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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Preliminary study on the influence of in situ filter size in CFd-dEM transfer kernel

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Particuology 2020年第4期18卷 205-209页

作者： william d.Fullmer Jordan Musser National Energy Technology Laboratory MorgantownWV26507USA Leidos Research Support Team MorgantownWV26507USA

An unknown in coupled Eulerian-Lagrangian models for particle flow,such as CFd-dEM,which has received fairly little attention in the literature to date is the size of the filter width in the transfer *** work provides a preliminary glimpse at how this parameter can influence the solution in cold-flow,unbounded *** to previously published direct numerical simulation data is used to suggest an appropriate range for this parameter.

关键词： CFd-dEM High-resolution Lagrangian-Eulerian kernel

Natural Killer Cells:Biology and Clinical Use in Cancer Therapy

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Cellular & Molecular Immunology 2004年第1期1卷 12-21页

作者： william H.d.Hallett william J.Murphy department of Microbiology and Immunology University of Nevada School of Medicine.University of Nevada.Reno.Reno.NV.USA.

Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote engraftment,as well as the ability to elicit potent anti-tumor *** the clinical results for these processes are still *** understanding of NK cell biology,from activating and inhibitory receptor functions to the role of NK cells in allogeneic transplantation,needs to be appreciated in order to draw out the clinical potential of NK *** of bone marrow cell (BMC) rejection are known to be dependant on inhibitory receptors specific for major histocompatibility complex (MHC) molecules and on activating receptors that have many potential *** modulation of activating and inhibitory receptors may hold the key to clinical success involving NK ***-clinical studies in mice have shown that different combinations of activating and inhibitory receptors on NK cells can reduce graft-versus-host disease (GVHd),promote engraftment,and provide superior graft-versus-tumor (GVT) *** clinical data have shown that the use of KIR-ligand incompatibility produces tremendous graft-versus-leukemia effect in patients with acute myeloid leukemia at high risk of *** review will attempt to be a synthesis of current knowledge concerning NK cells,their involvement in BMT,and their use as an immunotherapy for cancer and other hematologic *** & Molecular Immunology.2004;1(1):12-21.

关键词： NK cell BMT GVHd GVT

Molecular markers in prostate cancer. Part Ⅰ： predicting lethality

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Asian Journal of Andrology 2009年第1期11卷 14-21页

作者： Sachin Agrawal william d. dunsmuir department of Urology St. Peters Hospital Chertsey UK. agrawalsachin@***

Assessing the lethality of ‘early,’ potentially organ-confined prostate cancer （PCa） is one of the central controversies in modem-day urological clinical practice. Such cases are often considered for radical ‘curative’ treatment, although active surveillance may be equally appropriate for many men. Moreover, the balance between judicious intervention and overtreatment can be difficult to judge. The patient＇s age, comorbidities, family history and philosophy of self-health care can be weighed against clinical features such as the palpability of disease, the number and percentage of biopsy cores involved with the disease, histological grade, presenting prostate-specific antigen （PSA） and possible previous PSA kinetics. For many years, scientists and physicians have sought additional molecular factors that may be predictive for disease stage, progression and lethality. Usually, claims for a ‘new’ unique marker fall short of true clinical value. More often than not, such molecular markers are useful only in multivariate models. This review summarizes relevant molecular markers and models reported up to and including 2008.

关键词： genetics neoplasm metastasis prostate cancer

Composite Integers n for Which φ(n)|n-1

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Acta Mathematica Sinica,English Series 2007年第10期23卷 1915-1918页

作者： william d.BANKS Florian LUCA department of Mathematics University of MissouriColumbiaMO 65211USA Instituto de Matemáticas Universidad Nacional Autdnoma de MéxicoC.P.58089 MoreliaMichoacánMéxico

In this note, we show that the number of composite integers n ≤ x such that φ（n）｜n - 1 is at most O（x^1/2（loglog x）^1/2）, thus improving earlier results by Pomerance and by Shan.

关键词： Euler function Lehmer conjecture

Fundamentals of materials science and engineering an integrated approach william d. Callister, Jr. 2nd ed.

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Colorectal cancer surveillance in inflammatory bowel disease:Practice guidelines and recent developments

2005年

作者： william d. Callister Jr.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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World Journal of Gastroenterology 2019年第30期25卷 4148-4157页

作者： william T Clarke Joseph d Feuerstein department of Medicine and division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School

Patients with long-standing inflammatory bowel disease(IBd)involving at least 1/3 of the colon are at increased risk for colorectal cancer(CRC).Advancements in CRC screening and surveillance and improved treatment of IBd has reduced CRC incidence in patients with ulcerative colitis and Crohn’s *** cases of CRC are thought to arise from dysplasia,and recent evidence suggests that the majority of dysplastic lesions in patients with IBd are visible,in part thanks to advancements in high definition colonoscopy and *** practice guidelines have supported the use of chromoendoscopy with targeted biopsies of visible lesions rather than traditional random *** are encouraged to endoscopically resect visible dysplasia and only recommend surgery when a complete resection is not *** technologies such as virtual chromoendoscopy are emerging as potential tools in CRC *** with IBd at increased risk for developing CRC should undergo surveillance colonoscopy using new approaches and techniques.

关键词： Inflammatory bowel disease Colorectal cancer screening Ulcerative colitis Crohn’s disease Colonoscopy Chromoendoscopy

Time dependent differences in gray matter volume post mild traumatic brain injury

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Neural Regeneration Research 2016年第6期11卷 920-921页

作者： Prabhjyot Singh william d.S.Killgore department of Psychiatry University of Arizona

When the brain is subjected to excessive physical forces,including blunt impact,high-speed rotation,or blast overpressure waves,its tissue structure and function can be compromised,leading to traumatic brain injury（... 详细信息

关键词： traumatic rotation cortical fusiform blast cortex distraction blunt gyrus medial