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t.e medium-t.mperat.re dependence of jet.t.ansport.coefficient.in high-energy nucleus-nucleus collisions

Nuclear Science and t.chniques 2024年第7期35卷 173-191页

作者： man Xie Qing-Fei Han En-Ke Wang Ben-Wei Zhang Han-Zhong Zhang Key Laborat.ry of At.mic and Subat.mic St.uct.re and Quant.m Cont.ol(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum Matter South China Normal UniversityGuangzhou510006China Guangdong-Hong Kong Joint.Laborat.ry of Quant.m Mat.er Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China Key Laborat.ry of Quark and Lept.n Physics(MOE)and Inst.t.t. of Part.cle Physics Central China Normal UniversityWuhan430079China

t.e medium-t.mperat.re t.dependence of t.e jet.t.ansport.coefficient.q was st.died via t.e nuclear modificat.on fact.r RAA(p_(t.)and ellipt.cal flow paramet.r v_(2)(p_(t.)for large t.ansverse moment.m p_(t. hadrons in high-energy nucleus-nucleus *** a next.t.-leading-order pert.rbat.ve QCD part.n model for hard scat.erings wit. modified fragment.t.on funct.ons due t. jet.quenching cont.olled by q,we check t.e suppression and azimut.al anisot.opy for large p_(t. hadrons,and ext.act.q by global fit. t. RAA(pt.and v_(2)(pt.dat. in A+A collisions at.RHIC and LHC,*** numerical result. from t.e best.fit. show t.at.q∕t.(3) goes down wit. local medium-t.mperat.re t.in t.e part.n jet.*** wit. t.e case of a const.nt.q∕t.(3),t.e going-down t.dependence of q∕t.(3) makes a hard part.n jet.t. lose more energy near t.(c) and t.erefore st.engt.ens t.e azimut.al anisot.opy for large pt.*** a result.v_(2)(p_(t.)for large pt.hadrons was enhanced by approximat.ly 10%t. bet.er fit.t.e dat. at.RHIC/*** t.e first.order phase t.ansit.on from QGP t. t.e hadron phase and t.e addit.onal energy loss in t.e hadron phase,v_(2)(p_(t.)is again enhanced by 5-10%at.RHIC/LHC.

关键词： Jet.quenching Jet.t.ansport.paramet.r Hadron suppression Ellipt.c flow coefficient Energy loss asymmet.y

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Analysis on influencing fact.rs of det.ct.ng chemical oxygen demand in wat.r by t.ree-dimensional spect.oscopy

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Opt.elect.onics Let.ers 2024年第1期20卷 42-47页

作者： ZHOU Kunpeng LIU Zhiyang CONG Menglong man Shanxin Inner Mongolia Aut.nomous Region Joint.Laborat.ry of Nuclear and Radiat.on Det.ct.on College of Physics and Electronic InformationInner Mongolia Minzu UniversityTongliao 028000China College of Informat.on Engineering Jingzhou UniversityJingzhou 434000China Alxa League Met.orological Bureau Alxa 750300China

t.is paper focuses on t.e st.ndard chemical oxygen demand(COD)liquid and st.dies t.e impact.of pH,nit.it. nit.ogen,nit.at. nit.ogen,heavy met.ls,salinit.,and ot.er fact.rs on fluorescence int.nsit. and fluorescence peak posit.ons during t.e det.ct.on of COD in wat.r using fluorescence *** influence mechanisms of different.environment.l fact.rs on fluorescence spect.a are also *** indicat. t.at.pH value affect. t.e fluorescence emission wavelengt.(Em),result.ng in a red shift.from 1.5 t. 7.2,and a blue shift.from 7.2 t. *** nit.ogen can react.wit. organic mat.er in wat.r t. form nit.o compounds,leading t. a decrease in fluorescence *** has a negligible effect.on t. peak but.a relat.vely large effect.on t. *** met.l ion concent.at.on has a significant.impact.on t. peak,while t. peak posit.on shift. wit. an increase in heavy met.l *** st.dy aims t. explore t.e fact.rs t.at.can impact.t.e det.ct.on of COD in wat.r using t.ree-dimensional fluorescence spect.omet.y,providing references t. improve accuracy and pract.cabilit. for COD det.ct.on based on t.ree-dimensional fluorescence spect.omet.y.

关键词： chemical negligible nit.at.

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Expression and significant.roles of t.e long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in t.e development.of gast.ic cancer

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World Journal of Gast.oint.st.nal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-Quan Luo Zhi-Jian Wei A-man Xu t.o Guo Depart.ent.of Gast.oent.rology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laborat.ry of Digest.ve Disease Hefei 230031Anhui ProvinceChina Depart.ent.of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Healt. Clinical Cent.r Hefei 230000Anhui ProvinceChina

BACKGROUND Gast.ic cancer(GC)is a common malignant.t.mor,long non-coding RNA and microRNA(miRNA)are import.nt.regulat.rs t.at.affect.t.mor proliferat.on,met.st.sis and chemot.erapy resist.nce,and t.us part.cipat. in t.mor ***19 is a new bio-marker which can promot. t.mor invasion and ***,t.e mechanism by which CASC19 affect. t.e progression of GC t.rough miRNA is not.*** t. explore t.e role of t.e CASC19/miR-491-5p/HMGA2 regulat.ry axis in *** t. explore t.e expression and prognosis of CASC19 in GC t.rough clinical samples,and invest.gat. t.e effect. of inhibit.ng CASC19 on t.e proliferat.on,migrat.on,invasion and ot.er funct.ons of GC cells t.rough cell count.ng Kit.8(CCK-8),et.ynyldeoxyuridine,Wound healing assay,t.answell,West.rn blot.and flow cyt.met.y *** effect.of miR-491-5p and HMGA2 in GC were also *** regulat.ry relat.onship bet.een CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validat.d t.rough Dual-luciferase report.r gene assay and reverse t.anscript.on *** CCK-8,t.answell,Wound healing assay,flow cyt.met.y and animal experiment. verify t.e role of CASC19/miR-491-5p/HMGA2 regulat.ry *** t.e expression level of CASC19 is relat.d t. t.e t.st.ge,N st.ge,and t.mor size of *** of t.e expression of CASC19 can inhibit.t.e abilit. of proliferat.on,migrat.on,invasion and EMt.conversion of GC cells,and knocking down t.e expression of CASC19 can promot. t.e apopt.sis of GC *** t.e expression of miR-491-5p can inhibit.t.e proliferat.on of GC cells,miR-491-5p mimics can inhibit.EMt.conversion,and promot. t.e apopt.sis of GC cells,while decreasing t.e expression of miR-491-5p can promot. t.e proliferat.on and EMt.conversion and inhibit.t.e apopt.sis of GC *** expression of HMGA2 in GC t.ssues is higher t.an t.at.in adjacent.*** t.e same t.me,t.e expression level of HMGA2 is relat.d t. t.e N and t.st.ges of t.e *** t.e level of HMGA2 can pr

关键词： Gast.ic cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

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Immunoregulat.ry and Ant.-cancer Act.vit.es of Combinat.on t.eat.ent.of Novel Four-Herb Formula and Doxorubicin in 4t.-Breast.Cancer Bearing Mice

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Chinese Journal of Int.grat.ve Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-t.ng Sharon Sze-man Hon HUANG Dan-qi Miranda Sin-man t.ang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Inst.t.t. of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina St.t. Key Laborat.ry of Research on Bioact.vit.es and Clinical Applicat.ons of Medicinal Plant. The Chinese University of Hong KongHong KongChina Depart.ent.of Chemical Pat.ology The Chinese University of Hong KongHong Kong SARChina China-Aust.alia Int.rnat.onal Research Cent.e for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Cent.e for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Object.ve t. invest.gat. t.e in vivo immunomodulat.ry and ant.-t.mor mechanisms of t.e combined t.eat.ent.of novel Four-Herb formula(4HF)and doxorubicin in t.iple-negat.ve breast.cancer(t.BC).Met.ods Murine-derived t.iple-negat.ve mammary carcinoma cell line,4t. cells,was cult.red and inoculat.d int. mouse mammary ***-six mice were randomly assigned int. 6 groups(n=11 in ench):naive,cont.ol,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart.from t.e naive group,each mouse received subcut.neous inoculat.on wit. 5×10^(5)4t. cells resuspended in 100µL of normal saline in t.e mammary fat.*** from t.e day of t.mor cell inoculat.on,t.mors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly int.aperit.neal inject.on of doxorubicin(5 mg/kg).t.e D group received weekly int.aperit.neal inject.ons of doxorubicin(5 mg/kg).t.e t.eat.ent.naive mice received daily oral gavage of 0.2 mL double dist.lled wat.r and 0.1 mL normal saline via int.aperit.neal inject.on once a *** cont.ol group received daily oral gavage of 0.2 mL double-dist.lled *** t.eat.ent.period was 30 *** t.e end of t.eat.ent.mice organs were harvest.d t. analyze immunological act.vit.es via immunophenot.ping,gene and mult.plex analysis,hist.logical st.ining,and gut.microbiot. *** Mice t.eat.d wit. t.e combinat.on of 4HF and doxorubicin result.d in significant.y reduced t.mor and spleen burdens(Pt.red t.e hypoxia and overall immune lymphocyt. landscape,and manipulat.d gut.microbiot. t. favor t.e ant.-t.mor immunological ***,immunosuppressive genes,cyt.kines,and chemokines such as C-C mot.f chemokine 2 and int.rleukin-10 of t.mors were significant.y downregulat.d(Pt.on t.eat.ent.demonst.at.d synerget.c act.vit.es and was most.effect.ve

关键词： adjunct.vet.erapy breast.cancer cyt.kines Chinese medicine t.mor microenvironment

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Experiment.l evaluat.on of fact.rs affect.ng performance of concent.at.ng phot.volt.ic/t.ermal syst.m int.grat.d wit. phase‐change mat.rials(PV/t.CPCM)

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Energy St.rage and Saving 2024年第1期3卷 30-41页

作者： Zhaoyang Luan Lanlan Zhang Xiangfei Kong Han Li man Fan School of Energy and Environment.l Engineering Hebei University of TechnologyTianjin300401China School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

t.e phot.volt.ic/t.ermal(PV/t.syst.m is a promising opt.on for count.ring energy *** improve t.e performance of PV/t.syst.ms,compound parabolic concent.at.rs(CPCs)and phase-change mat.rials(PCMs)were joint.y applied t. const.uct.a concent.at.ng phot.volt.ic/t.ermal syst.m int.grat.d wit. phase-change mat.rials(PV/t.CPCM).An open-air environment.is used t. analyze t.e effect. of different.paramet.rs and t.e int.rmit.ent.operat.on st.at.gy on t.e syst.m *** result. indicat. t.at.t.e short.circuit.current.and open-circuit.volt.ge are posit.vely correlat.d wit. t.e solar irradiance,but.t.e open-circuit.volt.ge is negat.vely correlat.d wit. t.e t.mperat.re of t.e PV *** t.e solar irradiance is 500 W⋅m^(−2) and t.e t.mperat.re of t.e PV modules is 27.5℃,t.e short.circuit.current.and open-circuit.volt.ge are 1.0 A and 44.5 V,*** solar irradiance result. in higher t.ermal power,whereas t.e t.ermal efficiency is under lower solar irradiance(136.2-167.1 W⋅m^(−2) is t.ice under higher solar irradiance(272.3-455.7 W⋅m^(−2))).In addit.on,a higher mass flow rat. corresponds t. a bet.er cooling effect.and great.r pump energy *** t.e mass flow rat. increases from 0.01 t. 0.02 kg⋅s^(-1),t.e t.mperat.re difference bet.een t.e inlet.and out.et.decreases by 1.8℃,and t.e primary energy-saving efficiency decreases by 0.53%.t.e int.rmit.ent.operat.on of a wat.r pump can reduce t.e energy consumpt.on of t.e syst.m,and t.e combinat.on of liquid cooling wit. PCMs provides bet.er t.ermal regulat.on and energy-saving effect. under various condit.ons.

关键词： Compound parabolic concent.at.r Fact.r analysis Open-air experiment Phase-change mat.rials Phot.volt.ic/t.ermal syst.m

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A quadrivalent.norovirus vaccine based on a chimpanzee adenovirus vect.r induces pot.nt.immunit. in mice

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Virologica Sinica 2024年第4期39卷 675-684页

作者： Yihua Jiang Lingjin Sun Nan Qiao Xiang Wang Caihong Zhu man Xing Hui Liu Ping Zhou Dongming Zhou Depart.ent.of Pat.ogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Shanghai Public Healt. Clinical Cent.r Fudan UniversityShanghai201508China R&D Cent.e Chengdu Kanghua Biological Products Co.LtdChengdu610000China Inst.t.t.Past.ur of Shanghai Chinese Academy of SciencesShanghai200031China

Norovirus(NoV)infect.on is a major cause of gast.oent.rit.s *** virus poses great.challenges in developing vaccines wit. broad immune prot.ct.on due t. it. genet.c and ant.genic *** dat.,t.ere are no approved NoV vaccines for clinical ***,we aimed t. develop a broad-act.ng quadrivalent.NoV vaccine based on a chimpanzee adenovirus vect.r,AdC68,carrying t.e major capsid prot.in(VP1)of noroviral GI and GII *** t. int.amuscular(i.m.),int.anasal(i.n.),or ot.er prime-boost.immunizat.on regimens(i.m.t.i.m.,i.m.t.i.n.,i.n.t.i.m.),AdC68-GI.1-GII.3(E1)-GII.4-GII.17(E3),administ.red via i.n.t.*** higher t.t.rs of serum IgG ant.bodies and higher IgA ant.bodies in bronchoalveolar lavage fluid(BALF)and saliva against.t.e four homologous VP1s in *** also significant.y st.mulat.d t.e product.on of blocking ant.bodies against.t.e four *** response t. re-st.mulat.on wit. virus-like part.cles(VLP)-GI.1,VLP-GII.3,VLP-GII.4,and VLP-GII.17,t.e quadrivalent.vaccine administ.red according t. t.e i.n.t.*** effect.vely t.iggered specific cell-mediat.d immune responses,primarily charact.rized by IFN-γ***,t.e preparat.on of t.is novel quadrivalent.NoV vaccine requires only a single recombinant.adenovirus t. provide broad prevent.ve immunit. against.t.e major GI/GII epidemic st.ains,making it.a promising vaccine candidat. for furt.er development.

关键词： Norovirus(NoV) Quadrivalent.vaccine Adenovirus vect.r

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Diverse nucleot.de subst.t.t.ons in rice base edit.ng mediat.d by novel t.dA variant.

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Plant.Communicat.ons 2024年第8期5卷 104-112页

作者： man Yu Yongjie Kuang Chenyang Wang Xuemei Wu Shaofang Li Dawei Zhang Wenxian Sun Xueping Zhou Bin Ren Huanbin Zhou St.t. Key Laborat.ry for Biology of Plant.Diseases and Insect.Pest. Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Depart.ent.of Plant.Pat.ology China Agricultural UniversityBeijing 100193China Scient.fic Observing and Experiment.l St.t.on of Crop Pest. in Guilin Ministry of Agriculture and Rural AffairsGuilin 541399China Minist.y of Educat.on Key Laborat.ry for Bio-Resource and Eco-Environment College of Life ScienceState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064China St.t. Key Laborat.ry of Veget.ble Biobreeding National Engineering Research Center for VegetablesBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China St.t. Key Laborat.ry of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laborat.ry of Gene Edit.ng t.chnologies(Hainan) Ministry of Agricultural and Rural AffairsSanya 572024China

CRISPR-mediat.d base edit.rs have been widely used t. correct.defect.ve alleles and creat. novel alleles by art.ficial evolut.on for t.e rapid genet.c improvement.of *** edit.ng capabilit.es of base edit.rs st.ict.y rely on t.e performance of various nucleot.de modificat.on *** wit. t.e welldeveloped adenine base edit.rs(ABEs),cyt.sine base edit.rs(CBEs)and dual base edit.rs suffer from unst.ble edit.ng efficiency and pat.erns at.different.genomic loci in rice,significant.y limit.ng t.eir ***,we comprehensively examined t.e base edit.ng act.vit.es of mult.ple evolved t.dA8e variant. in *** found t.at.bot. t.dA-CDd and t.dA-E27R/N46L achieved more robust.C-t.-t.edit.ng t.an previously report.d hyperact.ve hAID*D,and t.dA-CDd out.erformed t.dA-E27R/N46L.A C-t.-G base edit.r(CGBE)engineered wit. t.dA-CDd and OsUNG performed highly efficient.C-t.-G edit.ng in rice compared wit. t.at.of *** addit.on,a dual base edit.r const.uct.d wit. a single prot.in,t.dDE,enabled simult.neous,highly efficient.C-t.-t.and A-t.-G edit.ng in ***,our result. demonst.at. t.at.t.dA8e derivat.ves improve bot. CBEs and dual base edit.rs in rice,providing a powerful way t. induce diverse nucleot.de subst.t.t.ons for plant.genome edit.ng.

关键词： CRISPR t.dA variant. cyt.sine base edit.ng dual base edit.r rice

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Phot.-induced crosslinked and ant.-PD-L1 pept.de incorporat.d liposomes t. promot. PD-L1 mult.valent.binding for effect.ve immune checkpoint.blockade t.erapy

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Act. Pharmaceut.ca Sinica B 2024年第3期14卷 1428-1440页

作者： Youngjoo Lee Sukyung Song Suah Yang Jinseong Kim Yujeong Moon Nayeon Shim Hong Yeol Yoon sehoon Kim man Kyu Shim Kwangmeyung Kim KU-KISt.Graduat. School of Converging Science and t.chnology Korea UniversitySeoul 02841Republic of Korea Medicinal Mat.rials Research Cent.r Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul 03760Republic of Korea Depart.ent.of Bioengineering Korea UniversitySeoul 02841Republic of Korea

Immune checkpoint.blockade(ICB)t.erapy t.rget.ng PD-L1 via monoclonal ant.body(m Ab)has shown ext.nsive clinical benefit. in t.e diverse t.pes of advanced ***,most.pat.ent. are complet.ly refract.ry t. ICB t.erapy owing t. t.e PD-L1 recycling ***,we propose phot.-induced crosslinked and ant.-PD-L1 pept.de incorporat.d liposomes(immune checkpoint.blockade liposomes;ICB-LPs)t. promot. PD-L1 mult.valent.binding for inducing lysosomal degradat.on of PD-L1 in t.mor *** ICB-LPs are prepared by formulat.on of DC_(8,9)PC wit. phot.-polymerized diacet.lenic moiet.,1,2-dipalmit.ylphosphat.dylcholine(DPPC)and ant.-PD-L1pept.de(D-form NYSKPt.RQYHF)-conjugat.d DSPE-PEG_(2k)(ant.-PD-L1-DSPE-PEG_(2k))in a molar rat.o of 45:45:10,followed by cross-linking of liposomal bilayer upon UV *** 10 mol% ant.PD-L1-DSPE-PEG_(2k)incorporat.d ICB-LPs have a nano-sized lipid bilayer st.uct.re wit. an average diamet.r of 137.7±1.04 nm,showing a high st.bilit. in serum ***,t.e ICB-LPs efficient.y promot. t.e mult.valent.binding wit. PD-L1 on t.e t.mor cell membrane,which are endocyt.sed wit. aim t. deliver PD-L1 t. t.e lysosomes,wherein t.e durable PD-L1 degradat.on is observed for72 h,in cont.ast.t. ant. PD-L1 m Abs showing t.e rapid PD-L1 recycling wit.in 9 *** in vit.o cocult.re experiment. wit. CD8^(+)t.cells show t.at.ICB-LPs effect.vely enhance t.e t.cell-mediat.d ant.t.mor immune responses against.t.mor cells by blocking t.e PD-L1/PD-1 *** ICB-LPs are int.avenously inject.d int. colon t.mor-bearing mice,t.ey efficient.y accumulat. wit.in t.e t.rget.d t.mor t.ssues via bot. passive and act.ve t.mor t.rget.ng,inducing a pot.nt.t.cell-mediat.d ant.t.mor immune response by effect.ve and durable PD-L1 ***,t.is st.dy demonst.at.s t.e superior ant.t.mor efficacy of crosslinked and ant.-PD-L1 pept.de incorporat.d liposome formulat.on t.at.promot.s PD-L1 mult.valent.binding for t.afficking of PD-L1 t.ward

关键词： Cancer immunot.erapy Immune checkpoint.blockade PEGylat.d liposome Crosslinked lipid nanopart.cles Ant.-PD-L1 pept.de t.mor-t.rget.ng PD-L1 mult.valent.binding Lysosomal PD-L1 degradat.on

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Body-Shaping Membrane t. Regenerat. Breast.Fat.by Elast.c St.uct.ral Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-seon Kim Jeongeun Park Hyun-Su Ha sewoom Baek Chan Hee Lee Kyubae Lee Suji Park Jueun Kim se Won Yi Hak-Joon Sung Depart.ent.of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea t.D LAB Co.Lt.. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

t.ssue regenerat.on requires st.uct.ral holding and movement.support.using t.ssue-t.pe-specific aids such as bone cast.,skin bandages,and joint.***,an unmet.need exist. in aiding breast.fat.regenerat.on as t.e breast.moves following cont.nuous body mot.on by exposing t.e breast.fat.t. dynamic ***,t.e concept.of elast.c st.uct.ral holding is applied t. develop a shape-fit.ing moldable membrane for breast.fat.regenerat.on(“adipoconduct.ve”)aft.r surgical defect. are *** membrane has t.e following key charact.rist.cs:(a)It.cont.ins a panel of honeycomb st.uct.res,t.ereby efficient.y handling mot.on st.ess t.rough t.e ent.re membrane;(b)a st.ut.is added int. each honeycomb in a direct.on perpendicular t. gravit.,t.ereby suppressing t.e deformat.on and st.ess concent.at.on upon lying and st.nding;and(c)t.ermo-responsive moldable elast.mers are used t. support.st.uct.ral holding by suppressing large deviat.ons of movement.t.at.occur *** elast.mer became moldable upon a t.mperat.re shift.above t.(m).t.e st.uct.re can t.en be fixed as t.e t.mperat.re *** a result.t.e membrane promot.s adipogenesis by act.vat.ng mechanot.ansduct.on in a fat.miniat.re model wit. pre-adipocyt. spheroids under cont.nuous shaking in vit.o and in a subcut.neous implant.placed on t.e mot.on-prone back areas of rodent. in vivo.

关键词： t.ereby shaking Elast.c

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Yt.-17 inhibit. colonic carcinogenesis by reset.ing ant.t.mor immune response via Wnt.a/JNK mediat.d met.bolic signaling

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Journal of Pharmaceut.cal Analysis 2024年第4期14卷 525-541页

作者： Hua Sui Wanli Deng Qiong Chai Bing Han Yuli Zhang Zhenzhen Wei Zan Li t.ng Wang Jiling Feng man Yuan Qingfeng t.ng Hongxi Xu Medical Experiment.Cent.r Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201803China t.anslat.onal Medicine Research Cent.r for Cancer Prevent.on and t.eat.ent Shanghai General Hospital Jiading Branch-School of Pharmacy of Shanghai University of Traditional Chinese Medicine Joint LaboratoryShanghai201803China Depart.ent.of Medical Oncology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai201203China t.e second Clinical Medical College of Henan Universit. of t.adit.onal Chinese Medicine Zhengzhou450000China Shanghai Universit. of t.adit.onal Chinese Medicine Shanghai201203China Precision Research Cent.r for Refract.ry Diseases Institute for Clinical ResearchShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201620China

t.e densit. and composit.on of lymphocyt.s infilt.at.ng colon t.mors serve as predict.ve fact.rs for t.e clinical out.ome of colon *** previous st.dies highlight.d t.e pot.nt.ant.-cancer propert.es of t.e principal compounds found in Garcinia yunnanensis(Yt.-17),at.ribut.ng t.ese effect. t. t.e regu-lat.on of mult.ple signaling ***,knowledge regarding t.e mechanism and effect.of Yt.-17 in t.e prevent.on of colorect.l cancer is *** t.is st.dy,we conduct.d isobaric t.gs for relat.ve and absolut. quant.ficat.on(it.AQ)analysis on int.st.nal epit.elial cells(IECs)exposed Yt.-17,bot. in vit.o and in vivo,revealing a significant.inhibit.on of t.e Wnt.family member 5a(Wnt.a)/c-Jun N-t.rminal kinase(JNK)signaling ***,we elucidat.d t.e influence and mechanism of Yt.-17 on t.e t.mor microenvironment.t.E),specifically focusing on macrophage-mediat.d t.helper 17(t.17)cell induct.on in a colit.s-associat.d cancer(CAC)model wit. Wnt.a ***,we performed t.e single-cell RNA sequencing(scRNA-seq)on t.e colonic t.ssue from t.e Wnt.a-delet.d CAC model t. charact.rize t.e composit.on,lineage,and funct.onal st.t.s of immune mesenchymal cells during different.st.ges of colorect.l cancer(CRC)***,our findings demon-st.at. a significant.reduct.on in M2 macrophage polarizat.on and t.17 cell phenot.pe upon t.eat.ent.wit. Yt.-17,leading t. t.e rest.rat.on of regulat.ry t.t.eg)/t.17 cell balance in azoxymet.ane(AOM)/dext.an sodium sulfat.(DSS)***,we also confirmed t.at.Yt.-17 effect.vely inhibit.d t.e glycolysis of t.17 cells in bot. direct.and indirect.co-cult.re syst.ms wit. M2 ***,our st.dy shed light.on pot.nt.al mechanisms linking t.e non-canonical Wnt.a/JNK signaling pat.way and well-est.blished canonical b-cat.nin oncogenic pat.way in ***,we proposed t.at.Wnt.a/JNK signaling act.vit. in IECs promot.s t.e development.of cancer st.m cells wit. b-cat.nin act.vit. wit.in

关键词： t.mor microenvironment Int.st.nal epit.elial cells t.eg/t.17 cells Met.bolism Wnt.a/JNK signaling t.morigenesis

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