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A solution scan of societal options to reduce transmission and spread of respiratory viruses:SARS-CoV-2 as a case study

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Journal of Biosafety and Biosecurity 2021年第2期3卷 84-90页

作者： william J.Sutherland Nigel G.Taylor David C.Aldridge Philip Martin Catherine Rhodes Gorm Shackelford Simon Beard haydn Belfield Andrew J.Bladon Cameron Brick Alec P.Christie Andrew P.Dobson harriet Downey Amelia S.C.hood Fangyuan hua Alice C.hughes Rebecca M.Jarvis Douglas MacFarlane william h.morgan Anne-ChristineMupepele Stefan J.Marciniak Cassidy Nelson SeánÓhÉigeartaigh Clarissa Rios Rojas Katherine A.Sainsbury Rebecca K.Smith Lalitha S.Sundaram Ann Thornton John Watkins Thomas B.White Kate Willott Silviu O.Petrovan BioRISC(Biosecurity Research Initiative at St Catharine’s) St Catharine’s CollegeCambridge CB21RLUK Department of Zoology University of CambridgeThe David Attenborough BuildingPembroke StreetCambridge CB23QZUK Tour du Valat Research Institute for the Conservation of Mediterranean Wetlands13200 ArlesFrance Centre for the Study of Existential Risk University of CambridgeCB21SBUK Department of Social Psychology University of AmsterdamNieuwe Achtergracht 129 B1018 WT AmsterdamNetherlands Department of Ecology and Evolutionary Biology 117 Eno HallPrinceton UniversityNJ 08544USA Institute of Ecology College of Urban and Environmental SciencesPeking UniversityBeijing 100871PR China Centre for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbannaYunnan 666303PR China Te Kura Putaiao-School of Science Auckland University of TechnologyAucklandNew Zealand School of Psychological Sciences University of Western AustraliaPerth35 Stirling HwyCrawley WA 6009Australia Nature Conservation and Landscape Ecology Biometry and Environmental System AnalysisUniversity of FreiburgGermany Cambridge Institute for Medical Research University of CambridgeCambridge Biomedical CampusThe Keith Peters BuildingHills RoadCambridge CB20XYUK Future of humanity Institute University of OxfordOxford OX11PTUK Faculty of Kinesiology Sportand RecreationUniversity of Alberta2-130V Van Vliet 21 Complex(University Hall)EdmontonAlberta T6G 2H9Canada Division of Population Medicine School of MedicineCardiff UniversityCardiff CF144YSUK

Societal biosecurity–measures built into everyday society to minimize risks from pests and diseases–is an important aspect of managing epidemics and *** aimed to identify societal options for reducing the transmission and spread of respiratory *** used SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)as a case study to meet the immediate need to manage the COVID-19 pandemic and eventually transition to more normal societal conditions,and to catalog options for managing similar pandemics in the *** used a‘solution scanning’*** read the literature;consulted psychology,public health,medical,and solution scanning experts;crowd-sourced options using social media;and collated comments on a ***,we present a list of 519 possible measures to reduce SARS-CoV-2 transmission and *** provide a long list of options for policymakers and businesses to consider when designing biosecurity plans to combat SARS-CoV-2 and similar pathogens in the *** also developed an online application to help with this *** encourage testing of actions,documentation of outcomes,revisions to the current list,and the addition of further options.

关键词： Biosecurity Coronavirus COVID-19 Disease control New normal Public health

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Two sample applications of a classical isoperimetric problem of the calculus of variations to fluid mechanical problems in fluidization and spouting

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Particuology 2010年第6期8卷 503-506页

作者： howard Littman Morris h.morgan Ⅲ Department of Chemical and Biological Engineering Rensselaer Polytechnic InstituteTroyNY 12180-3590USA Department of Chemical Engineering Hampton UniversityHamptonVA 23668USA

This paper is devoted to outlining precisely the basic mathematics of a classical isoperimetric problem of the calculus of variations and showing how significant fluid mechanical problems in fluidization and spouting ... 详细信息

关键词： Calculus of variations lsoperimetric problems Fluidization Spouting

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Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen hao Jun Liu Jing Liu Xin Du Louise morgan Gregg C.Fonarow Sidney C.Smith Jr Gregory Y.h.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;Pharge,the prescription rate of OAC was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all Phowed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95%confidence interval[CI]10.04-13.47;Phythmic drug use(adjusted OR 1.45,95%CI 1.38-1.53;Phospitals participated in the CCC-AF project,>70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

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Luminescence of Er^(3+) in Oxyfluoride Transparent Glass-Ceramics

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Journal of Rare Earths 2006年第6期24卷 699-705页

作者： Akira Ueda Steven h.morgan Richard Mu Department of Physics Fisk University NashvilleTN 37208 USA

Erbium doped silicate, germanate, and tellurium-germanate oxyfluoride glasses were prepared in a bulk form. Through appropriate heat treatment of the as-prepared glasses, transparent glass-ceramics （TGCs） were obtained with the formation of β-PbF2：Er^3＋ nanocrystals in the glass matrix were confirmed by X-ray ***-defined diffraction peaks were observed in the samples after heat-treatment. The average crystal diameter of these precipitated crystals from full-width at half-maximum （FWhM） of the diffraction peak was estimated to be between 8 and 13 nm. Optical absorption, photoluminescence, and upconversion luminescence were measured on as-prepared glass and glass-ceramics. Luminescence spectra in the TGC samples revealed well-resolved, sharp stark-splitting peaks, which indicates that a majority of Er^3＋ ions has been incorporated into the crystalline phase of the nanocrystals. The intensity of the visible and near infrared luminescence mostly increases in TSG compared to that in the as-prepared glass. In 1.53 μm absorption and emission bands, the maximum absorption peak is blue-shifted from 1531 to 1507 nm, whereas the maximum emission peak is redshifted from 1535 to 1543 nm in TGC, as compared with that in glass. The bandwidth at half-maximum （BWhM） of the emission band is significantly broader in TGC than in glass, which is beneficial to the erbium-doped fiber amplifier （EDFA）. Upconversion luminescence was measured using 800 nm near-infrared light excitation. Drastically increased upconversion 1 was observed from the TGC as compared to that from their corresponding as-prepared glasses. In addition to a strong green emission centered at 545 nm because of ^4S3/2→^4I15/2 transition and a weaker red emission centered at 662 nm because of ^4F9/2→^4I15/2 transition, generally seen from the Er^3＋ doped glasses, two violet emissions centered at 410 nm because of ^2h9/2→^4I15/2 transition and centered at 379 nm because of ^4G11/2→^4I15/2 transition were also o

关键词： luminescence transparent glass-ceramics rare earths

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Dietary soluble non-starch polysaccharide level and xylanase supplementation influence performance,egg quality and nutrient utilization in laying hens fed wheat-based diets

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Animal Nutrition 2021年第2期7卷 512-520页

作者： Xa h.Nguyen hong T.Nguyen Natalie K.morgan University of New England School of Environmental and Rural ScienceArmidaleNew South Wales2351Australia

The aim of this study was to evaluate the effects of dietary soluble non-starch polysaccharide(sNSP)content and xylanase supplementation on production performance,egg quality parameters,and nutrient di-gestibility in hy-line Brown layers from 25 to 32 wk of age.A total of 144 hy-line Brown laying hens(25 wk of age)were randomly allocated to 1 of 4 wheat-based dietary treatments in a 2×2 factorial experimental design,with 36 replicates of individual hens per *** diets were formulated to contain either a high or low sNSP level(at 13.3 or 10.8 g/kg)and were supplemented with either 0 or 12,000 BXU/kg exogenous *** were fed these treatment diets for an 8-wk period,and hen production perfor-mance,including daily egg production,average egg weight,daily egg mass,feed conversion ratio and pro-portion of dirty and abnormal eggs were measured at bird age 25 to 28 wk and 29 to 32 *** interaction between sNSP content of the diet and xylanase supplementation was observed on daily egg production from 25 to 28 wk of age(P-0.018);birds fed the high sNSP diet without xylanase had lower egg production than those fed any other *** interaction between the 2 dietary factors was also observed on hen weight gain at 29 to 32 wk of age(P=0.014),with birds fed the low sNSP diet with 12,000 BXU/kg xylanase presenting greater weight gain compared to those fed the high sNSP diet with 12,000 BXU/kg *** intake at 29 to 32 wk of age was reduced by xylanase supplementation(P=0.047).Xylanase supplemen-tation also increased yolk colour score at both 28 and 32 wk of age,and decreased yolk weight at 32 wk of age(P-0.014,0.037 and 0.013,respectively).Birds fed the low sNSP diet presented lower protein digestibility(P-0.024)than those fed the high sNSP ***,birds fed high sNSP presented higher shell reflectivity at both 28 and 32 wk of age(P-0.05 and 0.036,respectively).The influence of duration of feeding the treatment diets on egg quality was also

关键词： Soluble NSP Xylanase Laying hen Production performance Egg quality

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Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS‑C post‑COVID-19 infection

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World Journal of Pediatrics 2023年第6期19卷 595-604页

作者： Said Bichali Mathilde Bonnet Marie‑Emilie Lampin Jean‑Benoit Baudelet heloise Reumaux Olivia Domanski Thameur Rakza Alexandre Delarue morgan Recher Jerome Soquet Francois Dubos Stephane Leteurtre Ali houeijeh Francois Godart Pediatric Cardiology Univ.LilleCHU Lille2 Avenue Oscar Lambret59000 LilleFrance Pediatric Intensive Care Univ.LilleCHU Lille59000 LilleFrance ULR 2694‑Metrics:Evaluation des Technologies de Sante et des Pratiques Medicales Univ.Lille59000 LilleFrance Pediatric Rhumatology Univ.LilleCHU Lille59000 LilleFrance Cardiac Surgery Univ.LilleCHU Lille59000 LilleFrance Pediatric Emergency Univ.LilleCHU Lille59000 LilleFrance

Background In multisystem inflammatory syndrome in children(MIS-C),diagnostic delay could be associated with *** study aims to measure the time to diagnosis in MIS-C,assess its impact on the occurrence of cardiogenic shock,and specify its *** A single-center prospective cohort observational study was conducted between May 2020 and July 2022 at a tertiary care *** meeting the World health Organization MIS-C criteria were included.A long time to diagnosis was defined as six days or *** on time to diagnosis were collected by two independent *** primary outcome was the occurrence of cardiogenic *** regression and receiver operating characteristic curve analysis were used for outcomes,and a Cox proportional hazards model was used for *** Totally 60 children were assessed for inclusion,and 31 were finally analyzed[52%males,median age 8.8(5.7-10.7)years].The median time to diagnosis was 5.3(4.2-6.2)*** univariable analysis,age above the median,time to diagnosis,high C-reactive protein,and high N-terminal pro-B-type natriuretic peptide(NT-proBNP)were associated with cardiogenic shock[odds ratio(OR)6.13(1.02-36.9),2.79(1.15-6.74),2.08(1.05-4.12),and 1.70(1.04-2.78),respectively].In multivariable analysis,time to diagnosis≥6 days was associated with cardiogenic shock[adjusted OR(aOR)21.2(1.98-227)].Time to diagnosis≥6 days had a sensitivity of 89% and a specificity of 77% in predicting cardiogenic shock;the addition of age>8 years and NT-proBNP at diagnosis≥11,254 ng/L increased the specificity to 91%.Independent determinants of short time to diagnosis were agehR 0.34(0.13-0.88)],short distance to tertiary care hospital[ahR 0.27(0.08-0.92)],and the late period of the COVID-19 pandemic[ahR 2.48(1.05-5.85)].Conclusions Time to diagnosis≥6 days was independently associated with cardiogenic shock in *** diagnosis and treatment are crucial to avoid the use of inotropes and

关键词： COVID-19 Delay in diagnosis heart failure MIS-C SARS-CoV-2

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Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao huang Li Yin Zain husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric william Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi huang Nicholas hoyt Mengxue Zhang John A.hossack morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

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Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy

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Cancer Communications 2023年第6期43卷 706-710页

作者： Jinping Liu Lan Cheng hilana El-Mekkoussi Charles-Antoine Assenmacher Michelle Y.Y.Lee Danielle R.Jaffe Kaisha Garvin-Darby Ashleigh.morgan Elisabetta Manduchi Jonathan Schug Klaus h.Kaestner Department of Genetics and Center for Molecular Studies in Digestive and Liver Disease University of PennsylvaniaPhiladelphiaPAUSA Institute for Diabetes Obesity and MetabolismPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPAUSA Department of Pathobiology School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Dear Editor Combinatorial immunotherapy has provided patients with advanced hepatocellular carcinoma(hCC)the potential for long-term ***,sustained responses are seen only in a minority of patients[1].Thus,there is an unmet need for precision modeling to understand the different responses and uncover predictive biomarkers for treatment stratification.

关键词： immunotherapy hepatocellular sustained

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Triassic to Cenozoic multi-stage intra-plate deformation focused near the Bogd Fault system,Gobi Altai,Mongolia

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Geoscience Frontiers 2015年第5期6卷 723-740页

作者： Douwe J.J.van hinsbergen Dickson Cunningham Gijsbert B.Straathof morgan Ganerod Bart W.h.hendriks Arjan h.Dijkstra Department of Earth Sciences Utrecht University Department of Environmental Earth Science.Eastern Connecticut State University SGS horizon B.V. Stationsplein 6.2270 JB VoorburgThe Netherlands Geological Survey of Norway.Center of Geodynamics Statoil ASA.Rotvoll Norway School of Geography.Earth and Environmental Sciences.Plymouth University

The Gobi Altai region of southern Mongolia has been in the Eurasian plate interior since the midMesozoic,yet has experienced episodic phases of deformation since that *** this paper,we document field evidence to characterize and date the intra-plate tectonic history of the Gobi Altai region from the Triassic to the *** this end,we provide detailed mapping of the structure and stratigraphy of the eastern flanks of *** Bogd that contains the widest variety of rock-time units in the *** carry out geochronological analysis of basaltic lavas and basement granite in the *** demonstrate that a crystalline basement with a 502 ± 8 Ma granitoid（U/Pb） underwent two phases of basin formation in the *** we date with new40Ar/39Ar lava ages of 218.5 ± 1.5,123.2 ± 0.7 and 124.8 ± 1.2 Ma,*** phases are linked to deposition of fluvio-lacustrine sediments and trap-like basaltic volcanics,with cumulative thicknesses of 1000-1500 *** basins were likely north-facing half-grabens that developed underN-S extension,but were subsequently overthrusted by Paleozoic and older crystalline basement during a less well constrained,but likely mid-Cretaceous phase of N-S shortening and basin *** results are consistent with recent seismic imaging of rift basins100 km to the NE of the study area where a similar history was *** multiple phases of intra-plate deformation appear to have parallel structural trends,most likely due to reactivated Paleozoic basement structures created during the original terrane amalgamation of the Central Asian Orogenic Belt continental *** strong basement heterogeneity may predispose it to reactivation,and make it sensitive to changes in the overall stress field of the Eurasian plate driven by forces at its margins and *** study of Mongolia’s multi-stage tectonic history may thus provide a key proxy for the long-term dynamics of the Eurasian *** addition,the repeated reactivation

关键词： Ar/Ar geochronology Intra-plate deformation U/Pb geochronology Compression Extension

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Optical DE/MUX Components for Datacomunication Applications

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光学学报 2003年第S1期23卷 617-618页

作者： Ian h White Richard V Penty Kevin A williams Chris N morgan Cambridge University Engineering Department Trumpington Street Cambridge CB2 1PZ UKCambridge University Engineering Department Trumpington Street Cambridge CB2 1PZ UKCambridge University Engineering Department Trumpington Street Cambridge CB2 1PZ UKCambridge University Engineering Department Trumpington Street Cambridge CB2 1PZ UK

This paper reviews the potential for WDM systems to be implemented within datacommunication systems, and indicates future network functions. Spectral and temporal multiplexing functions are reviewed, with particular f... 详细信息

关键词： for be in Optical DE/MUX Components for Datacomunication Applications WDM

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