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Calculation on phase diagrams of polyetherimide/ N,N-dimethylacetamide/H2O-BuOH casting system and their relevance to membrane performances

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Frontiers of Chemical Science and Engineering 2014年第3期8卷 312-319页

作者： Ming TAN Gaohong HE Yan DAI Rujie WANG wenhua shi State Key Laboratory of Fine Chemicals R&D Center of Membrane Science and Technology School of Chemical Engineering Dalian University of Technology Dalian 116024 China Key Laboratory of Biobased Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China

The ternary phase diagrams of polyetherimide （PEI）/N,N-dimethylacetamide （DMAc） with H2O and BuOH as non-solvent were simulated using solubility parameter and Flory-Huggins theory. The phase diagrams show that 5.5% H2O/BuOH system containing 5% BuOH and 0.5% H2O or 6.5% H2O/BuOH system containing 6.2% BuOH and 0.3% H2O is required to induce liquid- liquid demixing for 20 wt-% PEI/DMAc casting solution. Therefore, BuOH can enhance the phase separation of the PEI casting solution and hereby induce higher porosity of the membrane, and the diffusion of BuOH into the water coagulation bath causes larger pore size easily compared with DMAc. Our predictions that the membrane pure water flux first increases then decreases, and the rejection ratio of bovine serum albumin decreases with the increasing concentration of BuOH were validated by the experiments using the prepared membranes.

关键词： phase diagram solubility parameter interaction parameter ultrafiltration Flory-Huggins theory

High responsivity photodetectors based on graphene/WSe_(2) heterostructure by photogating effect

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Chinese Physics B 2024年第1期33卷 728-733页

作者：李淑萍雷挺严仲兴王燕张黎可涂华垚时文华曾中明 Suzhou Industrial Park Institute of Services Outsourcing Suzhou 215123China Nanofabrication Facility Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China School of Nano Technology and Nano Bionics University of Science and Technology of ChinaHefei 230026China School of Electronics and Information Engineering Wuxi UniversityWuxi 214105China

Graphene, with its zero-bandgap electronic structure, is a highly promising ultra-broadband light absorbing ***, the performance of graphene-based photodetectors is limited by weak absorption efficiency and rapid recombination of photoexcited carriers, leading to poor photodetection performance. Here, inspired by the photogating effect, we demonstrated a highly sensitive photodetector based on graphene/WSe_(2) vertical heterostructure where the WSe_(2) layer acts as both the light absorption layer and the localized grating layer. The graphene conductive channel is induced to produce more carriers by capacitive coupling. Due to the strong light absorption and high external quantum efficiency of multilayer WSe_(2), as well as the high carrier mobility of graphene, a high photocurrent is generated in the vertical heterostructure. As a result, the photodetector exhibits ultra-high responsivity of 3.85×10~4A/W and external quantum efficiency of 1.3 × 10~7%.This finding demonstrates that photogating structures can effectively enhance the sensitivity of graphene-based photodetectors and may have great potential applications in future optoelectronic devices.

关键词： WSe_(2) heterostructure photodetector photogating effect

白藜芦醇调控肺动脉平滑肌细胞增殖的作用和分子机制

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国际呼吸杂志 2024年第7期44卷 825-830页

作者：史文花刘娟张永红柯蕊西安交通大学第二附属医院呼吸与危重症医学科西安710004

目的探讨白藜芦醇(Res)调控肺动脉平滑肌细胞(PASMCs)增殖的作用和分子机制。方法本研究为实验研究。体外分离培养大鼠原代PASMCs,采用免疫荧光法鉴定PASMCs,选用第3~6代细胞进行后续实验。比较不同浓度Res(10μmol/L Res干预组、30μmo... 详细信息

目的探讨白藜芦醇(Res)调控肺动脉平滑肌细胞(PASMCs)增殖的作用和分子机制。方法本研究为实验研究。体外分离培养大鼠原代PASMCs,采用免疫荧光法鉴定PASMCs,选用第3~6代细胞进行后续实验。比较不同浓度Res(10μmol/L Res干预组、30μmol/L Res干预组、100μmol/L Res干预组和300μmol/L Res干预组)对半乳糖凝集素3(Gal-3)诱导PASMCs增殖的影响,确定Res的最终干预浓度。根据给予Gal-3、Res、TD139处理和转染control干扰小RNA(siRNA)、Yes相关蛋白(YAP)siRNA的情况不同,将PASMCs分为7组:对照组(无处理)、Gal-3刺激组(30 nmol/L Gal-3刺激48 h)、Res刺激组(100μmol/L Res刺激48 h)、Res干预组(100μmol/L Res处理1 h,再加入30 nmol/L Gal-3刺激48 h)、TD139干预组(10μmol/L TD139作用1 h,再加入100μmol/L Res干预1 h和30 nmol/L Gal-3刺激48 h)、si-control组(转染control siRNA 24 h,再加入100μmol/L Res干预1 h和30 nmol/L Gal-3刺激48 h)和si-YAP组(转染YAP siRNA 24 h,再加入100μmol/L Res干预1 h和30 nmol/L Gal-3刺激48 h)。采用CCK-8实验检测PASMCs增殖能力。采用蛋白质印迹法检测对照组、Res刺激组PASMCs中Gal-3和YAP的表达水平,以及对照组、Gal-3刺激组、Res干预组和TD139干预组PASMCs中YAP的表达水平。结果Gal-3刺激组细胞增殖能力高于对照组,100μmol/L Res干预组、300μmol/L Res干预组细胞增殖能力均低于Gal-3刺激组[(1.36±0.10)比(0.87±0.13),(1.11±0.09)比(1.36±0.10),(1.00±0.11)比(1.36±0.10),均P<0.05],后续实验中将100μmol/L作为Res的干预浓度。Res刺激组Gal-3和YAP的表达水平均低于对照组[(0.49±0.12)比(1.00±0.10),(0.62±0.13)比(1.00±0.09),均P<0.05]。Gal-3刺激组YAP表达水平高于对照组,Res干预组YAP表达水平低于Gal-3刺激组,TD139干预组YAP表达水平低于Res干预组[(1.84±0.09)比(1.00±0.10),(1.13±0.11)比(1.84±0.09),(0.82±0.15)比(1.13±0.11),均P<0.05]。Gal-3刺激组细胞增殖能力高于对照组,Res干预组细胞增殖能力低于Gal-3刺激组,TD139干预组细胞增殖能力低于Res干预组,si-YAP组细胞增殖能力低于si-control组[(1.28±0.08)比(0.77±0.09),(1.03±0.07)比(1.28±0.08),(0.82±0.10)比(1.03±0.07),(0.80±0.06)比(1.02±0.09),均P<0.05]。结论Res可能通过抑制Gal-3/YAP信号通路抑制PASMCs增殖。

关键词：肺动脉高压肺动脉平滑肌细胞细胞增殖白藜芦醇半乳糖凝集素3 Yes相关蛋白

Yes相关蛋白调控肺动脉平滑肌细胞增殖的分子机制

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国际呼吸杂志 2024年第1期44卷 73-78页

作者：柯蕊和平张伟史文花张永红刘原西安交通大学第二附属医院呼吸与危重症医学科西安710004 西安交通大学第二附属医院健康体检部西安710004

目的研究Yes相关蛋白(YAP)调控肺动脉平滑肌细胞(PASMCs)增殖的分子机制。方法本研究为实验研究。选取健康SD大鼠,体质量70~80 g。培养大鼠PASMCs,根据是否给予S1P刺激将PASMCs分为S1P组和对照组,蛋白质印迹法检测细胞磷酸化YAP(p-YAP)... 详细信息

目的研究Yes相关蛋白(YAP)调控肺动脉平滑肌细胞(PASMCs)增殖的分子机制。方法本研究为实验研究。选取健康SD大鼠,体质量70~80 g。培养大鼠PASMCs,根据是否给予S1P刺激将PASMCs分为S1P组和对照组,蛋白质印迹法检测细胞磷酸化YAP(p-YAP)和β-catenin、CyclinD1蛋白水平。按照转染control干扰小RNA(siRNA)或YAP siRNA后再给予S1P刺激的情况不同,将PASMCs分为对照组、S1P组、si+S1P组、si-YAP+S1P组,蛋白质印迹法检测各组细胞中β-catenin和CyclinD1的蛋白水平。按照转染control siRNA或β-catenin siRNA后再给予S1P刺激的情况不同,将PASMCs分为对照组、S1P组、si+S1P组、si-β-catenin+S1P组,蛋白质印迹法检测各组细胞中CyclinD1的蛋白水平。按照转染control siRNA或YAP siRNA或β-catenin siRNA后再给予S1P刺激的情况不同,将PASMCs分为对照组、S1P组、si+S1P组、si-YAP+S1P组和si-β-catenin+S1P组,BrdU掺入法检测各组细胞增殖情况。结果S1P组p-YAP水平低于对照组[(0.61±0.09)比(1.00±0.11),P=0.009],β-catenin和CyclinD1蛋白水平高于对照组[(1.98±0.14)比(1.00±0.10),(1.94±0.15)比(1.00±0.08),均P=0.001]。si-YAP+S1P组β-catenin、CyclinD1水平均低于S1P组[(1.15±0.09)比(1.95±0.12),(1.18±0.16)比(1.96±0.05),均P<0.01]。si-β-catenin+S1P组CyclinD1水平低于S1P组[(1.18±0.24)比(1.95±0.24),P<0.01]。S1P组细胞增殖率高于对照组[(169.69±12.85)%比(100.00±12.52)%,P<0.01],si-YAP+S1P组、si-β-catenin+S1P组细胞增殖率均低于S1P组[(126.33±14.56)%比(169.69±12.85)%,(128.10±15.25)%比(169.69±12.85)%,均P<0.01]。结论YAP/β-catenin/CyclinD1信号通路可以调控PASMCs增殖。

关键词：肺动脉高压肺动脉平滑肌细胞细胞增殖 Yes相关蛋白 β-catenin

Dynamic Analysis of a 10 MW Floating Offshore Wind Turbine Considering the Tower and Platform Flexibility

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Journal of Ocean University of China 2024年第2期23卷 358-370页

作者： GAO Shan ZHANG Lixian shi Wei WANG wenhua WANG Bin LI Xin Key Laboratory of Far-Shore Wind Power Technology of Zhejiang Province Hangzhou 311122China State Key Laboratory of Coastal and Offshore Engineering Deepwater Engineering Research CenterDalian University of TechnologyDalian 116024China Powerchina Huadong Engineering Corporation Limited Hangzhou 311122China Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315000China

Recently,semisubmersible floating offshore wind turbine technologies have received considerable *** the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic *** dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed *** simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is *** effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are *** results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind *** the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid ***,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and ***,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.

关键词： floating offshore wind turbine TripleSpar semisubmersible platform rigidity and flexibility platform coupled simulation

Time-frequency mask estimation-based speech enhancement using deep encoder-decoder neural network

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Chinese Journal of Acoustics 2021年第1期40卷 141-154页

作者： shi wenhua ZHANG Xiongwei ZOU Xia SUN Meng LI Li REN Zhengbing Army Engineering University Nanjing 210007 Beijing Aeronautical Technology Research Center Nanjing 210028 First Military Representation Office of Air Force Equipment Department Changsha 410114

A time-frequency mask estimation using deep encoder-decoder neural network for speech enhancement is *** mask estimation is learned implicitly by the deep encoder-decoder neural network *** with the time-frequency representation of the noisy speech to learn the nonlinear mapping function between the noisy and target *** deep encoder-decoder neural network employs convolution and de-nonvolution *** convolution encoder makes use of the local perception characteristic of convolution network to model the typical structural features of noisy speech in the time-frequency *** features are extracted and the influence of background noise is *** the decoder end,the speech signal is reconstructed from the extracted speech features in the encoder end and the local details are recovered layer by ***,skip connections are introduced between homologous layers to circumvent the low level details losing problem induced by pooling and down-sampling *** are conducted on the TIMIT dataset and the results demonstrate that the proposed method can effectively suppress noise and recover the detailed information of speech.

关键词： decoder network neural

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不完全信息竞价模型在无线电频谱配置的应用

哈尔滨工业大学学报 2014年第5期46卷 125-128页

作者：刘纬华石文华东北大学工商管理学院沈阳110819 北京邮电大学经济管理学院北京100876

为探索资源产权制度和有偿使用制度的实现机制,以无线电频谱为例,依据一阶密封拍卖原理,通过建立运营商在无线电频谱拍卖过程中的不完全信息竞价模型,分析运营商的投标数量、竞价成功概率等因素对于运营商最优报价的影响以及中标者数量... 详细信息

为探索资源产权制度和有偿使用制度的实现机制,以无线电频谱为例,依据一阶密封拍卖原理,通过建立运营商在无线电频谱拍卖过程中的不完全信息竞价模型,分析运营商的投标数量、竞价成功概率等因素对于运营商最优报价的影响以及中标者数量对运营商期望利润函数的影响,并求解模型得出运营商报价的一般表达式.分析表明,将拍卖机制运用于无线电频谱资源分配,既充分体现频谱资源的经济价值,又有利于频谱资源的有效配置,同时是在运营商利润最大化前提下的优化决策.

关键词：资源配置频谱拍卖不完全信息

2022年福州市医疗卫生行业重点人群职业健康素养水平及影响因素分析

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社区医学杂志 2024年第8期22卷 253-257页

作者：邱凤金沈波刘建华刘佩芳吴京颖施文华韩仁杰郑敏芳高雅福州市疾病预防控制中心职业卫生科福建福州350004

目的了解福州市医疗卫生行业重点人群职业健康素养水平,分析其影响因素,为进一步实施干预措施提供依据。方法本研究对2022年福州市医疗卫生行业一线医护人员,采用概率比例规模抽样和分层整群随机抽样相结合的方法,应用《全国重点人群职... 详细信息

目的了解福州市医疗卫生行业重点人群职业健康素养水平,分析其影响因素,为进一步实施干预措施提供依据。方法本研究对2022年福州市医疗卫生行业一线医护人员,采用概率比例规模抽样和分层整群随机抽样相结合的方法,应用《全国重点人群职业健康素养监测调查个人问卷》进行调查;并采用χ^(2)检验、二分类logistic回归分析对调查结果进行统计学分析。结果2022年福州市医疗卫生行业一线医护人员职业健康素养率为54.58%(143/262,95%CI:48.49%~60.67%);二分类logistic回归分析显示,文化程度(OR值为2.895,95%CI:1.800~4.657)及户口性质(OR值为4.325,95%CI:1.749~10.693)是其重要影响因素,大专及以下学历组职业健康素养水平低于大学本科及以上学历组,农业户口性质组低于居民户口性质组,差异有统计学意义,均P<0.05。结论福州市医疗卫生行业重点人群职业健康素养水平有待提高,应从多层次、多维度、多方面采取措施对医护人员乃至全人群开展职业健康素养知识宣传与干预,以进一步提高医疗卫生行业重点人群乃至全人群职业健康素养水平。

关键词：医疗卫生行业重点人群职业健康素养影响因素

5省区2008年新课标生物学科高考模式及试卷的比较分析

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生物学通报 2009年第2期44卷 40-43页

作者：施问华江苏省滨海中学江苏滨海224500

广东、江苏等5个省区是全国实施高中新课程较早的地区。以这些省区的2008年高考为例,既比较分析了高考方案中生物学科的考查设置模式,又从高考试卷与新课程改革目标理念的相关性、反映新课程高考的创新性、与新课标不同版本教材的协同... 详细信息

广东、江苏等5个省区是全国实施高中新课程较早的地区。以这些省区的2008年高考为例,既比较分析了高考方案中生物学科的考查设置模式,又从高考试卷与新课程改革目标理念的相关性、反映新课程高考的创新性、与新课标不同版本教材的协同性、与以往高考的过渡性,以及课程标准内容在试卷中的分值和权重等方面,总结、归纳了生物学科高考试卷是如何与新课程改革进行对接的,获得了很多有益的启示。

关键词：新课程高考模式生物学科试卷分析