检索结果-南通市图书馆

Analysis of genotype polymorphism of tumor-related genes harbored in chromosome arm 1p and 8p in hepatocellular carcinoma patients by cSNP chip

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2009年第1期4卷 82-88页

作者： Juan WANG wenqin song College of Life Sciences Shenzhen UniversityShenzhen 518060China College of Life Sciences Nankai UniversityTianjin 300710China

The majority of single nucleotide polymorphisms(SNPs)found in the coding region(cSNPs)are single base substitutions that may or may not lead to amino acid substitutions,most of which are related to *** cSNPs may prove useful for their potential links to functional cSNPs via linkage disequilibrium *** have selected 48 cSNPs located in the coding regions of 25 genes to construct the cSNP *** genes are harbored in the high frequency loss regions of the chromosome 1p and 8p and related with apoptosis,cell cycles,signal transduction,oncogene,tumor suppressor genes and so *** of the cSNPs can lead to amino acid substitutions except TP73(rs1801174).The PCR products amplified from 31 hepatocellular carcinoma(HCC)specimens were labeled with Dig-dUTP and then hybridized with the cSNP *** results showed that there was no hybridization signal when there was more than one site of mutation in the amplification sequence,indicating that the cSNP chip had a high *** statistic data of the SNP(MT,homozygous and HT,heterozygous)in the HCC patients with different phenotypes(HBV+/-,differentiation stage,family history positive or negative,tumor size)indicated that the number of MT was distinctly different between patients with positive HBV and negative *** MT and HT numbers of all the 48 cSNPs were significantly different between low differentiation and high differentiation HCC *** numbers of MT and HT were not different between positived and negative family history groups and between tumor size>3 cm and≤3 cm *** study results provided useful information for understanding the molecular mechanisms of HCC development.

关键词： polymorphism hepatocellular carcinoma single nucleotide polymorphisms(SNPs)in coding region(cSNPs) tumor-related genes 1p and 8p

基于改进CART算法的退役动力电池等级筛选方法

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

燕山大学学报 2024年第1期48卷 48-53,76页

作者：刘永成刘杰文杨茜宋汶秦郭永吉王兴贵国网甘肃省电力公司经济技术研究院甘肃兰州730050 兰州理工大学电气工程与信息工程学院甘肃兰州730050

针对退役动力电池存在一致性差、等级筛选效率低的难题,提出了一种基于改进CART算法的退役动力电池等级筛选方法。首先,分析了传统CART算法的基本原理,为克服算法计算量大的缺陷,将Fayyad边界点判定定理与CART算法相结合,通过选取属性... 详细信息

针对退役动力电池存在一致性差、等级筛选效率低的难题,提出了一种基于改进CART算法的退役动力电池等级筛选方法。首先,分析了传统CART算法的基本原理,为克服算法计算量大的缺陷,将Fayyad边界点判定定理与CART算法相结合,通过选取属性最优阈值点来减少计算量,提高分类效率;其次,基于代价复杂度后剪枝算法,采用交叉验证法对算法进行进一步优化;最后,将改进CART算法用于退役动力电池筛选分类,实验结果表明改进CART算法在保持较高准确率的情况下,可以有效提高退役动力电池的等级筛选效率。

关键词：退役动力电池等级筛选改进CART算法最优阈值点

Homologous analysis on centromeric region sequences of A and B chromosomes from rye by FISH

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1999年第8期44卷 704-707页

作者： Rongxin Zhang Chengbin Chen wenqin song Xiulan Li Ruiyang Chen Nankai Univ Dept Biol Tianjin 300071 Peoples R China

Four centromeric segments from B chromosomes (Bs) of rye have been microdis-sected and amplified by linker adapter PCR (LA-PCR). The PCR products ranged from 100 to 2 000 bp. Fluorescence in situ hybridization (FISH) experiment has been carried out using PCR products as the probe, which was labeled by DIG-11-dUTP. The result confirms that these PCR products from Bs centromeric region are homologous with that of A chromosomes (As) in rye. It also proves that Bs are originated from As.

关键词： B chromosome of rye centromeric region microdissection homology FISH.

Polymorphism attribution of cSNPs in cancer-related genes located in loss regions with a high frequency of HCC between HBV and health groups

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2007年第3期2卷 272-275页

作者： WANG Juan NI Hong CHEN Li CHEN Chengbin song wenqin College of Life Sciences Nankai UniversityTianjin 300071China

Cancer-related genes harbored in the loss regions containing a high frequency of hepatocellular carcinoma(HCC)were *** information was gathered and the coding single nucleotide polymorphism(cSNP)sequenc-es were obtained from the single nucleotide polymorphism(SNP)*** appropriate primers and oligonucleotide probes were then designed in accordance with the SNP sites,and subsequently,the gene chips for detecting SNPs were *** DNA was extracted from blood sam-ples of healthy controls and from patients with HBV *** sequences,including the SNPs,were amplified via polymerase chain reaction(PCR)and labeled using digoxi-genin deoxyuridine tri-phosphate(Dig-dUTP).The labeled products were then hybridized with the SNP *** confirmed that the differences in allele frequencies of three SNPs EGFL3(rs947345),Caspase9(rs2308950),and E2F2(rs3218171)were distinct between HBV-infected patients and controls,suggesting that these SNPs ocuring in high frequency in HBV-infected individuals may be associated with susceptibility to HCC.

关键词： tumor-associated genes Hepatocellular B virus(HBV) single nucleotide polymorphism(SNP) susceptibility

右美托咪定与甲苯磺酸瑞马唑仑对麻醉恢复室成人苏醒期躁动的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

神经损伤与功能重建 2024年第8期19卷 452-456,492页

作者：汤艳辉李思琪黄丽丹宋文沁付湘云湖北省武汉市第九医院麻醉科武汉430081 湖北省武汉大学人民医院麻醉科武汉430060

目的:研究右美托咪定与甲苯磺酸瑞马唑仑对麻醉恢复室苏醒期躁动的影响。方法:本研究为单中心、双盲、随机对照临床研究。纳入麻醉恢复室发生急性躁动且符合纳入和排除标准的患者186例,随机分入甲苯磺酸瑞马唑仑组(R组)和右美托咪定组(D... 详细信息

目的:研究右美托咪定与甲苯磺酸瑞马唑仑对麻醉恢复室苏醒期躁动的影响。方法:本研究为单中心、双盲、随机对照临床研究。纳入麻醉恢复室发生急性躁动且符合纳入和排除标准的患者186例,随机分入甲苯磺酸瑞马唑仑组(R组)和右美托咪定组(D组)。分别静脉给予甲苯磺酸瑞马唑仑(0.1 mg/kg)或右美托咪定(0.4μg/kg),若患者未入睡,再重复给予上述剂量至患者入睡;之后持续泵注甲苯磺酸瑞马唑仑(20 mg/h)或右美托咪定(80μg/h)30 min。收集治疗期间生命体征、手术时间、手术类型、数字疼痛强度量表(numeric rating scale,NRS)评分、里士满焦虑量表(Richmond Agitation Sedation Scale,RASS)分级、4AT评分、用药次数、起效时间和苏醒时间,术后第1天~第3天对患者进行4AT测试、评估不良事件,记录住院时间数据。结果:最终158例完成研究,R组和D组各79例。2组一般资料差异无统计学意义(P>0.05)。R组用药次数低于D组(P0.05)。患者入睡(T2)及持续泵注10 min(T3)时,D组MBP高于R组,HR低于R组(P0.05)。在治疗期间D组窦性心动过缓的发生率高于R组,高血压的发生率也高于R组,低血压的发生率低于R组(均P0.05)。EA发生后药物治疗前,2组患者谵妄的发生率在差异无统计学意义(P>0.05);但经甲苯磺酸瑞马唑仑或右美托咪定治疗后,谵妄发生概率明显降低(P<0.05)。结论:甲苯磺酸瑞马唑仑和右美托咪定均对麻醉恢复室发生的EA有较好的疗效,甲苯磺酸瑞马唑仑起效更快、对循环的抑制更轻。

关键词：急性躁动右美托咪定甲苯磺酸瑞马唑仑

维普期刊数据库博看期刊

基于深度强化学习算法的储能系统盈利策略研究

在线全文

学校读者我要写书评

暂无评论

电力需求侧管理 2024年第2期26卷 20-26页

作者：杨国山董鹏旭姚苏航王永利宋汶秦周东国网甘肃省电力公司经济技术研究院兰州730050 华北电力大学经济与管理学院北京102206

在高比例新能源接入下,配置储能可以辅助电力系统削峰填谷,平抑波动。然而目前储能系统成本较高,需要政府进行支持。为此,提出了一种储能盈利策略,以在电网、储能运营商和用户组成的电力市场中实现运营利润最大化。结合智能算法提出了... 详细信息

在高比例新能源接入下,配置储能可以辅助电力系统削峰填谷,平抑波动。然而目前储能系统成本较高,需要政府进行支持。为此,提出了一种储能盈利策略,以在电网、储能运营商和用户组成的电力市场中实现运营利润最大化。结合智能算法提出了一种考虑激励的盈利策略,为每个峰值时段的储能系统运营商提供不同权重的奖励分配。该算法一方面基于最小二乘支持向量机的深度学习,来建立价格和负荷预测模型;另一方面基于深度强化学习,考虑电网的峰值状态、用户负荷需求和储能系统运营商利润,确定最优充放电策略。最后通过案例分析,验证该策略可以显著提高储能系统运营商利润并减轻电网压力。

关键词：储能系统盈利策略支持向量机深度强化学习算法

Biochemical analysis of argyrophilic nonhistone proteins in chromosomes of plant Triticum aestivum

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第17期42卷 1476-1481页

作者： PENG Yongkang, YU Jianchun, JIN Shaobo, ZHAO Jian, song wenqin and CHEN RuiyangDepartment of Biology, Nankai University, Tianjin 300071, China Department of Biology Nankai University Tianjin China

IN the late 1970s, biochemical analysis and electron microscopy of isolated, histone-depleted mitotic chromosomes demonstrated the existence of a central scaffold consisting mainly of nonhistone proteins (NHPs) in metaphase chromosomes. Subsequently, by using silver impregnation techniques and light microscopy, Howell et al. showed the presence of an axial chromatid core in relatively intact chromosomes of mammals; this core is believed to be

关键词： plant chromosome nonhistone chromosomal protein argyrophilic protein mitotic synchronization Triticumaestivum.

在线全文

学校读者我要写书评

暂无评论

邱祖萍三联疗法治疗腰椎间盘突出症经验撷菁

上海中医药杂志 2024年第10期58卷 51-54页

作者：陶燕华施玲玲陆梅宋文琴刘岳邱祖萍南通市通州区中医院江苏省名老中医药专家传承工作室

腰椎间盘突出症为现代常见病、多发病。邱祖萍教授在其研发的“921镇痛膏”技术成果的基础上，创制出一套适用于腰椎间盘突出症的“穴位靶向注射+中药透皮+汤药内调”的三联疗法，疗效显著。并附验案1则。

关键词：腰椎间盘突出症痹证 921镇痛膏穴位注射中医药疗法名医经验

Chromosome G-banding in plants by inducing with trypsin and urea

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell Research 1994年第1期4卷 79-87页

作者： CHEN RUITANG wenqin song XIULAN LI ZHUPING AN(Department of Biology, Nankai University, Tianjin 300071, China ) Department of Biology Nankai University Tianjin China

Clear G-bands were revealed by applying the TUG method on chromosomes of 5 species of higher plants (Lilium davdii, Viciafaba, Hordeum vulgare, Ginkgo biloba and Triticum monococcam). Some details of the TUG method which consisted of treating chromosomes with both trypsin and urea were also studied. The mechanisms that might account for the presence of G-bands in plants were discussed.

关键词： G-banding Lilium davidii Vicia faba Hordeum vulgare Ginkgo biloba Triticum monococcum