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SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation

Cancer Communications 2024年第3期44卷 384-407页

作者： Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu wenfeng song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong song Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China National Health Commission Key Laboratory of Combined Multi-organ Transplantation HangzhouZhejiangP.R.China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic CancerChinese Academy of Medical SciencesHangzhouZhejiangP.R.China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhouZhejiangP.R.China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China

Background:Liver cancer is a malignancy with high morbidity and mortality rates.Serpin family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many tumors.In this study,we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis.Methods:The Cancer Genome Atlas database(TCGA),including DNA methy-lation and transcriptome sequencing data,was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver can-cer.Data from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clin-ical parameters of patients.DNA methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and cells.RNA sequencing,cytokine assays,immunoprecipitation(IP)and mass spectrometry(MS)assays,protein stability assays,and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer metastasis.Patient-derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using sorafenib.Results:Based on the public database screening,SERPINE2 was identified as a tumor promoter regulated by DNA methylation.SERPINE2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver cancer.SERPINE2 promoted liver cancer metas-tasis by enhancing cell pseudopodia formation,cell adhesion,cancer-associated fibroblast activation,extracellular matrix remodeling,and angiogenesis.IP/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor(EGFR)and its downstream signaling pathways by interacting with EGFR.Mechanistically,SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase,c-Cbl.Additionally,EGFR was activated in liver cancer cells after sorafenib treatment,and SER-PINE2 knockdown-induced EGFR downregulation sig

关键词： liver cancer metastasis DNA methylation SERPINE2 EGFR c-Cbl ubiquitination

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Automatic image matting and fusing for portrait synthesis

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Science China(Information Sciences) 2022年第2期65卷 235-237页

作者： Zhike YI wenfeng song Shuai LI Aimin HAO State Key Laboratory of Virtual Reality Technology and Systems Beihang University

We propose an automatic image matting and fusing system for portrait synthesis in this study.We firstly use a face detection algorithm to determine if the input contains a face.Then,we use a semantic segmentation neural network to generate a trimap and feed the trimap and the portrait into the neural network to predict the alpha channel value.Finally,the input portrait’s background is replaced with the given background via an image synthesis algorithm to obtain the synthesized portrait.

关键词： Neural Network Automatic Image Matting Image Fusion Deep Learning Gradient Domain

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Effects of sulfur on variations in the chemical speciation of heavy metals from fly ash glass

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Frontiers of Environmental Science & Engineering 2023年第10期17卷 133-145页

作者： Yali Chang Jianwei Cao wenfeng song Zhi Wang Chenyang Xu Mengzhuo Long School of Mechanical Electronic and Information Engineering China University of Mining and TechnologyBeijing 100083China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center of Green Recycling for Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China

This work designed a new CaO-Al_(2)O_(3)-SiO_(2)-SO3 glass for the immobilization of multiple heavy metals found in dechlorinated fly ash having high amounts of calcium and sulfur. Increasing the (CaO + SO3)/SiO_(2) mass ratio (M(CS/S)) from 0.28 to 0.85 was found to lower the proportions of Mn, Ni and Zn in an unstable state, while an M(CS/S) ratio of 0.51 gave the lowest proportions of unstable Cr and Pb. Decreasing the degree of polymerization of the glassy network increased the proportions of Mn, Cr, Ni, Pb and Zn in the carbonate bound state. The leaching out of metals in this state was the primary cause of degradation of Q^(3) structural units in the glassy network. The amount of Mn in the iron-manganese oxide bound state was increased by increasing the number of Q^(2) units in the silicate network. Decreasing the CaO/SiO_(2) mass ratio (M(C/S)) raised the proportions of Mn, Ni and Zn in the unstable state. An M(C/S) value of 0.43 lowered the proportions of unstable Cr and Pb. A principal components analysis determined that the leaching of toxic heavy metals from the glass was primarily related to the proportions of these metals in the unstable state while there were no evident correlations between leaching and the proportions in stable states.

关键词： Dechlorinated fly ash SO_(3) Heavy metal Chemical speciation Glass solidification

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Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

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Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： Yang Zhao Junlin Lu Hongqi Zhang Tianxiao LI Donglei song Sheng Guan Aisha Maimaitili Yunyan Wang wenfeng Feng Yang Wang Jieqing Wan Guohua Mao Huaizhang Shi Xinjian Yang Jianmin Liu Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for patients.This study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world settings.Methods We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation.The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect relief.Subgroup analyses by aneurysm location,size and form were also performed.Results This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular aneurysms.Conclusions Our data confirmed the efficacy of PED in relieving mass effect.The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms.Trial registration number NCT03831672.

关键词： aneurysm intracranial Irvine

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Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening

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Bioactive Materials 2022年第12期7卷 164-177页

作者： Haijiang Dong Zequn Li Suchen Bian Guangyuan song wenfeng song Mingqi Zhang Haiyang Xie Shusen Zheng Xuxu Yang Tiefeng Li Penghong song Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineZhejiang ProvinceHangzhou310003China NHC Key Laboratory of Combined Multi-organ Transplantation Zhejiang ProvinceHangzhou310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment For Hepatobiliary and Pancreatic CancerChinese Academy of Medical Sciences(2019RU019)Zhejiang ProvinceHangzhou310003China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesZhejiang ProvinceHangzhou310003China Department of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s Hospital(People’s Hospital of Hangzhou Medical College)Zhejiang ProvinceHangzhou310014China Center for X-Mechanics Department of Engineering MechanicsZhejiang UniversityZhejiang ProvinceHangzhou310007China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang ProvinceHangzhou310007China

A personalized medication regimen provides precise treatment for an individual and can be guided by pre-clinical drug screening.The economical and high-efficiency simulation of the liver tumor microenvironment(TME)in a drug-screening model has high value yet challenging to accomplish.Herein,we propose a simulation of the liver TME with suspended alginate-gelatin hydrogel capsules encapsulating patient-derived liver tumor multicellular clusters,and the culture of patient-derived tumor organoids(PDTOs)for personalized pre-clinical drug screening.The hydrogel capsule offers a 3D matrix environment with mechanical and biological properties similar to those of the liver in vivo.As a result,18 of the 28 patient-derived multicellular clusters were successfully cultured as PDTOs.These PDTOs,along with hepatocyte growth factor(HGF)of non-cellular components,preserve stromal cells,including cancer-associated fibroblasts(CAFs)and vascular endothelial cells(VECs).They also maintain stable expression of molecular markers and tumor heterogeneity similar to those of the original liver tumors.Drugs,including cabazitaxel,oxaliplatin,and sorafenib,were tested in PDTOs.The sensitivity of PDTOs to these drugs differs between individuals.The sensitivity of one PDTO to oxaliplatin was validated using magnetic resonance imaging(MRI)and biochemical tests after oxaliplatin clinical treatment of the corresponding patient.Therefore,this approach is promising for economical,accurate,and high-throughput drug screening for personalized treatment.

关键词： Multicellular clusters Hydrogel capsules Tumor microenvironment Tumor heterogeneity Patient-derived tumor organoids Personalized pre-clinical drug screening

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齿轮高效精密磨削加工及表面完整性控制技术研究进展

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机械工程学报 2024年第7期60卷 350-373页

作者：丁文锋赵俊帅张洪港赵彪司文元宋强黄庆飞南京航空航天大学机电学院南京210016 中国航发中传机械有限公司长沙410200 苏州远东砂轮有限公司苏州215004

随着航空等高端装备工业的发展,传动齿轮高效率、高精度、高可靠性的需求日益增加。磨削加工技术是齿轮精密成形加工的重要工序,对齿轮的表面质量和服役寿命有着重要影响。由于齿轮的齿面结构复杂,淬硬表面材料难加工,齿轮磨削过程中存... 详细信息

随着航空等高端装备工业的发展,传动齿轮高效率、高精度、高可靠性的需求日益增加。磨削加工技术是齿轮精密成形加工的重要工序,对齿轮的表面质量和服役寿命有着重要影响。由于齿轮的齿面结构复杂,淬硬表面材料难加工,齿轮磨削过程中存在磨削力大、磨削温度高、磨削表面质量难以控制等问题,因此,国内外针对齿轮磨削加工技术开展了大量深入、系统研究并运用于实际生产中。在概述齿轮磨削加工研究发展现状的基础上,总结了国内外学者在齿轮高效加工、精密加工、磨削表面完整性创成机制等方面的主要研究成果。最后,对齿轮高效精密磨削加工技术的发展趋势进行了总结和展望,旨在为高性能齿轮制造提供理论和技术指导。

关键词：高效精密磨削齿轮磨削力磨削温度表面完整性

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具有飞行包线限制的飞翼无人机鲁棒自适应容错姿态控制

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兵工学报 2024年第1期45卷 231-240页

作者：禹志龙李颖晖裴彬彬徐文丰段效聪宋可鑫空军工程大学航空工程学院陕西西安710038 94657部队江西九江332024 95034部队广西百色533699

为实现复杂环境下飞翼无人机姿态的精确跟踪控制,考虑参数不确定性、外部扰动、执行器故障及飞行包线限制的影响,提出一种基于Nussbaum增益的鲁棒自适应容错控制方法。在受扰动的飞翼无人机姿态运动学与动力学模型基础上考虑执行器故障... 详细信息

为实现复杂环境下飞翼无人机姿态的精确跟踪控制,考虑参数不确定性、外部扰动、执行器故障及飞行包线限制的影响,提出一种基于Nussbaum增益的鲁棒自适应容错控制方法。在受扰动的飞翼无人机姿态运动学与动力学模型基础上考虑执行器故障与系统不确定的影响,建立面向控制的姿态控制模型。通过引入时变障碍Lyapunov函数,在保证飞行包线限制的同时确保姿态跟踪误差的瞬态与稳态性能。通过自适应的有界估计与Nussbaum增益,补偿总的不确定项与执行器故障的影响。通过稳定性分析严格证明新提出的控制方法的可行性。仿真结果表明,新的控制方法能够确保飞行包线限制,同时保证预设的瞬态与稳态性能,实现飞翼无人机高精度的姿态跟踪控制。

关键词：飞翼无人机飞行包线限制 Nussbaum增益自适应控制容错控制

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金属氧化物半导体MEMS气体传感器研究进展

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材料导报 2024年第1期38卷 34-47页

作者：尹嘉琦沈文锋吕大伍赵京龙胡鹏飞宋伟杰上海大学材料科学与工程学院中国科学院宁波材料技术与工程研究所中国科学院大学材料科学与光电子工程中心江西理工大学材料冶金化学学部

随着物联网的快速发展，各领域对气体监测的需求越来越大，基于先进微机电系统(Micro-electro-mechanical systems, MEMS)技术的金属氧化物半导体(Metal oxide semiconductor, MOS)气体传感器在过去几十年里取得了很大发展。MEMS微热板... 详细信息

随着物联网的快速发展，各领域对气体监测的需求越来越大，基于先进微机电系统(Micro-electro-mechanical systems, MEMS)技术的金属氧化物半导体(Metal oxide semiconductor, MOS)气体传感器在过去几十年里取得了很大发展。MEMS微热板的多样化设计、MOSs纳米结构的多样化以及机器学习算法的出现为MEMS的传感性能以及智能传感系统的构建提供了很大助力。本文从MEMS气体传感器的分类、制备和应用以及传感器阵列的构建等方面综述了金属氧化物半导体MEMS气体传感器的最新研究进展，并对MEMS基气体传感器的发展前景进行了总结和展望。

关键词：气体传感器金属氧化物半导体微机电系统传感器阵列智能传感系统

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Ammonia borane-enabled hydrogen transfer processes:Insights into catalytic strategies and mechanisms

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Green Energy & Environment 2023年第4期8卷 948-971页

作者： wenfeng Zhao Hu Li Heng Zhang song Yang Anders Riisager State Key Laboratory Breeding Base of Green Pesticide&Agricultural Bioengineering Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for Research&Development of Fine ChemicalsGuizhou UniversityGuiyang550025China Centre for Catalysis and Sustainable Chemistry Department of ChemistryKemitorvet Building 207Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark

Transfer hydrogenation(TH) with in situ generated hydrogen donor is of great importance in reduction reactions, and an alternative strategy to traditional hydrogenation processes involving pressurized molecular hydrogen. Ammonia borane(NH3BH3, AB) is a promising material of hydrogen storage, and it has attracted much attention in reductive organic transformations owing to its high activity, good atom economy, nontoxicity, sustainability, and ease of transport and storage. This review focuses on summarizing the recent progress of AB-mediated TH reactions of diverse substrates including nitro compounds, nitriles, imines, alkenes, alkynes, carbonyl compounds(ketones and aldehydes), carbon dioxide,and N-and O-heterocycles. Syntheses protocols(metal-containing and metal-free), the effect of reaction parameters, product distribution, and variation of reactivity are surveyed, and the mechanism of each reaction involving the action mode of AB as well as structure-activity relationships is discussed in detail. Finally, perspectives are presented to highlight the challenges and opportunities for AB-enabled TH reactions of unsaturated compounds.

关键词： Transfer hydrogenation Ammonia borane Hydrogen donor Reaction mechanism Catalytic strategies

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飞机动态RCS计算方法的修正与改进

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空军工程大学学报 2024年第1期25卷 39-46页

作者：徐文丰李颖晖裴彬彬宋亚南孙鹏飞空军工程大学航空工程学院西安710038 95841部队甘肃酒泉735000

飞机动态雷达散射截面(RCS)的分析能够为飞机隐身设计和测试评估提供重要理论支撑。针对现有动态RCS计算方法只能适用于有限角域的不足,对飞机本体系中雷达方位角的定义进行了修正,扩大了现有方法的适用范围。提出了一种新型的动态RCS... 详细信息

飞机动态雷达散射截面(RCS)的分析能够为飞机隐身设计和测试评估提供重要理论支撑。针对现有动态RCS计算方法只能适用于有限角域的不足,对飞机本体系中雷达方位角的定义进行了修正,扩大了现有方法的适用范围。提出了一种新型的动态RCS计算方法,解决了现有方法中雷达视线角与飞机RCS值无法建立一一映射关系的问题,使用飞机本体坐标系与雷达照射坐标系的欧拉旋转角表征飞机的动态RCS值,相比传统方法具有更高的准确性。最后,仿真验证了当飞机处于机动状态时,新型的动态RCS计算方法得出的结果与现有方法相比有显著差异,其有效提高了动态RCS计算的准确性。

关键词：飞机隐身雷达散射截面欧拉姿态角雷达视线角雷达照射坐标系

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