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NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry

Genes & Diseases 2023年第3期10卷 723-726页

作者： Tianyu Han Jiapeng Lei Yang Liu Yanan Wang wenze xun Qifan Hu Qi Peng Wei Zhang Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Clinical Research Center for Respiratory Diseases NanchangJiangxi 330006China Jiangxi Hospital of China-Japan Friendship Hospital NanchangJiangxi 330052China Department of Bacteriology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Since the end of 2019,COVID-19 has caused worldwide ***-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell *** studies showed that ACE2 expressed at a low level in the main target organs such as lung and bronchial *** SARS-CoV-2 efficiently invades into the respiratory system or other organs with low levels of ACE2 is an urgent problem to be solved.

关键词： ACE2 NSP1 organs

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Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making

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Chinese Journal of Cancer Research 2023年第2期35卷 126-139页

作者： Zejiang Zhan Yingying Huang Jiayu Zhou Zhuochen Cai Haoyang Huang Ying Deng wenze Qiu xun Cao Xi Chen Chixiong Liang Lulu Zhang Xiang Guo Taize Yuan Xing Lyu Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Centerthe State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Radiation Oncology Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Critical Care Medicine Sun Yat-sen University Cancer Centerthe State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Radiation Oncology Guangzhou Concord Cancer CenterGuangzhou 510045China

objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not *** study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and ***:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)*** enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the *** developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk ***:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,***-year survivals were similar among the three groups after PSM and confirmed by *** 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other *** exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by ***:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC

关键词： Nasopharyngeal carcinoma treatment modality chemotherapy cycle survival toxicity costeffectiveness real world

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Mapping essential urban land use categories in China(EULUC-China):preliminary results for 2018

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Science Bulletin 2020年第3期65卷 182-187页

作者： Peng Gong Bin Chen Xuecao Li Han Liu Jie Wang Yuqi Bai Jingming Chen Xi Chen Lei Fang Shuailong Feng Yongjiu Feng Yali Gong Hao Gu Huabing Huang Xiaochun Huang Hongzan Jiao Yingdong Kang Guangbin Lei Ainong Li Xiaoting Li xun Li Yuechen Li Zhilin Li Zhongde Li Chong Liu Chunxia Liu Maochou Liu Shuguang Liu Wanliu Mao Changhong Miao Hao Ni Qisheng Pan Shuhua Qi Zhehao Ren Zhuoran Shan Shaoqing Shen Minjun Shi Yimeng Song Mo Su Hoi Ping Suen Bo Sun Fangdi Sun Jian Sun Lin Sun Wenyao Sun Tian Tian Xiaohua Tong Yihsing Tseng Ying Tu Hong Wang Lan Wang Xi Wan Zongming Wang Tinghai Wu Yaowen Xie Jian Yang Jun Yang Man Yuan wenze Yue Hongda Zeng Kuo Zhang Neng Zhang Tao Zhang Yu Zhang Feng Zhao Yichen Zheng Qiming Zhou Nicholas Clinton Zhiliang Zhu Bing Xu Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Tsinghua Urban Institute Tsinghua UniversityBeijing 100084China Center for Healthy Cities Institute for China Sustainable UrbanizationTsinghua UniversityBeijing 100084China Department of Land Air and Water ResourcesUniversity of CaliforniaDavisCA 95616-8627USA Department of Geological and Atmospheric Sciences Iowa State UniversityAmesIA 50011USA State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijing 100101China AI for Earth Laboratory Cross-Strait InstituteTsinghua UniversityBeijing 100084China International Institute for Earth System Sciences Nanjing UniversityNanjing 210093China Research Center for Ecology and Environment of Central Asia Chinese Academy of SciencesUrumchi 830011China Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China National Engineering Laboratory for Applied Technology in Forestry&Ecology in South China College of Life Science and TechnologyCentral South University of Forestry and TechnologyChangsha 410004China College of Surveying&Geo-Informatics Tongji UniversityShanghai 200092China Department of Urban Planning College of Architecture and Urban PlanningTongji UniversityShanghai 200092China Beijing Institute of Urban Planning Beijing 100045China Department of Urban Planning School of Urban DesignWuhan UniversityWuhan 430072China College of Earth Sciences Jilin UniversityChangchun 130061China Research Center for Digital Mountain and Remote Sensing Application Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Institute of Remote Sensing and Geographic Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Department of Urban and Regional Planning School of Geography and PlanningSun Yat-sen Univ

Land use reflects human activities on *** land use is the highest level human alteration on Earth,and it is rapidly changing due to population increase and *** areas have widespread effects on local hydrology,climate,biodiversity,and food production[1,2].However,maps,that contain knowledge on the distribution,pattern and composition of various land use types in urban areas,are limited to city *** mapping standard on data sources,methods,land use classification schemes varies from city to city,due to differences in financial input and skills of mapping *** address various national and global environmental challenges caused by urbanization,it is important to have urban land uses at the national and global scales that are derived from the same or consistent data sources with the same or compatible classification systems and mapping *** is because,only with urban land use maps produced with similar criteria,consistent environmental policies can be made,and action efforts can be compared and assessed for large scale environmental ***,despite of the fact that a number of urban-extent maps exist at global scales[3,4],more detailed urban land use maps do not exist at the same *** at big country or regional levels such as for the United States,China and European Union,consistent land use mapping efforts are rare[5,6](e.g.,https://***/open_land_use/).

关键词： EULUC-China 土地利用类型

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