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Asian j.urnal of Andrology 2013年第6期15卷 795-798,I0009页

作者： j.Ullrich Schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann wolfgang Würfel Andrologie Centrum MOnchen MOnchen D-81241 Germany Kinderwunsch Centrum MOnchen MOnchen D-81241 Germany Andrologicum MOnchen MOnchen D-80331 Germany

In 220 consecutive patients with non-obstructive azoospermia, sperm retrieval was attempted by a combination of conventional and microdissection testicular sperm extraction （TESE）. For sperm retrieval, 2-3 conventional biopsies were performed followed by a microdissection TESE in cases of negative conventional biopsies. During the surgery, the vasculature of the testis was assessed using the operative microscope, and the location of positive biopsies was registered in relation to the blood supply. The overall sperm retrieval rate was 58.2%. From the initial conventional biopsies, sperm could be retrieved in 46.8% of the patients. With microdissection TESE, sperm could be retrieved from an additional 11.4% of the patients. The further use of microdissection TESE improved the sperm retrieval rate significantly （P=0.017）. No significant accumulation of positive biopsies was found towards the rete testis or the main testicular vessels.

关键词： intracytoplasmic sperm inj.ction male infertility microdissection testicular sperm extraction non-obstructiveazoospermia sperm retrieval

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

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Light(Science & Applications) 2021年第1期10卷 71-85页

作者： Elisabet A.Rank Ryan Sentosa Danielle j.Harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alej.ndro Maese-Novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister j.chen Kraft Rainer ALeitgeb wolfgang Drexler Center for Medical Physics and Biomedical Engineering Medical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for Microtechnology Vorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology GmbH Gieffinggasse 41210 ViennaAustria ams AG Tobelbader Strasse 308141 PremstaettenAustria

In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

关键词： waveguide arrayed optical

欧洲精神病学协会精神分裂症认知功能损害评估指引(全译)

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中华精神科杂志 2024年第9期57卷 543-561页

作者：蒲城城于欣石川邓红刘莎刘哲宁刘登堂张天宏陆峰李晓白胡婉珩高天奇黄冰洁北京大学第六医院、北京大学精神卫生研究所、国家卫生健康委员会精神卫生学重点实验室(北京大学)、国家精神心理疾病临床医学研究中心(北京大学第六医院) 四川大学华西医院心理卫生中心山西医科大学第一医院精神卫生科中南大学湘雅二医院精神病学科、国家精神心理疾病临床研究中心、国家精神疾病医学中心上海交通大学医学院附属精神卫生中心同济大学附属同济医院精神医学中心中国医科大学附属第一医院精神科

背景既往研究显示精神分裂症患者存在广泛的认知功能损害。神经认知功能损害和社会认知功能损害被认为是精神分裂症导致严重功能残疾的原因。尽管认知功能对精神分裂症预后起关键作用,但无论是在科研研究中,还是临床实践中,相关评估都... 详细信息

背景既往研究显示精神分裂症患者存在广泛的认知功能损害。神经认知功能损害和社会认知功能损害被认为是精神分裂症导致严重功能残疾的原因。尽管认知功能对精神分裂症预后起关键作用,但无论是在科研研究中,还是临床实践中,相关评估都非常不足。方法本文对科学文献进行系统综述,详细阐述在科研研究和临床实践中对精神分裂症认知功能评估的若干推荐。结果专家共识和系统综述为精神分裂症认知功能的最佳评估提供了指导。基于遴选的证据,本欧洲精神病学协会精神分裂症认识功能损害评估指引(下文简称指引)建议,在精神分裂症的全病程以及精神病风险人群中进行神经认知功能和社会认知功能2个领域的全面且系统的评估。指引不仅建议使用知情者报告,也建议使用自我报告和基于访谈的认知功能评估工具。指引还系统地回顾了首次发作精神病患者和精神病高危人群的评估现状。结论对证据的全面审查和推荐建议可能有助于推动这一领域的发展,有利于进行更好的认知功能评估,并避免与其他精神病理学维度重叠。该指导性文件的传播可促进涉及精神分裂症认知功能评估的相关指南的制定,从而提高医疗质量并获得临床痊愈。

关键词：精神分裂症精神病学精神病理学认知功能损害全病程精神病患者自我报告临床实践

Composition and Functional Properties of Yam Bean (<i>Pachyrhizus</i>spp.) Seed Flour

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Food and Nutrition Sciences 2015年第8期6卷 736-746页

作者： Abbas Kisambira j.hn H. Muyonga Yusuf B. Byaruhanga Phinehas Tukamuhabwa Silver Tumwegamire wolfgang j. Grüneberg School of Food Technology Nutrition and Bio-Engineering Makerere University Kampala Uganda School of Agricultural Sciences Makerere University Kampala Uganda International Institute of Tropical Agriculture Dar es Salaam Tanzania International Potato Centre Lima Peru

Yam bean (Pachyrhizus spp.) is legume crop that not only produces edible roots but also has a high yield of unutilized seeds. Although the yam bean seeds are rich in protein, they are not used due to a high content of toxic rotenone. In this study, yam bean seeds were detoxified and the nutritional and functional properties of their protein determined to assess the proteins’ potential for applications. Seeds of 10 accessions (2 accessions of P. erosus, 4 accessions of P. ahipa and 4 accessions of P. tuberosus) were analyzed for proximate composition, pasting and functional properties (bulk density, least gelation concentration, water absorption capacity, oil absorption capacity, emulsifying capacity, emulsion stability, foaming capacity, foam stability and protein solubility). The results showed that yam bean seeds contained: 29.2 - 32.1 g/100g proteins, 31.3 - 33.0 g/100 g carbohydrates, 24.1 - 25.6 g/100g total fat, 7.5 - 8.1 g/100g crude fiber and 3.4 - 4.1 g/100g ash. The defatted P. erosus seed flour contained 45.6 - 48.8 g/100g protein, 32.6 - 36.5 g/100g total carbohydrate, 6.7 - 7.1 g/100g crude fiber, 6.0 - 6.4 g/100g ash and 5.2/100 g crude fat. The defatted yam bean seed flour exhibited relatively high protein solubility (68.0% - 70.4%), least gelation concentration (14%), water absorption capacity (2.8% - 2.9%) and oil absorption capacity (1.5%). The defatted flour exhibited emulsifying capacity of 35.7% - 36.0%, emulsion stability of 33.2% - 33.5%, foaming capacities of 42% and foam stability of 25.1% - 25.8%. With respect to pasting properties, the defatted yam bean seed flours exhibited pasting temperature of 80.0?C - 81.3?C, peak viscosity of 145.5 - 146.7 RVU, trough viscosity of 95.1 - 102.0 RVU, break down of 43.5 - 51.6 RVU, set back of 252.9 - 258.1 RVU and final viscosity of 348 - 360 RVU. The results show that yam bean seed has potential for use in both food and non-food applications.

关键词： Yam Bean Seed Flour Proximate Composition Functional Properties

Software improvement for evaluation of laryngopharyngeal pH testing(Restech)——a comparison between Data View 3 and 4

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World j.urnal of Gastrointestinal Surgery 2020年第5期12卷 236-246页

作者： Dolores Thea Müller Elena Schulte Benj.min Babic Laura Knepper Claudia Fuchs wolfgang Schroder Christiane j.Bruns j.ssica M Leers Hans Friedrich Fuchs Department of General VisceralCancer and Transplant SurgeryUniversity of CologneKoln 50937Germany

BACKGROUND When gastroesophageal reflux contents reach above the upper esophageal sphincter,patients may,in addition to typical reflux symptoms,present with atypical,extraesophageal symptoms related to laryngopharyngeal reflux(LPR).Surgical treatment of LPR has shown to lead to 70%symptom improvement,however no gold standard for the diagnosis of LPR *** 2007,the Restech Dx-pH was released as a valid method to measure acid exposure above the upper esophageal ***,a new software update was introduced for analysis of measured pH data and calculation of composite *** effect of the changes applied to the new software version have not yet been *** To compare results generated by Data View 3 to the most recently released Data View *** All patients with gastroesophageal reflux disease symptoms were seen in a specialized surgical outpatient clinic for gastrointestinal function *** chart review was performed of all patients presenting with suspected gastroesophageal reflux disease and extraesophageal reflux symptoms,who underwent laryngopharyngeal pH monitoring using the Restech Dx-pH system(Respiratory Technology Corp.,Houston,TX,United States)and simultaneous esophageal pH *** View 3 and Data View 4 were used to evaluate Restech studies *** entries such as mealtimes,supine and upright periods,and symptoms were entered manually to ensure accuracy and precise conversion of data between both software *** t test was performed for statistical analysis of *** A total of 174 patients(63.8%female)met inclusion criteria,all suffering from extraesophageal reflux symptoms as well as typical gastroesophageal reflux disease *** RYAN score upright was 48.77 in Data View 3 compared to 22.17 in Data View 4,showing a significant difference(~aP=0.0001).Similar results were shown for supine period(mean RYAN Score Data View 35.29 vs 1.42 in Data View 4,~cP=0.0001).For upright pe

关键词： Gastroesophageal reflux disease Laryngopharyngeal reflux disease Esophageal pH testing Oropharyngeal pH testing Restech Dx pH DeMeester score RYAN Score

Liver metastases from pancreatic ductal adenocarcinoma:is there a place for surgery in the modern era?

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j.urnal of Pancreatology 2020年第2期3卷 81-85页

作者： Imai Katsunori Margonis Georgios A. Wang j.eyun wolfgang Christopher L. Baba Hideo Weiss Matthew j. Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamotoJapan Department of Surgery Johns Hopkins University School of MedicineBaltimoreMDNYUSA Northwell Health Cancer Institute Lake SuccessNYUSA

Pancreatic ductal adenocarcinoma(PDAC)represents one of the most aggressive malignancies,and the maj.rity of patients with PDAC present with metastatic disease,mainly in the liver,at the time of *** resection is the only treatment that can offer prolonged survival and possible ***,the indications for surgery for patients with PDAC metastases remain extremely limited to highly selected patients with localized disease,and metastatic disease is generally regarded as a contraindication to ***,however,the advent of more effective chemotherapy has changed the treatment strategy for metastatic *** fact,cases in which resection of synchronous or metachronous PDAC liver metastases lead to prolonged survival in highly selected patients have been *** this review,we provide current data regarding survival outcomes after surgery,and discuss the role of surgical resection and selection criteria for patients with PDAC liver metastases in the modern era.

关键词： Liver metastases Pancreatic cancer Surgery

Testicular expression of survivin and human telomerase reverse transcriptase(hTERT)associated with spermatogenic function in infertile patients

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Asian j.urnal of Andrology 2006年第1期8卷 95-100页

作者： Steffen Weikert Frank Christoph wolfgang Schulze Hans Krause Carsten Kempkensteffen Martin Schostak Kurt Miller Mark Schrader Department of Urology Charité-Universittsmedizin BerlinCampus B.FranklinD-12200 BerlinGermany Department of Andrology University of HamburgD-20246 HamburgGermany

Aim： To characterize the coexpression of survivin, an inhibitor of apoptosis （IAF）, and human telomerase reverse transcriptase （hTERT） in human testes with varying spermatogenic function. Methods： Transcript levels of survivin mRNA and hTERT mRNA were determined in normal testes （n = 11） and testes with defective spermatogenesis （n = 28） using real-time reverse-transcription polymerase chain reaction （RT-PCR）. The histological work-up was performed according to a modified j.hnsen score. Results： Expressions of both survivin and hTERT were highest at median levels of 96.8 and 709 in normal spermatogenesis and dropped to 53.3 and 534 in testes with postmeiotic spermatogenic arrest （n = 10）. In severe spermatogenic failure （n = 18）, survivin expression was lacking in most specimens （n = 16）, whereas at least low levels of testicular hTERT expression were largely detectable with a normalized expression of 73 in premeiotic spermatogenic arrest （n = 7） and 45 in patients with Sertoli cell-only syndrome （SCOS）（n = 3）. Both survivin and hTERT expressions increased with a progressing j.hnsen score （P for trend = 0.001）. Conclusion： Although both survivin and hTERT are correlated with spermatogenic function, they show different expression patterns in testes of infertile patients. These findings substantiate results from studies in the rodent testis suggesting a predominant expression of survivin in meiotically dividing germ cells. （Asian j.Andro12006 j.n; 8： 95-100）

关键词： survivin human telomerase reverse transcriptase apoptosis azoospermia male infertility spermatogenesis

工艺参数对可伐合金/DM308钼组玻璃激光焊接接头结合性能的影响

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焊接学报 2018年第5期39卷 5-9页

作者：贾林李红栗卓新 wolfgang Tillmann 北京工业大学材料科学与工程学院北京100124 德国多特蒙德工业大学材料工程研究所多特蒙德44227 北京汽车动力总成有限公司北京101108

采用YLS-6000型光纤激光器对可伐合金4j.9与钼组玻璃DM308进行激光焊接,研究了工艺参数对接头强度和界面结构的影响,分析了界面元素扩散行为.结果表明,激光功率为700~800 W,焊接速度为4.5 mm/s,离焦量为0时,接头抗剪强度达到最大值,为10... 详细信息

采用YLS-6000型光纤激光器对可伐合金4j.9与钼组玻璃DM308进行激光焊接,研究了工艺参数对接头强度和界面结构的影响,分析了界面元素扩散行为.结果表明,激光功率为700~800 W,焊接速度为4.5 mm/s,离焦量为0时,接头抗剪强度达到最大值,为10.97 MPa;4j.9/DM308激光焊接头界面结合良好,存在反应层,分界线清晰可见.玻璃侧有大量气孔产生,界面某些部位存在少量气孔,导致产生微裂纹;在高温条件下,元素扩散越均匀,界面反应生成Fe_2SiO_4越多,接头强度越高.

关键词：工艺参数可伐合金 DM308玻璃扩散激光焊接

Simulation and experimental study of a novel bifacial structure of silicon heteroj.nction solar cell for high efficiency and low cost

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Chinese Physics B 2018年第3期27卷 520-525页

作者： Haibin Huang Gangyu Tian Lang Zhou j.ren Yuan wolfgang R.Fahrner Wenbin Zhang Xingbing Li Wenhao Chen Renzhong Liu Institute of Photovoltaics Nanchang UniversityNanchang 330031China Department of Physics Nanchang UniversityNanchang 330031China GCL System Integration Technology Co.Ltd. Shanghai 201700China Hareon Solar Co.Ltd. Taicang 215400China

A novel structure of Ag gridlSiN_(x)/n+-c-Si/n-c-Si/i-a-Si:H/p^(+)-a-Si:HlTCO/Ag grid was designed to increase the ef-ficiency of bifacial amorphous/crystalline silicon-based solar cells and reduce the rear material consumption and production *** simulation results show that the new structure obtains higher efficiency compared with the typical bifa-cial amorphous/crystalline silicon-based solar cell because of an increase in the short-circuit current(j.(sc)),while retaining the advantages of a high open-circuit voltage,low temperature coefficient,and good weak-light ***,real cells composed of the novel structure with dimensions of 75 mm×75 mm were fabricated by a special fabrication recipe based on industrial *** parameter optimization,the cell efficiency reached 21.1%with the j.(sc)of 41.7 mA/cm^(2).In addition,the novel structure attained 28.55%potential conversion efficiency under an illumination of AM 1.5 G,100 mW/cm^(2).We conclude that the configuration of the Ag grid/SiN_(x)/n^(+)-c-Si/n-c-Si/i-a-Si:H/p^(+)-a-Si:H/TCO/Ag grid is a promising structure for high efficiency and low cost.

关键词： silicon solar cell a-Si:H/c-Si heteroj.nction short-circuit current