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LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice

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Journal of Genetics and Genomics 2021年第5期48卷 384-395页

作者： Li Yu Lina Wang Wufan Tao wenxiang zhang Shuanghao Yang Jian Wang Jia Fei Rui Peng Yiming Wu Xiumei Zhen Hong Shao Weiyue Gu Rong Li Bai-Lin Wu Hongyan Wang Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Children’s Hospital Institutes of Reproduction and DevelopmentFudan UniversityShanghai 201102China Department of Laboratory Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Boston Children's Hospital and NGS collaboration Harvard Medical SchoolBoston MA 02115USA National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Obstetrics and Gynecology Hospital NHC Key Laboratory of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research)State Key Laboratory of Genetic Engineering at School of Life SciencesInstitute of Metabolism and Integrative BiologyFudan UniversityShanghai 200011China Institute of Developmental Biology&Molecular Medicine Fudan UniversityShanghai 200433China Reproductive Medicine Centre Anhui Medical UniversityHefei 230032China Chigene Translational Medicine Research Center Beijing 100875China Shanghai Children’s Medical Center Shanghai Jiaotong UniversityShanghai 200127China Zhongke Genetics and Reproductive Medicine Institute Beijing 102600China

Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen *** studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS ***1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS *** whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS *** expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating ***~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and ***~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory *** showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.

关键词： LHCGR ALMS1 Anovulation Hyperandrogenemia PCOS

Pt supported on octahedral Fe_3O_4 microcrystals as a catalyst for removal of formaldehyde under ambient conditions

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Chinese Journal of Catalysis 2018年第9期39卷 1534-1542页

作者： Weiyi Cui Dan Xue Naidi Tan Bin Zheng Mingjun Jia wenxiang zhang Key Laboratory of Chemical Cleaner Production Technology of Jilin Province Jilin Institute of Chemical Technology Jilin 132022 Jilin China Key Laboratory of Surface and Interface Chemistry of Jilin Province College of Chemistry Jilin University Changchun 130021 Jilin China School of Chemistry﹠Chemical Engineering Xi’an Shiyou University Xi’an 710065 Shaanxi China

Several catalysts comprising Pt supported on octahedral Fe3O4（Pt/Fe3O4） were prepared by a facile method involving co-precipitation followed by thermal treatment at different temperatures. A variety of characterization results revealed that this preparation process afforded highly crystalline octahedral Fe3O4 with a uniform distribution of Pt nanoparticles on its surface. The thermal-treatment temperature significantly influenced the redox properties of the Pt/Fe3O4 catalysts. All the Pt/Fe3O4 catalysts were found to be catalytically active and stable for the oxidation of low-concentration formaldehyde（HCHO） with oxygen. The catalyst prepared by thermal treatment at 80 °C（labelled Pt/Fe3O4-80） exhibited the highest catalytic activity, efficiently converting HCHO to CO2 and H2 O under ambient temperature and moisture conditions. The excellent performance of Pt/Fe3O4-80 was mainly attributed to beneficial interactions between the Pt and Fe species that result in the formation a higher density of active interface sites（e.g., Pt-O-FeO x and Pt-OH-FeO x）. The introduction of water vapor improves the catalytic activity of the Pt/Fe3O4 catalysts as it participates in a water-assisted dissociation process.

关键词： Octahedral Fe3O4 Ptnanoparticles Interfacial interaction Catalytic oxidation Formaldehyde

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铁路机务车辆机械工程预算定额编制优化研究

铁道工程学报 2024年第9期41卷 114-117页

作者：张文祥闻方宇国家铁路局规划与标准研究院北京100055 中国铁路设计集团有限公司天津300308

研究目的:铁路机务车辆机械工程预算定额是铁路工程定额体系的重要组成部分,用于铁路机务、车辆、机械工程设计概(预)算编制,发挥了合理控制投资的作用。随着高铁建设的发展和技术的进步,对定额修编提出了新的要求。本文通过分析2017年... 详细信息

研究目的:铁路机务车辆机械工程预算定额是铁路工程定额体系的重要组成部分,用于铁路机务、车辆、机械工程设计概(预)算编制,发挥了合理控制投资的作用。随着高铁建设的发展和技术的进步,对定额修编提出了新的要求。本文通过分析2017年版《铁路机务车辆机械工程预算定额》的运用现状,基于定额编制原则,拟定新一版定额编制方案,优化章节设置,融入绿色低碳技术,以适应高铁快速发展的要求。研究结论:(1)新一版机务车辆机械工程预算定额编制方案充分吸纳了高铁建设最新经验,首次将“动车组检修设备安装工程”独立成章,新增了动车组高级修程内容,填补了动车组检修设备安装定额的空白,全面展示了近年来中国高铁领先世界的重大成果,有力支撑了“一带一路”重大高铁项目建设;(2)将“碳达峰、碳中和”融入定额,重点采用绿色低碳技术,删除燃煤锅炉,体现了绿色低碳的要求;(3)大量引入新设备、新技术,增加了探测站设备、大型养路机械检修设备和焊轨基地专用设备的安装定额;(4)优化章节设置,结合机车车辆机械的主要结构和维修工艺、工序对检修设备重新分类归纳,使得查询方式更加友好,提高了定额查询使用效率;(5)本文研究对编制铁路工程定额具有指导作用。

关键词：机务车辆机械预算定额修编编制方案

Aerobic oxidative coupling of alcohols and amines to imines over iron catalysts supported on mesoporous carbon

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Chinese Journal of Catalysis 2016年第9期37卷 1451-1460页

作者： Longlong Geng Jinling Song Bin Zheng Shujie Wu wenxiang zhang Mingjun Jia Gang Liu Key Laboratory of Surface and Interface Chemistry of Jilin Province College of Chemistry filin University Changchun 130012 filin China

Direct oxidative coupling of an alcohol and amine,with air or molecular oxygen as the oxygen source,is an environmentally friendly method for imine *** developed an Fe catalyst supported on mesoporous carbon（denoted by FeOx/HCMK-3） for this reaction with excellent activity and ***/HCMK-3 was prepared by impregnating HNO3-treated mesoporous carbon（CMK-3） with iron nitrate *** highly dispersed FeOx species give FeOx/HCMK-3 high reducibility and are responsible for the high catalytic *** synthesis over FeOx/HCMK-3 follows a redox *** oxygen species in FeOx/HCMK-3 participate in the reaction and are then regenerated by oxidation with molecular *** reaction involves two consecutive steps：oxidative dehydrogenation of an alcohol to an aldehyde and coupling of the aldehyde with an amine to give an *** dehydrogenation of the alcohol is the rate-determining step in the reaction.

关键词： Iron catalyst Imine synthesis Oxidative coupling Mesoporous carbon Molecular oxygen

FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of mi R-322-5p

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FAM3B mediates high glucose-induced vascular smooth muscle c...

Oxidative coupling of alcohols and amines to an imine over Mg-Al acid-base bifunctional oxide catalysts

中国生物化学与分子生物学会2016年全国学术会议

作者： wenxiang zhang Siyu Chen Tingming Liang Zhao zhang Chang Liu Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences Nanjing Normal University Jiangsu Key Laboratory of Human Functional Genomics Nanjing Medical University State Key Laboratory of Natural Medicines China Pharmaceutical University

The proliferation and migration of vascular smooth muscle cells(VSMCs)play an essential role during the development of atherosclerosis and *** many factors potentially contribute to the abnormal activation of VSMCs,hyperglycemia is generally believed to be a major causative *** the other hand,FAM3B(named PANDER for its secretory form)is a uniquely structured protein strongly expressed within

关键词： FAM3B vascular smooth muscle cells proliferation migration miR-322-5p

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Chinese Journal of Catalysis 2018年第2期39卷 309-318页

作者： Jinling Song Guiyang Yu Xi Li Xuwei Yang wenxiang zhang Wenfu Yan Gang Liu Key Laboratory of Surface and Interface Chemistry of Jilin Province College of Chemistry Jilin University Changchun 130012 Jilin China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 Jilin China

A series of Mg‐Al mixed oxide catalysts are prepared and introduced as efficient irreducible catalysts for the oxidative coupling of alcohols and amines to *** structure and surface properties of Mg‐Al oxides are modulated by changing the Mg/Al ratios,calcination temperature and treatment with probe *** characterization,including X‐ray diffraction,27Al magic angle spinning nuclear magnetic resonance spectroscopy,N2‐adsorption,NH3‐temperature‐programmed desorption,CO2‐temperature‐programmed desorption and X‐ray photoelectron spectroscopy are carried out to determine the physicochemical properties of these *** Mg‐Al oxides with Mg/Al=3exhibit the highest activity in the reaction,which possess a large number of surface weak basic sites and a relatively small number of weak acidic *** role of the acidic and basic sites in the reaction process is systematically investigated,and are shown to serve as adsorption and activation sites for amines and alcohols,*** the synergistic effect of these acid‐base centers,the oxidative coupling process successfully occurs on the surface of Mg‐Al mixed *** with the acidic sites,the weak basic sites play a more important role in the catalytic *** acidic sites are the catalytic centers for the benzyl alcohol activation,which control the reaction rate of the oxidative coupling reaction.

关键词： Oxidative coupling Imine synthesis Alcohol oxidation Mg‐Al mixed oxides Acid‐base catalysis

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高锰酸钾对耳萝卜螺的毒性作用

淡水渔业 2000年第8期30卷 32-33页

作者：张文香河北职业技术师范学院动物科学系昌黎066600

耳萝卜螺(Radiu auricularia)属于腹足纲、肺螺亚纲、基眼目、椎实螺科、耳萝卜螺属,别名痕螺、响螺、绿桑螺.分布在我国各地水草茂盛的淡水水域.常在沿岸爬行或匍匐水底、岩石或水草上,或在水面下游泳.耳萝卜螺含有丰富的蛋白质、氨基... 详细信息

耳萝卜螺(Radiu auricularia)属于腹足纲、肺螺亚纲、基眼目、椎实螺科、耳萝卜螺属,别名痕螺、响螺、绿桑螺.分布在我国各地水草茂盛的淡水水域.常在沿岸爬行或匍匐水底、岩石或水草上,或在水面下游泳.耳萝卜螺含有丰富的蛋白质、氨基酸和多种微量元素,繁殖率高,饲养方便,为鱼类及畜禽的优质饵料.高锰酸钾是较常用的药物,不管是在人工育苗过程中,还是在实际生产中,高锰酸钾都被普遍的应用.高锰酸钾虽在耳萝卜螺育苗、育成过程中也有防病、治病的作用,但耳萝卜螺对每种药物的耐受力有其极限浓度.这次试验是在耳萝卜螺人工繁殖试验成功后,又进一步研究了高锰酸钾对耳萝卜螺的毒性作用.

关键词：高锰酸钾耳萝卜螺毒性作用

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青海省干旱时空特征及与大气环流响应关系

干旱区资源与环境 2021年第12期35卷 60-65页

作者：范磊吕爱锋张文翔云南师范大学地理学部云南省高原地理过程与环境变化重点实验室昆明650500 中国科学院地理科学与资源研究所陆地水循环及地表过程重点实验室北京100101 中国科学院大学北京100049

研究干旱的时空特征和发展趋势,对加强水资源管理和提高抗旱防灾能力具有重要意义。文中基于青海省24个气象站1980~2018年的逐月气象数据计算标准化降水蒸散指数(SPEI),分析青海省干旱的时空变化特征,结合青海省干旱与厄尔尼诺-南方涛动... 详细信息

研究干旱的时空特征和发展趋势,对加强水资源管理和提高抗旱防灾能力具有重要意义。文中基于青海省24个气象站1980~2018年的逐月气象数据计算标准化降水蒸散指数(SPEI),分析青海省干旱的时空变化特征,结合青海省干旱与厄尔尼诺-南方涛动(ENSO)、太平洋年代际振荡(PDO)、北大西洋振荡(NAO)、北极振荡(AO)的滞后相关关系,确定了影响青海省干旱的主要大气环流因子。结果表明:1980~2018年青海省多发生轻度、中度干旱;春季干旱变化以5~6年为周期,秋季干旱变化以6~7年为周期,干旱的年际变化以12~13年为周期;干旱的空间特征存在差异,柴达木盆地、三江源流域干旱化趋势显著,青海湖流域呈现湿润化趋势;青海省的干旱受ENSO、PDO、NAO、AO的影响,其中PDO滞后5个月与干旱的响应关系最为强烈。

关键词：干旱时空特征大气环流响应关系青海省

网络谣言的行政规制与协同治理:兼论公共权力及其边界

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新闻界 2022年第5期 71-80页

作者：张文祥杨林浙江大学宁波理工学院山东大学新闻传播学院山东济南250100 浙江大学宁波理工学院网络空间治理与数字经济法治(长三角)研究基地浙江宁波315100

信息传播的移动化、社交化、智能化发展在拓宽公众获取信息的渠道、加速信息传播和流通的同时,也打开了谣言滋生扩散的方便之门,谣言问题显得比传统媒体时代更为严峻。网络谣言成为网络信息内容治理的重要对象。对网络谣言的法治化认识... 详细信息

信息传播的移动化、社交化、智能化发展在拓宽公众获取信息的渠道、加速信息传播和流通的同时,也打开了谣言滋生扩散的方便之门,谣言问题显得比传统媒体时代更为严峻。网络谣言成为网络信息内容治理的重要对象。对网络谣言的法治化认识、合理化规制与多元化治理是我国网络信息传播治理的重要内容,也是国家治理体系和治理能力现代化的重要命题。本文对作为政府行政规制对象的网络谣言弊害与功能进行剖析,界定法律规范意义上的谣言,分析网络谣言行政规制的现状和存在的问题,厘清网络谣言治理中的公共权力及其边界。认为对谣言进行法律制裁是应对网络谣言的最后一道防线,网络谣言的减少还依赖于网络平台企业社会责任的提高,以及公众网络素养、理性认识能力的提升。应构建硬法软法协调、多元主体协同的治理机制,以实现网络谣言的良法善治。

关键词：网络谣言行政规制政府责任信息公开协同治理