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Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis

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Chinese Journal of Cancer Research 2018年第3期30卷 373-381页

作者： Ning Li Jing Jin Jing yu Shuai Li yuan Tang Hua Ren wenyang Liu Shulian Wang yueping Liu Yongwen Song Hui Fang Zihao yu Yexiong Li Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College

Objective：Prognosis of patients with locally advanced rectal cancer（LARC）but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy（CRT）has been shown to be *** study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early ***：From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a *** with LARC underwent total mesorectal excision（TME）surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a *** a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery *** propensity score matching（PSM）,comparisons of local regional control（LC）,distant metastasis-free survival（DMFS）,disease-free survival（DFS）and overall survival（OS）were performed using Kaplan-Meier analysis and log-rank test between yp I and p I ***-staging depth score（DDS）,a novel method of evaluating CRT response,was used for subset ***：Of the 449 patients,168 matched cases were generated for ***-year LC,DMFS,DFS and OS for stage p I *** I groups were 96.7%vs.96.4%（P=0.796）,92.7%vs.73.6%（P=0.025）,91.2%vs.73.6%（P=0.080）and 93.1%vs.72.3%（P=0.040）,*** the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group（P=0.384,0.368,0.277 and0.458,respectively）.Conclusions：LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic *** can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort.

关键词： Rectal neoplasms neoadjuvant chemo-radiotherapy down-staging propensity score-matched analysis

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土工离心模拟高速滑坡碎屑流冲击过程的科氏效应研究

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中国科学：技术科学 2024年第4期54卷 734-746页

作者：张贝李文阳黄雨长安大学地质工程与测绘学院西安710054 同济大学土木工程学院上海200092

土工离心模拟是土木工程、地质工程等相关领域的重要技术.但在高速滑坡碎屑流模拟方面的应用仍然受限,主要原因在于科氏效应的影响难以避免且缺乏详细研究.本文特别针对高速滑坡碎屑流冲击效应这一防灾减灾工程重要问题,开展了一系列的... 详细信息

土工离心模拟是土木工程、地质工程等相关领域的重要技术.但在高速滑坡碎屑流模拟方面的应用仍然受限,主要原因在于科氏效应的影响难以避免且缺乏详细研究.本文特别针对高速滑坡碎屑流冲击效应这一防灾减灾工程重要问题,开展了一系列的物理离心试验与数值试验.相关结果表明,科氏加速度的方向对高速滑坡碎屑流冲击过程的影响更为显著,发散科氏作用强化了滑坡碎屑流与拦挡结构的相互作用,表现在其具有更高的流动性、更强的冲击效应、更大的堆积体高度.离心应力水平对压缩科氏效应作用效果的影响更为显著,且随着离心应力水平的增大,模拟结果向着无科氏条件影响结果的方向发展.因此,高速滑坡碎屑流冲击效应的土工离心模拟建议在发散科氏条件下开展,且不必刻意选取较小的离心应力水平.

关键词：离心模拟技术高速滑坡碎屑流冲击过程科氏效应离散元模拟

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Effectiveness and safety of combined nimotuzumab and S-1 chemotherapy with concurrent radiotherapy for locally advanced esophageal cancer in malnourished and elderly patients:A prospective phaseⅡstudy

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Chinese Journal of Cancer Research 2024年第3期36卷 270-281页

作者： Guojie Feng Jiao Li Nuo yu Ziyu Zheng Xiongtao Yang Lei Deng Tao Zhang Wenqing Wang wenyang Liu Jianyang Wang Qinfu Feng Jima Lyu Zefen Xiao Zongmei Zhou Nan Bi Jianjun Qin Xin Wang Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

Objective:Definitive chemoradiotherapy(dCRT)is the standard treatment for unresectable locally advanced esophageal ***,this treatment is associated with substantial toxicity,and most malnourished or elderly patients are unable to complete this ***,there is a need for a more suitable radiotherapy combination regimen for this *** study was aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab and S-1 and concurrent radiotherapy for patients with fragile locally advanced esophageal cancer with a high Nutritional Risk Screening 2002(NRS-2002)***:Eligible patients with unresectable esophageal carcinoma who had an NRS-2002 score of 2 or higher were *** were treated with S-1 and nimotuzumab with concurrent radiotherapy,followed by surgery or definitive *** primary endpoint was the locoregional control(LRC)***:A total of 55 patients who met the study criteria were *** completion of treatment,surgery was performed in 15 patients and radiotherapy was continued in 40 *** median follow-up period was 33.3[95%confidence interval(95%CI,31.4−35.1)]*** LRC rate was 77.2%(95%CI,66.6%−89.4%)at 1 year in the entire *** overall survival(OS)rate and event-free survival(EFS)rate were 57.5%and 51.5%at 3 years,*** was associated with better LRC[hazard ratio(HR)=0.16;95%CI,0.04−0.70;P=0.015],OS(HR=0.19;95%CI,0.04−0.80;P=0.024),and EFS(HR=0.25;95%CI,0.08−0.75;P=0.013).Most adverse events were of grade 1 or 2,and no severe adverse events ***:For malnourished or elderly patients with locally advanced esophageal cancer,radiotherapy combined with nimotuzumab and S-1 is effective and has a good safety profile.

关键词： Esophageal carcinoma squamous cell carcinoma nutritional risk score nimotuzumab S-1 definitive chemoradiotherapy

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治理现代化视域下老年群体的数字社会排斥与消解

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重庆大学学报（社会科学版） 2024年第3期30卷 306-318页

作者：徐文洋俞世伟宁夏大学民族与历史学院宁夏银川750021 宁夏医科大学国际教育学院宁夏银川750004

党的二十大报告强调,“人民健康是民族昌盛和国家强盛的重要标志。把保障人民健康放在优先发展的战略位置,完善人民健康促进政策”,要“推进健康中国建设”。显然,贯彻党的二十大精神的一个重要方面是实施积极应对人口老龄化战略,推动... 详细信息

党的二十大报告强调,“人民健康是民族昌盛和国家强盛的重要标志。把保障人民健康放在优先发展的战略位置,完善人民健康促进政策”,要“推进健康中国建设”。显然,贯彻党的二十大精神的一个重要方面是实施积极应对人口老龄化战略,推动实现全体老年人享有基本养老服务。与此同时,党的二十大报告擘画数字中国发展的新蓝图,提出要加快发展数字经济,促进数字经济和实体经济深度融合。但是,由于缺乏数字素养和日常生活实践的充分表达,老年群体面临“数字鸿沟”问题,这也成为社会治理现代化转型的一道障碍,引起广泛关注。为此,文章从老年人数字社会排斥的理论指向和现实问题出发,在老年人现实生活经验与实践中分析社会排斥的根源,探讨社会治理现代化转型的可能路径与未来方向。文章以65岁以上老年人为调查对象,对宁夏银川市和石嘴山市四个社区的老年人居住家庭和所属社区开展实地调查。调查发现,以数字技术的变革为驱动的数字社会重塑了人们的价值观念,改变着人们的态度和行为模式,重建了人们的社会联结纽带。这一点,在老年群体身上体现得较为明显。在融入数字社会的过程中,由于受到“数字鸿沟”限制,该群体受到了社会排斥。推进社会治理现代化转型,需要全面理解老年人所处的社会环境,也就是全面数字化、数字平台化和智能化以及社会个体化的现实。剖析老年群体在结构性排斥的驱动下,经由主体建构与策略选择共同作用下“复合型排斥”的生成机制。基于此,应当从社会、社区与个体的多维融合视野出发,始终秉持以人民为中心的价值理念,完善数字社会和数字中国的体制机制建设,完善政府各部门间的统筹协调机制,加强社区组织化建设,激发银发活力,再造老年人的主体性来消解社会排斥,满足人民群众对美好生活的向往。

关键词：健康中国数字中国人口老龄化老年群体数字社会社会排斥治理现代化

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大数据和学习分析在高校混合学习环境中的应用机理探究

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高校教育管理 2018年第3期12卷 72-79页

作者：杨文阳于晓西安石油大学计算机学院陕西西安710065

混合学习环境在当前各个高校教学改革中得到重视并逐步推广,大数据和学习分析可用于构建混合学习环境。文章首先探讨了混合学习的概念和类型,然后以技术支持下的决策过程为主线分析了大数据分别与数据驱动决策及学习分析之间的关系,通... 详细信息

混合学习环境在当前各个高校教学改革中得到重视并逐步推广,大数据和学习分析可用于构建混合学习环境。文章首先探讨了混合学习的概念和类型,然后以技术支持下的决策过程为主线分析了大数据分别与数据驱动决策及学习分析之间的关系,通过具体案例分析大数据和学习分析在当前高校混合学习环境中的应用效果,最后审视大数据和学习分析在未来混合学习环境中应用的基本要求。高校在教学改革和教育管理中应用大数据和学习分析时,应注意数据必须准确和及时,保护学生的隐私、安全和权利,强化训练具备丰富专业技能知识的数据库管理者。

关键词：大数据数据驱动决策学习分析混合学习环境

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圆盘水漂运动特性数值模拟研究

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北京理工大学学报 2021年第7期41卷 687-695页

作者：雷娟棉解文洋于勇刘奇北京理工大学宇航学院北京100081

为研究近水面的起飞再入式运动对飞行器近海面的高机动突防能力的影响,文中基于CFD数值模拟方法,湍流模型选取SST k-ω模型,利用重叠网格技术,将N~S方程与六自由度弹道方程耦合对三维空间内薄圆盘的水漂运动进行了数值模拟,研究了不同... 详细信息

为研究近水面的起飞再入式运动对飞行器近海面的高机动突防能力的影响,文中基于CFD数值模拟方法,湍流模型选取SST k-ω模型,利用重叠网格技术,将N~S方程与六自由度弹道方程耦合对三维空间内薄圆盘的水漂运动进行了数值模拟,研究了不同工况下水漂的入水特性和运动规律.结果表明:数值模拟计算得到的圆盘从接触水面到离开水面的时间与实验值吻合较好,圆盘的运动轨迹与实验结果相吻合;圆盘在打水漂向前运动的同时由于自身的旋转产生了马格努斯效应,从而使圆盘的运动轨迹产生了一定的侧向偏移以及圆盘自身的姿态发生了侧向偏转.

关键词：流固耦合打水漂水面弹跳运动数值模拟

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Elimination of the yellow pigment gene PSY-E2 tightly linked to the Fusarium head blight resistance gene Fhb7 from Thinopyrum ponticum

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The Crop Journal 2023年第3期11卷 957-962页

作者： Xuefeng Li Dong Li yu Xuan Ziming He Lanfei Zhao Yongchao Hao wenyang Ge Shoushen Xu Bingqian Hou Biao Wang Jun Guo Wenwen Liu Mingzhu Li Yi Han Cunyao Bo Yinguang Bao Zengjun Qi Steven S.Xu Guihua Bai Hongwei Wang Lingrang Kong State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop BiologyCollege of AgronomyShandong Agricultural UniversityTai’an 271018ShandongChina State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095JiangsuChina Department of Agronomy Kansas State University2004 Throckmorton HallManhattanKS 66506USA Crop Research Institute Shandong Academy of Agricultural SciencesJinan 250100ShandongChina Cereal Crops Research Unit Red River Valley Agricultural Research CenterUSDA-ARSFargoND 58102USA USDA Hard Winter Wheat Genetics Research Unit4008 Throckmorton HallManhattanKS 66506USA

Fhb7 is a major gene that was transferred from Thinopyrum ponticum to chromosome 7D of wheat(Triticum aestivum)and confers resistance to both Fusarium head blight(FHB)and Fusarium crown rot(FCR).However,Fhb7 is tightly linked to the PSY-E2 gene,which causes yellow flour,limiting its application in *** break this linkage,marker K-PSY was developed for tagging PSY-E2 and used with Fhb7 markers to identify recombination between the two *** 21,000 BC1F2 backcross progeny(Chinese Spring ph1bph1b*2/SDAU 2028)revealed two Fhb7^(+)wheat-Tp7el_(2)L lines,Shannong 2–16and Shannong 16–1,that carry a desired truncated Fhb7^(+)translocation segment without *** two lines show levels of resistance to FHB and FCR similar to those of the original translocation line SDAU 2028,but have white *** facilitate Fhb7 use in wheat breeding,STS markers were developed and used to isolate Fhb7 on a truncated Tp7el_(2) translocation ***-isogenic lines carrying the Fhb7^(+)segment were generated in the backgrounds of three commercial cultivars,and Fhb7^(+)lines showed increased FHB and FCR resistance without yield *** breakage of the tight linkage between Fhb7 and PSY-E2 via homoeologous recombination provides genetic resources for improvement of wheat resistance to FHB and FCR and permit the large-scale deployment of Fhb7 in breeding using marker-assisted selection.

关键词： Triticum aestivum Thinopyrum ponticum Fusarium head blight Fusarium crown rot Truncated Fhb7 translocation

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Monocular Vision-Based Real-time Vehicle Detection at Container Terminals

Monocular Vision-Based Real-time Vehicle Detection at Contai...

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2018中国汽车工程学会年会

作者： LIU Zijian ZHANG Tianlei HE Bei LIU yu SUN Li TANG wenyang Beihang University

We present a practical approach to vehicle detection at container terminals based on a single camera and prevailing convolutional neural network models in computer vision *** at container terminal scenarios,we introduce a specialized data labelling strategy for network training,as well as an optimized setting of crucial hyper-parameters,leading to a significant improvement on *** solution achieves 83%precision with 90%recall for semi-trailer trunks within 30 meters ahead of the vehicle-mounted monocular camera,at a speed of 32 frames per second（FPS） on a Nvidia Titan X for 416×416 image input,also providing more alternatives of fairly easy speed/accuracy *** to traditional lidar-based vehicle detection method for autonomous driving,our solution is more robust for particular container terminal scenarios while still maintaining a real-time performance by completely eliminating the region proposal stage.

关键词： vehicle detection convolutional neural network autonomous driving container terminal

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Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy

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Chinese Journal of Cancer Research 2021年第4期33卷 447-456页

作者： Ning Li Xin Wang yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi wenyang Liu Hua Ren Hui Fang yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang yueping Liu Yongwen Song Yexiong Li Jing Jin State Key Laboratory of Molecular Oncology Department of Radiation OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of Abdominal Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized *** examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative ***:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were *** patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were *** factors related to long-term prognosis were analyzed using univariate and multivariate *** down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term ***:The median follow-up period for survivors was 30 *** area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and *** curve analysis further affirmed that DDS had the largest net *** DDS cut-off value was *** and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS.

关键词： Gastric cancer preoperative chemoradiotherapy prediction long-term outcomes

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圆形区域分散布局问题研究

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运筹学学报 2018年第3期22卷 132-138页

作者：余善恩徐文洋刘光宇杭州电子科技大学自动化学院杭州310018 杭州电子科技大学理学院杭州310018

针对圆形区域分散布局问题,文中给出了一个带约束的非线性规划模型.当布局点数量较少时,通过将模型转化为无约束优化问题,利用梯度方法进行求解;对于布局点数量较多的情况,提出了一个界为1/2的多项式时间的近似算法,并进行了相应的算例... 详细信息

针对圆形区域分散布局问题,文中给出了一个带约束的非线性规划模型.当布局点数量较少时,通过将模型转化为无约束优化问题,利用梯度方法进行求解;对于布局点数量较多的情况,提出了一个界为1/2的多项式时间的近似算法,并进行了相应的算例分析,进一步来验证算法解的合理性.研究的结论及方法一定程度上丰富和完善了圆形区域的分散布局理论.

关键词：圆形区域分散布局规划模型近似算法

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