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Role of mitophagy in head and neck squamous cell carcinoma:Prognosis and immune insights

Radiation Medicine and Protection 2024年第2期5卷 100-112页

作者： Qin Ding Wei Liu Junping Pan Lihua Wang wenquan hong Sunqin Cai Xin Chen Duanyu Lin Sufang Qiu Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China Fujian Provincial Key Laboratory of Translational Cancer Medicine Fuzhou 350014China Department of Nuclear Medicine Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China

Objective:To explore the correlation between mitophagy and the tumor microenvironment(TME)in patients with head and neck squamous cell carcinoma(HNSCC),with an aim to enhance therapeutic efficacy for ***:A machine learning-based multigene prognostic signature was developed based on mitophagy-related differentially expressed genes(MRGs)identified in The Cancer Genome Atlas *** signature was correlated with the TME using gene set enrichment *** association between this prognostic signature and various immunological features of the TME was explored,including status of tumor-infiltrating immune cells,expression of immune checkpoint molecules,and the *** validated the expression of hub gene CSNK2A2 and assessed its relationship with immunomarker *** PCR validated CSNK2A2 knockdown in HNSCC cell *** experiments including Transwell assays to determine cell migration and invasion,Cell Counting Kit 8 assay,and 5-ethynyl-2-deoxyuridine assay were performed to confirm the role of CSNK2A2 in ***,a subcutaneous xenograft model was generated in C3H mice to validate our ***:The MRG-based prognostic signature showed excellent predictive ***-risk patients had significantly shorter progression-free and overall survival(P<0.0001)than low-risk ***8+T cell infiltration was lower in high-risk groups,whereas low-risk groups showed higher immunological marker ***,the low-risk HNSCC subtype may benefit from immune therapy,while high-risk subtypes may benefit from chemotherapy(P<0.001).CSNK2A2 was highly expressed and strongly correlated with CD8 and PD-L1 based on immunohistochemistry of the HNSCC tissue ***2A2 knockdown reduced cell migration,invasion,and proliferation,and arrested cells in G1 *** vivo,it led to slower tumor growth and smaller tumor ***:We established a potential prognostic signature that could impr

关键词： Head and neck squamous cell carcinoma Mitophagy Tumor microenvironment CSNK2A2 Prognostic model

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Impact of salvage radiotherapy combined with chemotherapy on long-term outcomes of patients with recurrent nasopharyngeal carcinoma:a retrospective study

Impact of salvage radiotherapy combined with chemotherapy on...

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2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Ying Li Wei Liu Lihua Wang wenquan hong Youliang Weng Sufang Qiu Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital 福建省肿瘤医院

Background:It remains controversial that the application of chemotherapy has an impact on recurrent nasopharyngeal carcinoma(r NPC) patients with salvage ***,we aimed to evaluate treatment outcomes of r NPC patients and derive a prognostic model to assess the benefit of chemotherapy in patients with ***:Totally 340 r NPC patients treated with salvage intensity-modulated radiotherapy(IMRT) or chemoradiotherapy(CRT) from October 2006 to September 2019 were included in this *** survival(OS) was the primary ***-Meier method was employed to detect the prognostic difference with Log-rank *** Cox regression analysis was performed to explore the potential prognostic factors while the multivariate Cox analysis was used to identify candidate variables for the prognostic model of ***:The 5-year actuarial rates of OS,progression-free survival,loco-regional progression-free survival,and distant metastases-free survival didn’t show significant difference between the IMRT and CRT groups(ps > 0.05).Age at recurrence was found to be the only independent prognostic factor for OS(HR = 2.076,95% CI 1.490-2.894,p < 0.001).Three factors(age at recurrence,r Stage,and initial treatment) were identified for the prognostic *** found that r NPC patients suffered poor OS in the high-risk group(p < 0.001).In the low-risk group,CRT failed to induce survival benefits when compared to RT alone(p = 0.036).Conclusions:Salvage RT combined with chemotherapy cannot improve survival outcomes for r *** novel clinical trials should be explored to develop individualized strategies to improve survival and minimize toxicities.

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A9.8-30.1GHzCMOSlow-noise amplifier with a 3.2-dB noise figure using inductor-and transformer-based gm-boosting techniques

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Frontiers of Information Technology & Electronic Engineering 2021年第4期22卷 586-598页

作者： hongchen CHEN Haoshen ZHU LiangWU wenquan CHE Quan XUE Guangdong Provincial Key Laboratory of Millimeter-Wave and Terahertz School of Electronic and Information EngineeringSouth China University of TechnologyGuangzhou 510641China School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhen 518172China

A 9.8–30.1 GHz CMOS low-noise amplifier(LNA)with a 3.2-dB minimum noise figure(NF)is *** the architecture level,a topology based on common-gate(CG)cascading with a common-source(CS)amplifier is proposed for simultaneous wideband input matching and relatively high *** the circuit level,multiple techniques are proposed to improve LNA ***,in the CG stage,loading effect is properly used instead of the conventional feedback technique,to enable simultaneous impedance and noise ***,based on in-depth theoretical analysis,the inductor-and transformer-based gm-boosting techniques are employed for the CG and CS stages,respectively,to enhance the gain and reduce power ***,the floating-body method,which was originally proposed to lower NF in CS amplifiers,is adopted in the CG stage to further reduce *** in a 65-nm CMOS technology,the LNA chip occupies an area of only 0.2 mm^(2)and measures a maximum power gain of 10.9 dB with−3 dB bandwidth from 9.8 to 30.1 *** NF exhibits a minimum value of 3.2 dB at 15 GHz and is below 5.7 dB across the entire *** LNA consumes 15.6 mW from a 1.2-V supply.

关键词： CMOS gm-boosting Low-noise amplifier Transformer Common-gate

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Photocatalytic defluorination of perfluorooctanoic acid by surface defective BiOCl:Fast microwave solvothermal synthesis and photocatalytic mechanisms

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Journal of Environmental Sciences 2019年第10期31卷 69-79页

作者： Yuanyuan Sun Guiying Li Wanjun Wang wenquan Gu Po Keung Wong Taicheng An Guangzhou Key Laboratory Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China School of Life Sciences The Chinese University of Hong Kong Shatin New Territories Hong Kong China

There is an urgent need for developing cost-effective methods for the treatment of perfluorooctanoic acid(PFOA)due to its global emergence and potential *** this study,taking surface-defective BiOCl as an example,a strategy of surface oxygen vacancy modulation was used to promote the photocatalytic defluorination efficiency of PFOA under simulated sunlight *** defective BiOCl was fabricated by a fast microwave solvothermal method,which was found to induce more surface oxygen vacancies than conventional solvothermal and precipitation *** a result,the asprepared BiOCl showed significantly enhanced defluorination efficiency,which was 2.7 and33.8 times higher than that of BiOCl fabricated by conventional solvothermal and precipitation methods,*** studies indicated that the defluorination of PFOA follows a direct hole(h^+)oxidation pathway with the aid of·OH,while the oxygen vacancies not only promote charge separation but also facilitate the intimate contact between the photocatalyst surface and PFOA by coordinating with its terminal carboxylate group in a bidentate or bridging *** work will provide a general strategy of oxygen vacancy modulation by microwave-assisted methods for efficient photocatalytic defluorination of PFOA in the environment using sunlight as the energy source.

关键词： Photocatalysis Perfluorooctanoic acid Oxygen vacancy Microwave method BiOCl

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质子交换膜燃料电池的三维数值模拟

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西安交通大学学报 2008年第1期42卷 41-45页

作者：林鸿陶文铨西安交通大学能源与动力工程学院西安710049

对一种质子交换膜燃料电池进行了整个单电池的三维数值模拟．计算中采用单相等温模型，数值求解用整场离散、整场求解的方法，同时采用已知电流通过Butler—Volmer方程修正过电位获得电池电压的方法模拟电化学动力学过程．数值结果与实... 详细信息

对一种质子交换膜燃料电池进行了整个单电池的三维数值模拟．计算中采用单相等温模型，数值求解用整场离散、整场求解的方法，同时采用已知电流通过Butler—Volmer方程修正过电位获得电池电压的方法模拟电化学动力学过程．数值结果与实验值的对比表明，所采用的单电池计算模型在大部分工况下获得的输出电压与实验值偏差均可控制在10％～20％以内．计算并分析了单电池局部电流密度分布，同时将单电池模型与典型单元模型的计算结果进行了对比，发现两者在电流密度、质量组分的分布上均存在明显的差异，其原因主要在于典型单元边界条件设置所致．该工作将有助于对质子交换膜燃料电池的流动、传质与电化学过程进行进一步的数值研究．

关键词：质子交换膜燃料电池三维数值模拟单电池典型单元

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温度对质子交换膜扩散性能影响的分子动力学模拟

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西安交通大学学报 2011年第7期45卷 1-4,14页

作者：陈磊林鸿陶文铨西安交通大学热流科学与工程教育部重点实验室西安710049

为了研究Nafion膜的微细观结构及其输运特性,针对目前广为采用的Nafion 117膜并基于Materials Studio软件平台构建了一种分子动力学计算模型,在温度分别为300、353 K时,对其实施了计算,得到了不同水含量下Nafion 117膜的元胞结构,并依... 详细信息

为了研究Nafion膜的微细观结构及其输运特性,针对目前广为采用的Nafion 117膜并基于Materials Studio软件平台构建了一种分子动力学计算模型,在温度分别为300、353 K时,对其实施了计算,得到了不同水含量下Nafion 117膜的元胞结构,并依据该模型计算了水分子和水合氢离子的扩散系数.模拟结果表明:质子交换膜元胞的密度随水含量的增加而下降,和实验值基本一致,最大偏差在8%以内(300 K);当温度升高时,膜元胞密度降低,这与温度升高、膜体积膨胀导致密度降低的宏观分析完全一致.同时,研究了膜水含量、温度对水分子和水合氢离子在膜内的扩散系数的影响,增加水含量可以提高膜的质子传导率,同一温度下水含量越大,水分子和水合氢离子的扩散系数越大,且同一水含量下温度越高,水分子和水合氢离子的扩散系数越大.

关键词：分子动力学模拟 Materials Studio软件扩散系数 Nafion117膜

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Tracing　technique　of　stable　^（15）N　isotope：　an　application　in　study　of　mariculture

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Acta Oceanologica Sinica 1995年第1期14卷 39-45页

作者： hong Ashi Li wenquan and Wang Mingliang(Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China)(Department of Oceanography, Xiamen University, Xiamen 361005, China) Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China

Using Na15NO3 and 15NH4Cl as tracer, we studied the transfer of 15N along the food chain composed oforganisms such as Platymonas subcordiformis, Artemia salina, Penaeus penicillatus and Liza carinatus . The abundanceand atomic percentage of 15N in each organism, as well as the transfer of 15N among different biological phases weremeasured. Results show that, in the nutrient transfer from low level to high level along the md chain in the mediaof 15NH4Cl, the transfer rate of Artemia salina→Liza carinatus exceeded 3% and was higher than that in Na15NO3; the accumulation of 15N in the bodies of Liza carinatus with 15NH4Cl as media was also higher than that withNa 15NO3 as media.

关键词： Stable isotopic tracing food chain material circulation mariculture ecology

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Ontogenetic resource use and trophic dynamics of endangered juvenile Tachypleus tridentatus among diversified nursery habitats in the northern Beibu Gulf,China

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Integrative Zoology 2021年第6期16卷 908-928页

作者： Kit Yue KWAN Justin BOPP Shuyan HUANG Qiao CHEN Chun-Chieh WANG Xueping WANG wenquan ZHEN Junhua ZHU Xing HUANG College of Marine Sciences Beibu Gulf UniversityQinzhouChina Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation QinzhouChina School of Marine and Atmospheric Sciences Stony Brook UniversityStony BrookNew YorkUSA Futian-CityU Mangrove R&D Center City University of Hong Kong Shenzhen Research InstituteShenzhenChina Guangxi Key Laboratory of Marine Environmental Science Guangxi Beibu Gulf Marine Research CenterGuangxi Academy of SciencesNanningChina Guangxi Key Laboratory of Marine Disaster in the Beibu Gulf QinzhouChina

Horseshoe crabs,the most well-known example of“living fossils”,are iconic and ecologically important macroinvertebrates in coastal and estuarine *** blood is a crucial resource for manufacturing Limulus or Tachypleus amebocyte lysate to detect bacterial endotoxins or fungal contamination in drug and medical *** enhanced understanding of their ecological roles and trophic interactions in the food webs is fundamental to facilitate resource management for the declining populations in *** information of the Asian species,however,is mainly derived from preliminary,scattered reports from a limited number of study *** this study,resource utilization,trophic niche dynamics,and trophic interaction of the juvenile tri-spine horseshoe crab,Tachypleus tridentatus(instars 1–12,approximately 0.5–8 years old)across ontogeny was assessed in diversified nursery habitats along the northern Beibu Gulf,China,using carbon and nitrogen stable *** results suggest that:(i)*** are ecological generalists given the vast range of carbon isotopic values and trophic niche width estimates exhibited between multiple instar groups;(ii)juvenile *** across most habitat types predominantly assimilated energy from a variety of basal production sources in the food web,but primarily depended on sedimentary organic matter and seagrass resource pools;(iii)ontogenetic shifts in juvenile dietary proportions were evident,with decreased reliance on sedimentary organic matter,coupled with increased reliance on benthic macroinvertebrate grazers,detritivores,and omnivores with age;and(iv)nearly all juvenile instars occupied similar trophic positions in the food web with slight shifts in trophic position present with increasing *** findings indicate that resource availability and ontogenetic diet shifts strongly influence horseshoe crab trophic dynamics,and age should be accounted when formulating habitat conservation measures based on resour

关键词： intertidal food webs ontogenetic shift stable isotopes Tachypleus tridentatus trophic niche width

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微型锚钉环绕法结合中节指骨克氏针内固定治疗近指间关节Ⅱ、Ⅲ型掌板损伤

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中华手外科杂志 2023年第3期39卷 237-239页

作者：王晓峰薛建波丁文全周映玲陈宏宁波市第六医院手外科宁波315040

目的探讨锚钉环绕法结合中节指骨克氏针内固定修复掌侧稳定结构治疗近指间关节Ⅱ、Ⅲ型掌板损伤的疗效.方法自2018年1月至2021年10月,我们共收治37例40指闭合性近指间关节Ⅱ、Ⅲ型掌板损伤的患者,用克氏针固定中节指骨基底骨折,两枚微... 详细信息

目的探讨锚钉环绕法结合中节指骨克氏针内固定修复掌侧稳定结构治疗近指间关节Ⅱ、Ⅲ型掌板损伤的疗效.方法自2018年1月至2021年10月,我们共收治37例40指闭合性近指间关节Ⅱ、Ⅲ型掌板损伤的患者,用克氏针固定中节指骨基底骨折,两枚微型锚钉环绕法修复掌板来复位,稳定近指间关节,不固定近指间关节下进行术后早期系统性关节活动康复锻炼,12周后随访指体功能恢复情况,评价临床疗效.结果术后伤口均Ⅰ期愈合,随访时间为6~14个月,平均为10个月.骨折愈合时间为6~8周,平均7周.无一例发生骨髓炎及骨折畸形愈合,关节功能恢复良好,按TAM标准评定手功能:优24例,良9例,差4例,优良率为89.2%.结论微型锚钉环绕法结合中节指骨克氏针内固定修复掌侧稳定结构治疗近指间关节Ⅱ、Ⅲ型掌板损伤,能有效固定骨折及关节脱位,在不固定近指间关节下能早期进行手指关节功能康复锻炼,术后指间关节功能恢复良好.

关键词：掌板治疗结果近指间关节骨折微型锚钉环绕法

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Report of 2.7 Ga zircon U-Pb age of orthogneiss in the wenquan metamorphic complex,West Tianshan,China

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China Geology 2023年第1期6卷 168-170页

作者： Chu Wu Tao hong Xing-wang Xu Cheng-xi Wang Lian-hui Dong Development and Research Center of China Geological Survey Beijing 100037China Guangdong Provincial Key Lab of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Institutions of Earth Science Chinese Academy of SciencesBeijing 100029China Xinjiang Bureau of Geology and Mineral Resources UrumqiXinjiang 830000China

*** The wenquan Group is one of the important medium-to low-grade metamorphic units within the wenquan metamorphic complexes which distributes in Chinese segment of the Tianshan Belt,the southern part of the Central Asian Orogenic *** mainly consists of pre-Neoproterozoic metamorphosed volcanic and sedimentary rocks(Wang B et al.,2014).

关键词： Tianshan metamorphic zircon

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