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Fact-condition statements and super relation extraction for geothermic knowledge graphs construction

Geoscience Frontiers 2023年第5期14卷 384-395页

作者： Qizhi Chen Hong Yao Shengwen Li Xinchuan Li Xiaojun Kang wenwen lai Jian Kuang School of Computer Science China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China School of Geography and Information Engineering China University of GeosciencesWuhan 430074China

Researchers utilize information from the geoscience literature to deduce the regional or global geological *** this process has relied on the labor of *** the number of papers continues to increase,acquiring domain-specific knowledge becomes a heavy *** Graph(KG)is proposed as a new knowledge representation technology to change this ***,the super relation is not considered in the previous KG,which bridges the geological phenomenon(fact)and its precondition(condition).For instance,in the statement(“the late Archean was a crucial transition period in the history of global geodynamics”),the condition statement(“crucial transition for global geodynamics”)works as the complementary fact statement(“the late Archean was a crucial transition period”),which defines the scale of crucial transition accurately in the late *** this study,fact-condition statement extraction is introduced to construct a geological knowledge graph.A rule-based multi-input multi-output model(R-MIMO)is proposed for information *** the R-MIMO,fact-condition statements and their super relation are considered and extracted for the first *** verify its performances,a GeothCF dataset with 1455 fact tuples and 789 condition tuples is *** experiments,the R-MIMO model achieves the best performance by using BERT as encoder and LSTM-d as decoder,achieving F180.24%in tuple extraction and F170.03%in tag prediction ***,the geothermic KG with super relation is automatically constructed for the first time by trained R-MIMO,which can provide structured data for further geothermic research.

关键词： Fact-condition statements Super relation Knowledge graph Rule-based multi-input multi-output model

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基于LGMM模型的中国老年人认知水平发展轨迹的异质性研究

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中国卫生统计 2024年第4期41卷 482-486页

作者：张诚赖文文杨善岚卢曲琴吴磊刘勇南昌大学公共卫生学院江西省预防医学重点实验室330006 南昌大学公共卫生学院卫生统计学教研室

目的基于潜变量增长混合模型(latent growth mixture model, LGMM)和中国健康与养老追踪调查(China Health and Retirement Longitudinal Survey, CHARLS)3期追踪数据,考察我国老年人认知水平的发展轨迹及影响因素。方法资料来源于CHA... 详细信息

目的基于潜变量增长混合模型(latent growth mixture model, LGMM)和中国健康与养老追踪调查(China Health and Retirement Longitudinal Survey, CHARLS)3期追踪数据,考察我国老年人认知水平的发展轨迹及影响因素。方法资料来源于CHARLS 2013年、2015年、2018年数据,共包含4662例60岁及以上老年人。采用MMSE量表对老年人的认知水平进行评估。利用Mplus工具构建适用于队列数据的LGMM模型探讨不同老年人群体的认知水平变化轨迹,考察时间恒定因素(性别、年龄、受教育程度、婚姻状况、吸烟、饮酒)和随时间变化因素(日常生活活动能力、睡眠时长、主观生活满意度)对老年人认知水平的影响。结果根据相关指标可将老年人认知水平的发展趋势划分为3个类型,分别是C1缓慢下降组(35.2%)、C2快速下降组(20.6%)和C3稳定组(44.2%);老年人的认知水平随着时间推移呈整体下降趋势,3个组别的认知水平发展轨迹均有显著的时间效应,C2快速下降组的认知水平随时间下降较快,C1缓慢下降组的认知水平随时间缓慢降低,C3稳定组的认知水平变化不明显,呈稳定态。结论老年人认知水平的发展轨迹具有显著的群体异质性和个体差异性,存在不同类别的发展趋势。

关键词：认知水平潜变量增长混合模型 CHARLS 发展轨迹

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沙库巴曲缬沙坦对心肌梗死大鼠模型心肌重构和心功能的影响

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中华老年医学杂志 2019年第9期38卷 1048-1052页

作者：卢辉耀徐训发郭佳音赵文安林志民赖文文福建医科大学附属第二医院心血管内科福州362000

目的探讨沙库巴曲缬沙坦对心肌梗死模型大鼠心肌重构和心功能的影响及其机制。方法本研究分为体内急性心肌梗死(AMI)大鼠模型和体外细胞实验。大鼠模型部分:将60只SPF级雄性大鼠,结扎冠状动脉前降支建立心肌梗死模型,1周后用随机数表法... 详细信息

目的探讨沙库巴曲缬沙坦对心肌梗死模型大鼠心肌重构和心功能的影响及其机制。方法本研究分为体内急性心肌梗死(AMI)大鼠模型和体外细胞实验。大鼠模型部分:将60只SPF级雄性大鼠,结扎冠状动脉前降支建立心肌梗死模型,1周后用随机数表法分为沙库巴曲缬沙坦组(30只)和模型组(30只),分别灌胃给予沙库巴曲缬沙坦68 mg/kg和溶媒(生理盐水),每日1次,共4周。最后1次给药后24 h,超声心动图检查大鼠左心室心功能、光镜下观察左心室病理变化,苦味酸-天狼猩红染色法定量分析心肌纤维化程度。体外细胞实验部分:制备同样品种幼鼠心脏的心肌细胞及成纤维细胞,分为模型组、AngⅡ组、LBQ657(脑啡肽酶抑制剂)组和valsartan组、LCZ696组,用3H-亮氨酸掺入法和3H-脯氨酸掺入法检测心肌细胞肥大及纤维化程度。结果用药前两组大鼠左心室功能各指标的差异无统计学意义(P>0.05),用药4周后,沙库巴曲缬沙坦组大鼠的左心室舒张期末直径及左心室收缩期末容积显著小于模型组[(9.73±0.26)mm比(10.52±0.21)mm,P<0.05,(0.19±0.03)ml比(0.31±0.02)ml,P<0.01];左心室射血分数大于模型组[(60.17±2.18)%比(47.16±5.14)%,P<0.01]。沙库巴曲缬沙坦组大鼠梗死区心肌细胞损伤程度低于模型组,沙库巴曲缬沙坦组大鼠非梗死区及梗死区周边的心肌纤维化面积小于模型组[非梗死区:(4.0±0.1)%比(6.1±0.8)%,P<0.001;梗死区周边:(15.7±0.8)%比(23.8±1.2)%,P<0.001]。体外培养心肌细胞实验见:valsartan组心肌成纤维细胞3H-脯氨酸渗入量低于AngⅡ组[(152.77±8.46)CPM比(221.87±13.41)CPM,P<0.01],心肌细胞3H-亮氨酸渗入量低于AngⅡ组[(113.47±2.33)CPM比(127.65±2.38)CPM,P<0.01],LBQ657组心肌细胞3H-亮氨酸渗入量低于AngⅡ组[(119.78±2.98)CPM比(127.65±2.38)CPM,P<0.05],联合应用能进一步减轻心肌肥大与纤维化(P<0.05)。结论沙库巴曲缬沙坦可有效缓解心梗后心肌重塑及心功能障碍,其作用机制可能与减轻AngⅡ引起的心肌细胞肥大及心肌纤维化有关。

关键词：心肌梗死大鼠沙库巴曲缬沙坦心室重构心脏功能试验

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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中医药大学生睡眠质量及其与心理健康相关性研究

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中医学报 2015年第3期30卷 433-435页

作者：郑浩涛赖雯雯虢周科薛红深圳市中医院广东深圳518000 广州中医药大学针灸康复临床医学院广东广州510000

目的:了解中医药大学大学生的睡眠质量及其与心理健康的关系,为改善睡眠质量提供参考。方法:采用随机抽样方法,以班级为单位,以匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)和症状自评量表-90(symptom cheeklist,SCL-90)... 详细信息

目的:了解中医药大学大学生的睡眠质量及其与心理健康的关系,为改善睡眠质量提供参考。方法:采用随机抽样方法,以班级为单位,以匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)和症状自评量表-90(symptom cheeklist,SCL-90)为评价工具进行问卷调查并当场收回。所有资料数量化后输入计算机,采用t检验、方差分析、相关性分析及回归分析进行统计学处理。结果:378名中医学生PSQI总分为(5.44±2.68)分,与大学生常模(5.26±2.58)分比较无显著差异。17.14%的学生睡眠质量差。PSQI总分在不同性别间、不同年级间、不同生源地间的差异无统计学意义;不同睡眠质量医学生SCL-90总分有显著性差异。SCL-90总分及各因子与PSQI总分得分呈正相关(P<0.05)。SCL-90的睡眠与饮食因子对睡眠质量有良好的预测作用。结论:中医药大学生睡眠质量与大学生常模并无显著差别,心理健康状况在很大程度上影响医学生的睡眠质量。因此开展心理健康卫生知识的健康教育,可改善睡眠质量。

关键词：中医药大学生睡眠质量心理健康匹兹堡睡眠质量指数症状自评量表-90

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神经发育障碍性疾病患儿照护者健康促进生活方式现状及影响因素

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中华行为医学与脑科学杂志 2021年第8期30卷 740-744页

作者：张燕娜黄婷赖雯雯候芳陈冬梅王文丹李丽深圳市罗湖区妇幼保健院儿童保健科 518055 深圳市罗湖区妇幼保健院计划生育服务部 518055

目的描述神经发育障碍性疾病患儿的照护者健康促进生活方式的现状,并分析其影响因素。方法选取就诊于深圳市某医院的神经发育障碍性疾病住院患儿的照护者352例为调查对象,使用健康促进生活方式量表Ⅱ,对其主要照护者进行调查,并使用SPSS... 详细信息

目的描述神经发育障碍性疾病患儿的照护者健康促进生活方式的现状,并分析其影响因素。方法选取就诊于深圳市某医院的神经发育障碍性疾病住院患儿的照护者352例为调查对象,使用健康促进生活方式量表Ⅱ,对其主要照护者进行调查,并使用SPSS 20.0和R 3.6.0软件,通过广义线性模型分析方法对照护者的健康促进生活方式得分影响因素进行分析。结果神经发育障碍性疾病患儿照护者的健康促进生活方式总得分为(127.66±17.87)分,标准化得分为(62.05±8.96)分,其中标准化得分最高的为营养维度(69.62±11.04)分,得分最低的为体育运动维度(51.67±11.45)分,各条目标准化得分组间比较差异有统计学意义(F=62.780,P3年"与"<1年"比:β=-7.156,t=-3.687,P=0.003)和家庭月收入("10000~20000元"与"<5000元"比:β=14.351,t=3.050,P=0.002)是影响照护者健康促进生活方式的因素。结论照护者的生活方式值得关注,需通过多形式的健康宣教方法,帮助其提高健康促进生活方式。

关键词：神经发育障碍性疾病照护者健康促进生活方式现况调查

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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益气活血方联合沙库巴曲缬沙坦对慢性心衰患者的疗效观察

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中国现代应用药学 2019年第18期36卷 2312-2316页

作者：赖文文赵文安陈国桢林伟强许朝祥蔡克锋林志民卢辉耀福建医科大学附属第二医院心血管内科

目的观察中药益气活血方配合沙库巴曲缬沙坦在慢性心衰治疗中的疗效及对患者心率变异性指标、血清NT-proBNP、MMP-9水平的影响。方法将2017年7月—2018年8月期间收治的126例慢性心衰患者随机分为沙库巴曲组(61例)和益气沙库组(65例),沙... 详细信息

目的观察中药益气活血方配合沙库巴曲缬沙坦在慢性心衰治疗中的疗效及对患者心率变异性指标、血清NT-proBNP、MMP-9水平的影响。方法将2017年7月—2018年8月期间收治的126例慢性心衰患者随机分为沙库巴曲组(61例)和益气沙库组(65例),沙库巴曲组均给予常规抗慢性心衰基本治疗和沙库巴曲缬沙坦治疗,益气沙库组在沙库巴曲组基础上加以益气活血方治疗,观察2组治疗6个月后的临床疗效、心率变异性指标、血清NT-proBNP、MMP-9及不良反应情况。结果益气沙库组的临床总有效率显著优于沙库巴曲组(89.23%vs 72.13%)(χ^2=5.979,P=0.031);治疗后,2组心率变异性指标(SDNN、SDANN、pNN50)及NT-proBNP、MMP-9比较均较治疗前改善和降低。益气沙库组治疗后心率变异性指标SDNN、SDANN、pNN50显著高于沙库巴曲组[(129.53±34.26 vs 114.28±31.84)ms、(112.31±36.02 vs 101.44±29.59)ms、(8.71±7.64 vs 6.37±5.80)%](P<0.05);益气沙库组治疗后血清NT-proBNP、MMP-9显著低于沙库巴曲组[(207.45±51.71 vs 268.62±74.15)pg·mL^-1、(561.79±64.03 vs 688.19±87.94)pg·mL^-1](P<0.05)。结论中药益气活血方配合沙库巴曲缬沙坦在慢性心衰治疗中的疗效显著,该治疗方案可改善患者心率变异性指标、NT-proBNP、MMP-9指标的异常情况。

关键词：益气活血方心衰沙库巴曲缬沙坦心率变异性 NT-proBNP MMP-9

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