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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. j., Xiao Teboul, Lydia Wong, Michael D. White, j.cqueline K. Meehan, Terrence F. weninger, wolfgang j. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, j.mes M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, j.mes Daly, Mark j. Denegre, j.mes M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, j.an Guo, Shiying Horner, Neil R. Hsu, Chih-Wei j.hnson, Sara j. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, j.remy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. j. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas j. Ryder, Edward Samocha, Kaitlin E. Seavitt, j.hn R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, j.nathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. j.stice, Monica j. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David j. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maj. Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada j.ckson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanj.ng Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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Classifying handedness in chiral nanomaterials using label error robust deep learning

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npj.Computational Materials 2022年第1期8卷 1417-1423页

作者： C.K.Groschner Alexander j.Pattison Assaf Ben-Moshe A.Paul Alivisatos wolfgang Theis M.C.Scott Department of Materials Science and Engineering UC BerkeleyBerkeleyCAUSA School of Physics and Astronomy University of BirminghamBirminghamUK Department of Chemistry University of CaliforniaBerkeleyBerkeleyCAUSA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCAUSA Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyBerkeleyCAUSA

High-throughput scanning electron microscopy(SEM)coupled with classification using neural networks is an ideal method to determine the morphological handedness of large populations of chiral *** labeling removes the time-consuming manual labeling of training data,but introduces label error,and subsequently classification error in the trained neural ***,we evaluate methods to minimize classification error when training from automated labels of SEM datasets of chiral Tellurium *** the mirror relationship between images of opposite handed particles,we artificially create populations of varying label *** analyze the impact of label error rate and training method on the classification error of neural networks on an ideal dataset and on a practical *** the three training methods considered,we find that a pretraining approach yields the most accurate results across label error rates on ideal datasets,where size and other morphological variables are held constant,but that a co-teaching approach performs the best in practical application.

关键词： error chiral remove

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COVID-19:Masks do not influence neurocognitive performance during a shift at the emergency department

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World j.urnal of Emergency Medicine 2023年第4期14卷 317-321页

作者： j.rgen Grafeneder Verena Fuhrmann Katharina Tscherny Maximilian Niederer wolfgang Schreiber Harald Herkner Dominik Roth Calvin Lukas Kienbacher Department of Emergency Medicine Medical University of ViennaWien 1090Austria Department of Anaesthesiology and Intensive Care Hospital ScheibbsScheibbs 3270Austria

The COVID-19 pandemic has led to the widespread mandatory use of personal protective equipment(PPE),including filtering face pieces(FFP).Emergency medical care providers now commonly use this equipment.

关键词： COV Mask protective

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How to Build the Engine of and to Provide the Fuel for Quasars

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天文研究与技术 2003年第S1期 147-150页

作者： wolfgang j. Duschl Institut für Theoretische Astrophysik Tiergartenstr. 15 69121 Heidelberg Germany

We present a model in which a galaxy galaxy merger can provide not only the fuel for quasar activity, but can also build a super massive black hole, i.e., the engine.

关键词： viscosity Barnes

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Implementing the GEOSS water strategy: from observations to decisions

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International j.urnal of Digital Earth 2023年第1期16卷 1439-1468页

作者： Richard Lawford Sushel Unninayar George j.Huffman wolfgang Grabs Angélica Gutiérrez Chu Ishida-Watanabe Toshio Koike Morgan State University BaltimoreUSA NASA Goddard Space Flight Center GreenbeltUSA International Water Affairs Federal Institute of HydrologyKoblenz National Oceanic and Atmospheric Administration Silver SpringUSA j.pan Aerospace Exploration Agency Tsukuba International Centre for Water Hazard and Risk Management Tsukuba

In 2014,The GEOSS Water Strategy–From Observations to Decisions was published and steps were taken to implement the Strategy’s *** Strategy highlighted priority areas where the application of Earth observations to water research and water management decisions would have significant scientific and societal *** article reviews the implementation of the Strategy’s recommendations over the past eight *** a review of the Strategy’s assessment of the needs for water observations and their applications,it then reviews actions taken in response to the Strategy’s recommendations in its four maj.r themes:improved data acquisition for Essential Water Variables,research and product development,interoperability,and capacity *** highlights significant achievements in the implementation of the Strategy including some motivated by factors beyond this Strategy,reviews actions taken by participating agencies and programs for each of the main themes and summarizes the remaining challenges in achieving the Strategy’s full *** article not only is an update for the Water Community regarding the GEOSS Water Strategy,but it is also an example of how other communities could develop and promulgate a set of strategic recommendations,monitor progress,and carry out assessments of their effectiveness.

关键词： Earth observations water essential water variables research interoperability capacity development

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Determination of quantitative structure-property and structure-process relationships for graphene production in water

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Nano Research 2015年第6期8卷 1865-1881页

作者： Thomas j. Nacken Cornelia Damm Haichen Xing Andreas ROger wolfgang Peukert Institute of Particle Technology (LFG) Friedrich-Alexander University Erlangen-NOrnberg (FAU) Cauerstrasse 4 91058 Erlangen Germany

为 graphene 和很少层 graphene (FLG ) 的一个可伸缩的方法由在 nonionic 表面活化剂 TWEEN 的水的答案的石墨分层的生产 ?(TW80 ) 80 用搅动媒介的工厂被介绍。用统计拉曼光谱学的 Delaminated 产品分析产出揭示了怎么强调紧张和特定... 详细信息

为 graphene 和很少层 graphene (FLG ) 的一个可伸缩的方法由在 nonionic 表面活化剂 TWEEN 的水的答案的石墨分层的生产 ?(TW80 ) 80 用搅动媒介的工厂被介绍。用统计拉曼光谱学的 Delaminated 产品分析产出揭示了怎么强调紧张和特定的精力输入的广泛的 processing-structure-property 关系，即，进程参数，管理 graphene 的收益生产和缺点形成。驱散的碳集中增加了，但是内容和 FLG 产品的质量与更高特定的精力输入严厉地减少了。产品的 FLG 内容直到 90% ，特别为低特定的精力输入。而且，拉曼分析表明比大约 1 nj.大的压力紧张与在产品粒子的重要缺点形成有关。为 graphene 生产的另一个关键参数是溶剂粘性。当溶剂粘性从 1 ～ 6 mPa 被增加时，在产品的 FLG 集中由 10

关键词：定量结构水溶液石墨生产性质非离子表面活性剂产品分析能量输入

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Ubiquitin-Specific Protease 14 （UBP14） Is Involved in Root Responses to Phosphate Deficiency in Arabidopsis

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Molecular Plant 2010年第1期3卷 212-223页

作者： Wen-Feng Li Paula j. Perry Nulu N. Prafulla wolfgang Schmidt Institute of Plant and Microbial Biology Academia Sinica 115 Taipei

A mutant isolated from a screen of EMS-mutagenized Arabidopsis lines, per1, showed normal root hair development under control conditions but displayed an inhibited root hair elongation phenotype upon Pi deficiency. Additionally, the per1 mutant exhibited a pleiotropic phenotype under control conditions, resembling Pi-deficient plants in several aspects. Inhibition of root hair elongation upon growth on low Pi media was reverted by treatment with the Pi analog phosphite, suggesting that the mutant phenotype is not caused by a lack of Pi. Reciprocal grafting experiments revealed that the mutant rootstock is sufficient to cause the phenotype. Complementation analyses showed that the PER1 gene encodes an ubiquitin-specific protease, UBP14. The mutation caused a synonymous substitution in the 12th exon of this gene, resulting in a lower abundance of the UBP14 protein, probably as a consequence of reduced translation efficiency. Transcriptional profiling of per1 and wild-type plants subj.cted to short-term Pi starvation revealed genes that may be important for the signaling of Pi deficiency. We conclude that UBP14 function is crucial for adapting root development to the prevailing local availability of phosphate.

关键词： Phosphate deficiency root hairs ubiquitin-specific protease root development.

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The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana

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Molecular Plant 2023年第7期16卷 1120-1130页

作者： Shiv Mani Dubey Soeun Han Nathan Stutzman Michael j.Prigge Eva Medvecka Matthieu Pierre Platre wolfgang Busch Matyas Fendrych Mark Estelle Department of Experimental Plant Biology Faculty of SciencesCharles UniversityPragueCzech Republic Section of Cell and Developmental Biology University of California San DiegoLa JollaCAUSA Plant Molecular and Cellular Biology Laboratory and Integrative Biology Laboratory Salk Institute for Biological StudiesLa JollaCAUSA Department of Biology Chungbuk National UniversityCheongjuKorea

The phytohormone auxin triggers root growth inhibition within seconds via a *** members of the TIR1/AFB auxin receptor family,AFB1 has a primary role in this rapidresponse. However, the unique features that confer this specific function have not been *** we show that the N-terminal region of AFB1, including the F-box domain and residues thatcontribute to auxin binding,is essential and sufficient for its specific role in the rapid response. Substitutionof the N-terminal region of AFB1 with that of TIR1 disrupts its distinct cytoplasm-enriched localizationand activity in rapid root growth inhibition by auxin. Importantly, the N-terminal region of AFB1 isindispensable for auxin-triggered calcium influx, which is a prerequisite for rapid root growth ***, AFB1 negatively regulates lateral root formation and transcription of auxin-induced genes,suggesting that it plays an inhibitory role in canonical auxin signaling. These results suggest that AFB1may buffer the transcriptional auxin response, whereas it regulates rapid changes in cell growth thatcontributeto rootgravitropism.

关键词： gravitropism calcium auxin signaling Arabidopsis lateral root

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Contributions of holography to the advancement of interferometric measurements of surface topography

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Light(Advanced Manufacturing) 2022年第2期3卷 80-99页

作者： Peter j.de Groot Leslie L.Deck Rong Su wolfgang Osten Zygo Corporation MiddlefieldCT USA Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghaiChina University of Stuttgart StuttgartGermany

Two maj.r fields of study in optics—holography and interferometry—have developed at times independently and at other times *** two methods share the principle of holistically recording as an intensity pattern the magnitude and phase distribution of a light wave,but they can differ significantly in how these recordings are formed and *** we review seven specific developments,ranging from data acquisition to fundamental imaging theory in three dimensions,that illustrate the synergistic developments of holography and interferometry.A clear trend emerges,of increasing reliance of these two fields on a common traj.ctory of enhancements and improvements.

关键词： holography topography interferometry metrology

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Rotational stability of plate haptic toric intraocular lenses after combined 25-gauge vitrectomy and cataract surgery

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International j.urnal of Ophthalmology(English edition) 2023年第8期16卷 1231-1236页

作者： Lara Buhl j.lian Langer Stefan Kassumeh Thomas C.Kreutzer wolfgang j.Mayer Siegfried G.Priglinger Department of Ophthalmology University HospitalLMU MunichMunich 80336Germany

AIM:To evaluate the postoperative intraocular lens(IOL)rotational stability and residual refractive astigmatism following combined 25-gauge vitrectomy and cataract surgery with implantation of a plate haptic toric ***:In this retrospective case series,32 eyes of 32 patients underwent a combined 25-gauge vitrectomy and phacoemulsification for vitreoretinal diseases and cataract with regular corneal astigmatism of at least 1 diopter(D).A plate haptic toric IOL(AT Torbi 709M,Carl Zeiss Meditec AG)was implanted in all *** outcome measures were rotational stability and refractive astigmatism up to 6mo postoperatively as well as the best corrected visual acuity(BCVA).RESULTS:Preoperative refractive astigmatism was 2.14±1.17 D,which was significantly reduced to 0.77±0.37 D six to eight weeks postoperatively and remained stable throughout the observation period(0.67±0.44 D at three months and 0.75±0.25 D at six months;for all groups:P<0.0001 compared to baseline).BCVA improved significantly from 0.36±0.33 logMAR preoperatively to 0.10±0.15 logMAR following surgery(P=0.02).Mean IOL axis deviation from the target axis was 3.4°±2.9°after six to eight weeks and significantly decreased over time(2.4°±2.6°six months after surgery;P=0.04).In one patient IOL,re-alignment was ***:Corneal astigmatism is significantly reduced following combined 25-gauge vitrectomy and cataract *** plate haptic toric IOL position and axis remain stable during the observation period of six months.

关键词： combined phaco-vitrectomy toric intraocular lens rotational stability corneal astigmatism cataract vitreoretinal disease

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