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Reproductive and Developmental Medicine 2024年第1期8卷 39-49页

作者： suranga P.Kodithuwakku Ernest H.Y.Ng William s.b.yeung Kai-Fai Lee Department of Obstetrics and Gynaecology LKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-shenzhen Hospital Shenzhen 518053China

Human fallopian tubes(FTs)play important roles in the whole reproductive *** are the site for the final maturation of gametes,fertilization,transport of preimplantation embryos,and early embryonic development before entering the *** these functions are critical in the establishment of a successful *** the embryo is in transit through the FT,the FT microenvironment changes through endocrine,paracrine,autocrine,and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring ***,the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of *** review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal ***,we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization(IVF)treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

The novel male meiosis recombination regulator coordinates the progression of meiosis prophase Ⅰ

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Journal of Genetics and Genomics 2020年第8期47卷 449-464页

作者： Miao Li Haiwei Feng Zexiong Lin Jiahuan Zheng Dongteng Liu Rui Guo Junshi Li Raymond H.W.Li Ernest H.Y.Ng Michael s.Y.Huen P.Jeremy Wang William s.b.yeung Kui Liu shenzhen Key Laboratory of Fertility Regulation Center of Assisted Reproduction and EmbryologyThe University of Hong Kong-Shenzhen HospitalShenzhen518000China Department of Obstetrics and Gynecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China Department of biomedical sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPA19104USA school of biomedical sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China

Meiosis is a specialized cell division for producing haploid gametes in sexually reproducing *** this study,we have independently identified a novel meiosis protein male meiosis recombination regulator(MAMERR)/4930432 K21 Rik and showed that it is indispensable for meiosis prophase I progression in male *** super-resolution structured illumination microscopy,we found that MAMERR functions at the same double-strand breaks as the replication protein A and meiosis-specific with Ob domains/spermatogenesis associated 22 *** generated a Mamerr-deficient mouse model by deleting exons 3 e6 and found that most of Mamerrà/àspermatocytes were arrested at pachynema and failed to progress to diplonema,although they exhibited almost intact synapsis and progression to the pachytene stage along with XY body *** mechanistic studies revealed that the recruitment of DMC1/RAD51 and heat shock factor 2 ebinding protein in Mamerrà/àspermatocytes was only mildly impaired with a partial reduction in double-strand break repair,whereas a substantial reduction in ubiquitination on the autosomal axes and on the XY body appeared as a major phenotype in Mamerrà/à*** propose that MAMERR may participate in meiotic prophase I progression by regulating the ubiquitination of key meiotic proteins on autosomes and XY chromosomes,and in the absence of MAMERR,the repressed ubiquitination of key meiotic proteins leads to pachytene arrest and cell death.

关键词： Meiosis 4930432K21Rik Recombination Ubiquitination

stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang sudini R.Fernando suranga P.Kodithuwakku Dandan Cao William s.b.yeung Kai-Fai Lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell RNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation Recurrent pregnancy loss Repeated implantation failure

background-free three-dimensional selective imaging of anisotropic plasmonic nanoparticles

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Nano Research 2017年第4期10卷 1423-1433页

作者： Xiaodong Cheng Xuan Cao bin Xiong Yan He Edward s. yeung state Key Laboratory of Chemo/biosensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology Hunan University Changsha 410082 China Department of Chemistry Tsinghua University Beijing 100084 China school of Medical Lab science and Life science Wenzhou Medical University Wenzhou 325035 China

There is an increasing demand for advanced optical imaging techniques that can detect and resolve nanosize objects at a spatial resolution below the optical diffraction limit, especially in three-dimensional （3D） cellular environments. In this study, using a polarization-activated localization scheme based on the orientation-dependent properties of anisotropic plasmonic metal nanoparticles （MNPs）, ＂photoswitchable＂ imaging of single gold nanorods （AuNRs） was accomplished not only in two dimensions but also in three dimensions. Moreover, the Rayleigh scattering background arising from the congested subcellular structures was efficiently suppressed. Thus, we obtained the 3D distributions of both the position and the orientation of the AuNRs inside the cells and investigated their intemalization kinetics. To our knowledge, this is the first demonstration of the confocal-like 3D imaging of non-fluorescence nanoparticles with a high resolution and almost zero background. This technique is easy to implement and should greatly facilitate MNP studies and applications in biomedicine and biology.

关键词： anisotropic nanopartide localized surface plasmon resonance (LsPR) scattering imaging polarization microscopy orientation-dependent localization microscopy three-dimensional (3D) imaging

Let-7 in endometrial exosome/microvesicles induces a pluripotent paused state in mice

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Let-7 in endometrial exosome/microvesicles induces a pluripo...

Effect of stimulated IVF cycles on global endometrial gene expression and receptivity

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Weimin Liu Ziru Niu Ranran Chen Ronald TK Pang Philip C.N.Chiu William s.b.yeung shenZhen institute University of HongKong Department of OG University of HongKong

Embryo dormancy(embryo diapause) is a reproductive strategy used by approximately 100 different mammals to avoid the risk of exposing their offsprings to unfavourable environmental conditions by delaying embryo *** molecular mechanism of embryonic diapause is not yet *** hypothesize that endometrial exosome/microvesicles(EV) regulates embryo *** detected miRNA profiles in EV between dormant and activated uterine fluid and found that the members of let-7 family were highly expressed in dormant uterine fluid ***,embryos have ability to take up endometrial exosomes/*** examine the roles of let-7 in embryo dormancy,we eletroporated let-7 a into embryos and found that embryos electroporated with let-7 can be alive even after the culture for up to Day 13.18.8%of embryos from let-7 g transgenic mice developed to term after culture for 6 days(ie Day 10).Microarray analysis showed that 47%gene expression were similar between let-7-treated and P4-induced dormant embryos compared to D4 or E2-activated embryos and most of genes were related to cell cycle and *** results showed that let-7 has an important role in the process of embryo dormancy in *** level of let-7 was elevated in Iin28 transgenic embryos which were transferred into wild-type delayed implantation model for 3 *** result suggests that the increased levels of let-7 in dormant embryo were mainly derived from outside *** exosomes/microvesicle of highly expressed let-7 prolonged the survival time of embryos in *** conclusion,our results demonstrated that let-7 of endometrial exosomes/microvesicles regulated embryo dormancy in mice.

关键词： exosome/microvesicle embryo diapause let-7

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Effect of stimulated IVF cycles on global endometrial gene e...

Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

第一届中华医学会生殖医学分会、中国动物学会生殖生物学分会联合年会

作者： Kai-Fai Lee Pak-Yiu Ng Ernest H.Y.Ng Pak-Chung Ho William s.b.yeung Department of Obstetrics and Gynaecology The University of Hong KongPokfulam Hong Kong CHINA

In human, the development of endometrium is regulated by steroid hormones and the endometrial lining undergoes cyclical morphological changes every 28 days. soon after fertilization, the developing embryo transverses to the fallopian tube and implants onto the endometriumn on days 19-24 of the menstrual cycle. This narrow period of time is commonly known as "receptive window".

关键词： IVF Effect of stimulated IVF cycles on global endometrial gene expression and receptivity

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： sudini R.Fernando Yang Yan Manish Kumar Hoi-Lam Lai Yin-Lau Lee Ernest H.Y.Ng William s.b.yeung Kai-Fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins steroid regulation Endometrial receptivity Receptivity marker Infertility

Polymetallaynes and Molecular Metallaynes Containing Platinum,Mercury and Gold for Optoelectronic and Magnetic Applications

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Chinese Journal of Chemistry 2023年第17期41卷 2159-2178页

作者： Chen Zhang Linli Xu Wai-yeung Wong Departmentof Applied biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong Kongchina

omprehensive summary,Polymetallaynes are a promising branch of metallopolymers,in which the introduction of metal building blocks to organic conjugated backbones leads to their unique skeletons and versatile ***,the chemical structures,geometric configurations and functional properties in these organometallic systems can be adjusted flexibly by the appropriate selection of metal centers,auxiliary ligands,or bridging *** recent years,both one-dimensional and two-dimensional polymetallaynes have attracted considerable attention owing to their excellent electronic,optical and magnetic ***,the studies on molecular metallaynes provide substantial insights for the exploration of the structure-property-activity relationships in these organometallic acetylide-containing *** recent research progress of polymeric and molecular metallaynes containing platinum,mercury and gold is discussed in this article.A series of functional properties have been realized in these acetylide-containing compounds by the rational structural design and refined synthetic strategies,leading to their emerging applications including energy conversion,nonlinear optics,data storage and memory,as well as chemo/biosensing.

关键词： Polymetallayne Molecular metallayne Metallated graphyne Platinum Mercury Gold

Atomically precise copper nanoclusters as ultrasmall molecular aggregates:Appealing compositions,structures,properties,and applications

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Aggregate 2023年第1期4卷 122-147页

作者： Leon Li-Min Zhang Wai-yeung Wong Department of Applied biology and Chemical Technology and Research Institute for smart Energy The Hong Kong Polytechnic UniversityHong KongP.R.China shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhenP.R.China

Metal nanoclusters(NCs)are ultrasmall molecular aggregates consisting of dozens to hundreds of metal atoms consolidated by organic ligands,which represent an emerging area of *** a myriad of metal NCs,copper NCs(CuNCs)comprise a low-cost,high-value subclass that has attracted great *** variable copper cores and diversity of protecting ligands have rendered CuNCs interesting molecular aggregates featuring structural and compositional versatility,hence showing distinctive properties and potential *** the present review,we have summarized the progress on atomically precise CuNCs that exhibit a range of appealing properties and applications in different *** review is expected to provide not only an overview of the current development on atomically precise CuNCs,but also possible directions for the future design of novel CuNCs for fundamental studies and practical applications.

关键词： applications atomically precise structures copper nanoclusters properties