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Tunable supramolecular hydrogels from polypeptidePEG-polypeptide triblock copolymers

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Science China Chemistry 2015年第6期58卷 1005-1012页

作者： Xiaohui fu Yong Shen Yinan Ma wenxin fu Zhibo Li Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences School of Polymer Science and Engineering Qingdao University of Science and Technology

A series of ABA triblock copolymers of poly(?-(2-methoxy ethoxy)esteryl-glutamate)-block-poly(ethylene glycol)-blockpoly(?-(2-methoxy ethoxy)esteryl-glutamate) with poly(ethylene glycol) as middle hydrophilic B block and oligo(ethylene glycol)-functionalized polyglutamate(poly-L-EG2Glu) as terminal A blocks were prepared via ring-opening polymerization of EG2 Glu N-carboxyanhydride(NCA). The resulting P(EG2Glu)-b-PEG-b-P(EG2Glu) triblocks can spontaneously form hydrogels in water. The intermolecular hydrogen bonding interactions between polypeptides blocks were responsible for the formation of gel network structure. These hydrogels displayed shear-thinning and rapid recovery properties, which endowed them potential application as injectable drug delivery system. The mechanical strength of hydrogels can be modulated by copolymer composition, molecular weight and concentrations. Also, it was found that the hydrogels' strength decreased with temperature due to dehydration of polypeptide segments. Atomic force microscopy and scanning electron microscopy images revealed that these hydrogels were formed through micelle packing mechanism. Circular dichroism and Fourier transform infrared spectroscopy characterizations suggested the poly-L-EG2 Glu block adopted mixed conformation. A preliminary assessment of drug release in vitro demonstrated the hydrogels can offer a sustained release of doxorubicin(DOX) and the release rate could be controlled by varying chemical composition.

关键词： hydrogel polypeptide N-carboxyanhydride (NCA) ring-opening polymerization (ROP) drug delivery

探究早期帕金森病Thy 1-SNCA模型小鼠运动学习障碍的时间特征

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首都医科大学学报 2024年第5期45卷 881-890页

作者：付文欣王铁杨汝宁曲明芹高歌杨慧贾军首都医科大学基础医学院生理学与病理生理学学系北京100069 首都医科大学基础医学院神经生物学学系北京100069

目的本实验通过建立早期帕金森病(Parkinson s disease,PD)小鼠模型,以探究PD模型出现运动学习障碍的时间特征。方法选用6月龄Thy 1-SNC A转基因(transgenic,TG)小鼠作为早期PD模型,与同龄野生型(wild type,WT)小鼠进行对比分析。通过... 详细信息

目的本实验通过建立早期帕金森病(Parkinson s disease,PD)小鼠模型,以探究PD模型出现运动学习障碍的时间特征。方法选用6月龄Thy 1-SNC A转基因(transgenic,TG)小鼠作为早期PD模型,与同龄野生型(wild type,WT)小鼠进行对比分析。通过旷场实验、爬杆实验和Y迷宫等行为学手段来评估小鼠的运动功能和空间工作记忆能力,并以经典的匀加速转棒实验作为运动学习的行为学范式,来评估其运动学习能力。结果6月龄的Thy 1-SNC A TG小鼠在运动功能和空间记忆能力方面并未显示出异常,却呈现出明显的运动学习障碍。结论在早期PD模型小鼠上存在着特定的运动学习障碍,可作为早期PD的一个重要诊断指标;同时匀加速转棒测试可作为检测PD运动学习障碍的一种重要的行为学手段。

关键词：帕金森病早期帕金森病模型运动学习障碍运动症状

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Low-Energy Driven Ring-Opening Behavior of Benzocyclobutene Derivatives

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Chinese Journal of Chemistry 2023年第23期41卷 3238-3244页

作者： Ziwei Yuan Quan Sun Jinchong Xiao Pingxia Zhang Konstantin S.Levchenko Dmitry Y.Demin wenxin fu Laboratory of Science and Technology on High-Tech Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing100190 China College of Chemistry and Material Science Hebei UniversityBaodingHebei071002 China University of Chinese Academy of Sciences Beijing100049 China MIREA — Russian Technological University Moscow119454 Russian Federation

It's urgent to develop benzocyclobutene(BCB)-based polymers with low curing temperature for temperature-sensitive applications such as liquid crystal displays(LCDs)and flexible ***,the effect of substituents on the ring-opening behavior of BCB derivatives was *** ring-opening activation energy barriers(ΔGA)of BCB derivatives with one or two substituents on the four-membered alkyl ring were systematically calculated using the B3LYP *** mono-and di-substituted BCBs adopted the conrotatory ring-opening process,obeying the Woodward-Hoffmann's Rules upon *** mono-/di-substituted BCBs exhibited 8.2%—69%lowerΔGA compared with BCB,attributed to the electronic effects of the *** BCBs with both electron-donating and electron-withdrawing groups,e.g.,1-NH_(2)-8-NO_(2)-BCB,demonstrated the lowestΔ*** addition,BCB derivatives with amide/ester/acyloxy group modified on C1 position were synthesized as model molecules,and their ring-opening temperature can be decreased by 20℃ compared to the unsubstituted one,also consistent with our calculation *** work combined theoretical calculation methods with experimental results to provide valuable insights into the design and synthesis of BCB derivatives and next-generation BCB functional packaging materials with low ring-opening temperature.

关键词： Benzocyclobutene Thermosets Monomers Low curing temperature Activation energy barrier Electronic effect Captodative effect

Spatial distributions of soil nutrients affected by land use,topography and their interactions,in the Loess Plateau of China

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International Soil and Water Conservation Research 2024年第1期12卷 227-239页

作者： wenxin Zhou Changjia Li Wenwu Zhao Lindsay C.Stringer Bojie fu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Institute of Land Surface System and Sustainable Development Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Department of Environment and Geography University of YorkYorkUK York Environmental Sustainability Institute University of YorkYorkUK

Soil nutrient availability and their spatial distributions are strongly related to land use and landscape *** study aims to address the knowledge gap regarding the interaction between these factors and the underlying *** selected five land uses(grassland with Artemisia gmelinii,woodland with Robinia pseudoacacia,shrubland with Caragana korshinskii and Hippophae rhamnoides,and apple orchard with Malus pumila)and nine slope positions across hillslopes in the Loess Plateau,China,to investigate their combined effects on the contents and stocks of soil organic carbon(SOC),total nitrogen(TN)and total phosphorus(TP).Parametric and non-parametric statistical tests were conducted to determine the significant differences in the means or the medians of the soil nutrient *** showed that the SOC and TN contents of shrubland with Caragana korshinskii were statistically significantly greater than those of the grassland(p<0.05).SOC and TN contents generally decreased from the upper slope to the middle slope,and to the foot slope for the grassland,woodland and shrublands,and on the contrary,an increasing trend from the upper slope,to the middle slope,and to the foot slope was identified for the apple *** study highlights that land use,slope position and their interaction have significant effects on the spatial distributions of soil *** provides essential empirical evidence for the identification of the optimal vegetation type and slope positions in land management and vegetation restoration activities.

关键词： Soil organic carbon Total nitrogen Total phosphorus Slope position Vegetation restoration

The expanded application of CAR-T cell therapy for the treatment of multiple non-tumoral diseases

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Protein & Cell 2024年第9期15卷 633-641页

作者： Zhuoqun Liu Yuchen Xiao Jianjun Lyu Duohui Jing Liu Liu Yanbin fu wenxin Niu Lingjing Jin Chao Zhang fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghai 201619China Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co. Ltd.East Lake High-Tech Development ZoneWuhan 430205China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Yuhui Pharmaceutical Technology(Group)Co. Ltd.and Shanghai Ruishen Technology Development Co.Ltd.Shanghai 201203China Shanghai Cancer Institute Department of Biliary-Pancreatic SurgeryRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China

As a powerful cell-based therapeutic approach,CAR-T therapy was originally designed for treating acquired immunodeficiency syndrome(AIDS)(Baker et al.,2023),but had been strikingly successful in curing hematologic malignancies and multiple solid *** evidence has expanded the medical application of CAR-T therapy for the treatment of many other human diseases beyond *** this article,we discuss the principle of CAR-T and enumerate the current application and limitation in ***,we provide a comprehensive perspective of current advance and future directions of CAR-T in treating multiple non-tumoral diseases.

关键词： diseases expanded treatment

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哈尔滨口岸出入境人员传染病感染情况的监测

中华流行病学杂志 1992年第5期13卷 285-287页

作者：付文新邢雅珊 150001

对哈尔滨口岸7 447名出国人员、70名归国人员进行健康体检，结果在出国人员中检出HBsAg阳性携带者349例，阳性率为4.7%；肺结核41例，阳性率0.6%；性病4例，阳性率0.05%。在归国人员中检出性病2例，检出率2.9%。在出国、归国人员中皆未... 详细信息

对哈尔滨口岸7 447名出国人员、70名归国人员进行健康体检，结果在出国人员中检出HBsAg阳性携带者349例，阳性率为4.7%；肺结核41例，阳性率0.6%；性病4例，阳性率0.05%。在归国人员中检出性病2例，检出率2.9%。在出国、归国人员中皆未检出艾滋病和梅毒感染者。对检出的传染病患者都采取了适当措施，达到了疾病监测的目的。

关键词：监测艾滋病性病肺结核

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温度响应性聚硅氧烷及其智能响应薄膜的制备

科学通报 2015年第36期60卷 3627-3633,1-5页

作者：邹方鑫符文鑫李志波中国科学院化学研究所高分子物理与化学实验室北京100190 青岛科技大学高分子科学与工程学院青岛266042

聚硅氧烷具有良好的化学稳定性、热稳定性、低毒性和生物相容性,在构筑刺激响应性聚合物方面有着广阔的应用前景.本文报道了寡聚三乙二醇化学修饰聚硅氧烷制备温度响应聚合物,并探索其在智能响应聚合物薄膜方面的潜在应用.利用Karstedt... 详细信息

聚硅氧烷具有良好的化学稳定性、热稳定性、低毒性和生物相容性,在构筑刺激响应性聚合物方面有着广阔的应用前景.本文报道了寡聚三乙二醇化学修饰聚硅氧烷制备温度响应聚合物,并探索其在智能响应聚合物薄膜方面的潜在应用.利用Karstedt催化剂催化的氢化硅烷加成反应制备了侧链接枝寡聚三乙二醇的聚硅氧烷前聚体(PMHS-OEG3),运用核磁共振谱、红外光谱和紫外-可见光谱详细表征了其化学结构,并系统研究了聚合物分子量与温度响应性之间的关系.浊度测试表明,当PMHS-OEG_3的聚合度由37变为79时,聚合物的浊点由29.4℃降为27.5℃.进一步将3种不同聚合度的PMHS-OEG3与1,3-二乙烯基-1,1,3,3-四甲基二硅氧烷分别交联固化成薄膜,得到具有温度响应性的薄膜.研究发现,随着PMHS-OEG_3聚合度的降低,相对应的聚硅氧烷薄膜的转变温度也随之降低.

关键词：聚硅氧烷聚乙二醇氢化硅烷化反应温度响应性智能响应薄膜

基于可逆离子氢键构筑室温快速自修复聚硅氧烷弹性体

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功能高分子学报 2020年第5期33卷 433-440页

作者：时金凤赵娜符文鑫李志波青岛科技大学高分子科学与工程学院山东青岛266042 中国科学院化学研究所先进高分子材料实验室北京100190

以环三聚磷腈碱(CTPB)为催化剂,合成不同分子量和不同硅氧乙烯基单元摩尔分数的线型聚硅氧烷(PDMS-g-Vi)前驱体,通过硫醇-烯点击化学反应获得侧链含羧基或氨基的聚硅氧烷(PDMS-g-COOH或PDMS-g-NH2),进而利用羧基与氨基之间的离子氢键成... 详细信息

以环三聚磷腈碱(CTPB)为催化剂,合成不同分子量和不同硅氧乙烯基单元摩尔分数的线型聚硅氧烷(PDMS-g-Vi)前驱体,通过硫醇-烯点击化学反应获得侧链含羧基或氨基的聚硅氧烷(PDMS-g-COOH或PDMS-g-NH2),进而利用羧基与氨基之间的离子氢键成功制备在室温条件下可快速自修复的聚硅氧烷(PDMS-g-[COOH/NH2])弹性体。采用凝胶渗透色谱、核磁共振、红外光谱等确定了聚合物的组成和结构。拉伸试验结果表明:通过控制PDMS-g-Vi前驱体的分子量和乙烯基含量可调节PDMS-g-[COOH/NH2]弹性体的力学性能和自修复性能。在50 mm/min的拉伸速率下,弹性体的拉伸强度为230.9 kPa,断裂伸长率高达877%,在快速拉伸的条件下(200 mm/min)也显示出了较高的断裂伸长率(>500%)。此外,所制备的弹性体显示出优异的快速自修复性能,室温静置30 min后其修复效率达到99%。

关键词：聚硅氧烷离子氢键非共价交联网络硫醇-烯加成反应自修复

遥感场景理解中视觉Transformer的参数高效微调

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电子与信息学报 2024年第9期46卷 3731-3738页

作者：尹文昕于海琛刁文辉孙显付琨中国科学院空天信息创新研究院北京100190 中国科学院大学电子电气与通信工程学院北京100049 中国科学院空天信息创新研究院网络信息体系技术科技创新重点实验室北京100190

随着深度学习和计算机视觉技术的飞速发展,遥感场景分类任务对预训练模型的微调通常需要大量的计算资源。为了减少内存需求和训练成本,该文提出一种名为“多尺度融合适配器微调(MuFA)”的方法,用于遥感模型的微调。MuFA引入了一个多尺... 详细信息

随着深度学习和计算机视觉技术的飞速发展,遥感场景分类任务对预训练模型的微调通常需要大量的计算资源。为了减少内存需求和训练成本,该文提出一种名为“多尺度融合适配器微调(MuFA)”的方法,用于遥感模型的微调。MuFA引入了一个多尺度融合模块,将不同下采样倍率的瓶颈模块相融合,并与原始视觉Transformer模型并联。在训练过程中,原始视觉Transformer模型的参数被冻结,只有MuFA模块和分类头会进行微调。实验结果表明,MuFA在UCM和NWPU-RESISC45两个遥感场景分类数据集上取得了优异的性能,超越了其他参数高效微调方法。因此,MuFA不仅保持了模型性能,还降低了资源开销,具有广泛的遥感应用前景。

关键词：遥感图像场景分类参数高效深度学习

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