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乡村振兴视域下红色文化资源的开发利用与实践创新

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红色文化学刊 2024年第1期 50-58,110-111页

作者：徐功献叶雯静赣南师范大学中国共产党革命精神与文化资源研究中心

红色文化资源是推进乡村振兴的重要内生动力。在当前乡村振兴实践中,红色文化资源的开发利用呈现出产业化、数字化、生态化的发展趋势和红色产业、红色人才、红色宣传、红色生态、红色组织等开发利用形态。在推进乡村振兴过程中,红色文... 详细信息

红色文化资源是推进乡村振兴的重要内生动力。在当前乡村振兴实践中,红色文化资源的开发利用呈现出产业化、数字化、生态化的发展趋势和红色产业、红色人才、红色宣传、红色生态、红色组织等开发利用形态。在推进乡村振兴过程中,红色文化资源的开发利用和实践创新也面临着联动开发有待提升、品牌打造尚有欠缺、推广人才较为稀缺、实践运用力度不足等困境。因此,要通过健全乡村红色文化资源联开机制,强化乡村红色文化资源品牌塑造,培养乡村红色文化资源人才队伍,推进乡村红色文化精神践行力度等路径,进一步促进红色文化资源的开发利用与实践创新,助推乡村振兴战略的全面、深入实施。

关键词：乡村振兴红色文化资源开发利用实践创新

An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

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Communications in Computational Physics 2014年第1期15卷 246-264页

作者： Tengfei Liang wenjing ye Department of Mechanical Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong KAUST-HKUST Micro/Nanofluidic Joint Laboratory Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong

Aiming at simulating micro gas flows with accurate boundary conditions,an efficient hybrid algorithm is developed by combining the molecular dynamics(MD)method with the direct simulation Monte Carlo(DSMC)*** efficiency comes from the fact that the MD method is applied only within the gas-wall interaction layer,characterized by the cut-off distance of the gas-solid interaction potential,to resolve accurately the gas-wall interaction process,while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer.A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface,hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation *** improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the“smart-wall model”proposed by Barisik et *** developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow *** the accuracy and efficiency of the hybrid algorithm are *** an application,the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth *** is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models.

关键词： Rarefied gas flows surface effect multi-scale methods

Impact Dynamics of a Dragonfly Wing

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Computer Modeling in Engineering & Sciences 2020年第3期122卷 889-906页

作者： Lihua Wang wenjing ye Yueting Zhou School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghaiChina.

The lift force was reported not to be high enough to support the dragonfly’s weight during flight in some conventional investigations,and higher lift force is required for its *** this study,by employing a thin plate model,impact effect is investigated for the wing deformation in dragonfly flapping during *** static displacement is formulated to compare with the dynamical displacement caused by *** governing equation of motion for the impact dynamics of a dragonfly wing is derived based on Newton’s second *** of variables technique and assumed modes method are introduced to solve the resulting ***,lift force is presented for the cases of considering and without considering the impact on the wing flapping which indicates that the impact has prominent effects for the dragonfly’s aerodynamic *** simulations demonstrate that considering the impact effect on the wing flapping can increase the wing deformation,which results in the rise of the lift *** enhanced lift force is of critical importance for the dragonfly’s takeoff.

关键词： Impact dynamics wing deformation thin plate model lift force.

Highly active binuclear Cu(Ⅱ) catalyst bearing an unsymmetrical bipyridine-pyrazole-amine ligand for the azide-alkyne cycloaddition reaction

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Chinese Journal of Catalysis 2016年第9期37卷 1446-1450页

作者： Baofeng Han Xiao Xiao Lan Wang wenjing ye Xiaoping Liu Key Laboratory of Structure-Based Drug Design and Discovery （Shenyang Pharmaceutical University） Ministry of Education Shenyang 110016 Liaoning China

Ligands containing NH groups often show special *** this paper,a well-defined dinuclear Cu（II） complex bearing an unsymmetrical bipyridine-pyrazole-amine ligand was synthesized by the condensation of N–H to release *** sodium L-ascorbate as a reductant,the binuclear complex showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles in 95%–99% isolated yields.

关键词： N-heterocycle ligand Cu complex 1 3-Dipolar cycloaddition Alkynes Azides

Multi-scale modeling of hemodynamics in the cardiovascular system

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Acta Mechanica Sinica 2015年第4期31卷 446-464页

作者： Hao Liu Fuyou Liang Jasmin Wong Takashi Fujiwara wenjing ye Ken-iti Tsubota Michiko Sugawara Graduate School of Engineering Chiba University Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CU ICRC) The Hong Kong University of Science and Technology(HKUST)

The human cardiovascular system is a closed- loop and complex vascular network with multi-scaled het- erogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale model- ing of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arter- ial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study： recent progress of patient-specific hemodynamic modeling in clinical applica- tions, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynarnic modeling.

关键词： Multi-scale modeling. Macro-hemodynamics.Micro-hemodynamics Cardiovascular system Endothelialcell

健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症的临床效果

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中国医药导报 2024年第1期21卷 87-91页

作者：吴小翠杨文奎邱晓堂叶文静海南省中医院内分泌科海南海口570203

目的探讨健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症的临床效果。方法选取2021年2月至2022年12月于海南省中医院内分泌科门诊或病房诊治的高尿酸血症患者106例,按随机数字表法分研究组(54例)和对照组(52例)。研究组服用健脾渗湿解毒汤,对... 详细信息

目的探讨健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症的临床效果。方法选取2021年2月至2022年12月于海南省中医院内分泌科门诊或病房诊治的高尿酸血症患者106例,按随机数字表法分研究组(54例)和对照组(52例)。研究组服用健脾渗湿解毒汤,对照组口服苯溴马隆片(50 mg/次,1次/d)。两组均治疗3个月。观察两组治疗前后血尿酸(UA)、胆固醇、甘油三酯(TG)、低密度脂蛋白(LDL-C)、空腹血糖(FPG)、中医证候积分及安全性分析。结果治疗后,两组尿酸低于治疗前,差异有统计学意义(P0.05)。治疗后,研究组FPG、TC低于治疗前,且低于对照组,差异有统计学意义(P0.05);两组TG、LDL-C比较,差异无统计学意义(P>0.05)。治疗后,两组症候总积分低于治疗前,且研究组低于对照组,差异有统计学意义(P0.05)。结论健脾渗湿解毒汤治疗湿浊中阻型高尿酸血症,能显著改善患者的中医临床症候,较好地降低尿酸水平,且安全性较高,具有较高的临床应用价值。

关键词：健脾渗湿解毒汤高尿酸血症湿浊中阻型血尿酸水平

Efficient Synthesis of a-Amino Acid Derivatives via Phase-transfer-catalyzed Directed Reductive Amination

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Chemical Research in Chinese Universities 2015年第2期31卷 203-207页

作者： ZHANG Xiaohua ye wenjing WANG Kuanglei TIAN Yongshou XIAO Xiao School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields（up to 99%）. Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.

关键词： Direcled reductive amination: α-Amino acid: Phase transfer catalyst

A Common Functional Variant at the Enhancer of the Rheumatoid Arthritis Risk Gene ORMDL3 Regulates its Expression Through Allele-Specific JunD Binding

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Phenomics 2023年第5期3卷 485-495页

作者： wenjing ye Yiyun Yu Xiaoxia Zhu Weiguo Wan Yun Liu Hejian Zou Zaihua Zhu Division of Rheumatology and Immunology Huashan HospitalFudan UniversityShanghai 200040China Institute of Rheumatology Immunology and AllergyFudan UniversityShanghai 200040China The Ministry of Education Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China

Genome-wide association studies(GWASs)have identified over 100 loci associated with rheumatoid arthritis(RA);how-ever,the functionally affected genes and the underlying molecular mechanisms contributing to these associations are often *** this study,we conducted an integrative genomic analysis incorporating multiple“omics”data and identified a functional regulatory DNA variant,rs56199421,and a plausible mechanism by which it regulates the expression of a puta-tive RA risk gene,ORMDL Sphingolipid Biosynthesis Regulator 3(ORMDL3).The T allele of rs56199421,located in the enhancer region of ORMDL3,exhibited stronger direct binding ability than the other C allele of rs56199421 did in vitro with the transcription factor JunD and demonstrated higher transcriptional ***,the T allele of rs56199421 is associated with elevated RA risk,and ORMDL3 expression is increased in RA ***,these findings suggest that the T allele of rs56199421 enhances JunD transcription factor binding,increases enhancer activity,and elevates the expression of the RA risk gene ORMDL3.

关键词： Rheumatoid arthritis Genome-wide association study Enhancer ORMDL Sphingolipid Biosynthesis Regulator 3

健脾渗湿解毒汤对高尿酸血症大鼠的作用及机制探讨

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中国中医基础医学杂志 2024年第1期30卷 41-45页

作者：叶文静杨文奎符芸瑜吴小翠邱晓堂海南省中医院海口570203

目的通过观察健脾渗湿解毒汤对高尿酸血症(hyperuricemia,HUA)模型大鼠尿酸盐转运蛋白表达的影响,探讨该方治疗HUA的作用机制。方法取健康雄性SD大鼠60只,随机分为空白对照组、模型组、苯溴马隆组和健脾渗湿解毒汤低、中、高剂量组。... 详细信息

目的通过观察健脾渗湿解毒汤对高尿酸血症(hyperuricemia,HUA)模型大鼠尿酸盐转运蛋白表达的影响,探讨该方治疗HUA的作用机制。方法取健康雄性SD大鼠60只,随机分为空白对照组、模型组、苯溴马隆组和健脾渗湿解毒汤低、中、高剂量组。除空白对照组大鼠给予灌胃蒸馏水外,其他各组大鼠分别灌胃氧嗪酸钾和腺嘌呤建立HUA模型,各药物治疗组大鼠在造模1 h后予相应药物灌胃,持续给药21 d后处死,检测各组大鼠血尿酸(serum uric acid,SUA)、血肌酐(serum creatinine,SCR)、尿素氮(blood urea nitrogen,BUN)、谷草转氨酶(aspartate aminotransferase,AST)、谷丙转氨酶(alanine aminotransferase,ALT)含量;苏木素-伊红(hematoxylin-eosin,HE)染色观察肾脏及肝脏组织病理学变化;Western blot和实时荧光定量PCR法检测肾脏组织尿酸盐转运蛋白(urate transporter,URAT)1、有机阴离子转运蛋白(organic anion transporter,OAT)3的表达。结果与空白对照组比较,模型组大鼠血清SUA、SCR含量明显升高(P<0.05),肾脏组织中URAT1蛋白和m RNA的表达水平明显升高(P<0.01)、OAT3蛋白和m RNA的表达水平明显降低(P<0.01)。与模型组比较,健脾渗湿解毒汤低剂量组大鼠SUA含量明显降低(P<0.01),健脾渗湿解毒汤中剂量和高剂量组大鼠SUA、SCR、BUN含量均明显降低(P<0.05)。此外,高剂量健脾渗湿解毒汤能够明显降低URAT1蛋白及m RNA(P<0.05)、升高OAT3蛋白及m RNA的表达水平(P<0.05),减轻肾脏损伤。结论健脾渗湿解毒汤有显著的降尿酸效果,具体机制可能与其抑制尿酸重吸收蛋白URAT1、上调尿酸分泌蛋白OAT3的表达相关。

关键词：高尿酸血症健脾渗湿解毒汤尿酸盐转运蛋白1 有机阴离子转运蛋白3