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Relation between stabilization energy, crystal field coefficient and the magnetic exchange interaction for Tb^(3+) ion

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Rare Metals 2006年第z1期25卷 602-604页

作者： ZHANG Xiangmu ma wenjuan CUI Shuwen WANG Lihua Physics Department Cangzhou Normal College Cangzhou 061001 China Physics Department Cangzhou Normal College Cangzhou 061001 China Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China Physics Department Cangzhou Normal College Cangzhou 061001 China

Based on a single ion model, Hamiltonian of the simplest form about magnetocrystalline anisotropy for Tb3+ ion was solved by using the numerical method. The relation between the stabilization energy, crystal field coefficient B20 and the magnetic exchange interaction was studied as temperature approaches to 0 K. The results show that the stabilization energy contributed by Tb3+ is linear with crystal field coefficient B20 approximately, but it is insensitive to the change of magnetic exchange interaction for the strong magnetic substances such as TbCo5, Tb2Co17 and Tb2Fe14B compounds.

关键词： single ion model magnetic exchange interaction crystal field coefficient stabilization energy

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绿色低碳,让城市更美好

科学 2024年第4期76卷 13-15+69页

作者：余兆武马文娟复旦大学环境科学与工程系

随着全球气候变化日益加剧，绿色低碳城市发展已成为当今社会关注的重要议题。研究城市低碳发展不仅有助于缓解全球气候变暖问题，还能促进城市经济、社会和环境的协调发展。因此，探讨绿色低碳城市发展的路径和策略，对于推动全球低碳... 详细信息

随着全球气候变化日益加剧，绿色低碳城市发展已成为当今社会关注的重要议题。研究城市低碳发展不仅有助于缓解全球气候变暖问题，还能促进城市经济、社会和环境的协调发展。因此，探讨绿色低碳城市发展的路径和策略，对于推动全球低碳转型具有重要意义。

关键词：气候变化绿色低碳城市基于自然的解决方案可持续发展

基于金纳米粒子荧光探针可视化快速检测复杂样品中氰化物

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食品与发酵工业 2024年第14期50卷 328-333页

作者：马文娟李蕊岑袁彩霞洪霞王玉何海宁甘肃中商食品质量检验检测有限公司甘肃兰州730010 甘肃省商业科技研究所有限公司甘肃兰州730010 甘肃省平凉市食品检验检测中心甘肃平凉744000

该研究利用水溶性的荧光素异硫氰酸酯(fluorescein isothiocyanate,FITC)覆盖石墨烯负载金纳米粒子复合材料,使探针分子FITC的荧光猝灭。然后,通过向体系中加入氰化物,氰根离子(CN-)对金纳米粒子的强络合作用形成稳定的络合物Au(CN)3-x... 详细信息

该研究利用水溶性的荧光素异硫氰酸酯(fluorescein isothiocyanate,FITC)覆盖石墨烯负载金纳米粒子复合材料,使探针分子FITC的荧光猝灭。然后,通过向体系中加入氰化物,氰根离子(CN-)对金纳米粒子的强络合作用形成稳定的络合物Au(CN)3-x而使探针分子荧光逐渐恢复,以此实现氰化物的快速检测。对试验条件溶液pH值、反应时间、干扰离子进行了优化。试验结果表明,在H_(2)O_(2)存在下,基于FITC-Au NPs荧光探针对CN-最低检测限达到了0.032μmol/L,在0.05~80μmol/L内具有良好的线性关系。利用FITC-Au NPs传感探针的高稳定性和选择性实现了复杂样品中CN-的快速检测。这种简单、快速、经济的荧光传感系统在实际样品中阴离子的检测方面显示出巨大的实用潜力。

关键词：荧光探针氰化物杏仁露异硫氰酸酯金纳米粒子

数字乳腺断层摄影及病理学特征与早期乳腺癌保乳手术结果的相关性研究

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中国肿瘤临床 2024年第12期51卷 611-615页

作者：刘梁生马文娟张宇李艳博王嘉慧路红天津医科大学肿瘤医院乳腺影像诊断科国家恶性肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心乳腺癌防治教育部重点实验室天津市"肿瘤防治"重点实验室天津市300060

目的:研究数字乳腺断层摄影(digital breast tomosynthesis,DBT)影像特征及病理学特征与早期乳腺癌保乳手术(breastconserving surgery,BCS)结果的相关性。方法:回顾性分析2019年1月至2023年12月天津医科大学肿瘤医院行BCS成功保留乳房... 详细信息

目的:研究数字乳腺断层摄影(digital breast tomosynthesis,DBT)影像特征及病理学特征与早期乳腺癌保乳手术(breastconserving surgery,BCS)结果的相关性。方法:回顾性分析2019年1月至2023年12月天津医科大学肿瘤医院行BCS成功保留乳房422例和术中改行乳房全切术(mastectomy)211例的早期乳腺癌患者术前临床资料。收集两组病例的术前DBT影像及临床病理学特征,采用单因素Logistic回归分析筛选出与BCS手术结果相关的特征,随后进行多因素Logistic回归分析。结果:单因素Logistic回归分析结果显示年龄(P=0.020)、结构扭曲(P<0.001)、乳腺构成类型(极致密型,P=0.001)和分子分型(Her2过表达型,P=0.001)在保留乳房组及乳房全切组间比较差异具有统计学意义;多因素Logistic回归分析结果显示结构扭曲(P<0.001)、乳腺构成类型(极致密型,P=0.003)和分子分型(Her2过表达型,P<0.001)在两组比较差异具有统计学意义。结论:乳腺构成类型、结构扭曲以及分子分型与BCS结果具有一定相关性,乳腺构成类型为极致密型、病变表现有结构扭曲以及分子分型为Her2过表达型的患者提示更大的改行乳房全切术可能性,可作为术前评估乳腺癌BCS结果的有效指标,从而制定准确的手术策略。

关键词：乳腺癌保乳手术数字乳腺断层摄影影像特征分子分型

The biological applications of DNA nanomaterials:current challenges and future directions

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3202-3229页

作者： wenjuan ma Yuxi Zhan Yuxin Zhang Chenchen mao Xueping Xie Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduPeople’s Republic of China College of Biomedical Engineering Sichuan UniversityChengduPeople’s Republic of China

DNA,a genetic material,has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in the past decades,including tissue regeneration,disease prevention,inflammation inhibition,bioimaging,biosensing,diagnosis,antitumor drug delivery,and *** the rapid progress in DNA nanotechnology,multitudinous DNA nanomaterials have been designed with different shape and size based on the classic Watson–Crick base-pairing for molecular *** DNA materials could functionally change cell biological behaviors,such as cell migration,cell proliferation,cell differentiation,autophagy,and anti-inflammatory *** single-stranded DNAs(ssDNAs)or RNAs with secondary structures via self-pairing,named aptamer,possess the ability of targeting,which are selected by systematic evolution of ligands by exponential enrichment(SELEX)and applied for tumor targeted diagnosis and *** DNA nanomaterials with three-dimensional(3D)nanostructures and stable structures are investigated as drug carrier systems to delivery multiple antitumor medicine or gene therapeutic *** the functional DNA nanostructures have promoted the development of the DNA nanotechnology with innovative designs and preparation strategies,and also proved with great potential in the biological and medical use,there is still a long way to go for the eventual application of DNA materials in real *** in this review,we conducted a comprehensive survey of the structural development history of various DNA nanomaterials,introduced the principles of different DNA nanomaterials,summarized their biological applications in different fields,and discussed the current challenges and further directions that could help to achieve their applications in the future.

关键词： diagnosis prevention pairing

Multi?targeted Antisense Oligonucleotide Delivery by a Framework Nucleic Acid for Inhibiting Biofilm Formation and Virulence

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Nano-Micro Letters 2020年第6期12卷 113-125页

作者： Yuxin Zhang Xueping Xie wenjuan ma Yuxi Zhan Chenchen mao Xiaoru Shao Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041People’s Republic of China

Biofilm formation is responsible for numerous chronic infections and represents a serious health *** and the extracellular polysaccharides(EPS)cause biofilms to become adherent,toxic,resistant to antibiotics,and ultimately difficult to *** of EPS synthesis can prevent the formation of bacterial biofilms,reduce their robustness,and promote ***,we have developed a framework nucleic acid delivery system with a tetrahedral *** can easily access bacterial cells and functions by delivering antisense oligonucleotides that target specific *** designed antisense oligonucleotide sequences with multiple targets based on conserved regions of the VicK protein-binding *** delivered to bacterial cells,they significantly decreased EPS synthesis and biofilm *** to existing approaches,this system is highly efficacious because it simultaneously reduces the expression of all targeted genes(gtfBCD,gbpB,ftf).We demonstrate a novel nucleic acid-based nanomaterial with multi-targeted inhibition that has great potential for the treatment of chronic infections caused by biofilms.

关键词： Biofilm Framework nucleic acid Multi-targeting Antisense oligonucleotide Delivery system

乳腺MRI图像特征与保乳手术可行性的相关性分析

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磁共振成像 2024年第1期15卷 43-47,60页

作者：刘梁生刘佩芳马文娟张宇李艳博王嘉慧路红天津医科大学肿瘤医院乳腺影像诊断科国家恶性肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心乳腺癌防治教育部重点实验室天津300060

目的探讨乳腺癌保乳手术(breast conserving surgery, BCS)成功及失败相关的术前MRI影像特征和临床病理特征,为BCS可行性分析提供影像学依据。材料与方法回顾性分析2018年3月至2021年5月行BCS且术前行MRI检查的患者资料,并根据是否最... 详细信息

目的探讨乳腺癌保乳手术(breast conserving surgery, BCS)成功及失败相关的术前MRI影像特征和临床病理特征,为BCS可行性分析提供影像学依据。材料与方法回顾性分析2018年3月至2021年5月行BCS且术前行MRI检查的患者资料,并根据是否最终改行全乳切除术的手术结果分为失败组和成功组。收集的影像特征包括:病灶大小、左右侧、是否肿块、深度、纤维腺体组织量、是否对称、相关征象、背景实质强化(background parenchymal enhancement, BPE)、时间强度曲线、T1信号以及T2信号。临床病理特征包括:患者年龄、人表皮生长因子受体2 (human epidermal growth factor receptor 2, HER-2)、雌激素受体(estrogen receptor, ER)、孕激素受体(progesterone receptor, PR)状态及增殖指数Ki-67水平、分子分型以及是否导管内癌。采用单因素及多因素logistic回归对两组间的影像特征及临床病理特征进行分析,以P<0.05为差异具有统计学意义。结果 BCS失败和成功组的样本量分别为47例和91例。单因素及多因素logistic回归分析显示BPE在两组间差异有统计学意义。使用BPE极少强化作为参考,它与BPE轻度强化之间差异没有统计学意义[优势比(odds ratio, OR)=0.317,95%置信区间(confidence interval, CI):0.374~6.552,P=0.654]。它与中度强化之间差异具有统计学意义(OR=1.674,95%CI:1.392~26.420,P=0.022)和BPE重度增强(OR=1.569,95%CI:1.128~25.809,P=0.044)。然而,其他临床病理和影像学特征在BCS成功组与失败组间差异无统计学意义。结论 BPE与BCS成功与否具有一定相关性,更高的BPE程度提示更大的BCS失败可能性,BPE可能作为术前MRI评估乳腺癌BCS可行性分析的有效指标,有助于医生制订准确的手术策略。

关键词：癌症乳腺癌保乳手术影像特征磁共振成像

Effects of Fe^(2+), Co^(2+) and Ni^(2+) Ions on Biological Methane Production from Residual Heavy Oil

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China Petroleum Processing & Petrochemical Technology 2015年第2期17卷 32-38页

作者： Liu Chunshuang ma wenjuan Zhao Dongfeng Jia Kuili Zhao Chaocheng College of Chemical Engineering China University of Petroleum

On the basis of single factor tests, the effect of trace elements—Fe2+, Co2+ and Ni2+ ions—on biological methane production from heavy oil was investigated by the response surface method. A three-level Box-Behnken design was employed to study the relationship between the independent variables and the dependent variable by applying initial Fe2+, Co2+ and Ni2+ concentration as the independent variables(factors) and using the methane production after 270 days of cultivation as the dependent variable(response). A prediction model of quadramatic polynomial regression equation was obtained. The results showed that the methane production could be as high as 240.69 μmol after optimization compared with 235.74 μmol obtained under un-optimized condition. Furthermore, the microbial communities before and after biodegradation were analyzed by PCR-DGGE method. The dominant bands were recovered and sequenced. Three strains were obtained; the strain T1 has 97% similarity with Bacillus thermoamylovorans, the strain H3 has 97% similarity with Bacillus thermoamylovorans and the strain H4 has 99% similarity with Bacillus vietnamensis.

关键词： residual heavy oil methane PCR-DGGE response surface method

吸入制剂在老年慢性阻塞性肺疾病中应用研究进展

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老年医学与保健 2024年第3期30卷 878-881页

作者：刘黎杨荀马文娟苏科文屈云四川大学华西医院呼吸与危重症医学科四川成都610041

慢性阻塞性肺病(chronic obstructive pulmonary dis ease,COPD)作为一种呼吸系统疾病,主要以不可逆呼吸气流受阻为特征,并伴随肺部吸入毒性气体或微粒后出现不正常炎症反应,为中国老年人慢性疾病患病与死亡的主要原因之一[1]。人口老... 详细信息

慢性阻塞性肺病(chronic obstructive pulmonary dis ease,COPD)作为一种呼吸系统疾病,主要以不可逆呼吸气流受阻为特征,并伴随肺部吸入毒性气体或微粒后出现不正常炎症反应,为中国老年人慢性疾病患病与死亡的主要原因之一[1]。人口老龄化导致COPD的患病率不断上升,相关研究预测,至2030年,COPD将从全球第4位死亡原因上升至第3位[2]。老年COPD患者机体免疫力低、全身营养状态差,较易受到外界环境、病毒感染等因素的影响导致肺功能恶化,对生命健康及生存质量造成严重影响[3]。

关键词：老年慢性阻塞性肺疾病吸入药物疗法