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Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： william Chung Kevin Wong Noel Ravindranayagam Lauren Tang Josephine Grace Darren Wong Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(HCC).HCC-recurrence following LT is associated with reduced *** is increasing interest in chemoprophylaxis to improve HCC-related outcomes *** To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against HCC,and patient outcomes following *** This was a retrospective study of adult patients who received Deceased Donor LT for HCC from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy for≥29 days,within 24 months post-LT.A cox proportional-hazards model with time-dependent covariates was used for survival *** measures were the composite-endpoint of HCC-recurrence and all-cause mortality,HCC-recurrence and HCC-related *** analysis was performed to account for immortality time bias and statin *** Three hundred and five patients were included in this study,with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis C,73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed HCC-recurrence,48(15.74%)died,17(5.57%)from HCC-related ***,aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of HCC-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%CI:0.58-2.30;HR:1.21,95%CI:0.28-5.27;HR:0.61,95%CI:0.27-1.36],HCC-recurrence(HR:0.52,95%CI:0.20-1.35;HR:0.51,95%CI:0.14-1.93;HR 1.00,95%CI:0.37-2.72),or HCC-related mortality(HR:0.32,95%CI:0.033-3.09;HR:0.71,95%CI:0.14-3.73;HR:1.57,95%CI:0.61-4.04)*** dosing was not associated with statist-ically significant differences in HCC-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-Co-A reductase Aspirin Metformin Mammalian target of rapamycin

A comprehensive simulation-based assessment of office building performance adaptability to teleworking scenarios in different Canadian climate zones

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Building Simulation 2022年第6期15卷 995-1014页

作者： Farzam Kharvari Sara Azimi william O’Brien Department of Civil and Environmental Engineering Carleton University1125 Colonel by DriveOttawaOntarioK1S 5B6Canada

Recent studies have shown that office building systems do not adapt well to partial occupancy(e.g.,from teleworking)and thus perform *** a result,this study aims to assess office building performance adaptability by investigating the impact of four different technologies,including occupancy-based lighting,smart plugs(occupancy-based plug load),demand-controlled ventilation(DCV),occupancy-based thermostat,and their cumulative effect in office buildings in six different Canadian climates.A three-story office building is simulated in EnergyPlus version 9.3.0 under five occupancy scenarios,including 0%occupancy,100%occupancy,50%uniformly distributed occupancy across the floor,50%consolidated occupancy scenario where occupants work in core zones,and 50%consolidated occupancy scenario where occupants work in perimeter *** results are compared using energy use intensity(EUI),energy use intensity per occupant(EUP),and the corresponding greenhouse gas(GHG)emissions.A total of 180 simulations demonstrate the occupancy-adaptive technologies are generally most beneficial for low occupancy scenarios and milder *** results also show the cumulative impact of all these technologies on the potential energy savings is significant in the climates under ***,the results show office buildings can improve their performance adaptability during partial occupancy by implementing the studied *** from filling in the current knowledge gap in the literature on partial occupancy,the for the first time results of this study systemically demonstrate how each technology performs under different partial occupancy scenarios and how they perform together at each climate.

关键词： partial occupancy thermostat setpoint smart plug demand-controlled ventilation(DCV) lighting

Symphyseal Disjunction after Dystocic Vaginal Delivery: About Two Cases at the SourôSanou University Hospital of Bobo-Dioulasso (CHUSS)

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 1-6页

作者： Millogo Jean De La Croix Sanou Jean de Dieu Gadigbé Akofa Méré Godé Sabi Tokobou william Ouédraogo André Togbé Eric Serge Alihonou Yaméogo Rélwendé Barnabé Dembélé Adama Somé Der Adolphe Ouattara Souleymane Obstetrics-Gynecology and Reproductive Medecine Departement of Sourô Sanou Teaching Hospital Bobo-Dioulasso Burkina Faso Higher Institute of health Sciences (INSSA) Université nazi Boni Bobo-Dioulasso Burkina Faso

Diastasis of the symphysis pubis is a rare postpartum complication. We report two cases of symphysis diastasis after dystocic delivery, in two patients who presented in the postpartum period with functional impotence, pubalgia and acute urine retention. A frontal radiograph of the pelvis confirmed the diagnosis, showing a symphyseal separation of 12 mm and 18 mm. In our case, management was mainly medical, with a favorable clinical outcome.

关键词： Pelvis Symphyseal Disjunction/Diastasis Post-Partum Burkina Faso

Forty years of HIV research inspires the development of SARS-CoV-2 therapy

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Journal of Molecular Cell Biology 2023年第10期15卷 1-4页

作者： Roberto Patarca william A.Haseltine ACCESS Health International RidgefieldCT 06877USA

Almost four decades ago,the characterization of the human immunodeficiency virus type 1(HIV-1)genome with the participation of the Haseltine laboratory at Harvard Medical School(Ratner et al.,1985)ushered in the antiretroviral era and established the framework for the genomic-and later multiple omics-based development of targeted antiviral *** with pandemic HIV-1 taught us that multitargeted combination antiviral therapy is needed to control pathogens that rapidly adapt to selective pressures from the immune system,vaccines,and therapeutic monoclonal antibodies.

关键词： drugs targeted

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厦航故事是中国故事的缩影

厦门航空 2024年第7期 80-81页

作者：阿夏潘维廉(图) 不详厦门大学管理学院

在厦大校园,几乎没有人不认识潘维廉,所以不识路也没关系,会有许多热心人帮忙指路。但要去到潘维廉家,并不太容易,要走过一段长坡,再登上两段高高的台阶,才能抵达。掩映在一片浓绿中的房子不大,小小的客厅像个收藏室,柜子里是各色石头... 详细信息

在厦大校园,几乎没有人不认识潘维廉,所以不识路也没关系,会有许多热心人帮忙指路。但要去到潘维廉家,并不太容易,要走过一段长坡,再登上两段高高的台阶,才能抵达。掩映在一片浓绿中的房子不大,小小的客厅像个收藏室,柜子里是各色石头、绝版书,桌上摆着福船、漆线雕和其它工艺品,一把写着“讲好中国故事”的白色折扇,引人注目。

关键词：讲好中国故事漆线雕绝版书工艺品

Differential Privacy via a Truncated and Normalized Laplace Mechanism

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Journal of Computer Science & Technology 2022年第2期37卷 369-388页

作者： william Croft Jorg-Rudiger Sack Wei Shi School of Computer Science Carleton UniversityOttawa K1S 5B6Canada School of Information Technology Carleton UniversityOttawa K1S 5B6Canada

When querying databases containing sensitive information,the privacy of individuals stored in the database has to be *** guarantees are provided by differentially private mechanisms which add controlled noise to the query ***,most such mechanisms do not take into consideration the valid range of the query being ***,noisy responses that fall outside of this range may potentially be *** rectify this and therefore improve the utility of the mechanism,the commonly-used Laplace distribution can be truncated to the valid range of the query and then ***,such a data-dependent operation of normalization leaks additional information about the true query response,thereby violating the differential privacy ***,we propose a new method which preserves the differential privacy guarantee through a careful determination of an appropriate scaling parameter for the Laplace *** adapt the privacy guarantee in the context of the Laplace distribution to account for data-dependent normalization factors and study this guarantee for different classes of range constraint *** provide derivations of the optimal scaling parameter(i.e.,the minimal value that preserves differential privacy)for each class or provide an approximation *** a result of this work,one can use the Laplace distribution to answer queries in a range-adherent and differentially private *** demonstrate the benefits of our proposed method of normalization,we present an experimental comparison against other range-adherent *** show that our proposed approach is able to provide improved utility over the alternative mechanisms.

关键词： differential privacy Laplace mechanism query range constraint

Sharing Results with Clinical Trial Participants： Insights from an Online Survey of Chinese Consumers

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Chinese Medical Journal 2016年第8期129卷 1007-1008页

作者： Janelle R keys Julie A Monk Karen L Woolley ProScribe-Envision Pharma Group Sydney NSW 2113 Australia Faculty of Science Health Education and Engineering University of the Sunshine Coast Maroochydore DC Queensland Australia Faculty of Health and Behavioural Sciences University of Queensland Brisbane Queensland Australia

To the Editor：Clinical trial participants have a right to know the results from the trials that they enable. European and North American research,however,shows that trial results are rarely shared with participants. Given the increase in industry-sponsored trials in China,we conducted the first investigation into Chinese consumer views about sharing the clinical trial results with participants.

关键词： Sharing Results Clinical Trial Participants Chinese Consumers

Linking uplift and mineralisation at the Mount Novit Zn-Pb-Ag Deposit,Northern Australia:Evidence from geology,U-Pb geochronology and sphalerite geochemistry

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Geoscience Frontiers 2022年第2期13卷 333-350页

作者： Bradley Cave william Perkins Richard Lilly Department of Earth Sciences University of AdelaideAdelaideSAAustralia Geological Survey of Queensland BrisbaneQLDAustralia

The subeconomic Mount Novit Zn-Pb-Ag deposit is located approximately 20 km south of Mount Isa,*** contrast to the nearby Mount Isa,Hilton and George Fisher Zn-Pb-Ag deposits,mineralisation at Mount Novit is situated to the west of the regional-scale Mount Isa Fault and is hosted in the Moondarra Siltstone as opposed to the Urquhart ***-grade(10 wt.%Zn+Pb)mineralisation occurs as a matrix supported breccia dominated by sphalerite and pyrrhotite with galena,pyrite,and ***-situ U-Pb geochronology was completed on apatite and two textural varieties of ***-grained(10 ppm),possibly reflecting the leaching of the metals from an underlying basement *** GGIMFis geothermometer(Frenzel et al.,2016)produced a mean formation temperature of 345±52℃.The timing and temperature of Zn-Pb-Ag mineralisation is consistent with the age and cooling temperature of apatite presented in this *** on these correlations,we

关键词： Mount Isa Mount Novit Zn-Pb-Ag mineralisation Monazite Apatite Geochronology

Analytical and Observational Investigation of Colors Effects on Drag Reduction in Penguins

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Journal of Bionic Engineering 2022年第4期19卷 1036-1053页

作者： Grace Tenorio Anna Zagrai william Allen Mostafa Hassanalian Department of Mechanical Engineering New Mexico TechSocorroNM87801USA Cottonwood Valley Charter School SocorroNM87801USA Depertment of Biosciences Swansea UniversitySwanseaSA28PPUK

All 18 extant species of penguin are strongly countershaded,having dark dorsal and light ventral *** this paper,the thermal effects of this body color in penguins are investigated through analytical and observational ***,a thermal analysis that takes into account the environmental characteristics of penguins’habitats,fluxes,and morphology is used to analytically calculate penguin dorsal surface ***,a turbulent analytical solution for a heated boundary layer over a flat plate is applied to show that the dark color on the top of the penguins’bodies is very effective at skin drag *** verify this result,a 2D model penguin is computationally analyzed at different temperatures,confirming in principle underwater skin drag reduction through color-based surface warming with efficiency savings of up to 30%.Finally,to study how color-based increases in body surface temperatures are maintained through foraging dives,thermal cameras are used to measure the surface temperature of captive penguins before and after *** study shows conceptually that dark dorsal coloration in penguins could have a significant influence on in-water drag.

关键词： Animal coloration Drag Energy balance Irradiation Penguin Thermal imaging Skin friction