Risk factors for sporadic colorectal cancer in southern Chinese

作     者：Yi-Sheng Wei Jia-Chun Lu Lei Wang Ping Lan Hong-Jun Zhao Zhi-Zhong Pan Jun Huang Jian-Ping Wang 

作者机构：Gastrointestinal Institute of Sun Yat-Sen University Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510655 Guangdong Province China Institute for Chemical Carcinogenesis Guangzhou Medical College Guangzhou 510182 Guangdong Province China Department of Abdominal Surgery Sun Yat- Sen University Cancer Center Guangzhou 510060 Guangdong Province China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第20期

页      面：2526-2530页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071005[理学-微生物学] 

基　　金：Supported by Grants from Guangdong Provincial Scientific Research, No. 06104601 the National Natural Science Foundation of China, No. 30872488, 30671813 and 30872178 

主　　题：危险因素 大肠癌 散发性 华南 

摘      要：AIM:To investigate the role of smoking, alcohol drinking, family history of cancer, and body mass index(BMI) in sporadic colorectal cancer in southern Chinese.METHODS:A hospital-based case-control study was conducted from July 2002 to December 2008.There were 706 cases and 723 controls with their sex and age(within 5 years) matched.An unconditional logistic regression model was used to analyze the association between smoking, alcohol drinking, family history of cancer, BMI and sporadic colorectal cancer.RESULTS:No positive association was observed between smoking status and sporadic colorectal cancer risk.Compared with the non alcohol drinkers, the current and former alcohol drinkers had an increased risk of developing sporadic colorectal cancer(CRC)(adjusted OR = 8.61 and 95% CI = 6.15-12.05;adjusted OR = 2.30, 95% CI = 1.27-4.17).Moreover, the increased risk of developing sporadic CRC was significant in those with a positive family history of cancer(adjusted OR = 1.62, 95% CI = 1.12-3.34) and in those with their BMI ≥ 24.0 kg/m2(adjusted OR = 1.39, 95% CI = 1.10-1.75).Stratification analysis showed that the risk of developing both colon and rectal cancers was increased in current alcohol drinkers(adjusted OR = 7.60 and 95% CI = 5.13-11.25;adjusted OR = 7.52 and 95% CI = 5.13-11.01) and in those with their BMI ≥ 24.0 kg/m2(adjusted OR = 1.38 and 95% CI = 1.04-1.83;adjusted OR = 1.35 and 95% CI = 1.02-1.79).The risk of developing colon cancer, but not rectal cancer, was found in former alcohol drinkers and in those with a positive family history of cancer(adjusted OR = 2.51 and 95% CI = 1.24-5.07;adjusted OR = 1.82 and 95% CI = 1.17-2.82).CONCLUSION:Alcohol drinking, high BMI(≥ 24.0 kg/m2) and positive family history of cancer are the independent risk factors for colorectal cancer in southern Chinese.