Efficient Synthesis of a-Amino Acid Derivatives via Phase-transfer-catalyzed Directed Reductive Amination
Efficient Synthesis of a-Amino Acid Derivatives via Phase-transfer-catalyzed Directed Reductive Amination作者机构：School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2015年第31卷第2期
页 面：203-207页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学]
基 金：Supported by the Natural Science Foundation of China(No.21402127). Foundation of Liaoning Province Education Department(No.l 2013381) PhD Research Startup Foundation of Liaoning Province(No.20131110) and Career Dcvclopment Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University
主 题：Direcled reductive amination: α Amino acid: Phase transfer catalyst
摘 要：An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields（up to 99%）. Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.
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