检索结果-南通市图书馆

Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis

World Journal of Gastroenterology 2017年第11期23卷 2023-2028页

作者： Animesh Jain Evan J Lipson william h sharfman Steven R Brant Mark G Lazarev Division of Gastroenterology and hepatology Department of Internal MedicineUniversity of North Carolina Chapel Hill Department of Oncology Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center Division of Gastroenterology and hepatology Department of Internal MedicineJohns Hopkins University School of Medicine

AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line *** We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were *** A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were *** In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course.

关键词： Ipilimumab Melanoma Enterocolitis Colitis Infliximab Corticosteroid Colonic ulcer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

引用

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neuroinflammation as a therapeutic target in huntington's disease

引用

Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glial response in the midcingulate cortex in huntington’s disease

引用

Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Essence of progress in geriatric cardiology

引用

Journal of Geriatric Cardiology 2012年第1期9卷 3-4页

作者： william h Wehrmacher Suite 716 55 E. Washington Chicago 60602 USA

1 Introduction Prior to 1970,the slow,steady and substantial development of medical knowledge over centuries for improved well being and survival from birth was not matched by the elderly *** 1970,however,the elderly have also shared in these developments,exhibiting substantial improvement in survival among people over 60 years of *** is also been since 1970 that geriatric cardiology has experienced dynamic *** is indicated by the US vital statistics,Table 1.

关键词： Acute myocardial infarction Comorbidity Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

引用

Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural Killer Cells:Biology and Clinical Use in Cancer Therapy

引用

Cellular & Molecular Immunology 2004年第1期1卷 12-21页

作者： william h.D.hallett william J.Murphy Department of Microbiology and Immunology University of Nevada School of Medicine.University of Nevada.Reno.Reno.NV.USA.

Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote engraftment,as well as the ability to elicit potent anti-tumor *** the clinical results for these processes are still *** understanding of NK cell biology,from activating and inhibitory receptor functions to the role of NK cells in allogeneic transplantation,needs to be appreciated in order to draw out the clinical potential of NK *** of bone marrow cell (BMC) rejection are known to be dependant on inhibitory receptors specific for major histocompatibility complex (MhC) molecules and on activating receptors that have many potential *** modulation of activating and inhibitory receptors may hold the key to clinical success involving NK ***-clinical studies in mice have shown that different combinations of activating and inhibitory receptors on NK cells can reduce graft-versus-host disease (GVhD),promote engraftment,and provide superior graft-versus-tumor (GVT) *** clinical data have shown that the use of KIR-ligand incompatibility produces tremendous graft-versus-leukemia effect in patients with acute myeloid leukemia at high risk of *** review will attempt to be a synthesis of current knowledge concerning NK cells,their involvement in BMT,and their use as an immunotherapy for cancer and other hematologic *** & Molecular Immunology.2004;1(1):12-21.

关键词： NK cell BMT GVhD GVT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于敏感性分析的h_2/O_2反应机理最优简化

引用

中国电机工程学报 2006年第4期26卷 16-20页

作者：乔瑜徐明厚 william h.Green 华中科技大学煤燃烧国家重点实验室湖北省武汉市430074 麻省理工学院化学工程系

已有的反应流计算方法通常采用简单的化学反应机理。由于火焰中不同区域的化学特性变化较大,有时简单反应机理不能精确描述燃烧过程的化学特性;而计算包含详细反应机理的复杂反应流问题仍然是十分费时的。最优简化法可根据设定的化学精... 详细信息

已有的反应流计算方法通常采用简单的化学反应机理。由于火焰中不同区域的化学特性变化较大,有时简单反应机理不能精确描述燃烧过程的化学特性;而计算包含详细反应机理的复杂反应流问题仍然是十分费时的。最优简化法可根据设定的化学精度要求实现详细反应机理的最优简化。通过对包含20个可逆基元反应的h2/O2燃烧机理的简化结果与原机理计算结果的比较,取得了良好的效果。同时,结合敏感性分析法深入揭示了氢、氧燃烧的化学过程。

关键词：最优简化法机理简化敏感性分析氢气燃烧

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distal-less homeobox genes of insects and spiders： genomic organization, function, regulation and evolution

引用

Insect Science 2016年第3期23卷 335-352页

作者： Bin Chen william h. Piel Antonia Monteiro Institute of Entomology and Molecular Biology College of Life Sciences Chongqing Normal University Chongqing 401331 P.R. China Yale-NUS College Singapore Department of Biological Sciences National University of Singapore Singapore

The Distal-less （DlI） genes are homeodomain transcription factors that are present in most Metazoa and in representatives of all investigated arthropod groups. In Drosophila, the best studied insect, Dll plays an essential role in forming the proximodistal axis of the legs, antennae and analia, and in specifying antennal identity. The initiation of Dll expression in clusters of cells in mid-lateral regions of the Drosophila embryo represents the earliest genetic marker of limbs. Dll genes are involved in the development of the peripheral nervous system and sensitive organs, and they also function as master regulators of black pigmentation in some insect lineages. here we analyze the complete genomes of six insects, the nematode Caenorhabditis elegans and homo sapiens, as well as multiple Dll sequences available in databases in order to examine the structure and protein features of these genes. We also review the function, expression, regulation and evolution of arthropod Dll genes with emphasis on insects and spiders.

关键词： Distal-less evolution function genomic organization regulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Convection–Diffusion Model for the Prediction of Anthropogenically-Initiated Wildfire Ignition

引用

International Journal of Disaster Risk Science 2014年第4期5卷 274-295页

作者： Ravi Sadasivuni Shanti Bhushan william h.Cooke Department of Geosciences Mississippi State UniversityStarkvilleMS 39759USA Center for Advance Vehicular Systems Mississippi State UniversityStarkvilleMS 39759USA

A spatial interaction model to predict anthropogenically-initiated accidental and incendiary wildfire ignition probability is developed using fluid flow analogies for human movement patterns. Urban areas with large populations are identified as the sites of global influencing factors, and are modeled as the gravity term. The transportation corridors are identified as local influencing factors, and are modeled using fluid flow analogy as diffusion and convection terms. The model is implemented in ArcGIS, and applied for the prediction of wildfire hazard distribution in southeastern Mississippi. The model shows87 % correlation with historic data in the winter season,whereas the previously developed gravity model shows only 75 % correlation. The normalized error for convection–diffusion model predictions is about 5 % in the winter season, whereas the gravity model shows an error of 7 %.The proposed model is robust as it couples a multi-criteria behavioral pattern within a single dynamic equation to enhance predictive capability. At the same time, the proposed model is more costly than the gravity model as it requires evaluation of distance from intermodal transportation corridors, transportation corridor density, and traffic volume maps. Nonetheless, the model is developed in a modular fashion, such that either global or local terms can be neglected if required.

关键词： Anthropogenic-fire Convection–diffusion model Fire ignition potential Mississippi Wildfire hazard

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：