** projected increase of plastic production and waste generation over the coming years makes the situation even more *** after stagnation in 2020 due to the COVID-19 pandemic,the global plastic production has also increased from 335 to 391 million metric tons(Mt)between 2016 and 2021(Fig.S1 online);yet currently post-consumer recycled and bio-based/attributed plastics only accounts~9%of the world’s plastic production[1].Statistically.

关键词：微塑料 attributed plastics