检索结果-南通市图书馆

Combinatorial therapies for spinal cord injury repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Revealing and exploiting hierarchical material structure through complex atomic networks

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2017年第1期3卷 163-170页

作者： Sebastian E.Ahnert william P.Grant Chris j.Pickard Theory of Condensed Matter Group Cavendish LaboratoryUniversity of CambridgeJJ Thomson AvenueCambridge CB30HEUK Sainsbury Laboratory University of CambridgeBateman StreetCambridge CB21LRUK Department of Materials Science&Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB30FSUK Advanced Institute for Materials Research Tohoku University 2-1-1 KatahiraAobaSendai 980-8577Japan

One of the great challenges of modern science is to faithfully model,and understand,matter at a wide range of *** with atoms,the vastness of the space of possible configurations poses a formidable challenge to any simulation of complex atomic and molecular *** introduce a computational method to reduce the complexity of atomic configuration space by systematically recognising hierarchical levels of atomic structure,and identifying the individual *** a list of atomic coordinates,a network is generated based on the distances between the *** the technique of modularity optimisation,the network is decomposed into *** procedure can be performed at different resolution levels,leading to a decomposition of the system at different scales,from which hierarchical structure can be *** considering the amount of information required to represent a given modular decomposition we can furthermore find the most succinct descriptions of a given atomic *** straightforward,automatic and general approach is applied to complex crystal *** show that modular decomposition of these structures considerably simplifies configuration space,which in turn can be used in discovery of novel crystal structures,and opens up a pathway towards accelerated molecular dynamics of complex atomic *** power of this approach is demonstrated by the identification of a possible allotrope of boron containing 56 atoms in the primitive unit cell,which we uncover using an accelerated structure search,based on a modular decomposition of a known dense phase of boron,γ-B_(28).

关键词： structure atomic complex

Expansion properties for finite subdivision rules I Dedicated to the Memories of william P. Thurston and Lei Tan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2018年第12期61卷 2237-2266页

作者： william j.Floyd Walter R.Parry Kevin M.Pilgrim Department of Mathematics Virginia Tech Department of Mathematics and Statistics Eastern Michigan University Department of Mathematics Indiana University

Among Thurston maps (orientation-preserving, postcritically finite branched coverings of the 2-sphere to itself), those that arise as subdivision maps of a finite subdivision rule form a special family. For such maps, we investigate relationships between various notions of expansion—combinatorial, dynamical, algebraic,and coarse-geometric.

关键词： finite subdivision rule expanding map postcritically finite Thurston map

A new species of sisorid catfish of the genus Exostoma from the Salween drainage, Yunnan, China

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2017年第5期38卷 291-299页

作者： Xiao-Yong Chen william j. Poly David Catania Wan-Sheng jiang Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences Yezin Nay Pyi Taw 05282 Myanmar Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China Department of lchthyology California Academy of Sciences 55 Music Concourse Drive San Francisco CA 94118 USA

A new species of the sisorid catfish genus Exostoma Blyth, 1860 was collected from two hill-stream tributaries of the Nujiang （Salween River） drainage in Gaoligong Mountain, south-western Yunnan Province, China from 2003 to 2006 and from two tributaries of the Salween River in Cangyuan County Lingcang Prefecture, Yunnan Province, China （in 2007） and in Yongde County, Lingcang Prefecture, Yunnan Province, China （in 2015）. Exostoma gaoligongense sp. nov. is the 10th species of the genus and is most similar to E. vinciguerrae in morphology but can be distinguished by pelvic fin reaching anus vs. not reaching; maxillary barbels just reaching or slightly surpassing pectoral-fin origin vs. surpassing pectoral-fin origin or even reaching posterior end of gill membrane; abdominal vertebrae 23-25 vs. 25-27; length of dorsal fin/dorsal to adipose distance 90.3%-287.0% vs. 59.2-85.7. A key to Exostoma spp. is provided.

关键词： Glyptosterninae Sisoridae Nujiang Gaoligong Mountain Yunnan

Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

在线全文

学校读者我要写书评

暂无评论

Nano Research 2014年第1期7卷 1-62页

作者： Mark j. Armstrong Colm O'Dwyer william j. Macklin justin. D. Holmes Materials Chemistry & Analysis Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Applied Nanoscience Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin 2 Ireland Nexeon Limited Abingdon Oxfordshire UK.

The performance of the lithium-ion cell is heavily dependent on the ability of the host electrodes to accommodate and release Li＋ ions from the local structure. While the choice of electrode materials may define parameters such as cell potential and capacity, the process of intercalation may be physically limited by the rate of solid-state Li＋ diffusion. Increased diffusion rates in lithium-ion electrodes may be achieved through a reduction in the diffusion path, accomplished by a scaling of the respective electrode dimensions. In addition, some electrodes may undergo large volume changes associated with charging and discharging, the strain of which, may be better accommodated through nanostructuring. Failure of the host to accommodate such volume changes may lead to pulverisation of the local structure and a rapid loss of capacity. In this review article, we seek to highlight a number of significant gains in the development of nanostructured lithium-ion battery architectures （both anode and cathode）, as drivers of potential next-generation electrochemical energy storage devices.

关键词： lithium ion batteries nanostructuring anodes cathodes

Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity:their action in Alzheimer's disease prevention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第12期18卷 2675-2676页

作者： Rayudu Gopalakrishna Andrew Oh Narayan R.Bhat william j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neuroscience Medical University of South CarolinaCharlestonSCUSA

Recently,we have found that various intracellular cyclic adenosine monophosphate(cAMP)-e leva ting agents,both pharmacological(dibutyryl-cAMP,forskolin,and rolipram)and physiological(pituitary adenylate cyclase-activa... 详细信息

关键词： action prevention Cyclic

Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 91-92页

作者： Rayudu Gopalakrishna Charlotte Lin Mark S.Kindy william j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Pharmaceutical Sciences College of PharmacyUniversity of South FloridaTampaFLUSA

Currently,there are no clinically proven drugs for recovery from stroke and other neuronal injuries such as traumatic brain injury and spinal cord *** therapy requires axonal regeneration,which is inhibited by diverse axonal growth inhibitors,such as Nogo-A,myelin-associated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp),and chondroitin sulfate proteoglycans(CSPGs)(Chaudhry and Filbin,2007;Carmichael,2010;Schwab and Strittmatter,2014).

关键词： axonal injuries inhibited

在线全文

学校读者我要写书评

暂无评论

解析西格蒙德·弗洛伊德《梦的解析》

Comparative efficacy of gypsy moth(Lepidoptera:Erebidae)entomopathogens on transgenic blight-tolerant and wild-type American,Chinese,and hybrid chestnuts(Fagales:Fagaceae)

作者： william j. jenkins

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Insect Science 2020年第5期27卷 1067-1078页

作者： Aaron j.Brown Andrew E.Newhouse william A.Powell Dylan Parry Department of Environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[Marsh.]Borkh.)was once the dominant hardwood species in Eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(Murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is development of blight-tolerant trees using genetic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars were fed leaf disks excised from two transgenic events,Darling 54 and Darling 58,and four control American chestnut *** disks were previously treated with an LDso dose of either the speces-specific Lymantria dispar multiple nucleopolyhedrovirus(LdMNPV)or the generalist pathogen Bacillus thuringiensis ***(Btk).Mortality was quantified and compared to water blank *** genotype had a strong efect on the efficacies of both *** mortality from Btk-treated foliage from only one transgenic event,Darling 54,differed from its isogenic progenitor,Ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by genetic *** suggest that although genetic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon diMterent genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transgene presence.

关键词： Bacillus thuringiensis LdMNPV nontarget restoration tri-trophic unin-tended effects