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乳腺癌患者的青少年子女心理体验质性研究的Meta整合

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中华护理杂志 2024年第8期59卷 1005-1012页

作者：张倩高文娟韩静徐州医科大学护理学院徐州市221004

目的系统评价与整合乳腺癌患者的青少年子女心理体验的质性研究,为进一步开展家庭康复干预提供依据。方法检索PubMed、Web of Science、Cochrane Library、Embase、CINAHL、澳大利亚乔安娜布里格斯研究(Joanna Briggs Institute,JBI)循... 详细信息

目的系统评价与整合乳腺癌患者的青少年子女心理体验的质性研究,为进一步开展家庭康复干预提供依据。方法检索PubMed、Web of Science、Cochrane Library、Embase、CINAHL、澳大利亚乔安娜布里格斯研究(Joanna Briggs Institute,JBI)循证卫生保健中心数据库、中国知网、万方数据库、维普数据库和中国生物医学文献数据库中关于乳腺癌患者的子女在母亲罹患乳腺癌后的经历与感受的质性研究。检索时限为建库至2.2.年10月。采用2.2.版JBI的质性研究质量评价标准对纳入文献进行方法学质量评价,采用汇集性整合方法对原始研究结果进行整合。结果共纳入10篇文献,提炼出49个结果,归纳形成10个类别,综合成4个整合结果:觉察到母亲罹患乳腺癌带来的变化与新需求;体验到负性情绪与遗传担忧;努力应对母亲罹患乳腺癌后的生活;发现母亲罹患乳腺癌带来的积极意义。结论医护人员应重视乳腺癌患者的青少年子女的心理健康,提供相应的心理支持与健康指导,促进其积极适应母亲罹患乳腺癌后的生活。

关键词：乳腺肿瘤子女心理体验质性研究 Meta整合

Pathogenicity Analysis on Magnaporthe oryzae from Hybrid Combination Wuyou 308

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Agricultural Biotechnology 2024年第4期13卷 11-13,17页

作者： Kailing CHEN Bing CHEN Xiaopeng LIN wenjuan WANG Xiaoyuan ZHU Jianyuan YANG Jing SU Guangdong Provincial Key Laboratory of High Technology for Plant Protection Plant Protection Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China

Eighteen blast isolates were obtained from hybrid combination Wuyou308 using the Magnaporthe oryzae pathogen isolation *** identification of these isolates was conducted based on seven Chinese blast differentials and 11 blast monogenic *** results indicated that the isolates were identified as the races of ZB13,ZB15 and ZC13,accounting for 66.67%,2..78%,5.56%,respectively,and the resistance genes including Pi-ta2.and Pi-sh,Pi-i were highly susceptible to these isolates,while the resistance genes like Pi-kh,Pi-1,Pi2.Pi-9 and Pi-50 showed good resistance to tested *** isolates were compatible to the original rice hybrid *** isolates including GDHY-308-1401 were used for testing their pathogenicity to 45 local *** results demonstrated that 13 varieties appeared highly susceptible to the tested isolates,accounting for 2..89%;two varieties appeared moderately susceptible to the tested isolates,accounting for 4.44%;30 varieties showed moderately/highly resistance,accounting for 66.67%.Among them,some of new hybrid combinations such as Wufengyou 9802.Wuyou 613,Wuyou 1179 showed good resistance to the inoculated strains,and they were recommended to be candidates in the rice region where Wuyou308 showed susceptibility.

关键词： Wuyou308 Magnaporthe grisea Pathogenicity Rice variety Combination

The BCL-2.inhibitor APG-2.75 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan Luo Han Li wenjuan Ma Jiaxin Cao Qun Chen Feiteng Lu Miaozhen Qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua Zhan Ting Zhou Qiuyun Luo Wentao Pan Lin Zhang Chaozhuo Lin Yan Huang Li Zhang Dajun Yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2.inhibitor APG-2.75 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APG-2.75 polarized M2.like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2.75 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2.75-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD2.6 expression on ***,these data provide evidence that further study on APG-2.75 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2.75 ICIs Macrophages NLRP3

Cellular metabolism: A key player in cancer ferroptosis

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Cancer Communications 2024年第2期44卷 185-204页

作者： Xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Public Service Platform of Tumor Organoids Technology ChangshaHunanP.R.China Department of Head and Neck Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Hengyang Medical School University of South ChinaHengyangHunanP.R.China

Cellular metabolism is the fundamental process by which cells maintain growth and *** produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular *** metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell *** is a recently discovered form of iron-dependent programmed cell *** inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor ***,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well ***,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this ***,we provided a detailed overview of agents used to induce cancer *** explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell *** combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

关键词： cancer therapy cellular metabolism ferroptosis inducer ferroptosis

Co-enhancement of thermal conduction and radiation through morphologies controlling of graphene functional layer for chip thermal management

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Nano Research 2024年第10期17卷 8885-8892页

作者： Shuting Cheng Kun Wang Shichen Xu Yi Cheng Ruojuan Liu Kewen Huang Hao Yuan wenjuan Li Yuyao Yang Fushun Liang Fan Yang Kangyi Zheng Zhiwei Liang Ce Tu Mengxiong Liu Xiaomin Yang Jingnan Wang Xuzhao Gai Yuejie Zhao Xiaobai Wang Yue Qi Zhongfan Liu State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing 102249China Centre for Nanochemistry Beijing Science and Engineering Centre for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute(BGI) Beijing 100095China College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)Jiangsu Provincial Key Laboratory for Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySuzhou 215006China Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China

With the continuous advancements in electronics towards downsizing and integration,efficient thermal dissipation from chips has emerged as a critical factor affecting their lifespan and operational *** fan-less chip cooling system has two critical interfaces for thermal transport,which are the contact interface between the base and the chip dominated by thermal conduction,and the surface of the fins dominated by thermal *** different thermal transfer modes of these two critical interfaces pose different requirements for thermal management *** the study,a novel approach was proposed by developing graphene thermal transport functional material whose morphology could be intentionally designed via reformed plasmaenhanced chemical vapor deposition(PECVD)methods to meet the diverse requirements of heat transfer ***,graphene with multilevel branching structure of vertical graphene(BVG)was fabricated through the hydrogenassisted PECVD(H_(2.-PECVD)strategy,which contributed a high emissivity of~*** was deposited on the fins’surface and functioned as the radiation enhanced layer to facilitate the rapid radiation of heat from the heat sinks into the surrounding ***,the well-oriented vertical graphene(OVG)was successfully prepared through the vertical electric field-assisted PECVD process(EF-PECVD),which showed a high directional thermal conductivity of~53.5 W·m^(-1)·K^(-1).OVG was deposited on the contact interface and functioned as the thermal conduction enhanced layer,allowing for the quick transmission of heat from the chip to the heat *** this design concept,the two critical interfaces in the chip cooling system can be jointly enhanced,resulting in a remarkable cooling efficiency enhancement of~30.7%,demonstrating that this novel material possessed enormous potential for enhancing the performance of cooling ***,this research not only provided new design concepts for the cooling system

关键词： chip thermal management thermal conduction thermal radiation graphene morphology control

这一天,值得永恒铭记——写在西藏百万农奴解放纪念日之际

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China's Tibet 2024年第2期35卷 8-11页

作者： Yang Meixiao Huang wenjuan 不详

The year 2.2. marks the 65th anniversary of democratic reform in *** 2.th of this year is the 15th anniversary of establishing the commemoration day for the emancipation of one million serfs in ***'s democratic reform is the greatest and most profound social transformation in the history of *** the leadership of the Communist Party of China(CPC),within just a few decades,these one million former serfs in old Xizang were not only liberated but also transformed into the masters of their nation and society.

关键词： anniversary establishing transformed

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独具魅力的察隅木碗

China's Tibet 2024年第1期35卷 29-33页

作者： Phurbu Dorje Huang wenjuan 不详

From ancient times to the present,the Tibetan people have considered bowls as the most important,beloved,and precious items among their daily ***'s archaeological excavations provide evidence that the traces of stoneand pottery bowls have been found among the ancient Tibetan ancestors dating back to the Neolithic *** era spans from around 5000 BC to 2.00 ***,the cultureof Tibetan bowls can betraced backto 70oo to5000 yearsago.

关键词： Tibetan dating ancient

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墨脱公路通车十周年:高原孤岛变身美丽边城

China's Tibet 2024年第1期35卷 4-11页

作者： Zhao Zhenyu Degyi Drolma Huang wenjuan 不详

Editor's Notes:Medog County in Nyingchi Cityis situated in thesoutheast oftheXizang Autonomous ***,it lies upon the far east of *** andin theheartof the Yarlung Tsangpo Grand Canyon,where multiple ethnic groups reside,such as Monba,Lhopaand *** years ago,Medog was still an almost isolated place due to its poor transportation situation.

关键词： southeast Canyon Tibetan

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雍和宫:沧桑300年

China's Tibet 2024年第2期35卷 38-43页

作者： Zhang Min Zhou Jing Huang wenjuan 不详

Thanks to Prince Yinzhen's ascension to the throne in the winter of 172.(the Yongzheng Year),his palace was subsequently repurposed for official use,later renamed Yonghe *** 1744,it was transformed into a Tibetan Buddhist temple,known today as the Yonghe Lama *** its 300-year history,the temple has experienced both flourishing and lean ***,the Yonghe Lama Temple radiates with vitality in this new era.

关键词： Tibetan 雍和宫 winter