检索结果-南通市图书馆

Risk factors for sporadic colorectal cancer in southern Chinese

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第20期15卷 2526-2530页

作者： Yi-Sheng Wei Jia-Chun Lu Lei Wang Ping lan Hong-Jun Zhao Zhi-Zhong Pan Jun Huang Jian-Ping Wang Gastrointestinal Institute of Sun Yat-Sen University Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510655 Guangdong Province China Institute for Chemical Carcinogenesis Guangzhou Medical College Guangzhou 510182 Guangdong Province China Department of Abdominal Surgery Sun Yat- Sen University Cancer Center Guangzhou 510060 Guangdong Province China

AIM:To investigate the role of smoking, alcohol drinking, family history of cancer, and body mass index(BMI) in sporadic colorectal cancer in southern ***:A hospital-based case-control study was conducted from July 2002 to December *** were 706 cases and 723 controls with their sex and age(within 5 years) *** unconditional logistic regression model was used to analyze the association between smoking, alcohol drinking, family history of cancer, BMI and sporadic colorectal ***:No positive association was observed between smoking status and sporadic colorectal cancer *** with the non alcohol drinkers, the current and former alcohol drinkers had an increased risk of developing sporadic colorectal cancer(CRC)(adjusted OR = 8.61 and 95% CI = 6.15-12.05;adjusted OR = 2.30, 95% CI = 1.27-4.17).Moreover, the increased risk of developing sporadic CRC was significant in those with a positive family history of cancer(adjusted OR = 1.62, 95% CI = 1.12-3.34) and in those with their BMI ≥ 24.0 kg/m2(adjusted OR = 1.39, 95% CI = 1.10-1.75).Stratification analysis showed that the risk of developing both colon and rectal cancers was increased in current alcohol drinkers(adjusted OR = 7.60 and 95% CI = 5.13-11.25;adjusted OR = 7.52 and 95% CI = 5.13-11.01) and in those with their BMI ≥ 24.0 kg/m2(adjusted OR = 1.38 and 95% CI = 1.04-1.83;adjusted OR = 1.35 and 95% CI = 1.02-1.79).The risk of developing colon cancer, but not rectal cancer, was found in former alcohol drinkers and in those with a positive family history of cancer(adjusted OR = 2.51 and 95% CI = 1.24-5.07;adjusted OR = 1.82 and 95% CI = 1.17-2.82).CONCLUSION:Alcohol drinking, high BMI(≥ 24.0 kg/m2) and positive family history of cancer are the independent risk factors for colorectal cancer in southern Chinese.

关键词： Case-control Colorectal cancer Risk factors Smoking Alcohol drinking Body mass index Family history

Expression of Vascular Endothelial Growth Factor C and Its Clinical Significance in Human Esophageal Squamous Cell Carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Clinical Oncology 2007年第2期4卷 83-88页

作者： Hongxin Zhang lan Zhang Kuisheng Chen Dongling Gao Fucheng He Yunhan Zhang Department of Pathology the First Affiliated Hospital Zhengzhou University Henan Key Laboratory of Tumor Pathology Zhengzhou 450052 China Department of Clinical Laboratory the First Affiliated Hospital Zhengzhou University Zhengzhou 450052 China

OBJECTIVE To examine the expression of vascular endothelial growth factor C （VEGF-C） in human esophageal squamous cell carcinoma （ESCC）, and to clarify its role in lymphatic metastasis in ESCC patients.METHODS Esophageal carcinoma EC9706 cells and samples from 49 patients with primary ESCC were investigated by using S-P immunohistochemistry （IHC）, the semi-quantitative reverse transcriptase-polymerase chain reaction （RT-PCR） and in situ hybridization （ISH） methods for VEGF-C expression. RESULTS VEGF-C positive expression was found in EC9706 cells through IHC, ISH and RT-PCR. Positive IHC for VEGF-C was observed in 36 of 49 cases of ESCC. There was a significant difference between the expression of VEGF-C in a lymph-node-positive group compared to a node-negative group （χ^2=4.7, P〈0.05）. Positive ISH for VEGF-C mRNA was observed in 23 of 49 cases of ESCC. There was a significant difference between the expression of VEGF-C in the lymph-node-positive group and node-negative group （χ^2=31.3, P〈0.01）. The expression of VEGF-C was significantly higher in the lymph-node-positive group compared to the node-negative group. Of 49 ESCC tissues, RT-PCR for VEGF-C mRNA was observed positively in 29 cases. There was a significant difference between the expression of VEGF-C in the lymph-node-positive group and node-negative group （χ^2=23.3, P〈0.01）. The expression of VEGF-C was significantly higher in the lymphnode-positive group compared to the node-negative group. Expressions of VEGF-C were not significantly associated with age, gender, and pathological grade. There was a relationship between VEGF-C mRNA expressions by RT-PCR and ISH （χ^2=18.5, P〈0.01） in ESCC cases, but with no significant difference between the two methods. CONCLUSION VEGF-C expression may induce lymphangiogenesis in human ESCC. There was a close correlation between VEGF-C expression and lymph node metastasis. VEGF-C can serve as a useful prognostic factor for ESCC patients.

关键词： esophageal squamous cell carcinoma(ESCC) esophageal cancer EC9706 cells vascular endothelial growth factor C (VEGF-C) lymphatic metastasis immunohistochemistry (IHC) RT-PCR in situ hybridization (ISH).

Widely targeted metabolomics analysis of the effects of probiotic fermentation on the phytochemicals of kiwifruit juice and prediction of key metabolic pathways

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Tian lan Qinyu Zhao Jiaqi Wang Xiangyu Sun Yulin Fang Tingting Ma College of Food Science and Engineering， Northwest A&F University College of Enology， Northwest A&F University

Metabolomics can be used to identify the changes and metabolic pathways of nutrients and flavor substances in foods at specific processing or fermentation stages. This study revealed the accumulation and degradation of phytochemicals during the fermentation of kiwifruit juice (KJ) by lactic acid bacteria (LAB) through widely targeted metabolomics and explored the impact of different fermentation strategies on the nutritional quality and functional characteristics of KJ. LAB utilized the original sugars， acids， amino acids， and nucleotides of the matrix to produce numerous bioactive compounds， including phenols， organic acids， free fatty acids， and vitamins， while achieving bacterial proliferation and reduced anti-nutritional factors such as alkaloids， thus improving the nutritional and functional properties of KJ. Moreover， compared with monoculture fermentation， mixed fermentation promoted the production of more biologically active phenols and alkaloids， among which vanillic acid and luteolin-8-C-arabinoside were the characteristic metabolites of mixed and mono- fermentation. Subsequently， the metabolic pathways of key metabolites were predicted， including the glycolytic Embden–Meyerhof–Parnas pathway， pentose phosphoketolase pathway， organic acid metabolic and arginine deiminase pathways for improving the acid resistance of LAB， and the phenolic-acid–based phenylalanine and tyrosine metabolic pathway.

关键词：

Polarization Jitters Caused by Fiber Nonlinearity in PM Optical Communication System

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optics and Photonics Journal 2013年第2期3卷 202-208页

作者： lan-lan Liu Chong-Qing Wu Wei Yang Jian Wang Guo-Dong Liu Institute of Optical Information School of Science Beijing Jiaotong University Key Lab of Education Ministry on Luminescence and Optical Information Technology Beijing China

The phenomenon of polarization jitters caused by fiber nonlinearity is investigated. A general formula about the polarization jitter is concluded in polarization multiplexing (PM) system based on two orthogonal linear polarization states when the best polarization correction is used. A 100 Gb/s PM system based on NRZ code is investigated by simulation, and the Stocks parameter about polarization jitter and Poincare sphere diagrams are got for different power and phase difference of two orthogonal polarized light. The results show that the polarization jitters will be suppressed when the combined PM signal is the linear or circular polarization state.

关键词： Optical Fiber Communication Polarization Multiplexing (PM) Fiber Nonlinearity Nonlinear Polarization Jitter

Role of defensins in diabetic wound healing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2022年第11期13卷 962-971页

作者： Zhi-Xiang Tan Rui Tao Si-Cheng Li Bing-Zheng Shen lan-Xia Meng Zhan-Yong Zhu Department of Plastic Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pharmacy Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

The adverse consequences resulting from diabetes are often presented as severe *** wounds are one of the most commonly occurring complications in diabetes,and the control and treatment of this is *** to a series of pathophysiological mechanisms,diabetic wounds remain in the inflammatory phase for a prolonged period of time,and face difficulty in entering the proliferative phase,thus leading to chronic non-healing *** current consensus on the treatment of diabetic wounds is through multidisciplinary comprehensive management,however,standard wound treatment methods are still limited and therefore,more effective methods are *** recent years,defensins have been found to play diverse roles in a variety of diseases;however,the molecular mechanisms underlying these activities are still largely *** can be constitutively or inductively produced in the skin,therefore,their local distribution is affected by the microenvironment of these diabetic *** evidence suggests that defensins are involved in the diabetic wound pathogenesis,and can potentially promote the early completion of each stage,thus making research on defensins a promising area for developing novel treatments for diabetic *** this review,we describe the complex function of human defensins in the development of diabetic wounds,and suggest potential therapeutic benefits.

关键词： Defensin Diabetic wound Wound healing Inflammation Re-epithelialization Tissue regeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

网络中的最优控制树问题

系统工程理论与实践 2006年第5期26卷 83-87页

作者：林浩林澜河南工业大学理学院河南郑州450052 同济大学计算机科学与工程系上海200092

众所周知,从通讯网络建设中提出著名的最优支撑树问题,即在一个赋权连通图中求一个包含所有顶点而权(费用)最小的连通子图(支撑树).进而,在交通、通讯、供销系统的干线设计中,考虑的连线(干线)不一定连接网络的所有顶点,但被连接的顶点... 详细信息

众所周知,从通讯网络建设中提出著名的最优支撑树问题,即在一个赋权连通图中求一个包含所有顶点而权(费用)最小的连通子图(支撑树).进而,在交通、通讯、供销系统的干线设计中,考虑的连线(干线)不一定连接网络的所有顶点,但被连接的顶点必须构成一个控制集,即其余任一顶点都有一条边直接与此主干部分相连.这就提出了最优控制树问题.似乎此问题与最优支撑树问题十分类似,但我们将证明它是NP-困难的,并给出一个分枝定界算法及相关性质.

关键词：网络优化支撑树控制树计算复杂性分枝定界算法

Effect of Seismic Permanent Deformation on Safety and Stability of Earth-Rock Dam Slope

在线全文

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2015年第2期21卷 167-171页

作者：戚蓝陈启振蔡建成 State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Management Bureau of Panjiakou Reservoir

In order to study the effect of seismic permanent deformation on the safety and stability of earth-rock dam, the permanent deformation is considered as the non-design permanent load, and the stress-strain hysteresis curve is also considered when the earth is under cyclic load. The research work can make the calculation results of plastic collapse more accurate by including the effect of the post-earthquake degree of plastic deformation on the stability of the earth-rock dam, and the dam safety factor decreases from 2.50 to 1.90 after the magnitude-8 earthquake. Moreover, the research work will also improve the design of the earth-rock dam under abnormal operating conditions.

关键词： earthquake permanent deformation earth-rock dam safety factor sensitivity analysis

Towards a Public Management Paradigm for Global Governance： An Analysis Based on an Issue-Actor-Mechanism Framework

在线全文

学校读者我要写书评

暂无评论

Social Sciences in China 2017年第1期38卷 26-45页

作者： Xue lan Yu Hanzhi School of Public Policy & Management Tsinghua University

The concept of global governance first appeared in research on international political governance in the early 1990s. At the time much of the theoretical research on global governance was to some extent isolated from the realities of world development, but since the beginning of the 21th century, global governance research has been turning to real world issues, We propose the construction, from a public management perspective, of a governance ＂issue-actor-mechanism＂ framework. This sees postwar global governance practice as the old paradigm. The paper points out that the rapid global development after the end of the Cold War has had a crucial impact on the traditional governance paradigm, followed by the emergence of new global governance issues and changes in new governance actors resulting from the changing world of the last twenty or thirty years which have led to the failure of traditional governance mechanisms. These ＂issue-actor-mechanism＂ changes are closely interlocked, and hence require a new global governance paradigm that can reflect the complex interconnections of governance issues, actors and mechanisms. We thus need to reexamine and refresh our perceptions of the world and open up a new research agenda.

关键词： global governance public management issue-actor-mechanism framework paradigm shift world changes

Polyacrylamide gel migration after injection for breast augmentation:A case report

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Plastic and Reconstructive Surgery 2022年第1期4卷 20-24页

作者： Rongshuai Yan Yujie lan Zeyuan Lei Yao Chen Dongli Fan Yiming Zhang Shaoliang Wang Department of Plastic and Cosmetic Surgery Xinqiao HospitalArmy Medical UniversityChongqing 400037China

Polyacrylamide hydrogel(PAAG)was once considered a safe,reliable,and compatible injected filler and was widely used in breast augmentation,rhinoplasty,and other cosmetic ***,numerous complications,such as implant migration,have been observed after PAAG ***,we report a rare case of distant implant migration after PAAG injection for breast augmentation in which the material became displaced along the abdominal wall to the perineum and pelvic extraperitoneal *** a well-prepared preoperative evaluation involving magnetic resonance imaging(MRI)and computed tomography(CT)examinations and threedimensional hologram,debridement surgery was performed to remove the injected *** the operation,the patient was followed up for two years and was not scheduled for a second *** complications of breast augmentation after PAAG injection,especially gel migration,still affect thousands of *** material migration occurs,surgical removal becomes *** diagnosis and treatment are recommended.

关键词： Polyacrylamide hydrogel Surgical complication Material migration Breast augmentation