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Epithelial ovarian cancer:An overview

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World Journal of Translational Medicine 2014年第1期3卷 1-8页

作者： Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh william grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao Department of Internal Medicine University of Buffalo Erie County Medical Center Buffalo NY 14215 United States Department of OB/GYN Cancer Biology ProgramMorehouse School of Medicine Georgia Cancer Center for ExcellenceGrady Health SystemAtlantaGA 30303United States Department of Internal Medicine Morehouse School of Medicine Grady Health System Atlanta GA 30303 United States Department of Surgery Morehouse School of Medicine Grady Health System Atlanta GA 30303 United States NCI Cancer Program Northside Hospital Atlanta GA 30342 United States University of Alabama at Birmingham Comprehensive Cancer Center Birmingham AL 35294 United States

Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions.

关键词： Epithelial ovarian cancer Breast cancer type 1 Chemotherapy

卵巢储备减少妇女增值或凋亡相关标记物的卵巢表达

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维普期刊数据库

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 43-44页

作者： Vital-Reyes V. Rodrguez-Burford C. Chhieng D.C. W.E. grizzle 张旸 Department of Pathology University of Alabama at Birmingham Birmingham AL United States Dr.

Objective: To determine DNA fragmentation and several molecules associated with apoptosis or proliferation in ovaries of patients with diminished ovarian reserve. Design: Cross-sectional analysis. Setting: Tertiary institutional hospital. Patient(s): Patients with benign uterine pathology who had undergone a hysterectomy and oophorectomy were categorized by the citrate clomiphene challenge test in diminished ovarian reserve or control group. Intervention(s): None. Main Outcome Measure(s): Apoptosis was determined using TUNEL (terminal deoxynucleotidyl transferase biotin-dUTP nick end- labeling) assay and p53, p27, Bax, caspase- 3, caspase- 8, caspase- 9, Fas- L, Bcl- 2, GATA- 4, Ki- 67, proliferating- cell nuclear antigen (PCNA), estrogen receptor, P receptor, and androgen receptor expression by immunohistochemistry. Result( s): Fifteen patients were studied. DNA fragmentation and expression of Bax, caspase-3, caspase-8, caspase-9, Fas-L, Bcl- 2, GATA- 4, Ki- 67, and PCNA were observed in the whole ovary in both groups. In the control group, the expression of caspase- 3 and caspase-8 in the ovarian stroma was significantly higher. Conclusion(s): DNA fragmentation and the expression of several molecules that participate in ovarian proliferation or apoptosis are present in cycling ovaries, but these markers were not significantly different in patients with diminished ovarian reserve. Thus, the mechanism leading to diminished ovarian reserve does not involve an easily detectable dysregulation in apoptosis or proliferation of ovarian follicles.

关键词：卵巢储备末端标记雄激素受体 caspase 子宫切除术克罗米芬脱氧核糖核苷雌激素受体免疫

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光影·梦境

现代装饰 2018年第7期 84-91页

作者： Erik Bele Hoglund Slamp Tuomas Markunpoika Parachilna Partisans Louis Lim Makingworks & 3form we+ Hokuto Ando & Toshiya Hayashi Judith Rozas Cabanas Yuji Okitsu Filippo Mambretti Daisuke Kitagawa Graypants Seth grizzle & Jon Junker Andrea Trimarchi Simone Farresin Formafantasma 彭佳 Dechem Studio Zaha Hadid Design

一梦忽觉夏日长。倏忽间,夏天似乎已经停留了好久好久。燥热的天气、黏人的衬衫、提不起的食欲,所有这些都与冗长的夏季有关。但所幸还有些可喜的地方：例如小店里刚买的绿豆糖水、道路两旁悦耳的蝉鸣,以及微风轻拂的凉爽夏夜。也许正... 详细信息

一梦忽觉夏日长。倏忽间,夏天似乎已经停留了好久好久。燥热的天气、黏人的衬衫、提不起的食欲,所有这些都与冗长的夏季有关。但所幸还有些可喜的地方：例如小店里刚买的绿豆糖水、道路两旁悦耳的蝉鸣,以及微风轻拂的凉爽夏夜。也许正因为白日里的夏天过于＂毒辣＂,所以它的夜晚才显得那么温柔可爱。

关键词：梦境光影夏天

用MR扩散加权成像评价新型凋亡诱导的抗DR-5抗体对异种移植乳腺肿瘤的早期治疗效果

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国际医学放射学杂志 2008年第A6期31卷 486-486页

作者： H.Kim D.E.Morgan W.E.grizzle J.M.Warram C.R.Stockard 冯洁玲 Department of Radiology University of Alabama at Birmingham1530 3rd Ave SBDB 11BirminghamAL 35294USA.

目的应用MR扩散加权成像评价小鼠乳腺癌模型中应用新型凋亡诱导抗体TRA-8进行治疗的早期治疗反应。方法该动物实验已获得动物实验伦理委员会批准。

关键词：扩散加权成像 DR-5 凋亡诱导异种移植小鼠乳腺癌伦理委员会动物实验早期治疗效果表观扩散