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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

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Frontiers of Medicine 2017年第3期11卷 386-392页

作者： li Zhuo Nianrong Zhang Guming Zou Dapeng Chen wenge li Department of Nephrology China-Japan Friendship Hospital Beijing 100029 China

Kidney damage is common in patients with diabetes mellitus （DM）. However, whether the type of kidney damage can be reliably diagnosed using clinical data alone remains unclear. Predictive factors for diabetic nephropathy （DN） outcomes are also poorly understood. In this study, the clinical manifestations of 111 cases of biopsy-proven DN were described, and the clinical and pathological parameters of patients with different DN outcomes were compared. Results showed that long DM duration （〉 10 years in 32.4% of patients）, severe proteinuria （62.2%）, and renal dysfunction （estimated glomerular filtration rate [eGFR] 〈 60 mL/（min. 1.73 m2））（52.3%） did not accurately indicate whether the condition of these patients progressed to DN. Hematuria （48.6%） failed to specify either DN or nondiabetic renal disease. Diabetic retinopathy （78.4%） was a crucial complication in patients with DN. Kaplan-Meier analysis revealed that the renal survival of 53 patients who were diagnosed with DN and were followed up was not significantly associated with glomerular classification （P 〉 0.05）. Cox＇s regression analysis demonstrated that renal survival time was significantly influenced by sex （β = 1.394, P = 0.038）, hematuria （β= 0.036, P = 0.029）, and eGFR （β= - 0.039, P = 0.002） but was not significantly affected by age, 24 h urinary protein excretion, or glomerular classification （P 〉 0.05）. In conclusion, the clinical characteristics of DN vary, and renal biopsy is necessary to determine renal damage patterns. Sex, hematuria, and the eGFR may affect DN outcomes, whereas the glomerular classification may not.

关键词： diabetic nephropathy clinical characteristics renal biopsy outcomes

A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds

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Bioactive Materials 2024年第4期34卷 298-310页

作者： Shunlai Shang Kaiting Zhuang Jianwen Chen Ming Zhang Shimin Jiang wenge li Department of Nephrology China-Japan Friendship HospitalBeijingChina Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing100853China Department of Nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing100020China

Mesenchymal stem cell derived exosomes(MSC-Exos)demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic ***(CS)exhibits excellent biocompatibility and accelerates cellular migration,adhesion,and *** ions released from bioactive glass(BG)and titanium dioxide(TiO_(2))nanoparticles exhibit sustained angiogenic and antibacterial *** this study,CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan(CMCS),chitosan nanoparticles(CS-NPs),BG,and TiO_(2)nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects,diabetic wounds,and burn skin injury due to *** vitro analysis indicated that the hydrogel exhibits excellent cell compatibility,stimulates endothelial cell adhesion and proliferation,and presents anti-inflammatory,angiogenic,and antibacterial *** vivo,the composite hydrogel dressing accelerated a wound healing acceleration effect,stimulated angiogenesis,and increased collagen deposition and the expression of anti-inflammatory *** innovative composite hydrogel dressing as a potential clinical therapy,utilizing bioactive materials,holds promise as a potential clinical therapy that aims to facilitate the regeneration of acute and chronically damaged skin tissue.

关键词： Exosomes Bioactive glass Diabetic wound Anti-inflammatory Titanium dioxide

Nano High Entropy Alloy Catalyst-A New Technology

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材料导报 2021年第22期35卷 I0001-I0002页

作者： ZHANG Shitao li wenge The Merchant Marine College Shanghai Maritime UniversityShanghai 201306China

Traditional material design concept has limited the development of higher performance *** a type of multi-element material,the high-entropy alloy(HEA),renovates the traditional alloy concept and exhibits excellent catalytic activity due to the high configuration entropy and catalytic *** nanoparticles(NPs)like Ru-NPs,Pt-NPs with a diameter of less than 10 nm have a better catalytic effect than large-size ***,the synergistic catalytic effect of HEA and NPs has been of great interest to researchers,creating a kind of new catalytic materials,namely HEA-NPs composites[1-2].

关键词： stability alloy catalytic

Robust UV/moisture dual curable PDMS-microcapsule-silica functional material for self-healing,antifouling,and antibacterial applications

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Nano Research 2023年第5期16卷 7810-7819页

作者： Nan Zheng Jie liu Guoqing Wang Pan Yao lihong Dang Ze liu Jiufu Lu wenge li Shaanxi Key Laboratory of Catalysis School of Chemical and Environmental ScienceShaanxi University of TechnologyHanzhong 723001China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China School of Biological Sciences and Engineering Shaanxi University of TechnologyHanzhong 723001China Merchant Marine College Shanghai Maritime UniversityShanghai 201306China

Polydimethylsiloxane containing methacryloyloxy and methoxy silane groups(MAPDMS)-microcapsule-SiO_(2)(MPMS)functional materials were prepared by constructing micro-nano hierarchical structures on the surface of MAPDMS ***,MAPDMS@1,1-stilbene-modified hydrolyzed polyglycidyl methacrylate/graphene oxide/dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride(MAPDMS@PGMA_(m)/GO/QC18)self-healing microcapsules with compact multi-shell structure were synthesized and combined with nano-SiO_(2)to construct the hierarchical ***,ultraviolet(UV)/moisture dual curing mode was introduced into deep curing reaction and efficient self-healing reaction of the *** results show that the introduction of UV/moisture dual curing mode and micro-nano hierarchical structure gives MPMS functional materials excellent mechanical properties,antifouling properties,self-healing properties,antibacterial *** shear strength and tensile strength of MPMS increase from 3.32 and 4.26 MPa of MAPDMS to 3.81 and 5.06 MPa,*** static contact angle increases from 115.9°of MAPDMS to 156.5°,its slide angle decreases from 68.5°of MAPDMS to 7.8°,*** antifouling performance of MPMS against seawater,soy sauce,juice,coffee,protein,other contaminants is effectively improved compared with MAPDMS *** the same time,the tensile strength and elongation at break of MPMS after healing reach 98.22%and 96.57%of those in original state,*** addition,the antibacterial rates of MPMS against Escherichia coli and Staphylococcus aureus reach 99.85%and 100%,*** MPMS prepared in this paper is expected to be widely used in marine antifouling,pipeline network,anti-icing,microfluidics,wearable devices,medical devices,electrochemical biosensors,other fields.

关键词： ultraviolet(UV)/moisture dual curing mechanism self-healing microcapsules micro-nano hierarchical structure antifouling antibacterial

Targeted therapy of kidney disease with nanoparticle drug delivery materials

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Bioactive Materials 2024年第7期37卷 206-221页

作者： Shunlai Shang Xiangmeng li Haoran Wang Yena Zhou Keying Pang Ping li Xiaomin liu Min Zhang wenge li Qinggang li Xiangmei Chen Department of Nephrology China-Japan Friendship HospitalBeijingChina Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province China Peking Union Medical College BeijingChina Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijingChina School of Medicine Nankai UniversityTianjinChina College of Pharmacy Hebei University of Chinese MedicineShijiazhuangHebei ProvinceChina Department of Nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijingChina

With the development of nanomedicine,nanomaterials have been widely used,offering specific drug delivery to target sites,minimal side effects,and significant therapeutic *** kidneys have filtration and reabsorption functions,with various potential target cell types and a complex structural environment,making the strategies for kidney function protection and recovery after injury *** also lays the foundation for the application of nanomedicine in kidney ***,evidence in preclinical and clinical settings supports the feasibility of targeted therapy for kidney diseases using drug delivery based on *** prerequisite for nanomedicine in treating kidney diseases is the use of carriers with good biocompatibility,including nanoparticles,hydrogels,liposomes,micelles,dendrimer polymers,adenoviruses,lysozymes,and elastin-like *** carriers have precise renal uptake,longer half-life,and targeted organ distribution,protecting and improving the efficacy of the drugs they ***,attention should also be paid to the toxicity and solubility of the *** the carriers mentioned above have been used in preclinical studies for targeted therapy of kidney diseases both in vivo and in vitro,extensive clinical trials are still needed to ensure the short-term and long-term effects of nano drugs in the human *** review will discuss the advantages and limitations of nanoscale drug carrier materials in treating kidney diseases,provide a more comprehensive catalog of nanocarrier materials,and offer prospects for their drug-loading efficacy and clinical applications.

关键词： Nanomedicine Materials Targeted drugs Kidney disease

Baseline proteinuria, urinary osmotic pressure, and renal function as positive predictors of corticosteroids plus cyclophosphamide treatment efficacy in IgA nephropathy

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Chinese Medical Journal 2014年第9期127卷 1710-1714页

作者： Fang Jing li wenge li Duo Tan Zhao Nephrology Department China-Japan Friendship Hospital Beijing 100029 China

Background Very limited data are available on factors predictive of corticosteroids plus cyclophosphamide treatment efficacy on IgA nephropathy （IgAN）.The aim of the study was to research the clinical factors predictive of treatment efficacy in *** One hundred and fifty-nine patients with IgAN （proteinuria ≥2 g/d and estimated glomerular filtration rate 30-89 ml·min-1·1.73 m-2） were treated with corticosteroids/cyclophosphamide followed by a 12-month *** to their response,these patients were divided into remission group （proteinuria ＜0.5 g/d） and non-remission group （proteinuria ≥0.5 g/d）,and their clinical data *** In the present study,72.96％ of the individuals underwent a complete remission,and their response was related to baseline proteinuria,urinary osmotic pressure,and renal function （P ＜0.05）.Patients with baseline proteinuria more than 3 g/d,urinary osmotic pressure greater than 600 mOsm/L,and eGFR 60-89 ml·min-1·1.73 m-2 responded well to the combination of corticosteroids and cyclophosphamide （86.90％ vs.57.33％,P=0.000; 81.48％ vs.64.10％,P=0.014; 83.17％ vs.55.17％,P=0.000）.Conclusion The response to the combination of corticosteroids and cyclophosphamide might be well associated with baseline proteinuria,urinary osmotic pressure,and renal function in patients with IgAN.

关键词： IgA nephropathy, proteinuria urinary osmotic pressure renal function treatment efficacy

Establishment and maintenance of autogenous arteriovenous fistula in hemodialysis patients:A new beacon

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Chronic Diseases and Translational Medicine 2021年第4期7卷 217-219页

作者： Hongtao Zhang wenge li Department of Nephrology Henan Provincial People's HospitalZhengzhouHenan 450003China Department of Nephrology China-Japan Friendship HospitalBeijing 100029China

Autogenous arteriovenous fistula(AVF)is a lifeline for maintenance hemodialysis *** 2006,the vascular access guidelines issued by the Kidney Disease Outcomes Quality Initiative(KDOQI)introduced the concept of“Fistula first”.1 In 2019,the same organization updated these vascular access guidelines and proposed the concept of“Patient first”,2 sparking a wide range of controversy and discussion on whether to abandon the“Fistula first”*** this context,experts from across China mainland conducted a comprehensive and systematic evaluation of the relevant literature,evidence-based medical guidelines,and international guidelines.

关键词： Hemodialysis Vascular access Autogenous arteriovenous fistula

Epidemiology of biopsy-proven glomerular diseases in Chinese children: A scoping review

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Chronic Diseases and Translational Medicine 2022年第4期8卷 271-280页

作者： Yetong li Yue Yang li Zhuo Dan Wu wenge li Xiaorong liu Department of Nephrology Beijing Children's HospitalNational Centerfor Children's HealthCapital Medical UniversityBeijingChina Department.of Nephrology China-Japan Friendship HospitalCapital Medical UniversityBeijingChina

Background: Glomerular disease is the leading cause of chronic kidney disease globally. No scoping review reports have focused on China’’s spectrum of glomerular diseases in children. This study aimed to systematically identify and describe retrospective studies on pediatric glomerular disease based on available data on sex, age, study period, and ***: Six databases were systematically searched for relevant studies from initiation to December 2021 in PubMed, Embase, Web of Science, Global Health library, Wangfang Database, and ***: Thirty-four studies were identified in the scoping review, including 40,430 patients with biopsy-proven diagnoses. The proportion of boys was significantly higher than that of girls. In this study, 28,280 (70%) cases were primary glomerular disease, 10,547 (26.1%) cases were diagnosed as secondary glomerular disease, and 1146 (2.8%) cases were hereditary glomerular disease. Minimal change disease is the most common glomerular disease among children in China, followed by mesangial proliferative glomerulonephritis, IgA nephropathy, and purpura nephritis. We observed increments in glomerular diseases in periods 2 (2001–2010) and 3 (2011–2021). The proportion of major glomerular diseases varies significantly in the different regions of ***: The spectrum of pediatric glomerular diseases varied across sex, age groups, study periods, and regions, and has changed considerably over the past 30 years.

关键词： child and adolescent China glomerular disease kidney glomerulus renal biopsy

工读学生攻击性行为与社会问题解决特点的研究

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中国特殊教育 2006年第2期 81-86页

作者：李闻戈广东外语艺术职业学院学前系广州510507

本研究采用投射测验,通过集体开放式问卷的形式来比较工读生和普通生攻击性行为社会问题解决的特点。结果表明:(1)和普通生相比,工读生在社会问题的解决中攻击性和操纵性反应比较明显,亲社会的策略较少。(2)当被要求寻找其他替代性的策... 详细信息

本研究采用投射测验,通过集体开放式问卷的形式来比较工读生和普通生攻击性行为社会问题解决的特点。结果表明:(1)和普通生相比,工读生在社会问题的解决中攻击性和操纵性反应比较明显,亲社会的策略较少。(2)当被要求寻找其他替代性的策略去解决问题时,工读生提出的解决问题的策略的数量通常少于普通学生,解决问题的方式、变通性和可行性都较普通学生差,可以看出他们缺乏人际冲突解决的必要技巧和方法。他们在社会问题解决上表现出的这些特点都和他们的攻击性行为有一定的关系。

关键词：工读学生攻击性行为社会问题解决