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肥胖导致的T细胞代谢障碍及相关疾病的研究进展

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现代免疫学 2024年第5期44卷 459-464页

作者：杨丽陶玲翁翔宇王辉信阳职业技术学院信阳464000 新乡医学院河南省免疫与靶向药物重点实验室新乡453003

肥胖会增加感染性疾病与肿瘤的发病风险。研究发现,肥胖可能从影响T细胞脂类和糖类代谢、促进炎性因子释放和T细胞衰老等方面造成T细胞代谢障碍,进而使机体发生感染后病死率增加,也是导致这些疾病流行的重要危险因素。肥胖和肿瘤预后不... 详细信息

肥胖会增加感染性疾病与肿瘤的发病风险。研究发现,肥胖可能从影响T细胞脂类和糖类代谢、促进炎性因子释放和T细胞衰老等方面造成T细胞代谢障碍,进而使机体发生感染后病死率增加,也是导致这些疾病流行的重要危险因素。肥胖和肿瘤预后不良相关,是其影响免疫代谢和促炎性作用的多因素综合结果。该文综述了肥胖对T淋巴细胞代谢障碍的研究进展,及T细胞代谢障碍在感染性疾病和肿瘤中的作用与治疗前景。

关键词：肥胖 T细胞代谢感染肿瘤

Ontogeny of immune organs during early development stage of P. crocea

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Acta Oceanologica Sinica 2007年第6期26卷 72-82页

作者： XU Xiaojin weng Zhaohong wang Jun SU Yongquan Department of Oceanography Institute of Subtropical Oceanography Xiamen University Xiamen 361005 China Key Laboratory of Science and Technology for Aquaculture and Food Safety Fisheries College Jimei University Xiamen 361021 China

A histological and ultrastructural study was performed on the development of the head kidney, thymus, and spleen in Pseudosciaena crocea aging in range from just hatching to the 60th day after hatching （DAH）. Head kidney was first present on the 3rd DAH. Primordial haemopoietic stem cells were first observed in the head kidney which rapidly differentiate into different cellular types. Progenitor spleen was present on the 4th DAH, located close to the gut, which soon became rich in blood capillaries, red blood cells and thrombocytes. The thymus was obvious on the 4th DAH, and was located on either side of the upper comer of the opercular cavity, closely under the membrance of the opercuhr cavity. The thymus was the last lymphoid organ to appear but showed a quick development. This organ seemed to originate from haemopoietic stem cells migrating from the head region of the kidney. The thymus consisted of outer thymocytic and inner epithelioid zones. There was no obvious demarcation between them, but both zones were visible. Small lymphocytes appeared, or lymphoid organs become lymphoid, in the sequence thymus, head kidney and spleen. Only a small number of lymphocytes appeared in the later stages. Non-specific systems may play an important role in the immunocompetence mechanisms of P. crocea during its early development stage.

关键词： Pseudosciaena crocea immune organs development ontogeny

Review of analyses on crowd-gathering risk and its evaluation methods

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Journal of Safety Science and Resilience 2023年第1期4卷 93-107页

作者： wenguo weng Jiayue wang Liangchang Shen Yushan Song Institute of Public Safety Research Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Public Order School People's Public Security University of ChinaBeijing 100038China

Overcrowding and stampedes may occur in public places with the gathering of *** mitigate and prevent risk,the accident mechanism and methods for monitoring and evaluating crowd-gathering risk were *** studies are reviewed and summarized in this *** evolution process of crowd-gathering risk and precipitating factors were explained *** monitoring methods are classified into three types according to the key technologies *** exploring risk evaluation methods for crowd gathering are outlined,and the three main paradigms were ***,the shortcomings and future research points are summarized to promote more in-depth and comprehensive studies on crowd-gathering risk,develop monitoring technologies,and build an integrated system of risk management.

关键词： Crowd-gathering risk Accident mechanism Risk monitoring Risk assessment

Preparation methods and thermal stability of Ba-Mn-Ce oxide catalyst for NOx-assisted soot oxidation

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Journal of Environmental Sciences 2011年第7期23卷 1205-1210页

作者： Xiaodong Wu Fan Lin Lei wang Duan weng Zhou Zhou Laboratory of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

Manganese oxide-loaded and -doped ceria as well as the corresponding barium-modified oxide catalysts were prepared for soot oxidation in the presence of NOx, and were characterized by using X-ray diffraction, Brunauer-Emmett-Teller and NO temperature- programmed oxidation measurements. The activity of catalyst depended strongly on the NO 2 production capacity, and the importance of surface nitrates was weakened without heat transfer limitations. The formation of perovskite-type oxides after the high-temperature calcination caused the loss of NOx storage capacity for the Ba-modified catalysts, but did not seem to affect the NO oxidation activity obviously. The addition of barium did not prevent the phase separation of MnOx-CeO 2 solid solutions, whereas it inhibited the sintering of oxide crystallites effectively. This, as well as the relatively high surface area, resulted in a small increase in soot oxidation temperature for the thermally aged Ba/Mn-Ce catalyst.

关键词： manganese oxide ceria barium soot oxidation NO 2 ageing

末道次冷轧变形量对Al-Mg-Si-Cu合金织构和力学性能的影响

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材料热处理学报 2024年第1期45卷 62-69页

作者：邱铨强吴蔚袁悠悠王茹翁瑶瑶吴萌南京工程学院材料科学与工程学院江苏南京211167

通过X射线衍射、电子背散射衍射技术和拉伸测试等研究了末道次冷轧变形量对汽车车身板用Al-Mg-Si-Cu合金板材织构、晶粒形貌和力学性能的影响。结果表明:在成分和冷轧后固溶处理工艺相同的情况下,织构是决定Al-Mg-Si-Cu合金板材力学性... 详细信息

通过X射线衍射、电子背散射衍射技术和拉伸测试等研究了末道次冷轧变形量对汽车车身板用Al-Mg-Si-Cu合金板材织构、晶粒形貌和力学性能的影响。结果表明:在成分和冷轧后固溶处理工艺相同的情况下,织构是决定Al-Mg-Si-Cu合金板材力学性能的主要因素。晶粒尺寸最大的33%试样反而获得了最高的抗拉强度和较低的屈强比。这是因为减小末道次冷轧变形量可以降低固溶及预时效处理状态下板材Cube和Cube+ND_(20)织构的含量,从而减少立方型织构对板材强度的损害。而末道次大变形量冷轧会促进再结晶时Copper、S和Brass织构向Cube和Cube+ND_(20)织构的转变,并抑制S织构转变成R织构,在实际生产中应当避免。

关键词： Al-Mg-Si-Cu合金冷轧变形量分配织构

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纳米C-S-H早强剂对水泥水化的影响研究

混凝土与水泥制品 2024年第3期 12-15,20页

作者：王可汗李伟郑春扬吉飞孔祥发王学川江苏奥莱特新材料股份有限公司江苏南京210000 东南大学江苏南京210000

通过凝结时间、水化温度、XRD、SEM、抗压强度试验等研究了纳米C-S-H早强剂对水泥水化及混凝土强度的影响,并分析了作用机理。结果表明:纳米C-S-H早强剂明显缩短了水泥的凝结时间;随着纳米C-S-H早强剂掺量的增加,水化温度峰出现时间缩短... 详细信息

通过凝结时间、水化温度、XRD、SEM、抗压强度试验等研究了纳米C-S-H早强剂对水泥水化及混凝土强度的影响,并分析了作用机理。结果表明:纳米C-S-H早强剂明显缩短了水泥的凝结时间;随着纳米C-S-H早强剂掺量的增加,水化温度峰出现时间缩短,且峰值提高;掺入适量的纳米C-S-H早强剂不改变水泥的水化产物种类,但加速了水泥水化进程,提高了混凝土的早期抗压强度,且后期(28 d、56 d)抗压强度无倒缩。

关键词：早强剂水化进程水化产物抗压强度

Enhanced CO_2 adsorptive performance of PEI/SBA-15 adsorbent using phosphate ester based surfactants as additives

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Journal of Environmental Sciences 2015年第12期27卷 1-7页

作者： Dandan Cheng Yue Liu Haiqiang wang Xiaole weng Zhongbiao Wu Department of Environmental Engineering Zhejiang University Zhejiang Provincial Engineering Research Center of Industrial Boiler and Furnace Flue Gas Pollution Control

In this study,a series of polyetherimide/SBA-15： 2-D hexagonal P6 mm,Santa Barbara USA（PEI/SBA-15） adsorbents modified by phosphoric ester based surfactants（including tri（2-ethylhexyl）phosphate（TEP）,bis（2-ethylhexyl） phosphate（BEP） and trimethyl phosphonoacetate（TMPA））were prepared for CO2 *** results indicated that the addition of TEP and BEP had positive effects on CO2 adsorption capacity over PEI/*** particular,the CO2 adsorption amount could be improved by around 20% for 45PEI-5TEP/SBA-15 compared to the additive-free *** could be attributed to the decrease of CO2 diffusion resistance in the PEI bulk network due to the interactions between TEP and loaded PEI molecules,which was further confirmed by adsorption kinetics *** addition,it was also found that the cyclic performance of the TEP-modified adsorbent was better than the surfactant-free *** could be due to two main reasons,based on the results of in situ DRIFT and TG-DSC *** and more importantly,adsorbed CO2 species could be desorbed more rapidly over TEP-modified adsorbent during the thermal desorption ***,the enhanced thermal stability after TEP addition ensured lower degradation of amine groups during adsorption/desorption cycles.

关键词： CO2 adsorption Tri(2-ethylhexyl) phosphate PEI/SBA-15 adsorbent Dispersion Surfactant

Quantifying the adsorption and uptake of CuO nanoparticles by wheat root based on chemical extractions

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Journal of Environmental Sciences 2011年第11期23卷 1852-1857页

作者： Dongmei Zhou Shengyang Jin Lianzhen Li Yu wang Nanyan weng Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

Extensive application of metal nanoparticles is attracting more attention because of their potential environmental *** studies have focused on the uptake of metal nanoparticles （NPs） by plant,but the adsorption of nanoparticles on root surface is often mistakenly regarded as their *** study optimized the methods to distinguish the adsorption and uptake of CuO-NPs on the wheat root by applying different metal competing ions （Na ＋,Mg 2＋,and La 3＋）,surfactant （i.e.,sodium dodecyl benzene sulfonate,SDBS）,or complexing agents like NaOAc and Na 4 EDTA,as well as ultrasonic *** results indicated that some CuO-NPs is strongly adsorbed on the plant root surface,and part of them by mechanical *** ions could not desorb the CuO-NPs from the root surface,while NaOAc and Na 4 EDTA well dissolved the adsorbed *** addition,the uptake and adsorption of CuO-NPs increased with increasing exposure concentrations of CuO-NPs in the range of 5–200 mg/*** amount of CuO-NPs adsorption is always lower than that of their uptake.

关键词： CuO-NPs root surface adsorption uptake

High-cycle Fatigue Fracture Behavior of Ultrahigh Strength Steels

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Journal of Materials Science & Technology 2008年第5期24卷 787-792页

作者： Weijun HUI Yihong NIE Han DONG Yuqing weng Chunxu wang State Key Laboratory of Advanced Steel Processing and Products Beijing 100081 China National Engineering Research Center of Advanced Steel Technology Beiing 100081 China Yanshan University Qinhuangdao 066004 China The Chinese Society for Metals Beijing 100711 China

The fatigue fracture behavior of four ultrahigh strength steels with different melting processes and therefore different inclusion sizes were studied by using a rotating bar two-point bending fatigue machine in the high-cycle regime up to 107 cycles of loading. The fracture surfaces were observed by field emission scanning electron microscopy （FESEM）. It was found that the size of inclusion has significant effect on the fatigue behavior. For AtSI 4340 steel in which the inclusion size is smaller than 5.5 μm, all the fatigue cracks except one did not initiated from inclusion but from specimen surface and conventional S-N curve exists. For 65Si2MnWE and Aermet 100 steels in which the average inclusion sizes are 12.2 and 14.9 μm, respectively, fatigue cracks initiated from inclusions at lower stress amplitudes and stepwise S-N curves were observed. The S-N curve displays a continuous decline and fatigue failures originated from large oxide inclusion for 60Si2CrVA steel in which the average inclusion size is 44.4 pro. In the case of internal inclusion-induced fractures at cycles beyond about 1×10^6 for 65Si2MnWE and 60Si2CrVA steels, inclusion was always found inside the fish-eye and a granular bright facet （GBF） was observed in the vicinity around the inclusion. The GBF sizes increase with increasing the number of cycles to failure Nf in the long-life regime. The values of stress intensity factor range at crack initiation site for the GBF are almost constant with Nf, and are almost equal to that for the surface inclusion and the internal inclusion at cycles lower than about 1×10^6. Neither fish-eye nor GBF was observed for Aermet 100 steel in the present study.

关键词： High-cycle fatigue Ultrahigh strength steel Inclusion S-N curve Fish-eye fracture