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Liver transplantation as an alternative for the treatment of intrahepatic cholangiocarcinoma: Past, present, and future directions

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 129-138页

作者： Sudha Kodali Ashton A Connor Souhail Thabet Elizabeth w Brombosz R Mark Ghobrial Sherrie and Alan Conover Center for Liver Disease and Transplantation Houston Methodist HospitalHoustonTX 77030USA JC walter Jr Transplant Center Houston Methodist HospitalHoustonTX 77030USA Department of Medicine Weill Cornell Medical CollegeNew YorkNYUSA Department of Surgery Houston Methodist HospitalHoustonTX 77030USA Department of Surgery Weill Cornell Medical CollegeNew YorkNYUSA School of Medicine New Giza UniversityGizaEgypt

Intrahepatic cholangiocarcinoma(iCCA)is a rare biliary tract cancer with high mortality *** resection of the iCCA lesion is the first choice of treatment,with good prognosis after margin-negative ***,only 12%-40% of patients are eligible for resection at presentation due to cirrhosis,portal hypertension,or large tumor *** transplantation(LT)offers margin-negative iCCA extirpation for patients with unresectable ***,iCCA was a contraindication for LT until size-based selection criteria were introduced to identify patients with satisfied post-LT *** studies have shown that tumor biology-based selection can yield high post-LT survival in patients with locally advanced *** selection criterion is the tumor response to neoadjuvant *** with response to neoadjuvant therapy have better outcomes after LT compared with those without tumor response to neoadjuvant *** index that helps predict the treatment outcome is the *** survival outcomes have also opened the door for living donor LT for *** undergoing LT for iCCA now have statistically similar survival rates as patients undergoing *** combination of surgery and locoregional and systemic therapies improves the prognosis of iCCA patients.

关键词： Liver transplantation Cholangiocarcinoma Hepatectomy Transplant oncology Liver neoplasm

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Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

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Zoological Research 2024年第4期45卷 805-820页

作者： wei Yan Zi-Jie Li Zi-Yi Lin Shu-Qin Ji william Ka Fai Tse Zhi-Qiang Meng Chang Liu Lei Li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

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Food intolerance and the few-foods(or oligoantigenic)diet in children with attention-deficit hyperactivity disorder

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Food Science and Human wellness 2024年第4期13卷 1729-1738页

作者： Klaus w.Lange Andreas Reissmann Yukiko Nakamura Katharina M.Lange Faculty of Human Sciences University of RegensburgRegensburg 93040Germany Department of Psychology University of BathBath BA27AYUnited Kingdom

The hypothesis that some children with attention-deficit hyperactivity disorder(ADHD)may show sensitivity or allergic reactions to various food items has led to the development of the the few-foods(or oligoantigenic)*** rationale of the diet is to eliminate certain foods from the diet in order to exclude potential allergens contained either naturally in food or in artificial ingredients with allergenic *** oligoantigenic diet attempts to identify individual foods to which a person might be ***,ADHD symptoms are monitored while multiple foods are excluded from the ***,if symptoms remit,foods are re-introduced,while observing the individual for the return of *** advantage of the oligoantigenic diet is that it can be tailored to the individual.A growing body of evidence suggests that behavioral symptoms of subgroups of children with ADHD may benefit from the elimination of certain *** effect sizes of an oligoantigenic diet regarding improvement of ADHD symptoms have been found to be medium to *** evidence suggests that the investigation of the role of food hypersensitivities in ADHD is a promising avenue worthy of further *** large-scale,randomized controlled studies including assessment of long-term outcome are therefore warranted.

关键词： Attention-deficit hyperactivity disorder Food intolerance Few-foods diet Etiology Treatment

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Resolving controversies surrounding carbon sinks from carbonate weathering

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Science China Earth Sciences 2024年第9期67卷 2705-2717页

作者： Xiaoyong BAI Sirui ZHANG Pete smith Chaojun LI Lian XIONG Chaochao DU Yingying XUE Zilin LI Mingkang LONG Minghui LI Xiaoyun ZHANG Shu YANG Qing LUO Xiaoqian SHEN State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB243UUUK College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550025China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

The importance of carbonate weathering carbon sinks(CCSs)is almost equal to that of vegetation photosynthesis in the global carbon ***,CCSs have become controversial in formulating carbon neutral policies to deal with global climate problems in various countries,since the carbonate dissolution is *** order to address these controversies,we reviewed recent advances in understanding CCSs and examined the outstanding controversies surrounding *** have analyzed the five controversies,revealing the existence of CCSs,quantifying their magnitude,clarifying their spatiotemporal pattern,and documenting how they have increased and how they evolved under the background of global *** addressing these five controversies,we help to bring clarity to the role of CCSs in the carbon cycle of global terrestrial ecosystems.

关键词： Carbon sink Carbonate weathering Carbon cycle Climate change Anthropogenic driver

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Chlorantraniliprole exposure aggravates high-fat diet-induced metabolic disorders in mice by regulating gut microbiota and its metabolites

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Food Science and Human wellness 2024年

作者： Ting Gu Jie Lin Jiani Yang william Mumby Quancai Sun Ye Peng Faculty of Medicine， Macau University of Science and Technology School of Food and Biological Engineering， Jiangsu University Department of Health， Nutrition， and Food Sciences， Florida State University

Food contaminants， particularly insecticides， are important factors contributing to obesity and other adverse effects. As the most widely used diamide insecticide worldwide， chlorantraniliprole (CP) is ubiquitous in food and the environment. However， the influence of CP on obesity and the gut microbiota remains unknown. In this study， we administered CP/carboxymethyl cellulose sodium to C57BL/6J mice with a high-fat diet (HFD) via gavage for 13 weeks. The CP exposure induced significant increases in body weight gain， fat mass， serum total cholesterol (TC)， and low-density lipoprotein cholesterol (LDL-C). Moreover， CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial bacteria. Based on untargeted metabolomics analysis， CP was found to be involved in the regulation of pathways including ‘alanine， aspartate and glutamate metabolism’ and ‘arginine and proline metabolism’. Notably， CP exposure primarily induced alterations in microbial metabolites within these pathways， such as L-(+)-aspartic acid and L-glutamic acid. Additionally， individual metabolites， such as the lipid mediator (oleoyl ethanolamide)， also demonstrated alterations upon CP exposure. Furthermore， Spearman correlation analysis revealed several noteworthy associations between microbial alterations， metabolite changes， and phenotypes. The results of the study demonstrate a connection between microbiota， metabolites， and the effects of CP exposure on HFD-induced obesity， elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.

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Reversed charge transfer induced by nickel in Fe-Ni/Mo_(2)C@nitrogen-doped carbon nanobox for promoted reversible oxygen electrocatalysis

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Journal of Energy Chemistry 2024年第1期88卷 202-212,I0005页

作者： Zhicheng Nie Lei Zhang Qiliang Zhu Zhifan Ke Yingtang Zhou Thomas wågberg Guangzhi Hu School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001AnhuiChina Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504YunnanChina National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316004ZhejiangChina Department of Physics UmeåUniversityUmeåS-90187Sweden

The interaction between metal and support is critical in oxygen catalysis as it governs the charge transfer between these two entities,influences the electronic structures of the supported metal,affects the adsorption energies of reaction intermediates,and ultimately impacts the catalytic *** this study,we discovered a unique charge transfer reversal phenomenon in a metal/carbon nanohybrid ***,electrons were transferred from the metal-based species to N-doped carbon,while the carbon support reciprocally donated electrons to the metal domain upon the introduction of *** led to the exceptional electrocatalytic performances of the resulting Ni-Fe/Mo_(2)C@nitrogen-doped carbon catalyst,with a half-wave potential of 0.91 V towards oxygen reduction reaction(ORR)and a low overpotential of 290 m V at 10 mA cm^(-2)towards oxygen evolution reaction(OER)under alkaline ***,the Fe-Ni/Mo_(2)C@carbon heterojunction catalyst demonstrated high specific capacity(794 mA h g_(Zn)~(-1))and excellent cycling stability(200 h)in a Zn-air *** calculations revealed that Mo_(2)C effectively inhibited charge transfer from Fe to the support,while secondary doping of Ni induced a charge transfer reversal,resulting in electron accumulation in the Fe-Ni alloy *** local electronic structure modulation significantly reduced energy barriers in the oxygen catalysis process,enhancing the catalytic efficiency of both ORR and ***,our findings underscore the potential of manipulating charge transfer reversal between the metal and support as a promising strategy for developing highly-active and durable bi-functional oxygen electrodes.

关键词： Metal-support interaction Charge transfer reversal Oxygen reduction reaction Oxygen evolution reaction Zinc-air battery

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Out-of-Equilibrium Assembly Based on Host-Guest Interactions

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CCS Chemistry 2024年第1期6卷 27-40页

作者： Guotai Li Reece w.Lewis Rienk Eelkema School of Rehabilitation Sciences and Engineering University of Health and Rehabilitation SciencesQingdao 266071 Department of Chemical Engineering Delft University of Technology2629 HZ Delft

The field of supramolecular chemistry is rapidly progressing,transitioning from the creation of thermodynamically stable systems found in local or global minima on the free energy landscape to the development of out-of-equilibrium systems that rely on chemical reactions to establish and maintain their *** the past decade,numerous artificial out-of-equilibrium systems have been devised in various domains of supramolecular chemistry,many of which have been extensively ***,one area that has received limited attention thus far is the use of out-of-equilibrium processes to regulate host-guest *** minireview aims to address this gap by exploring the construction of out-ofequilibrium systems based on host-guest complexation,which likely employs similar strategies to those employed in analogous noncovalent *** review begins with a summary of these shared ***,it discusses representative publications that exemplify these strategies and classifies thembased onwhich component is being modulated-host,guest,or competitive *** this examination,our objective is to shed light on the design of out-of-equilibrium systems relying on host-guest interactions and provide valuable insights into the preparation strategies for various transient materials.

关键词： out-of-equilibrium host-guest chemistry self-assembly supramolecular materials chemical fuel

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wild Nutrition’s Food-Grown® Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult Population: A Double-Blind, Randomised, Placebo-Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 509-523页

作者： David Briskey Jane Erickson Chelsie smith Amanda Rao School of Human Movement and Nutrition Sciences University of Queensland Brisbane Australia RDC Clinical Brisbane Australia

Background: Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown® magnesium in enhancing sleep quality and duration, as well as overall well-being. Methods: Eighty participants were randomly assigned to receive either 80 mg of Food-Grown® magnesium or a placebo (microcrystalline cellulose) daily for 8 weeks. Participants completed questionnaires assessing sleep quality, daytime drowsiness, quality of life, anxiety, and stress levels. Additionally, participants maintained daily sleep diaries and wore wrist-worn actigraphy devices. The primary outcome measured was the change in sleep quality and duration. Results: Seventy-one participants fulfilled all study requirements (35 in the active group and 36 in the placebo group). Magnesium supplementation significantly improved reported sleep quality, with the active group showing a 32% increase compared to 16% in the placebo group (p = 0.034). Moreover, magnesium supplementation led to a decrease in reported stress scores at week 8 compared to the placebo group (3.7 ± 2.6 vs. 5.5 ± 3.1, respectively). Both the magnesium and placebo groups exhibited significant increases in reported sleep duration and reductions in time to fall asleep, sleep disturbance, sleep latency, sleep medication usage, and total Pittsburgh Sleep Quality Index score at week 8 compared to baseline. Conclusion: Magnesium supplementation notably enhanced sleep quality and reduced stress levels compared to the placebo group. These findings highlight the potential of magnesium as a beneficial supplement for improving sleep quality and overall well-being.

关键词： Magnesium Sleep Quality Sleep Duration Stress Food-Grown

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Hybrid Scalable Researcher Recommendation System Using Azure Data Lake Analytics

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Journal of Data Analysis and Information Processing 2024年第1期12卷 76-88页

作者： Dinesh Kalla Nathan smith Fnu Samaah Kiran Polimetla Department of Doctoral Studies Colorado Technical University Colorado Springs CO USA Department of Computer Science Harrisburg University of Science and Technology Harrisburg PA USA Adobe Technology Service (ATS) Department Adobe San Jose CA USA

This research paper has provided the methodology and design for implementing the hybrid author recommender system using Azure Data Lake Analytics and Power BI. It offers a recommendation for the top 1000 Authors of computer science in different fields of study. The technique used in this paper is handling the inadequate Information for citation;it removes the problem of cold start, which is encountered by very many other recommender systems. In this paper, abstracts, the titles, and the Microsoft academic graphs have been used in coming up with the recommendation list for every document, which is used to combine the content-based approaches and the co-citations. Prioritization and the blending of every technique have been allowed by the tuning system parameters, allowing for the authority in results of recommendation versus the paper novelty. In the end, we do observe that there is a direct correlation between the similarity rankings that have been produced by the system and the scores of the participant. The results coming from the associated scrips of analysis and the user survey have been made available through the recommendation system. Managers must gain the required expertise to fully utilize the benefits that come with business intelligence systems [1]. Data mining has become an important tool for managers that provides insights about their daily operations and leverage the information provided by decision support systems to improve customer relationships [2]. Additionally, managers require business intelligence systems that can rank the output in the order of priority. Ranking algorithm can replace the traditional data mining algorithms that will be discussed in-depth in the literature review [3].

关键词： Azure Data Lake U-SQL Author Recommendation System Power BI Microsoft Academic Big Data word Embedding

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喀麦隆初级汉语综合课教学设计 ——以喀麦隆Bilingual Grammar School Molyko为例

喀麦隆初级汉语综合课教学设计 ——以喀麦隆Bilingual Grammar S...

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作者： AGBOR smith FOMBO 重庆交通大学

学位级别：硕士

本文主要探讨了喀麦隆“Bilingual Grammar School Molyko”初级汉语综合课的教学设计与实践。通过对该校汉语学习情况的调查研究,以及对综合课教学设计的深入分析,评估和反思,为喀麦隆中学汉语教学提供理论依据和实践指导。本研究具有... 详细信息

本文主要探讨了喀麦隆“Bilingual Grammar School Molyko”初级汉语综合课的教学设计与实践。通过对该校汉语学习情况的调查研究,以及对综合课教学设计的深入分析,评估和反思,为喀麦隆中学汉语教学提供理论依据和实践指导。本研究具有重要的学术和实际意义,既丰富了国际汉语教育理论,又为汉语教师在非洲国家的教学实践提供了具体参考。在第二章中,研究对喀麦隆“Bilingual Grammar School Molyko”中学汉语学习情况进行了详尽调查。调查采用问卷、访谈等方法,收集了学生、教师和学校管理者的多维度数据。分析结果显示,该校学生对汉语学习具有较高兴趣,但在学习过程中也面临诸多挑战,如语言环境缺乏、学习资源不足和教学方法单一等问题。这些问题的存在,不仅制约了学生的汉语学习效果,也影响了汉语教学的进一步发展。第三章聚焦于“Bilingual Grammar School Molyko”中学生综合课的教学设计。根据调查结果和教学实践经验,结合汉语国际教育的理论和方法,设计了一套适合喀麦隆中学生的汉语综合课教学方案。该方案从教学目标、课程设置、教学内容、教学方法和评价体系等方面进行了系统规划。教学目标明确,注重听、说、读、写四项技能的全面发展;课程设置合理,既有基础知识的传授,又有文化素养的培养;教学内容丰富,涵盖语言知识、文化知识和交际能力的培养;教学方法多样,采用任务型教学、情景教学等方法,提高学生的学习兴趣和参与度;评价体系完善,既有形成性评价,又有终结性评价,全面监测学生的学习效果。第四章对“Bilingual Grammar School Molyko”初级中文综合课的教学设计进行了评估与反思。评估采用质性和量性相结合的方法,通过课堂观察、学生测试、教师访谈等途径,全面分析了教学设计的实施效果。评估结果表明,该教学设计在提高学生汉语水平和学习兴趣方面取得了一定成效,但也存在一些不足,如教学资源有限、师资力量不足、教学方法需要进一步改进等。基于评估结果,研究提出了一系列改进建议,如增加教学资源投入、加强教师培训、改进教学方法等,为后续的教学实践提供了有益参考。本研究通过对喀麦隆“Bilingual Grammar School Molyko”初级汉语综合课教学设计的调查、分析和反思,不仅丰富了国际汉语教育理论,也为喀麦隆中学汉语教学实践提供了重要参考。研究结果显示,科学合理的教学设计对提高学生汉语学习效果具有重要作用,但同时也需要持续关注和解决实际教学中存在的问题,才能真正实现汉语教育的长远发展。本论文的研究方法具有一定创新性,通过综合运用问卷调查、访谈、课堂观察和教学评估等多种方法,获取了详实的数据,确保了研究结果的可靠性和科学性。研究不仅对喀麦隆汉语教学具有重要指导意义,也对其他非洲国家的汉语教育实践具有参考价值。希望本研究能够为喀麦隆及其他非洲国家的汉语教学提供有益借鉴,推动国际汉语教育事业的发展。

关键词：喀麦隆中学汉语教学教学设计你好喀麦隆

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